{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T20:12:09Z","timestamp":1793391129824,"version":"4.5.0"},"reference-count":159,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2021,12,14]],"date-time":"2021-12-14T00:00:00Z","timestamp":1639440000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>Arachidonic acid (AA) metabolism is critical in the initiation and resolution of inflammation. Prostaglandin E2 (PGE2) and leukotriene B4\/D4\/E4 (LTB4\/LD4\/LTE4), derived from AA, are involved in the initiation of inflammation and regulation of immune response, hematopoiesis, and M1 (pro-inflammatory) macrophage facilitation. Paradoxically, PGE2 suppresses interleukin-6 (IL-6) and tumor necrosis factor-\u03b1 (TNF-\u03b1) production and triggers the production of lipoxin A4 (LXA4) from AA to initiate inflammation resolution process and augment regeneration of tissues. LXA4 suppresses PGE2 and LTs\u2019 synthesis and action and facilitates M2 macrophage generation to resolve inflammation. AA inactivates enveloped viruses including SARS-CoV-2. Macrophages, NK cells, T cells, and other immunocytes release AA and other bioactive lipids to produce their anti-microbial actions. AA, PGE2, and LXA4 have cytoprotective actions, regulate nitric oxide generation, and are critical to maintain cell shape and control cell motility and phagocytosis, and inflammation, immunity, and anti-microbial actions. Hence, it is proposed that AA plays a crucial role in the pathobiology of ischemia\/reperfusion injury, sepsis, COVID-19, and other critical illnesses, implying that its (AA) administration may be of significant benefit in the prevention and amelioration of these diseases.<\/jats:p>","DOI":"10.3390\/biom11121873","type":"journal-article","created":{"date-parts":[[2021,12,14]],"date-time":"2021-12-14T09:34:25Z","timestamp":1639474465000},"page":"1873","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":175,"title":["Essential Fatty Acids and Their Metabolites in the Pathobiology of Inflammation and Its Resolution"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0191-9508","authenticated-orcid":false,"given":"Undurti N","family":"Das","sequence":"first","affiliation":[{"name":"UND Life Sciences, 2221 NW 5th St., Battle Ground, WA 98604, USA"},{"name":"International Research Centre, Biotechnologies of the Third Millennium, ITMO University, Saint Petersburg 191002, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,12,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1001\/jama.2020.12839","article-title":"Pathophysiology, Transmission, Diagnosis, and Treatment of Coronavirus Disease 2019 (COVID-19): A Review","volume":"324","author":"Wiersinga","year":"2020","journal-title":"JAMA"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/S2213-2600(20)30076-X","article-title":"Pathological findings of COVID-19 associated with acute respiratory distress syndrome","volume":"8","author":"Xu","year":"2020","journal-title":"Lancet Respir. Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"57555","DOI":"10.7554\/eLife.57555","article-title":"Kallikrein-kinin blockade in patients with COVID-19 to prevent acute respiratory distress syndrome","volume":"9","author":"Netea","year":"2020","journal-title":"eLife"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.cell.2020.08.025","article-title":"Loss of Bcl-6-Expressing T Follicular Helper Cells and Germinal Centers in COVID-19","volume":"183","author":"Kaneko","year":"2020","journal-title":"Cell"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1001\/jama.2020.17052","article-title":"Cytokine Levels in Critically Ill Patients With COVID-19 and Other Conditions","volume":"324","author":"Kox","year":"2020","journal-title":"JAMA"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1126\/science.abc6261","article-title":"Systems biological assessment of immunity to mild versus severe COVID-19 infection in humans","volume":"369","author":"Arunachalam","year":"2020","journal-title":"Science"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"8511","DOI":"10.1126\/science.abc8511","article-title":"Deep immune profiling of COVID-19 patients reveals distinct immunotypes with therapeutic implications","volume":"369","author":"Mathew","year":"2020","journal-title":"Science"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Das, U. (2021). \u201cCell Membrane Theory of Senescence\u201d and the Role of Bioactive Lipids in Aging, and Aging Associated Diseases and their Therapeutic Implications. Biomolecules, 11.","DOI":"10.3390\/biom11020241"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/0952-3278(95)90066-7","article-title":"Essential fatty acid metabolism in patients with essential hypertension, diabetes mellitus and coronary heart disease","volume":"52","author":"Das","year":"1995","journal-title":"Prostaglandins Leukot. Essent. Fat. Acids"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.ejphar.2015.08.049","article-title":"COX-2, aspirin and metabolism of arachidonic, eicosapentaenoic and docosahexaenoic acids and their physiological and clinical significance","volume":"785","author":"Poorani","year":"2016","journal-title":"Eur. J. Pharmacol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/1476-511X-7-37","article-title":"Essential fatty acids and their metabolites could function as endogenous HMG-CoA reductase and ACE enzyme inhibitors, anti-arrhythmic, anti-hypertensive, anti-atherosclerotic, anti-inflammatory, cytoprotective, and cardioprotective molecules","volume":"7","author":"Das","year":"2008","journal-title":"Lipids Health Dis."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/978-3-030-42667-5_3","article-title":"Bioactive Lipids in Age-Related Disorders","volume":"1260","author":"Das","year":"2020","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.nut.2016.10.004","article-title":"Arachidonic acid and lipoxinA4 attenuate streptozotocin-induced cytotoxicity to RIN5 F cells in vitro and type 1 and type 2 diabetes mellitus in vivo","volume":"35","author":"Gundala","year":"2017","journal-title":"Nutrition"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/j.arcmed.2020.05.002","article-title":"Resolvin D1 Ameliorates Nicotinamide-streptozotocin-induced Type 2 Diabetes Mellitus by its Anti-inflammatory Action and Modulating PI3K\/Akt\/mTOR Pathway in the Brain","volume":"51","author":"Bathina","year":"2020","journal-title":"Arch. Med. Res."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Bathina, S., and Das, U. (2021). Resolvin D1 Decreases Severity of Streptozotocin-Induced Type 1 Diabetes Mellitus by Enhancing BDNF Levels, Reducing Oxidative Stress, and Suppressing Inflammation. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22041516"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1038\/ni.1627","article-title":"Resolvin E1 regulates interleukin 23, interferon-\u03b3 and lipoxin A4 to promote the resolution of allergic airway inflammation","volume":"9","author":"Haworth","year":"2008","journal-title":"Nat. Immunol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1002\/biof.1336","article-title":"Arachidonic acid and lipoxin A4 attenuate alloxan-induced cytotoxicity to RIN5F cellsin vitroand type 1 diabetes mellitusin vivo","volume":"43","author":"Gundala","year":"2017","journal-title":"BioFactors"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1136\/bmj.292.6533.1423","article-title":"Linoleic acid content in adipose tissue and coronary heart disease","volume":"292","author":"Riemersma","year":"1986","journal-title":"BMJ"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0140-6736(84)91044-4","article-title":"Adipose tissue and platelet fatty acids and coronary heart disease in Scottish men","volume":"324","author":"Wood","year":"1984","journal-title":"Lancet"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0140-6736(87)90001-8","article-title":"Linoleic and eicosapentaenoic acids in adipose tissue and platelets and risk of coronary heart disease","volume":"329","author":"Wood","year":"1987","journal-title":"Lancet"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1738","DOI":"10.1136\/bmj.285.6356.1738-a","article-title":"Does low dietary and serum linoleic acid predispose to myocardial infarction?","volume":"285","author":"Wood","year":"1982","journal-title":"BMJ"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1055\/s-0038-1660071","article-title":"Platelet Aggregation in Finnish Men and Its Relation to Fatty Acids in Platelets, Plasma and Adipose Tissue","volume":"54","author":"Salo","year":"1985","journal-title":"Thromb. Haemost."},{"key":"ref_23","first-page":"1485","article-title":"Biological significance of arachidonic acid","volume":"15","author":"Das","year":"1987","journal-title":"Med. Sci. Res."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/S0140-6736(84)91256-X","article-title":"Dihomo-\u03b3-Linolenic acid as the endogenous protective agent for myocardial infarction","volume":"324","author":"Willis","year":"1984","journal-title":"Lancet"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/0262-1746(85)90162-3","article-title":"Dihomo-\u03b4-linolenic acid increases the metabolism of eicosapentaenoic acid in perfused vascular tissue","volume":"19","author":"Juan","year":"1985","journal-title":"Prostaglandins Leukot. Med."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1046\/j.1365-2567.2003.01749.x","article-title":"Dihomo-\u03b3-linolenic acid inhibits tumour necrosis factor-\u03b1 production by human leucocytes independently of cyclooxygenase activity","volume":"110","author":"Dooper","year":"2003","journal-title":"Immunology"},{"key":"ref_27","first-page":"1225","article-title":"Gamma-Linolenic Acid Suppresses NF-\u03ba\u0392 Signaling via CD36 in the Lipopolysaccharide-Induced Inflammatory Response in Primary Goat Mammary Gland Epithelial Cells","volume":"39","author":"Cao","year":"2016","journal-title":"Inflammation"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1007\/s10753-009-9157-8","article-title":"Gamma-Linolenic Acid Inhibits Inflammatory Responses by Regulating NF-\u03baB and AP-1 Activation in Lipopolysaccharide-Induced RAW 264.7 Macrophages","volume":"33","author":"Chang","year":"2010","journal-title":"Inflammation"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"531","DOI":"10.2174\/138920106779116874","article-title":"Gamma Linolenic Acid: An Antiinflammatory Omega-6 Fatty Acid","volume":"7","author":"Kapoor","year":"2006","journal-title":"Curr. Pharm. Biotechnol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.jnutbio.2014.12.007","article-title":"18-Carbon polyunsaturated fatty acids ameliorate palmitate-induced inflammation and insulin resistance in mouse C2C12 myotubes","volume":"26","author":"Chen","year":"2015","journal-title":"J. Nutr. Biochem."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.nutres.2019.10.004","article-title":"Fish oil supplementation with various lipid emulsions suppresses in vitro cytokine release in home parenteral nutrition patients: A crossover study","volume":"72","author":"Novak","year":"2019","journal-title":"Nutr. Res."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"2412","DOI":"10.1016\/j.jpedsurg.2010.08.044","article-title":"\u03c9-3 fatty acids suppress inflammatory cytokine production by macrophages and hepatocytes","volume":"45","author":"Hao","year":"2010","journal-title":"J. Pediatr. Surg."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"143","DOI":"10.2147\/JIR.S9425","article-title":"Current and emerging strategies for the treatment and management of systemic lupus erythematosus based on mo-lecular signatures of acute and chronic inflammation","volume":"3","author":"Das","year":"2010","journal-title":"J. Inflamm. Res."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"eaar8320","DOI":"10.1126\/sciadv.aar8320","article-title":"PGE 2 production at sites of tissue injury promotes an anti-inflammatory neutrophil phenotype and determines the outcome of inflammation resolution in vivo","volume":"4","author":"Loynes","year":"2018","journal-title":"Sci. Adv."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"6418","DOI":"10.4049\/jimmunol.0903816","article-title":"Resolution of inflammation in murine autoimmune arthritis is disrupted by cyclooxygenase-2 inhibi-tion and restored by prostaglandin E2-mediated lipoxin A4 production","volume":"184","author":"Chan","year":"2010","journal-title":"J. Immunol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1038\/9550","article-title":"Inducible cyclooxygenase may have anti-inflammatory properties","volume":"5","author":"Gilroy","year":"1999","journal-title":"Nat. Med."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Gobbetti, T., Le Faouder, P., Bertrand, J., Dubourdeau, M., Barocelli, E., Cenac, N., and Vergnolle, N. (2013). Polyunsaturated Fatty Acid Metabolism Signature in Ischemia Differs from Reperfusion in Mouse Intestine. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0075581"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1111\/bph.12957","article-title":"Protective effects of n-6 fatty acids-enriched diet on intestinal ischaemia\/reperfusion injury involve lipoxin A4and its receptor","volume":"172","author":"Gobbetti","year":"2014","journal-title":"Br. J. Pharmacol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1126\/science.aad9903","article-title":"Prostaglandin E 2 constrains systemic inflammation through an innate lymphoid cell\u2013IL-22 axis","volume":"351","author":"Duffin","year":"2016","journal-title":"Science"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"94463","DOI":"10.1172\/jci.insight.94463","article-title":"Pro-resolving mediators promote resolution in a human skin model of UV-killed Escherichia coli\u2013driven acute inflammation","volume":"3","author":"Motwani","year":"2018","journal-title":"JCI Insight"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"aaa2340","DOI":"10.1126\/science.aaa2340","article-title":"Inhibition of the prostaglandin-degrading enzyme 15-PGDH potentiates tissue regeneration","volume":"348","author":"Zhang","year":"2015","journal-title":"Science"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1084\/jem.20142235","article-title":"Biomechanical forces promote blood development through prostaglandin E2 and the cAMP\u2013PKA signaling axis","volume":"212","author":"Diaz","year":"2015","journal-title":"J. Exp. Med."},{"key":"ref_43","first-page":"1007","article-title":"Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis","volume":"447","author":"North","year":"2007","journal-title":"Nat. Cell Biol."},{"key":"ref_44","first-page":"365","article-title":"Differential stem- and progenitor-cell trafficking by prostaglandin E2","volume":"495","author":"Hoggatt","year":"2013","journal-title":"Nat. Cell Biol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"5444","DOI":"10.1182\/blood-2009-01-201335","article-title":"Prostaglandin E2 enhances hematopoietic stem cell homing, survival, and proliferation","volume":"113","author":"Hoggatt","year":"2009","journal-title":"Blood"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1995","DOI":"10.1182\/blood-2012-06-437889","article-title":"Prostaglandin E2 regulates murine hematopoietic stem\/progenitor cells directly via EP4 receptor and indirectly through mesenchymal progenitor cells","volume":"121","author":"Ikushima","year":"2013","journal-title":"Blood"},{"key":"ref_47","first-page":"346","article-title":"Lipoxin A4selectively programs the profile of M2 tumor-associated macrophages which favour control of tumor progression","volume":"140","author":"Morandi","year":"2016","journal-title":"Int. J. Cancer"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"7360","DOI":"10.1096\/fj.201902055R","article-title":"Prostaglandin E2 confers protection against diabetic coronary atherosclerosis by stimulating M2 macrophage polarization via the activation of the CREB\/BDNF\/TrkB signaling pathway","volume":"34","author":"Bi","year":"2020","journal-title":"FASEB J."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Yang, X., Li, S., Zhao, Y., Li, S., Zhao, T., Tai, Y., Zhang, B., Wang, X., Wang, C., and Chen, J. (2019). GRK2 Mediated Abnormal Transduction of PGE2-EP4-cAMP-CREB Signaling Induces the Imbalance of Macrophages Polarization in Collagen-Induced Arthritis Mice. Cells, 8.","DOI":"10.3390\/cells8121596"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"15642","DOI":"10.1073\/pnas.1519644112","article-title":"CREB pathway links PGE2 signaling with macrophage polarization","volume":"112","author":"Luan","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"2378","DOI":"10.1002\/jor.23553","article-title":"Pro-inflammatory M1 macrophages promote Osteogenesis by mesenchymal stem cells via the COX-2-prostaglandin E2 pathway","volume":"35","author":"Lu","year":"2017","journal-title":"J. Orthop. Res."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"5348","DOI":"10.7150\/thno.27385","article-title":"Prostaglandin E2 hydrogel improves cutaneous wound healing via M2 macrophages polarization","volume":"8","author":"Zhang","year":"2018","journal-title":"Theranostics"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"2573","DOI":"10.1096\/fj.13-227728","article-title":"The novel 13 S, 14 S-epoxy-maresin is converted by human macrophages to maresin 1 (MaR1), inhibits leukotriene A 4 hydrolase (LTA 4 H), and shifts macrophage phenotype","volume":"27","author":"Dalli","year":"2013","journal-title":"FASEB J."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1194\/jlr.RA119000281","article-title":"Macrophage polarization is linked to Ca2+-independent phospholipase A2\u03b2-derived lipids and cross-cell signaling in mice","volume":"61","author":"Nelson","year":"2020","journal-title":"J. Lipid Res."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.bbrc.2018.01.007","article-title":"Amelioration of streptozotocin-induced type 2 diabetes mellitus in Wistar rats by ara-chidonic acid","volume":"496","author":"Naveen","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Das, U.N. (2020). Molecular Biochemical Aspects of Cancer, Humana Press.","DOI":"10.1007\/978-1-0716-0741-1"},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Das, U.N. (2011). Molecular Basis of Health and Disease, Springer.","DOI":"10.1007\/978-94-007-0495-4"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"5335","DOI":"10.1073\/pnas.81.17.5335","article-title":"Lipoxins: Novel series of biologically active compounds formed from arachidonic acid in human leukocytes","volume":"81","author":"Serhan","year":"1984","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_59","first-page":"1","article-title":"Lipoxins: A New Series of Eicosanoids (Biosynthesis, Stereochemistry, and Biological Activities)","volume":"229","author":"Serhan","year":"1988","journal-title":"Lipoxins"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1161\/CIRCULATIONAHA.108.191627","article-title":"Omega-6 fatty acids and risk for cardiovascular disease: A science advisory from the American Heart Association Nutrition Subcommittee of the Council on Nutrition, Physical Activity, and Metabolism; Council on Cardiovascular Nursing; and Council on Epidemiology and Prevention","volume":"119","author":"Harris","year":"2009","journal-title":"Circulation"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"4713","DOI":"10.1128\/AAC.48.12.4713-4717.2004","article-title":"n-6 Polyunsaturated Fatty Acids Enhance the Activities of Ceftazidime and Amikacin in Experimental Sepsis Caused by Multidrug-Resistant Pseudomonas aeruginosa","volume":"48","author":"Mouktaroudi","year":"2004","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/1476-511X-13-30","article-title":"Dietary supplementation of arachidonic acid increases arachidonic acid and lipoxin A4 contents in colon, but does not affect severity or prostaglandin E2 content in murine colitis model","volume":"13","author":"Tateishi","year":"2014","journal-title":"Lipids Health Dis."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1476-511X-14-3","article-title":"Dietary supplementation with arachidonic acid increases arachidonic acid content in paw, but does not affect arthritis severity or prostaglandin E2 content in rat adjuvant-induced arthritis model","volume":"14","author":"Tateishi","year":"2015","journal-title":"Lipids Health Dis."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1186\/1476-511X-10-241","article-title":"Supplementation of arachidonic acid-enriched oil increases arachidonic acid contents in plasma phospholipids, but does not increase their metabolites and clinical parameters in Japanese healthy elderly individuals: A randomized controlled study","volume":"10","author":"Kakutani","year":"2011","journal-title":"Lipids Health Dis."},{"key":"ref_65","first-page":"179","article-title":"Arachidonic acid fights palmitate: New insights into fatty acid toxicity in \u03b2-cells","volume":"120","year":"2010","journal-title":"Clin. Sci."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1042\/CS20100282","article-title":"Arachidonic acid actions on functional in-tegrity and attenuation of the negative effects of palmitic acid in a clonal pancreatic \u03b2-cell line","volume":"120","author":"Keane","year":"2011","journal-title":"Clin. Sci."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s11010-011-1200-z","article-title":"Protective effects of arachidonic acid against palmitic acid-mediated lipotoxicity in HIT-T15 cells","volume":"364","author":"Cho","year":"2012","journal-title":"Mol. Cell. Biochem."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.nut.2019.05.007","article-title":"Arachidonic acid rich ARASCO oil has anti-inflammatory and anti-diabetic actions against high fat diet-induced type 2 diabetes mellitus in Wistar rats","volume":"66","author":"Naveen","year":"2019","journal-title":"Nutrition"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"38308","DOI":"10.1038\/srep38308","article-title":"Human Mesenchymal stem cells program macrophage plasticity by altering their metabolic status via a PGE2-dependent mechanism","volume":"6","author":"Vasandan","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1016\/j.bbrc.2018.03.096","article-title":"Adipose-derived stem cells ameliorate colitis by suppression of inflammasome formation and regulation of M1-macrophage population through prostaglandin E2","volume":"498","author":"Park","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"An, J.-H., Song, W.-J., Li, Q., Kim, S.-M., Yang, J.-I., Ryu, M.-O., Nam, A.R., Bhang, D.H., Jung, Y.-C., and Youn, H.-Y. (2018). Prostaglandin E2 secreted from feline adipose tissue-derived mesenchymal stem cells alleviate DSS-induced colitis by increasing regulatory T cells in mice. BMC Vet.-Res., 14.","DOI":"10.1186\/s12917-018-1684-9"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.5966\/sctm.2015-0243","article-title":"Human Mesenchymal Stem Cells Impact Th17 and Th1 Responses Through a Prostaglandin E2 and Myeloid-Dependent Mechanism","volume":"5","author":"Rozenberg","year":"2016","journal-title":"Stem Cells Transl. Med."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/0167-5699(91)90064-Z","article-title":"A new view of prostaglandin E regulation of the immune response","volume":"12","author":"Phipps","year":"1991","journal-title":"Immunol. Today"},{"key":"ref_74","first-page":"42","article-title":"Bone marrow stromal cells attenuate sepsis via prostaglandin E2\u2013dependent reprogramming of host macrophages to increase their interleukin-10 production","volume":"15","author":"Leelahavanichkul","year":"2008","journal-title":"Nat. Med."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"2283","DOI":"10.1002\/stem.1191","article-title":"Human Mesenchymal Stem\/Stromal Cells Cultured as Spheroids are Self-activated to Produce Prostaglandin E2 that Directs Stimulated Macrophages into an Anti-inflammatory Phenotype","volume":"30","author":"Bartosh","year":"2012","journal-title":"Stem Cells"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.molimm.2012.12.010","article-title":"PGE2 differentially regulates monocyte-derived dendritic cell cytokine responses depending on receptor usage (EP2\/EP4)","volume":"54","author":"Poloso","year":"2013","journal-title":"Mol. Immunol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1016\/j.tube.2015.08.003","article-title":"Immune parameters differentiating active from latent tuberculosis infection in humans","volume":"95","author":"Lee","year":"2015","journal-title":"Tuberculosis"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/j.tube.2014.07.002","article-title":"Circulating mycobacterial-reactive CD4+ T cells with an immunosuppressive phenotype are higher in active tuberculosis than latent tuberculosis infection","volume":"94","author":"Kim","year":"2014","journal-title":"Tuberculosis"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.tube.2010.05.003","article-title":"Regulatory T cell frequency and modulation of IFN-gamma and IL-17 in active and latent tuberculosis","volume":"90","author":"Marin","year":"2010","journal-title":"Tuberculosis"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1006\/clim.1999.4752","article-title":"CD4(+) T cell clones producing both inter-feron-gamma and interleukin-10 predominate in bronchoalveolar lavages of active pulmonary tuberculosis patients","volume":"92","author":"Gerosa","year":"1999","journal-title":"Clin. Immunol."},{"key":"ref_81","first-page":"1128","article-title":"Analysis of Th1 and Th2 cytokines expressing CD4+ and CD8+ T cells in rheumatoid arthritis by flow cytometry","volume":"27","author":"Berner","year":"2000","journal-title":"J. Rheumatol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.cyto.2007.11.022","article-title":"IL-23 and IL-17 in tuberculosis","volume":"41","author":"Khader","year":"2008","journal-title":"Cytokine"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1111\/iej.12871","article-title":"Up-regulation of IL-23 expression in human dental pulp fibroblasts by IL-17 via activation of the NF-\u03baB and MAPK pathways","volume":"51","author":"Wei","year":"2018","journal-title":"Int. Endod. J."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/j.molimm.2010.11.008","article-title":"IL-17R activation of human periodontal ligament fibroblasts induces IL-23 p19 production: Differential involvement of NF-\u03baB versus JNK\/AP-1 pathways","volume":"48","author":"Zhu","year":"2011","journal-title":"Mol. Immunol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1093\/rheumatology\/kem055","article-title":"Interleukin (IL)-23 p19 expression induced by IL-1beta in human fibroblast-like synoviocytes with rheumatoid arthritis via active nuclear factor-kappaB and AP-1 dependent pathway","volume":"46","author":"Liu","year":"2007","journal-title":"Rheumatology"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1093\/rheumatology\/kel159","article-title":"Up-regulation of IL-23p19 expression in rheumatoid arthritis synovial fibroblasts by IL-17 through PI3-kinase-, NF- B- and p38 MAPK-dependent signalling pathways","volume":"46","author":"Kim","year":"2007","journal-title":"Rheumatology"},{"key":"ref_87","first-page":"187","article-title":"Polarization of the Innate Immune Response by Prostaglandin E2: A Puzzle of Receptors and Signals","volume":"85","author":"Domingo","year":"2013","journal-title":"Mol. Pharmacol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"163","DOI":"10.18240\/ijo.2020.01.23","article-title":"Molecular pathobiology of scleritis and its therapeutic implications","volume":"13","author":"Das","year":"2020","journal-title":"Int. J. Ophthalmol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"20192117","DOI":"10.1042\/BSR20192117","article-title":"Bioactive lipids in intervertebral disc degeneration and its therapeutic implications","volume":"39","author":"Das","year":"2019","journal-title":"Biosci. Rep."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"673","DOI":"10.2147\/JIR.S278335","article-title":"Inflammatory Cytokine: IL-17A Signaling Pathway in Patients Present with COVID-19 and Current Treatment Strategy","volume":"13","author":"Shibabaw","year":"2020","journal-title":"J. Inflamm. Res."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/s41577-020-0312-7","article-title":"COVID-19: Risk for cytokine targeting in chronic inflammatory diseases?","volume":"20","author":"Schett","year":"2020","journal-title":"Nat. Rev. Immunol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1089\/vim.2020.0177","article-title":"T Helper 17 Response to Severe Acute Respiratory Syndrome Coronavirus 2: A Type of Immune Response with Possible Therapeutic Implications","volume":"34","author":"Garavito","year":"2021","journal-title":"Viral Immunol."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"892","DOI":"10.4049\/jimmunol.2000554","article-title":"A Case for Targeting Th17 Cells and IL-17A in SARS-CoV-2 Infections","volume":"205","author":"Orlov","year":"2020","journal-title":"J. Immunol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.jmii.2020.03.005","article-title":"TH17 responses in cytokine storm of COVID-19: An emerging target of JAK2 inhibitor Fedratinib","volume":"53","author":"Wu","year":"2020","journal-title":"J. Microbiol. Immunol. Infect."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13578-020-00431-1","article-title":"Interleukin-17 promotes nitric oxide-dependent expression of PD-L1 in mesenchymal stem cells","volume":"10","author":"Wang","year":"2020","journal-title":"Cell Biosci."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.cytogfr.2003.10.003","article-title":"Inducible nitric oxide synthase activation by interleukin-17","volume":"15","author":"Miljkovic","year":"2004","journal-title":"Cytokine Growth Factor Rev."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1007\/s000180300043","article-title":"The role of interleukin-17 in inducible nitric oxide synthase-mediated nitric oxide production in endothelial cells","volume":"60","author":"Miljkovic","year":"2003","journal-title":"Cell Mol. Life Sci."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"1758","DOI":"10.1038\/cdd.2014.85","article-title":"Interleukin-17 enhances immunosuppression by mesenchymal stem cells","volume":"21","author":"Han","year":"2014","journal-title":"Cell Death Differ."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.jdermsci.2017.10.016","article-title":"Resolvin D1 attenuates imiquimod-induced mice psoriasiform dermatitis through MAPKs and NF-\u03baB pathways","volume":"89","author":"Xu","year":"2018","journal-title":"J. Dermatol. Sci."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"637983","DOI":"10.3389\/fimmu.2021.637983","article-title":"Resolvin E1 Regulates Th17 Function and T Cell Activation","volume":"12","author":"Oner","year":"2021","journal-title":"Front. Immunol."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"8","DOI":"10.33160\/yam.2018.03.002","article-title":"Resolvin E1 Inhibits Osteoclastogenesis and Bone Resorption by Suppressing IL-17-induced RANKL Expression in Osteo-blasts and RANKL-induced Osteoclast Differentiation","volume":"61","author":"Funaki","year":"2018","journal-title":"Yonago Acta Med."},{"key":"ref_102","first-page":"2758","article-title":"Maresin 1 ameliorates iron-deficient anemia in IL-10(\u2212\/\u2212) mice with spontaneous colitis by the inhibition of hepcidin expression though the IL-6\/STAT3 pathway","volume":"8","author":"Wang","year":"2016","journal-title":"Am. J. Transl. Res."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"745","DOI":"10.5152\/tjg.2019.18276","article-title":"A bioactive product lipoxin A4 at-tenuates liver fibrosis in an experimental model by regulating immune response and modulating the expression of regeneration genes","volume":"30","author":"Kayhan","year":"2019","journal-title":"Turk. J. Gastroenterol."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"875","DOI":"10.4049\/jimmunol.1500244","article-title":"Human Mesenchymal Stem (Stromal) Cells Promote the Resolution of Acute Lung Injury in Part through Lipoxin A4","volume":"195","author":"Fang","year":"2015","journal-title":"J. Immunol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.freeradbiomed.2016.01.026","article-title":"Lipoxin A4 attenuates LPS-induced mouse acute lung injury via Nrf2-mediated E-cadherin expression in airway epithelial cells","volume":"93","author":"Cheng","year":"2016","journal-title":"Free Radic. Biol. Med."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"216","DOI":"10.14336\/AD.2020.0228","article-title":"Transplantation of ACE2- Mesenchymal Stem Cells Improves the Outcome of Patients with COVID-19 Pneumonia","volume":"11","author":"Leng","year":"2020","journal-title":"Aging Dis."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1038\/ni.3002","article-title":"Plasticity of mesenchymal stem cells in immunomodulation: Pathological and thera-peutic implications","volume":"15","author":"Wang","year":"2014","journal-title":"Nat. Immunol."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"873","DOI":"10.17219\/acem\/73720","article-title":"Anti-inflammatory and antioxidant effects of mesenchymal and hematopoietic stem cells in a rheumatoid arthritis rat model","volume":"27","author":"Abdelmawgoud","year":"2018","journal-title":"Adv. Clin. Exp. Med."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.ebiom.2019.06.016","article-title":"Clearance of apoptotic cells by mesenchymal stem cells contributes to immunosuppression via PGE2","volume":"45","author":"Zhang","year":"2019","journal-title":"EBioMedicine"},{"key":"ref_110","first-page":"1350","article-title":"Polyunsaturated fatty acids modify the extracellular vesicle membranes and increase the production of proresolving lipid mediators of human mesenchymal stromal cells","volume":"1864","author":"Holopainen","year":"2019","journal-title":"Biochim. Biophys. Acta (BBA)-Mol. Cell Biol. Lipids"},{"key":"ref_111","first-page":"771","article-title":"Mesen-chymal Stromal Cells and Their Extracellular Vesicles Enhance the Anti-Inflammatory Phenotype of Regulatory Macrophages by Downregulating the Production of Interleukin (IL)-23 and IL-22","volume":"8","author":"Holopainen","year":"2018","journal-title":"Front. Immunol."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1177\/0963689718780304","article-title":"Preconditioning Enhances the Therapeutic Effects of Mesenchymal Stem Cells on Colitis Through PGE2-Mediated T-Cell Modulation","volume":"27","author":"Yang","year":"2018","journal-title":"Cell Transplant."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.rvsc.2018.05.011","article-title":"Canine mesenchymal stem cells treated with TNF-\u03b1 and IFN-\u03b3 enhance anti-inflammatory effects through the COX-2\/PGE2 pathway","volume":"119","author":"Yang","year":"2018","journal-title":"Res. Vet. Sci."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13287-017-0744-6","article-title":"mTOR inhibition improves the immunomodulatory properties of human bone marrow mesenchymal stem cells by inducing COX-2 and PGE2","volume":"8","author":"Wang","year":"2017","journal-title":"Stem Cell Res. Ther."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1007\/s12015-017-9793-6","article-title":"Involvement of TLR3-Dependent PGES Expression in Immunosuppression by Human Bone Marrow Mesenchymal Stem Cells","volume":"14","author":"Kim","year":"2018","journal-title":"Stem Cell Rev. Rep."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"746","DOI":"10.14336\/AD.2020.0521","article-title":"Bioactive Lipids as Mediators of the Beneficial Action(s) of Mesenchymal Stem Cells in COVID-19","volume":"11","author":"Das","year":"2020","journal-title":"Aging Dis."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"3069","DOI":"10.12659\/MSM.914860","article-title":"Mesenchymal stem cells reverse diabetic nephropathy disease via lipoxin A4 by targeting transforming growth factor \u03b2 (TGF-\u03b2)\/smad pathway and pro-Inflammatory cytokines","volume":"25","author":"Bai","year":"2019","journal-title":"Med. Sci. Monit."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1128\/iai.26.3.1202-1210.1979","article-title":"Bactericidal Effect of Oleic Acid on Group A Streptococci: Mechanism of Action","volume":"26","author":"Speert","year":"1979","journal-title":"Infect. Immun."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1172\/JCI108468","article-title":"Enhancement of bactericidal capacity of alveolar macrophages by human alveolar lining material","volume":"58","author":"Juers","year":"1976","journal-title":"J. Clin. Investig."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1128\/br.18.2.147-163.1954","article-title":"Influence of trace amounts of fatty acids on the growth of microorganisms","volume":"18","author":"Nieman","year":"1954","journal-title":"Bacteriol. Rev."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1128\/AAC.2.1.23","article-title":"Fatty Acids and Derivatives as Antimicrobial Agents","volume":"2","author":"Kabara","year":"1972","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1128\/AAC.8.6.742","article-title":"Antimicrobial Effect of Simple Lipids with Different Branches at the Methyl End Group","volume":"8","author":"Larsson","year":"1975","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1128\/jcm.9.3.333-335.1979","article-title":"Susceptibility of Staphylococcus aureus and group A, B, C, and G streptococci to free fatty acids","volume":"9","author":"Heczko","year":"1979","journal-title":"J. Clin. Microbiol."},{"key":"ref_124","first-page":"415","article-title":"The fungistatic and fungicidal action of fatty acids and related compounds","volume":"7","author":"Wyss","year":"1945","journal-title":"Arch. Biochem."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1084\/jem.71.5.661","article-title":"The inactivation of the virus of epidemic influenza by soaps","volume":"71","author":"Stock","year":"1940","journal-title":"J. Exp. Med."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1128\/AAC.15.1.67","article-title":"Extreme Sensitivity of Enveloped Viruses, Including Herpes Simplex, to Long-Chain Unsaturated Monoglycerides and Alcohols","volume":"15","author":"Sands","year":"1979","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1007\/BF01320626","article-title":"Unsaturated free fatty acids inactivate animal enveloped viruses","volume":"66","author":"Kohn","year":"1980","journal-title":"Arch. Virol."},{"key":"ref_128","first-page":"14","article-title":"Inactivation of lipid-enveloped viruses in labile blood derivatives by unsaturated fatty acids","volume":"54","author":"Horowitz","year":"1988","journal-title":"Vox Sang."},{"key":"ref_129","first-page":"1350","article-title":"Anti-biotic-like action of essential fatty acids","volume":"132","author":"Das","year":"1985","journal-title":"Can. Med. Assoc. J."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1093\/ajcn\/83.2.390","article-title":"Do unsaturated fatty acids function as endogenous anti-bacterial and anti-viral molecules?","volume":"83","author":"Das","year":"2006","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_131","first-page":"900","article-title":"Can essential fatty acid deficiency predispose to AIDS?","volume":"132","author":"Das","year":"1985","journal-title":"Can. Med. Assoc. J."},{"key":"ref_132","first-page":"RA206","article-title":"Essential fatty acids and acquired immunodeficiency syndrome","volume":"11","author":"Das","year":"2005","journal-title":"Med. Sci. Monit."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.jare.2018.01.001","article-title":"Arachidonic acid and other unsaturated fatty acids and some of their metabolites function as endogenous antimi-crobial molecules: A review","volume":"11","author":"Das","year":"2018","journal-title":"J. Adv. Res."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1128\/jb.111.2.525-530.1972","article-title":"Effects of Acetate and Other Short-Chain Fatty Acids on Sugar and Amino Acid Uptake of Bacillus subtilis","volume":"111","author":"Sheu","year":"1972","journal-title":"J. Bacteriol."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/BF01870466","article-title":"Unsaturated fatty acid requirement in Escherichia coli. Mechanism of palmitate-induced inhibition of growth by strain WNl","volume":"1982","author":"Ingram","year":"1982","journal-title":"J. Membr. Biol."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1128\/jb.132.3.790-795.1977","article-title":"Inhibitory action of a non-metabolizable fatty acid on the growth of Escherichia coli: Role of metabolism and outer membrane integrity","volume":"132","author":"Fay","year":"1977","journal-title":"J. Bacteriol."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.plefa.2016.01.001","article-title":"Resolvin D3 multi-level proresolving actions are host protective during infection","volume":"138","author":"Norris","year":"2018","journal-title":"Prostaglandins Leukot. Essent. Fat. Acids"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.arcmed.2020.03.004","article-title":"Can Bioactive Lipids Inactivate Coronavirus (COVID-19)?","volume":"51","author":"Das","year":"2020","journal-title":"Arch. Med. Res."},{"key":"ref_139","doi-asserted-by":"crossref","unstructured":"Das, U.N. (2020). Can Bioactive Lipid Arachidonic Acid Prevent and Ameliorate COVID-19?. Medicina (Kaunas), 56.","DOI":"10.3390\/medicina56090418"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.arcmed.2020.09.006","article-title":"Bioactive Lipids in COVID-19-Further Evidence","volume":"52","author":"Das","year":"2021","journal-title":"Arch. Med. Res."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"111052","DOI":"10.1016\/j.nut.2020.111052","article-title":"Essential fatty acids and their metabolites in the pathobiology of (coronavirus disease 2019) COVID-19","volume":"82","author":"Das","year":"2020","journal-title":"Nutrition"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1126\/science.abd3255","article-title":"Free fatty acid binding pocket in the locked structure of SARS-CoV-2 spike protein","volume":"370","author":"Toelzer","year":"2020","journal-title":"Science"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"5207","DOI":"10.1038\/s41598-021-84850-1","article-title":"Polyunsaturated \u03c9-3 fatty acids inhibit ACE2-controlled SARS-CoV-2 binding and cellular entry","volume":"11","author":"Goc","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.cell.2020.05.032","article-title":"Proteomic and Metabolomic Characterization of COVID-19 Patient Sera","volume":"182","author":"Shen","year":"2020","journal-title":"Cell"},{"key":"ref_145","doi-asserted-by":"crossref","unstructured":"Yan, B., Chu, H., Yang, D., Sze, K.-H., Lai, P.-M., Yuan, S., Shuai, H., Wang, Y., Kao, R.Y.-T., and Chan, J.F.-W. (2019). Characterization of the Lipidomic Profile of Human Coronavirus-Infected Cells: Implications for Lipid Metabolism Remodeling upon Coronavirus Replication. Viruses, 11.","DOI":"10.3390\/v11010073"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"864","DOI":"10.4049\/jimmunol.1801674","article-title":"Cyclooxygenase-1 Regulates the Development of Follicular Th Cells via Prostaglandin E2","volume":"203","author":"Liu","year":"2019","journal-title":"J. Immunol."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1007\/s11596-020-2225-x","article-title":"Deficiency of Tfh Cells and Germinal Center in Deceased COVID-19 Patients","volume":"40","author":"Duan","year":"2020","journal-title":"Curr. Med. Sci."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"e59177","DOI":"10.7554\/eLife.59177","article-title":"A mechanistic model and therapeutic interventions for COVID-19 involving a RAS-mediated bradykinin storm","volume":"9","author":"Garvin","year":"2020","journal-title":"eLife"},{"key":"ref_149","doi-asserted-by":"crossref","unstructured":"Candelario, J., and Chachisvilis, M. (2013). Activity of Bradykinin B2 Receptor Is Regulated by Long-Chain Polyunsaturated Fatty Acids. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0068151"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"6197","DOI":"10.1126\/sciimmunol.abd6197","article-title":"Longitudinal immune profiling reveals key myeloid signatures associated with COVID-19","volume":"5","author":"Mann","year":"2020","journal-title":"Sci. Immunol."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"4235","DOI":"10.4049\/jimmunol.1401313","article-title":"Aging delays resolution of acute inflammation in mice: Repro-gramming the host response with novel nano-proresolving medicines","volume":"193","author":"Arnardottir","year":"2014","journal-title":"J. Immunol."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1186\/s13054-020-03249-y","article-title":"Vitamin C levels in patients with SARS-CoV-2-associated acute respiratory distress syndrome","volume":"24","author":"Roca","year":"2020","journal-title":"Crit. Care"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/0952-3278(88)90073-7","article-title":"Enhanced prostaglandin synthesis as a mechanism for inhibition of melanoma cell growth by ascorbic acid","volume":"34","author":"Gardiner","year":"1988","journal-title":"Prostaglandins Leukot. Essent. Fat. Acids"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/0262-1746(85)90022-8","article-title":"Ascorbic acid enhances the formation of prostaglandin E1 in washed human platelets and prostacyclin in rat aortic rings","volume":"18","author":"Srivastava","year":"1985","journal-title":"Prostaglandins Leukot. Med."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"1943","DOI":"10.1097\/00003246-200110000-00016","article-title":"Intraoperative prostaglandin E1 improves antimicrobial and inflammatory responses in alveolar immune cells","volume":"29","author":"Kotani","year":"2001","journal-title":"Crit. Care Med."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/S0899-9007(01)00518-4","article-title":"Is insulin an anti-inflammatory molecule?","volume":"17","author":"Das","year":"2001","journal-title":"Nutrition"},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1007\/s001250051497","article-title":"Possible beneficial action(s) of glucose-insulin-potassium regimen in acute myocardial infarction and inflammatory conditions: A hypothesis","volume":"43","author":"Das","year":"2000","journal-title":"Diabetologia"},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1097\/CCM.0b013e3181782335","article-title":"Insulin inhibits tumor necrosis factor-alpha induction in myocardial ische-mia\/reperfusion: Role of Akt and endothelial nitric oxide synthase phosphorylation","volume":"36","author":"Li","year":"2008","journal-title":"Crit. 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