{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T14:22:46Z","timestamp":1790432566386,"version":"4.1.0"},"reference-count":196,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2021,12,21]],"date-time":"2021-12-21T00:00:00Z","timestamp":1640044800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministerio de Educaci\u00f3n Nacional, Ministerio de Industria, Comercio y Turismo, ICETEX and World Bank","award":["792-2017 2a Convocatoria Ecosistema Cient\u00edfico\u2010Colombia Cient\u00edfica para la financiaci\u00f3n de pro-yectos de I+D+i"],"award-info":[{"award-number":["792-2017 2a Convocatoria Ecosistema Cient\u00edfico\u2010Colombia Cient\u00edfica para la financiaci\u00f3n de pro-yectos de I+D+i"]}]},{"name":"Vicerrector\u00eda de investigaci\u00f3n, Pontificia Universidad Javeriana","award":["20278"],"award-info":[{"award-number":["20278"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>Transient receptor potential (TRP) channels are critical receptors in the transduction of nociceptive stimuli. The microenvironment of diverse types of cancer releases substances, including growth factors, neurotransmitters, and inflammatory mediators, which modulate the activity of TRPs through the regulation of intracellular signaling pathways. The modulation of TRP channels is associated with the peripheral sensitization observed in patients with cancer, which results in mild noxious sensory stimuli being perceived as hyperalgesia and allodynia. Secondary metabolites derived from plant extracts can induce the activation, blocking, and desensitization of TRP channels. Thus, these compounds could act as potential therapeutic agents, as their antinociceptive properties could be beneficial in relieving cancer-derived pain. In this review, we will summarize the role of TRPV1 and TRPA1 in pain associated with cancer and discuss molecules that have been reported to modulate these channels, focusing particularly on the mechanisms of channel activation associated with molecules released in the tumor microenvironment.<\/jats:p>","DOI":"10.3390\/biom12010001","type":"journal-article","created":{"date-parts":[[2021,12,21]],"date-time":"2021-12-21T04:35:57Z","timestamp":1640061357000},"page":"1","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["TRP Channels as Molecular Targets to Relieve Cancer Pain"],"prefix":"10.3390","volume":"12","author":[{"given":"Milena","family":"Duitama","sequence":"first","affiliation":[{"name":"Departamento de Nutrici\u00f3n y Bioqu\u00edmica, Pontificia Universidad Javeriana, Bogot\u00e1 110231, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yurany","family":"Moreno","sequence":"additional","affiliation":[{"name":"Department of Lymphoma & Myeloma, MD Anderson Cancer Center, The University of Texas, Houston, TX 77030, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra Paola","family":"Santander","sequence":"additional","affiliation":[{"name":"Phytoimmunomodulation Research Group, Juan N. Corpas University Foundation, Bogot\u00e1 111111, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zulma","family":"Casas","sequence":"additional","affiliation":[{"name":"Departamento de Nutrici\u00f3n y Bioqu\u00edmica, Pontificia Universidad Javeriana, Bogot\u00e1 110231, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jhon Jairo","family":"Sutachan","sequence":"additional","affiliation":[{"name":"Departamento de Nutrici\u00f3n y Bioqu\u00edmica, Pontificia Universidad Javeriana, Bogot\u00e1 110231, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yolima P.","family":"Torres","sequence":"additional","affiliation":[{"name":"Departamento de Nutrici\u00f3n y Bioqu\u00edmica, Pontificia Universidad Javeriana, Bogot\u00e1 110231, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia L.","family":"Albarrac\u00edn","sequence":"additional","affiliation":[{"name":"Departamento de Nutrici\u00f3n y Bioqu\u00edmica, Pontificia Universidad Javeriana, Bogot\u00e1 110231, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,12,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1124\/mol.114.097659","article-title":"Structural basis for pharmacology of voltage-gated sodium and calcium channels","volume":"88","author":"Catterall","year":"2015","journal-title":"Mol. 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