{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T17:45:05Z","timestamp":1791827105067,"version":"4.3.4"},"reference-count":91,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2021,12,22]],"date-time":"2021-12-22T00:00:00Z","timestamp":1640131200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-20-CE14-0002-01"],"award-info":[{"award-number":["ANR-20-CE14-0002-01"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>Extracellular matrix (ECM) in the vascular wall is a highly dynamic structure composed of a set of different molecules such as elastins, collagens, fibronectin (Fn), laminins, proteoglycans, and polysaccharides. ECM undergoes remodeling processes to regulate vascular smooth muscle and endothelial cells\u2019 proliferation, differentiation, and adhesion. Abnormalities affecting the ECM can lead to alteration in cellular behavior and from this, this can conduce to the development of pathologies. Metalloproteases play a key role in maintaining the homeostasis of ECM by mediating the cleavage of different ECM components. There are different types of metalloproteases: matrix metalloproteinases (MMPs), disintegrin and metalloproteinases (ADAMs), and ADAMs with thrombospondin motifs (ADAMTSs). ADAMTSs have been found to participate in cardiovascular physiology and diseases and specifically in aortic aneurysms. This review aims to decipher the potential role of ADAMTS proteins in the physiopathologic development of Thoracic Aortic Aneurysms (TAA) and Abdominal Aortic Aneurysms (AAA). This review will focus on what is known on the ADAMTS family involved in human aneurysms from human tissues to mouse models. The recent findings on THSD4 (encoding ADAMTSL6) mutations in TAA give a new insight on the involvement of the ADAMTS family in TAA.<\/jats:p>","DOI":"10.3390\/biom12010012","type":"journal-article","created":{"date-parts":[[2021,12,22]],"date-time":"2021-12-22T10:24:52Z","timestamp":1640168692000},"page":"12","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["ADAMTS Proteins and Vascular Remodeling in Aortic Aneurysms"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9429-2865","authenticated-orcid":false,"given":"Zakaria","family":"Mougin","sequence":"first","affiliation":[{"name":"INSERM U1148, Laboratory of Vascular Translational Science, Universit\u00e9 de Paris, H\u00f4pital Bichat, F-75018 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Huguet Herrero","sequence":"additional","affiliation":[{"name":"INSERM U1148, Laboratory of Vascular Translational Science, Universit\u00e9 de Paris, H\u00f4pital Bichat, F-75018 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0371-7539","authenticated-orcid":false,"given":"Catherine","family":"Boileau","sequence":"additional","affiliation":[{"name":"INSERM U1148, Laboratory of Vascular Translational Science, Universit\u00e9 de Paris, H\u00f4pital Bichat, F-75018 Paris, France"},{"name":"D\u00e9partement de G\u00e9n\u00e9tique, AP-HP, H\u00f4pital Bichat, F-75018 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7788-708X","authenticated-orcid":false,"given":"Carine","family":"Le Goff","sequence":"additional","affiliation":[{"name":"INSERM U1148, Laboratory of Vascular Translational Science, Universit\u00e9 de Paris, H\u00f4pital Bichat, F-75018 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,12,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1161\/ATVBAHA.118.310956","article-title":"Therapies for Thoracic Aortic Aneurysms and Acute Aortic Dissections: Old Controversies and New Opportunities","volume":"39","author":"Milewicz","year":"2019","journal-title":"Arterioscler. 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