{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T19:08:34Z","timestamp":1788030514480,"version":"build-2784847793"},"reference-count":81,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2021,12,27]],"date-time":"2021-12-27T00:00:00Z","timestamp":1640563200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003329","name":"Ministry of Economy, Industry and Competitiveness","doi-asserted-by":"publisher","award":["SAF2017-88812 R"],"award-info":[{"award-number":["SAF2017-88812 R"]}],"id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003329","name":"Ministry of Economy, Industry and Competitiveness","doi-asserted-by":"publisher","award":["PID2020-119236RB-I00"],"award-info":[{"award-number":["PID2020-119236RB-I00"]}],"id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003329","name":"Ministry of Economy, Industry and Competitiveness","doi-asserted-by":"publisher","award":["RTI2018-094678-A-I00"],"award-info":[{"award-number":["RTI2018-094678-A-I00"]}],"id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003329","name":"Ministry of Economy, Industry and Competitiveness","doi-asserted-by":"publisher","award":["SAF2017-88076"],"award-info":[{"award-number":["SAF2017-88076"]}],"id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003329","name":"Ministry of Economy, Industry and Competitiveness","doi-asserted-by":"publisher","award":["PID2020-119386R-100"],"award-info":[{"award-number":["PID2020-119386R-100"]}],"id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>RTP801\/REDD1 is a stress-regulated protein whose levels are increased in several neurodegenerative diseases such as Parkinson\u2019s, Alzheimer\u2019s, and Huntington\u2019s diseases (HD). RTP801 downregulation ameliorates behavioral abnormalities in several mouse models of these disorders. In HD, RTP801 mediates mutant huntingtin (mhtt) toxicity in in vitro models and its levels are increased in human iPSCs, human postmortem putamen samples, and in striatal synaptosomes from mouse models of the disease. Here, we investigated the role of RTP801 in the hippocampal pathophysiology of HD. We found that RTP801 levels are increased in the hippocampus of HD patients in correlation with gliosis markers. Although RTP801 expression is not altered in the hippocampus of the R6\/1 mouse model of HD, neuronal RTP801 silencing in the dorsal hippocampus with shRNA containing AAV particles ameliorates cognitive alterations. This recovery is associated with a partial rescue of synaptic markers and with a reduction in inflammatory events, especially microgliosis. Altogether, our results indicate that RTP801 could be a marker of hippocampal neuroinflammation in HD patients and a promising therapeutic target of the disease.<\/jats:p>","DOI":"10.3390\/biom12010034","type":"journal-article","created":{"date-parts":[[2021,12,28]],"date-time":"2021-12-28T01:18:15Z","timestamp":1640654295000},"page":"34","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["RTP801\/REDD1 Is Involved in Neuroinflammation and Modulates Cognitive Dysfunction in Huntington\u2019s Disease"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9682-9811","authenticated-orcid":false,"given":"Leticia","family":"P\u00e9rez-Sisqu\u00e9s","sequence":"first","affiliation":[{"name":"Departament de Biomedicina, Facultat de Medicina i Ci\u00e8ncies de la Salut, Institut de Neuroci\u00e8ncies, Universitat de Barcelona, 08036 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00falia","family":"Solana-Balaguer","sequence":"additional","affiliation":[{"name":"Departament de Biomedicina, Facultat de Medicina i Ci\u00e8ncies de la Salut, Institut de Neuroci\u00e8ncies, Universitat de Barcelona, 08036 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4235-7628","authenticated-orcid":false,"given":"Gen\u00eds","family":"Campoy-Campos","sequence":"additional","affiliation":[{"name":"Departament de Biomedicina, Facultat de Medicina i Ci\u00e8ncies de la Salut, Institut de Neuroci\u00e8ncies, Universitat de Barcelona, 08036 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N\u00faria","family":"Mart\u00edn-Flores","sequence":"additional","affiliation":[{"name":"Departament de Biomedicina, Facultat de Medicina i Ci\u00e8ncies de la Salut, Institut de Neuroci\u00e8ncies, Universitat de Barcelona, 08036 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Sancho-Balsells","sequence":"additional","affiliation":[{"name":"Departament de Biomedicina, Facultat de Medicina i Ci\u00e8ncies de la Salut, Institut de Neuroci\u00e8ncies, Universitat de Barcelona, 08036 Barcelona, Spain"},{"name":"Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red Sobre Enfermedades Neurodegenerativas (CIBERNED), 28031 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcel","family":"Vives-Isern","sequence":"additional","affiliation":[{"name":"Departament de Biomedicina, Facultat de Medicina i Ci\u00e8ncies de la Salut, Institut de Neuroci\u00e8ncies, Universitat de Barcelona, 08036 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5007-0486","authenticated-orcid":false,"given":"Ferran","family":"Soler-Palaz\u00f3n","sequence":"additional","affiliation":[{"name":"Departament de Biomedicina, Facultat de Medicina i Ci\u00e8ncies de la Salut, Institut de Neuroci\u00e8ncies, Universitat de Barcelona, 08036 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Garcia-Forn","sequence":"additional","affiliation":[{"name":"Departament de Biomedicina, Facultat de Medicina i Ci\u00e8ncies de la Salut, Institut de Neuroci\u00e8ncies, Universitat de Barcelona, 08036 Barcelona, Spain"},{"name":"Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red Sobre Enfermedades Neurodegenerativas (CIBERNED), 28031 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1392-4774","authenticated-orcid":false,"given":"Merc\u00e8","family":"Masana","sequence":"additional","affiliation":[{"name":"Departament de Biomedicina, Facultat de Medicina i Ci\u00e8ncies de la Salut, Institut de Neuroci\u00e8ncies, Universitat de Barcelona, 08036 Barcelona, Spain"},{"name":"Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red Sobre Enfermedades Neurodegenerativas (CIBERNED), 28031 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordi","family":"Alberch","sequence":"additional","affiliation":[{"name":"Departament de Biomedicina, Facultat de Medicina i Ci\u00e8ncies de la Salut, Institut de Neuroci\u00e8ncies, Universitat de Barcelona, 08036 Barcelona, Spain"},{"name":"Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red Sobre Enfermedades Neurodegenerativas (CIBERNED), 28031 Madrid, Spain"},{"name":"Production and Validation Center of Advanced Therapies (Creatio), Faculty of Medicine and Health Science, Universitat de Barcelona, 08036 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"P\u00e9rez-Navarro","sequence":"additional","affiliation":[{"name":"Departament de Biomedicina, Facultat de Medicina i Ci\u00e8ncies de la Salut, Institut de Neuroci\u00e8ncies, Universitat de Barcelona, 08036 Barcelona, Spain"},{"name":"Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red Sobre Enfermedades Neurodegenerativas (CIBERNED), 28031 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert","family":"Giralt","sequence":"additional","affiliation":[{"name":"Departament de Biomedicina, Facultat de Medicina i Ci\u00e8ncies de la Salut, Institut de Neuroci\u00e8ncies, Universitat de Barcelona, 08036 Barcelona, Spain"},{"name":"Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red Sobre Enfermedades Neurodegenerativas (CIBERNED), 28031 Madrid, Spain"},{"name":"Production and Validation Center of Advanced Therapies (Creatio), Faculty of Medicine and Health Science, Universitat de Barcelona, 08036 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7185-436X","authenticated-orcid":false,"given":"Cristina","family":"Malagelada","sequence":"additional","affiliation":[{"name":"Departament de Biomedicina, Facultat de Medicina i Ci\u00e8ncies de la Salut, Institut de Neuroci\u00e8ncies, Universitat de Barcelona, 08036 Barcelona, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red Sobre Enfermedades Neurodegenerativas (CIBERNED), 28031 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,12,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/0092-8674(93)90585-E","article-title":"A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington\u2019s disease chromosomes","volume":"72","year":"1993","journal-title":"Cell"},{"key":"ref_2","first-page":"1202","article-title":"The likelihood of being affected with huntington disease by a particular age, for a specific CAG size","volume":"60","author":"Brinkman","year":"1997","journal-title":"Am. 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