{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T05:39:52Z","timestamp":1791178792925,"version":"4.1.0"},"reference-count":106,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2021,12,29]],"date-time":"2021-12-29T00:00:00Z","timestamp":1640736000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["Project INBIO (No. CZ.02.1.01\/0.0\/0.0\/16_026\/0008451)"],"award-info":[{"award-number":["Project INBIO (No. CZ.02.1.01\/0.0\/0.0\/16_026\/0008451)"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>Formation of peritoneal adhesions (PA) is one of the major complications following intra-abdominal surgery. It is primarily caused by activation of the mesothelial layer and underlying tissues in the peritoneal membrane resulting in the transition of mesothelial cells (MCs) and fibroblasts to a pro-fibrotic phenotype. Pro-fibrotic transition of MCs\u2014mesothelial-to-mesenchymal transition (MMT), and fibroblasts activation to myofibroblasts are interconnected to changes in cellular metabolism and culminate in the deposition of extracellular matrix (ECM) in the form of fibrotic tissue between injured sides in the abdominal cavity. However, ECM is not only a mechanical scaffold of the newly synthetized tissue but reciprocally affects fibrosis development. Hyaluronan (HA), an important component of ECM, is a non-sulfated glycosaminoglycan consisting of N-acetyl-D-glucosamine (GlcNAc) and D-glucuronic acid (GlcUA) that can affect the majority of processes involved in PA formation. This review considers the role of endogenously produced HA in the context of different fibrosis-related pathologies and its overlap in the development of PA.<\/jats:p>","DOI":"10.3390\/biom12010045","type":"journal-article","created":{"date-parts":[[2021,12,29]],"date-time":"2021-12-29T02:31:27Z","timestamp":1640745087000},"page":"45","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Endogenously-Produced Hyaluronan and Its Potential to Regulate the Development of Peritoneal Adhesions"],"prefix":"10.3390","volume":"12","author":[{"given":"Anna","family":"Kocurkova","sequence":"first","affiliation":[{"name":"Institute of Biophysics, Academy of Sciences of the Czech Republic, 612 65 Brno, Czech Republic"},{"name":"Institute of Experimental Biology, Faculty of Science, Masaryk University, 611 37 Brno, Czech Republic"},{"name":"International Clinical Research Center, St. Anne\u2019s University Hospital, 656 91 Brno, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristina","family":"Nesporova","sequence":"additional","affiliation":[{"name":"Contipro a.s., Doln\u00ed Dobrou\u010d 401, 561 02 Doln\u00ed Dobrou\u010d, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"Sandanusova","sequence":"additional","affiliation":[{"name":"Institute of Biophysics, Academy of Sciences of the Czech Republic, 612 65 Brno, Czech Republic"},{"name":"Institute of Experimental Biology, Faculty of Science, Masaryk University, 611 37 Brno, Czech Republic"},{"name":"International Clinical Research Center, St. Anne\u2019s University Hospital, 656 91 Brno, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michaela","family":"Kerberova","sequence":"additional","affiliation":[{"name":"Institute of Biophysics, Academy of Sciences of the Czech Republic, 612 65 Brno, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katerina","family":"Lehka","sequence":"additional","affiliation":[{"name":"Contipro a.s., Doln\u00ed Dobrou\u010d 401, 561 02 Doln\u00ed Dobrou\u010d, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir","family":"Velebny","sequence":"additional","affiliation":[{"name":"Contipro a.s., Doln\u00ed Dobrou\u010d 401, 561 02 Doln\u00ed Dobrou\u010d, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7729-7338","authenticated-orcid":false,"given":"Lukas","family":"Kubala","sequence":"additional","affiliation":[{"name":"Institute of Biophysics, Academy of Sciences of the Czech Republic, 612 65 Brno, Czech Republic"},{"name":"Institute of Experimental Biology, Faculty of Science, Masaryk University, 611 37 Brno, Czech Republic"},{"name":"International Clinical Research Center, St. Anne\u2019s University Hospital, 656 91 Brno, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8172-9746","authenticated-orcid":false,"given":"Gabriela","family":"Ambrozova","sequence":"additional","affiliation":[{"name":"Institute of Biophysics, Academy of Sciences of the Czech Republic, 612 65 Brno, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,12,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1007\/s11605-011-1819-9","article-title":"Current strategies and future perspectives for intraperitoneal adhesion prevention","volume":"16","author":"Brochhausen","year":"2012","journal-title":"J. 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