{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T19:35:05Z","timestamp":1790883305190,"version":"4.1.0"},"reference-count":79,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2022,1,21]],"date-time":"2022-01-21T00:00:00Z","timestamp":1642723200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["F32-DK117545"],"award-info":[{"award-number":["F32-DK117545"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HL156274-01A1"],"award-info":[{"award-number":["R01HL156274-01A1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>Abdominal aortic aneurysm (AAA) is a life-threatening disease associated with high morbidity and mortality in the setting of acute rupture. Recently, advances in surgical and endovascular repair of AAA have been achieved; however, pharmaceutical therapies to prevent AAA expansion and rupture remain lacking. This highlights an ongoing need to improve the understanding the pathological mechanisms that initiate formation, maintain growth, and promote rupture of AAA. Over the past decade, epigenetic modifications, such as DNA methylation, posttranslational histone modifications, and non-coding RNA, have emerged as important regulators of cellular function. Accumulating studies reveal the importance of epigenetic enzymes in the dynamic regulation of key signaling pathways that alter cellular phenotypes and have emerged as major intracellular players in a wide range of biological processes. In this review, we discuss the roles and implications of epigenetic modifications in AAA animal models and their relevance to human AAA pathology.<\/jats:p>","DOI":"10.3390\/biom12020172","type":"journal-article","created":{"date-parts":[[2022,1,21]],"date-time":"2022-01-21T08:37:18Z","timestamp":1642754238000},"page":"172","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["The Role of Epigenetic Modifications in Abdominal Aortic Aneurysm Pathogenesis"],"prefix":"10.3390","volume":"12","author":[{"given":"Kevin","family":"Mangum","sequence":"first","affiliation":[{"name":"Section of Vascular Surgery, Department of Surgery, University of Michigan, 5364 Cardiovascular Center, 1500 E. Medical Center Drive, Ann Arbor, MI 48109, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Gallagher","sequence":"additional","affiliation":[{"name":"Section of Vascular Surgery, Department of Surgery, University of Michigan, 5364 Cardiovascular Center, 1500 E. Medical Center Drive, Ann Arbor, MI 48109, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank M.","family":"Davis","sequence":"additional","affiliation":[{"name":"Section of Vascular Surgery, Department of Surgery, University of Michigan, 5364 Cardiovascular Center, 1500 E. Medical Center Drive, Ann Arbor, MI 48109, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,1,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1016\/j.jvs.2009.07.001","article-title":"SVS practice guidelines for the care of patients with an abdominal aortic aneurysm: Executive summary","volume":"50","author":"Chaikof","year":"2009","journal-title":"J. Vasc. Surg."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"516","DOI":"10.7326\/0003-4819-139-6-200309160-00016","article-title":"Ultrasonographic screening for abdominal aortic aneurysms","volume":"139","author":"Lederle","year":"2003","journal-title":"Ann. Intern. Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/j.ejvs.2010.09.011","article-title":"European Society for Vascular Surgery. Management of abdominal aortic aneurysms clinical practice guidelines of the European society for vascular surgery","volume":"41","author":"Moll","year":"2011","journal-title":"Eur. J. Vasc. Endovasc. Surg."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.gheart.2013.12.010","article-title":"Global and regional burden of aortic dissection and aneurysms: Mortality trends in 21 world regions, 1990 to 2010","volume":"9","author":"Sampson","year":"2014","journal-title":"Glob. Heart"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/s41569-018-0114-9","article-title":"Abdominal aortic aneurysm: Update on pathogenesis and medical treatments","volume":"16","author":"Golledge","year":"2019","journal-title":"Nat. Rev. Cardiol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"e83","DOI":"10.1161\/ATVBAHA.119.312000","article-title":"Updates of recent aortic aneurysm research","volume":"39","author":"Davis","year":"2019","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.atherosclerosis.2021.05.001","article-title":"Systematic review of genome-wide association studies of abdominal aortic aneurysm","volume":"327","author":"Singh","year":"2021","journal-title":"Atherosclerosis"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"0039","DOI":"10.1016\/0741-5214(89)90283-8","article-title":"Are familial abdominal aortic aneurysms different?","volume":"10","author":"Darling","year":"1989","journal-title":"J. Vasc. Surg."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.jvs.2009.08.036","article-title":"Genetic and environmental contributions to abdominal aortic aneurysm development in a twin population","volume":"51","author":"Wahlgren","year":"2010","journal-title":"J. Vasc. Surg."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.ejvs.2016.03.012","article-title":"Editor\u2019s Choice-High Heritability of Liability to Abdominal Aortic Aneurysms: A Population Based Twin Study","volume":"52","author":"Joergensen","year":"2016","journal-title":"Eur. J. Vasc. Endovasc. Surg."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1161\/CIRCULATIONAHA.120.047544","article-title":"Genetic Architecture of Abdominal Aortic Aneurysm in the Million Veteran Program","volume":"142","author":"Klarin","year":"2020","journal-title":"Circulation"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1161\/CIRCRESAHA.116.308765","article-title":"Meta-Analysis of Genome-Wide Association Studies for Abdominal Aortic Aneurysm Identifies Four New Disease-Specific Risk Loci","volume":"120","author":"Jones","year":"2017","journal-title":"Circ. Res."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1111\/cge.13705","article-title":"Genetic and epigenetic regulation of abdominal aortic aneurysms","volume":"97","author":"Mangum","year":"2020","journal-title":"Clin. Genet."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.immuni.2010.07.006","article-title":"Maintaining cell identity through global control of genomic organization","volume":"33","author":"Natoli","year":"2010","journal-title":"Immunity"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1126\/science.187.4173.226","article-title":"DNA modification mechanisms and gene activity during development","volume":"187","author":"Holliday","year":"1975","journal-title":"Science"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"2395","DOI":"10.1093\/hmg\/9.16.2395","article-title":"The DNA methyltransferases of mammals","volume":"9","author":"Bestor","year":"2000","journal-title":"Hum. Mol. Genet."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"3740","DOI":"10.1073\/pnas.052410099","article-title":"Comprehensive analysis of CpG islands in human chromosomes 21 and 22","volume":"99","author":"Takai","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1097\/MOL.0000000000000109","article-title":"Macrophage polarization: The epigenetic point of view","volume":"25","author":"Neele","year":"2014","journal-title":"Curr. Opin. Lipidol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1128\/MMBR.64.2.435-459.2000","article-title":"Acetylation of histones and transcription-related factors","volume":"64","author":"Sterner","year":"2000","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.it.2012.11.001","article-title":"Epigenetic regulation of macrophage polarization and function","volume":"34","author":"Ivashkiv","year":"2013","journal-title":"Trends Immunol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1186\/s13059-017-1348-2","article-title":"The multidimensional mechanisms of long noncoding RNA function","volume":"18","author":"Marchese","year":"2017","journal-title":"Genome Biol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mrrev.2014.04.002","article-title":"lncRNAs: Insights into their function and mechanics in underlying disorders","volume":"762","author":"Li","year":"2014","journal-title":"Mutat. Res. Mutat. Res."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"165","DOI":"10.3389\/fgene.2015.00165","article-title":"The role of long non-coding RNAs in genome formatting and expression","volume":"6","author":"Angrand","year":"2015","journal-title":"Front Genet."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/nrm2085","article-title":"Illuminating the silence: Understanding the structure and function of small RNAs","volume":"8","author":"Rana","year":"2007","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"4663","DOI":"10.1093\/emboj\/cdf476","article-title":"MicroRNA maturation: Stepwise processing and subcellular localization","volume":"21","author":"Lee","year":"2002","journal-title":"EMBO J."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"429","DOI":"10.3389\/fphys.2017.00429","article-title":"Non-coding RNA contribution to thoracic and abdominal aortic aneurysm disease development and progression","volume":"8","author":"Li","year":"2017","journal-title":"Front. Physiol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1101\/gr.082701.108","article-title":"Most mammalian mRNAs are conserved targets of microRNAs","volume":"19","author":"Friedman","year":"2009","journal-title":"Genome Res."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1136\/heartjnl-2014-305648","article-title":"Mechanisms of aortic aneurysm formation: Translating preclinical studies into clinical therapies","volume":"100","author":"Davis","year":"2014","journal-title":"Heart"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/nrcardio.2017.52","article-title":"Monocytes and macrophages in abdominal aortic aneurysm","volume":"14","author":"Raffort","year":"2017","journal-title":"Nat. Rev. Cardiol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/s13148-018-0460-9","article-title":"SMYD2 promoter DNA methylation is associated with abdominal aortic aneurysm (AAA) and SMYD2 expression in vascular smooth muscle cells","volume":"10","author":"Toghill","year":"2018","journal-title":"Clin. Epigenetics"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"e20201839","DOI":"10.1084\/jem.20201839","article-title":"Inhibition of macrophage histone demethylase JMJD3 protects against abdominal aortic aneurysms","volume":"218","author":"Davis","year":"2021","journal-title":"J. Exp. Med."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1242\/dmm.024513","article-title":"Induction of histone deacetylases (HDACs) in human abdominal aortic aneurysm: Therapeutic potential of HDAC inhibitors","volume":"9","author":"Varona","year":"2016","journal-title":"Dis. Model. Mech."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"5214","DOI":"10.1038\/ncomms6214","article-title":"MiR-24 limits aortic vascular inflammation and murine abdominal aneurysm development","volume":"5","author":"Maegdefessel","year":"2014","journal-title":"Nat. Commun."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"2161","DOI":"10.1161\/ATVBAHA.117.309768","article-title":"Genetic Ablation of MicroRNA-33 Attenuates Inflammation and Abdominal Aortic Aneurysm Formation via Several Anti-Inflammatory Pathways","volume":"37","author":"Nakao","year":"2017","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.atherosclerosis.2015.05.001","article-title":"The potential role of DNA methylation in the pathogenesis of abdominal aortic aneurysm","volume":"241","author":"Toghill","year":"2015","journal-title":"Atherosclerosis"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1002\/2211-5463.12643","article-title":"Epigenetic regulation of regulatory T cells in patients with abdominal aortic aneurysm","volume":"9","author":"Xia","year":"2019","journal-title":"FEBS Open Bio"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1042\/CS20130599","article-title":"microRNA profiling in patients with abdominal aortic aneurysms: The significance of miR-155","volume":"126","author":"Biros","year":"2014","journal-title":"Clin. Sci."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1038\/nri3108","article-title":"The emerging role of CTLA4 as a cell-extrinsic regulator of T cell responses","volume":"11","author":"Walker","year":"2011","journal-title":"Nat. Rev. Immunol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1038\/nature09130","article-title":"Chromatin regulation by Brg1 underlies heart muscle development and disease","volume":"466","author":"Hang","year":"2010","journal-title":"Nature"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.yjmcc.2018.10.012","article-title":"Brg1 trans-activates endothelium-derived colony stimulating factor to promote calcium chloride induced abdominal aortic aneurysm in mice","volume":"125","author":"Zhang","year":"2018","journal-title":"J. Mol. Cell Cardiol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1038\/s41419-020-02744-y","article-title":"Dual roles of chromatin remodeling protein BRG1 in angiotensin II-induced endothelial\u2013mesenchymal transition","volume":"11","author":"Li","year":"2020","journal-title":"Cell Death Dis."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1172\/JCI62204","article-title":"MicroRNAs, fibrotic remodeling, and aortic aneurysms","volume":"122","author":"Milewicz","year":"2012","journal-title":"J. Clin. Investig."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"e006798","DOI":"10.1161\/JAHA.117.006798","article-title":"Molecular fingerprint for terminal abdominal aortic aneurysm disease","volume":"6","author":"Northoff","year":"2017","journal-title":"J. Am. Heart Assoc."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"e131178","DOI":"10.1172\/JCI131178","article-title":"Histone deacetylase 9 promotes endothelial-mesenchymal transition and an unfavorable atherosclerotic plaque phenotype","volume":"131","author":"Lecce","year":"2021","journal-title":"J. Clin. Investig."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.atherosclerosis.2020.01.014","article-title":"Role of ADAM9 and miR-126 in the development of abdominal aortic aneurysm","volume":"297","author":"Shen","year":"2020","journal-title":"Atherosclerosis"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"e000745","DOI":"10.1161\/JAHA.112.000745","article-title":"Tissue-and plasma-specific MicroRNA signatures for atherosclerotic abdominal aortic aneurysm","volume":"1","author":"Kin","year":"2012","journal-title":"J. Am. Heart Assoc."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1038\/s41419-020-02745-x","article-title":"Circ-ADAM9 targeting PTEN and ATG7 promotes autophagy and apoptosis of diabetic endothelial progenitor cells by sponging mir-20a-5p","volume":"11","author":"Tian","year":"2020","journal-title":"Cell Death Dis."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1007\/s10456-012-9283-z","article-title":"MIR-20a represses endothelial cell migration by targeting MKK3 and inhibiting p38 MAP kinase activation in response to VEGF","volume":"15","author":"Pin","year":"2012","journal-title":"Angiogenesis"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1182\/blood-2011-08-373886","article-title":"MicroRNA-27a\/b controls endothelial cell repulsion and angiogenesis by targeting semaphorin 6A","volume":"119","author":"Urbich","year":"2012","journal-title":"Blood"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.lfs.2019.04.038","article-title":"miR-27a promotes endothelial-mesenchymal transition in hypoxia-induced pulmonary arterial hypertension by suppressing BMP signaling","volume":"227","author":"Liu","year":"2019","journal-title":"Life Sci."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"2492","DOI":"10.1161\/ATVBAHA.119.312707","article-title":"Extracellular MicroRNA-92a Mediates Endothelial Cell-Macrophage Communication","volume":"39","author":"Chang","year":"2019","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.devcel.2012.01.008","article-title":"MiR-221 Is Required for Endothelial Tip Cell Behaviors during Vascular Development","volume":"22","author":"Nicoli","year":"2012","journal-title":"Dev. Cell."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"104134","DOI":"10.1016\/j.mvr.2021.104134","article-title":"MiR-222-3p downregulation prompted the migration, invasion and recruitment of endothelial progenitor cells via ADIPOR1 expression increase-induced AMKP activation","volume":"135","author":"Gao","year":"2021","journal-title":"Microvasc. Res."},{"key":"ref_54","first-page":"592","article-title":"Interleukin 6 induces expression of NADPH oxidase 2 in human aortic endothelial cells via long noncoding RNA MALAT1","volume":"71","author":"Wang","year":"2016","journal-title":"Pharmazie"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1007\/s00125-018-4797-6","article-title":"lncRNA H19 prevents endothelial\u2013mesenchymal transition in diabetic retinopathy","volume":"62","author":"Thomas","year":"2019","journal-title":"Diabetologia"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1038\/mt.2016.41","article-title":"A role for the long noncoding RNA SENCR in commitment and function of endothelial cells","volume":"24","author":"Boulberdaa","year":"2016","journal-title":"Mol. Ther."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1196\/annals.1383.011","article-title":"Endothelial progenitor cells and abdominal aortic aneurysms","volume":"Volume 1085","author":"Dawson","year":"2006","journal-title":"Annals of the New York Academy of Sciences"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1073\/pnas.1810729116","article-title":"SENCR stabilizes vascular endothelial cell adherens junctions through interaction with CKAP4","volume":"116","author":"Lyu","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s13148-016-0169-6","article-title":"Histone acetylation and histone acetyltransferases show significant alterations in human abdominal aortic aneurysm","volume":"8","author":"Han","year":"2016","journal-title":"Clin. Epigenetics"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"2166","DOI":"10.1101\/gad.1842409","article-title":"MicroRNAs miR-143 and miR-145 modulate cytoskeletal dynamics and responsiveness of smooth muscle cells to injury","volume":"23","author":"Xin","year":"2009","journal-title":"Genes. Dev."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1161\/CIRCRESAHA.106.141986","article-title":"MicroRNA expression signature and antisense-mediated depletion reveal an essential role of MicroRNA in vascular neointimal lesion formation","volume":"100","author":"Ji","year":"2007","journal-title":"Circ. Res."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1038\/s41374-020-0454-z","article-title":"MiR-126-5p promotes contractile switching of aortic smooth muscle cells by targeting VEPH1 and alleviates Ang II-induced abdominal aortic aneurysm in mice","volume":"100","author":"Shi","year":"2020","journal-title":"Lab. Investig."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"9336","DOI":"10.1002\/jcp.29736","article-title":"A novel role of VEPH1 in regulating AoSMC phenotypic switching","volume":"235","author":"Shi","year":"2020","journal-title":"J. Cell Physiol."},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Si, X., Chen, Q., Zhang, J., Zhou, W., Chen, L., Chen, J., Deng, N., Li, W., Liu, D., and Wang, L. (2021). MicroRNA-23b prevents aortic aneurysm formation by inhibiting smooth muscle cell phenotypic switching via FoxO4 suppression. Life Sci., 119092.","DOI":"10.1016\/j.lfs.2021.119092"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1093\/cvr\/cvv141","article-title":"Down-regulation ofmiR-23b induces phenotypic switching of vascular smoothmuscle cells in vitro and in vivo","volume":"107","author":"Iaconetti","year":"2015","journal-title":"Cardiovasc. Res."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.avsg.2016.10.062","article-title":"Abdominal Aortic Aneurysm\u2013Associated MicroRNA-516a-5p Regulates Expressions of Methylenetetrahydrofolate Reductase, Matrix Metalloproteinase-2, and Tissue Inhibitor of Matrix Metalloproteinase-1 in Human Abdominal Aortic Vascular Smooth Muscle Cells","volume":"42","author":"Chan","year":"2017","journal-title":"Ann. Vasc. Surg."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.jvs.2013.02.244","article-title":"Identification and characterization of microRNAs in vascular smooth muscle cells from patients with abdominal aortic aneurysms","volume":"59","author":"Cheuk","year":"2014","journal-title":"J. Vasc. Surg."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"7896","DOI":"10.1111\/jcmm.15422","article-title":"MiR-126a-5p limits the formation of abdominal aortic aneurysm in mice and decreases ADAMTS-4 expression","volume":"24","author":"Li","year":"2020","journal-title":"J. Cell Mol. Med."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"2570","DOI":"10.3892\/mmr.2017.6873","article-title":"miRNA-504 inhibits p53-dependent vascular smooth muscle cell apoptosis and may prevent aneurysm formation","volume":"16","author":"Cao","year":"2017","journal-title":"Mol. Med. Rep."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.3892\/etm.2021.10642","article-title":"hsa-miR-15b-5p regulates the proliferation and apoptosis of human vascular smooth muscle cells by targeting the ACSS2\/PTGS2 axis","volume":"22","author":"Gan","year":"2021","journal-title":"Exp. Ther. Med."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1159\/000505457","article-title":"MiR-96-5p Regulates Proliferation, Migration, and Apoptosis of Vascular Smooth Muscle Cell Induced by Angiotensin II via Targeting NFAT5","volume":"57","author":"Tian","year":"2020","journal-title":"J. Vasc. Res."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"6056","DOI":"10.1111\/jcmm.16485","article-title":"MicroRNA-199a-5p aggravates angiotensin II\u2013induced vascular smooth muscle cell senescence by targeting Sirtuin-1 in abdominal aortic aneurysm","volume":"25","author":"Tao","year":"2021","journal-title":"J. Cell Mol. Med."},{"key":"ref_73","first-page":"218","article-title":"Knockdown of lncRNA PVT1 inhibits vascular smooth muscle cell apoptosis and extracellular matrix disruption in a murine abdominal aortic aneurysm model","volume":"42","author":"Zhang","year":"2019","journal-title":"Mol. Cells"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1161\/CIRCULATIONAHA.117.032184","article-title":"H19 induces abdominal aortic aneurysm development and progression","volume":"138","author":"Li","year":"2018","journal-title":"Circulation"},{"key":"ref_75","first-page":"713","article-title":"Long Noncoding RNA Expression Signatures of Abdominal Aortic Aneurysm Revealed by Microarray","volume":"29","author":"Yang","year":"2016","journal-title":"Biomed. Environ. Sci."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1080\/15384101.2020.1743915","article-title":"LncRNA CRNDE affects the proliferation and apoptosis of vascular smooth muscle cells in abdominal aortic aneurysms by regulating the expression of Smad3 by Bcl-3","volume":"19","author":"Li","year":"2020","journal-title":"Cell Cycle"},{"key":"ref_77","first-page":"323","article-title":"LncRNA SENCR suppresses abdominal aortic aneurysm formation by inhibiting smooth muscle cells apoptosis and extracellular matrix degradation","volume":"21","author":"Cai","year":"2021","journal-title":"Bosn. J. Basic Med. Sci."},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Gurung, R., Choong, A.M., Woo, C.C., Foo, R., and Sorokin, V. (2020). Genetic and epigenetic mechanisms underlying vascular smooth muscle cell phenotypic modulation in abdominal aortic aneurysm. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21176334"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.ejphar.2015.03.101","article-title":"Epigenetic pathways in macrophages emerge as novel targets in atherosclerosis","volume":"763","author":"Neele","year":"2015","journal-title":"Eur. J. 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