{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T18:39:43Z","timestamp":1792003183898,"version":"4.4.0"},"reference-count":46,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2022,2,18]],"date-time":"2022-02-18T00:00:00Z","timestamp":1645142400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003407","name":"Ministry of Education, Universities and Research","doi-asserted-by":"publisher","award":["2017M42834"],"award-info":[{"award-number":["2017M42834"]}],"id":[{"id":"10.13039\/501100003407","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>Schizophrenia (SCZ) is a polygenic severe mental illness. Genome-wide association studies (GWAS) have detected genomic variants associated with this psychiatric disorder and pathway analyses have indicated immune system and dopamine signaling as core components of risk in dorsolateral-prefrontal cortex (DLPFC) and hippocampus, but the mechanistic links remain unknown. The RasGRP1 gene, encoding for a guanine nucleotide exchange factor, is implicated in dopamine signaling and immune response. RasGRP1 has been identified as a candidate risk gene for SCZ and autoimmune disease, therefore representing a possible point of convergence between mechanisms involving the nervous and the immune system. Here, we investigated RasGRP1 mRNA and protein expression in post-mortem DLPFC and hippocampus of SCZ patients and healthy controls, along with RasGRP1 protein content in the serum of an independent cohort of SCZ patients and control subjects. Differences in RasGRP1 expression between SCZ patients and controls were detected both in DLPFC and peripheral blood of samples analyzed. Our results indicate RasGRP1 may mediate risk for SCZ by involving DLPFC and peripheral blood, thus encouraging further studies to explore its possible role as a biomarker of the disease and\/or a target for new medication.<\/jats:p>","DOI":"10.3390\/biom12020328","type":"journal-article","created":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T08:14:46Z","timestamp":1645431286000},"page":"328","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Abnormal RasGRP1 Expression in the Post-Mortem Brain and Blood Serum of Schizophrenia Patients"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4985-1677","authenticated-orcid":false,"given":"Arianna","family":"De Rosa","sequence":"first","affiliation":[{"name":"Laboratory of Translational Neuroscience, CEINGE Biotecnologie Avanzate, 80145 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Di Maio","sequence":"additional","affiliation":[{"name":"Laboratory of Translational Neuroscience, CEINGE Biotecnologie Avanzate, 80145 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Torretta","sequence":"additional","affiliation":[{"name":"Group of Psychiatric Neuroscience, Department of Basic Medical Sciences, Neuroscience and Sense Organs, University of Bari Aldo Moro, 70124 Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Garofalo","sequence":"additional","affiliation":[{"name":"Laboratory of Translational Neuroscience, CEINGE Biotecnologie Avanzate, 80145 Naples, Italy"},{"name":"Department of Environmental, Biological and Pharmaceutical Science and Technologies, Universit\u00e0 degli Studi della Campania \u201cLuigi Vanvitelli\u201d, 81100 Caserta, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Giorgelli","sequence":"additional","affiliation":[{"name":"Group of Psychiatric Neuroscience, Department of Basic Medical Sciences, Neuroscience and Sense Organs, University of Bari Aldo Moro, 70124 Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4817-3707","authenticated-orcid":false,"given":"Rita","family":"Masellis","sequence":"additional","affiliation":[{"name":"Group of Psychiatric Neuroscience, Department of Basic Medical Sciences, Neuroscience and Sense Organs, University of Bari Aldo Moro, 70124 Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tommaso","family":"Nuzzo","sequence":"additional","affiliation":[{"name":"Laboratory of Translational Neuroscience, CEINGE Biotecnologie Avanzate, 80145 Naples, Italy"},{"name":"Department of Environmental, Biological and Pharmaceutical Science and Technologies, Universit\u00e0 degli Studi della Campania \u201cLuigi Vanvitelli\u201d, 81100 Caserta, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3636-7395","authenticated-orcid":false,"given":"Francesco","family":"Errico","sequence":"additional","affiliation":[{"name":"Laboratory of Translational Neuroscience, CEINGE Biotecnologie Avanzate, 80145 Naples, Italy"},{"name":"Department of Agricultural Sciences, University of Naples \u201cFederico II\u201d, 80055 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Bertolino","sequence":"additional","affiliation":[{"name":"Group of Psychiatric Neuroscience, Department of Basic Medical Sciences, Neuroscience and Sense Organs, University of Bari Aldo Moro, 70124 Bari, Italy"},{"name":"Azienda Ospedaliero Universitaria Consorziale Policlinico, 70124 Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Srinivasa","family":"Subramaniam","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, The Scripps Research Institute, Jupiter, FL 33458, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9654-3266","authenticated-orcid":false,"given":"Antonio","family":"Rampino","sequence":"additional","affiliation":[{"name":"Group of Psychiatric Neuroscience, Department of Basic Medical Sciences, Neuroscience and Sense Organs, University of Bari Aldo Moro, 70124 Bari, Italy"},{"name":"Azienda Ospedaliero Universitaria Consorziale Policlinico, 70124 Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Usiello","sequence":"additional","affiliation":[{"name":"Laboratory of Translational Neuroscience, CEINGE Biotecnologie Avanzate, 80145 Naples, Italy"},{"name":"Department of Environmental, Biological and Pharmaceutical Science and Technologies, Universit\u00e0 degli Studi della Campania \u201cLuigi Vanvitelli\u201d, 81100 Caserta, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,2,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1002\/wps.20385","article-title":"The current conceptualization of negative symptoms in schizophrenia","volume":"16","author":"Marder","year":"2017","journal-title":"World Psychiatry"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.biopsych.2016.07.014","article-title":"The Role of Genes, Stress, and Dopamine in the Development of Schizophrenia","volume":"81","author":"Howes","year":"2017","journal-title":"Biol. 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