{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T22:24:14Z","timestamp":1793744654114,"version":"4.6.1"},"reference-count":225,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2022,2,25]],"date-time":"2022-02-25T00:00:00Z","timestamp":1645747200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006545","name":"National Institute on Minority Health and Health Disparities","doi-asserted-by":"publisher","award":["U54 MD 007582"],"award-info":[{"award-number":["U54 MD 007582"]}],"id":[{"id":"10.13039\/100006545","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>Alzheimer\u2019s and Parkinson\u2019s diseases are the two most common forms of neurodegenerative diseases. The exact etiology of these disorders is not well known; however, environmental, molecular, and genetic influences play a major role in the pathogenesis of these diseases. Using Alzheimer\u2019s disease (AD) as the archetype, the pathological findings include the aggregation of Amyloid Beta (A\u03b2) peptides, mitochondrial dysfunction, synaptic degradation caused by inflammation, elevated reactive oxygen species (ROS), and cerebrovascular dysregulation. This review highlights the neuroinflammatory and neuroprotective role of epigallocatechin-3-gallate (EGCG): the medicinal component of green tea, a known nutraceutical that has shown promise in modulating AD progression due to its antioxidant, anti-inflammatory, and anti-aging abilities. This report also re-examines the current literature and provides innovative approaches for EGCG to be used as a preventive measure to alleviate AD and other neurodegenerative disorders.<\/jats:p>","DOI":"10.3390\/biom12030371","type":"journal-article","created":{"date-parts":[[2022,2,27]],"date-time":"2022-02-27T20:46:17Z","timestamp":1645994777000},"page":"371","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":166,"title":["Epigallocatechin-3-Gallate (EGCG): New Therapeutic Perspectives for Neuroprotection, Aging, and Neuroinflammation for the Modern Age"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7925-6230","authenticated-orcid":false,"given":"Ashley","family":"Payne","sequence":"first","affiliation":[{"name":"Division of Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences, Institute of Public Health, Florida A&M University, Tallahassee, FL 32307, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Nahashon","sequence":"additional","affiliation":[{"name":"Department of Agricultural and Environmental Sciences, College of Agriculture, Tennessee State University, Nashville, TN 37209, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Equar","family":"Taka","sequence":"additional","affiliation":[{"name":"Division of Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences, Institute of Public Health, Florida A&M University, Tallahassee, FL 32307, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2085-9627","authenticated-orcid":false,"given":"Getinet M.","family":"Adinew","sequence":"additional","affiliation":[{"name":"Division of Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences, Institute of Public Health, Florida A&M University, Tallahassee, FL 32307, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0600-1085","authenticated-orcid":false,"given":"Karam F. A.","family":"Soliman","sequence":"additional","affiliation":[{"name":"Division of Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences, Institute of Public Health, Florida A&M University, Tallahassee, FL 32307, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,2,25]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (2006). Neurological Disorders: Public Health Challenges, World Health Organization."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.2147\/CIA.S264688","article-title":"Activities of Daily Living and Associated Costs in the Most Widespread Neurodegenerative Diseases: A Systematic Review","volume":"15","author":"Maresova","year":"2020","journal-title":"Clin. Interv. Aging"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1093\/toxsci\/kfr239","article-title":"The role of environmental exposures in neurodegeneration and neurodegenerative diseases","volume":"124","author":"Cannon","year":"2011","journal-title":"Toxicol. Sci."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1007\/s13311-013-0192-7","article-title":"Natural compounds may open new routes to treatment of amyloid diseases","volume":"10","author":"Bieschke","year":"2013","journal-title":"Neurotherapeutics"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"548","DOI":"10.3389\/fphar.2018.00548","article-title":"Anti-neuroinflammatory Potential of Natural Products in Attenuation of Alzheimer\u2019s Disease","volume":"9","author":"Shal","year":"2018","journal-title":"Front. Pharmacol."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Sternke-Hoffmann, R., Peduzzo, A., Bolakhrif, N., Haas, R., and Buell, A.K. (2020). The Aggregation Conditions Define Whether EGCG is an Inhibitor or Enhancer of \u03b1-Synuclein Amyloid Fibril Formation. Int. J. Mol. Sci., 21.","DOI":"10.20944\/preprints202002.0018.v1"},{"key":"ref_7","first-page":"563481","article-title":"Neurodegenerative Diseases: Multifactorial Conformational Diseases and Their Therapeutic Interventions","volume":"2013","author":"Sheikh","year":"2013","journal-title":"J. Neurodegener. Dis."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s40035-017-0099-z","article-title":"Current understanding of the molecular mechanisms in Parkinson\u2019s disease: Targets for potential treatments","volume":"6","author":"Maiti","year":"2017","journal-title":"Transl. Neurodegener."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1089\/jmf.2017.4078","article-title":"Beneficial Effects of Flavonoids Against Parkinson\u2019s Disease","volume":"21","author":"Jung","year":"2018","journal-title":"J. Med. Food"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.arr.2014.01.004","article-title":"Ageing and Parkinson\u2019s disease: Why is advancing age the biggest risk factor?","volume":"14","author":"Reeve","year":"2014","journal-title":"Ageing Res. Rev."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/s40035-019-0165-9","article-title":"The interplay of aging, genetics and environmental factors in the pathogenesis of Parkinson\u2019s disease","volume":"8","author":"Pang","year":"2019","journal-title":"Transl. Neurodegener."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Badanjak, K., Fixemer, S., Smaji\u0107, S., Skupin, A., and Gr\u00fcnewald, A. (2021). The Contribution of Microglia to Neuroinflammation in Parkinson\u2019s Disease. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22094676"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Lee, J.W., Chun, W., Lee, H.J., Kim, S.M., Min, J.H., Kim, D.Y., Kim, M.O., Ryu, H.W., and Lee, S.U. (2021). The Role of Microglia in the Development of Neurodegenerative Diseases. Biomedicines, 9.","DOI":"10.3390\/biomedicines9101449"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"110090","DOI":"10.1016\/j.celrep.2021.110090","article-title":"Alpha synuclein, the culprit in Parkinson disease, is required for normal immune function","volume":"38","author":"Alam","year":"2022","journal-title":"Cell Rep."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"759571","DOI":"10.3389\/fncel.2021.759571","article-title":"Functions of Intracellular Alpha-Synuclein in Microglia: Implications for Parkinson\u2019s Disease Risk","volume":"15","author":"Booms","year":"2021","journal-title":"Front. Cell. Neurosci."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"683459","DOI":"10.3389\/fcell.2021.683459","article-title":"The Ageing Brain: Molecular and Cellular Basis of Neurodegeneration","volume":"9","author":"Azam","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"461","DOI":"10.3233\/JPD-130230","article-title":"The role of oxidative stress in Parkinson\u2019s disease","volume":"3","author":"Dias","year":"2013","journal-title":"J. Parkinsons Dis."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Stoker, T.B., and Barker, R.A. (2020). Recent developments in the treatment of Parkinson\u2019s Disease. F1000Research, 9, F1000 Faculty Rev-862.","DOI":"10.12688\/f1000research.25634.1"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1056\/NEJMra0909142","article-title":"Alzheimer\u2019s disease","volume":"362","author":"Querfurth","year":"2010","journal-title":"N. Engl. J. Med."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Lines, L., Sherif, N., and Wiener, J. (2014). Racial and Ethnic Disparities Among Individuals with Alzheimer\u2019s Disease in the United States: A Literature Review, RTI Press.","DOI":"10.3768\/rtipress.2014.RR.0024.1412"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0896-6273(01)00476-7","article-title":"New frontiers in Alzheimer\u2019s disease genetics","volume":"32","author":"Tanzi","year":"2001","journal-title":"Neuron"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1177\/0891988710383571","article-title":"Genetics of Alzheimer disease","volume":"23","author":"Bekris","year":"2010","journal-title":"J. Geriatr. Psychiatry Neurol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/alzrt59","article-title":"Autosomal-dominant Alzheimer\u2019s disease: A review and proposal for the prevention of Alzheimer\u2019s disease","volume":"3","author":"Bateman","year":"2011","journal-title":"Alzheimers Res. Ther."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1038\/gim.2015.117","article-title":"The genetic landscape of Alzheimer disease: Clinical implications and perspectives","volume":"18","author":"Sleegers","year":"2016","journal-title":"Genet. Med."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"2919","DOI":"10.1038\/s41380-019-0410-8","article-title":"Familial Alzheimer\u2019s disease patient-derived neurons reveal distinct mutation-specific effects on amyloid beta","volume":"25","author":"Arber","year":"2020","journal-title":"Mol. Psychiatry"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1172\/JCI124853","article-title":"APOE4-mediated amyloid-\u03b2 pathology depends on its neuronal receptor LRP1","volume":"129","author":"Tachibana","year":"2019","journal-title":"J. Clin. Investig."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Safieh, M., Korczyn, A.D., and Michaelson, D.M. (2019). ApoE4: An emerging therapeutic target for Alzheimer\u2019s disease. BMC Med., 17.","DOI":"10.1186\/s12916-019-1299-4"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/nrn2168","article-title":"Intracellular amyloid-beta in Alzheimer\u2019s disease","volume":"8","author":"LaFerla","year":"2007","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_29","first-page":"8342","article-title":"Neuroinflammation in Alzheimer\u2019s disease: Chemokines produced by astrocytes and chemokine receptors","volume":"7","author":"Liu","year":"2014","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/S0197-4580(00)00124-X","article-title":"Inflammation and Alzheimer\u2019s disease","volume":"21","author":"Akiyama","year":"2000","journal-title":"Neurobiol. Aging"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Cummings, J.L., Goldman, D.P., Simmons-Stern, N.R., and Ponton, E. (2021). The costs of developing treatments for Alzheimer\u2019s disease: A retrospective exploration. Alzheimers Dement., in press.","DOI":"10.1002\/alz.12450"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1177\/1756285612461679","article-title":"Current and future treatments for Alzheimer\u2019s disease","volume":"6","author":"Yiannopoulou","year":"2013","journal-title":"Ther. Adv. Neurol. Disord."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Yiannopoulou, K.G., and Papageorgiou, S.G. (2020). Current and Future Treatments in Alzheimer Disease: An Update. J. Cent. Nerv. Syst. Dis., 12.","DOI":"10.1177\/1179573520907397"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"247","DOI":"10.7861\/clinmedicine.16-3-247","article-title":"Drug treatments in Alzheimer\u2019s disease","volume":"16","author":"Briggs","year":"2016","journal-title":"Clin. Med."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Breijyeh, Z., and Karaman, R. (2020). Comprehensive Review on Alzheimer\u2019s Disease: Causes and Treatment. Molecules, 25.","DOI":"10.3390\/molecules25245789"},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Cruz-Vicente, P., Passarinha, L.A., Silvestre, S., and Gallardo, E. (2021). Recent Developments in New Therapeutic Agents against Alzheimer and Parkinson Diseases: In-Silico Approaches. Molecules, 26.","DOI":"10.3390\/molecules26082193"},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Ohishi, T., Fukutomi, R., Shoji, Y., Goto, S., and Isemura, M. (2021). The Beneficial Effects of Principal Polyphenols from Green Tea, Coffee, Wine, and Curry on Obesity. Molecules, 26.","DOI":"10.3390\/molecules26020453"},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Loera-Valencia, R., Eroli, F., Garcia-Ptacek, S., and Maioli, S. (2021). Brain Renin-Angiotensin System as Novel and Potential Therapeutic Target for Alzheimer\u2019s Disease. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms221810139"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"119985","DOI":"10.1016\/j.lfs.2021.119985","article-title":"Mitochondrial defects: An emerging theranostic avenue towards Alzheimer\u2019s associated dysregulations","volume":"285","author":"Mani","year":"2021","journal-title":"Life Sci."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"3087475","DOI":"10.1155\/2018\/3087475","article-title":"Neuroinflammatory Cytokines Induce Amyloid Beta Neurotoxicity through Modulating Amyloid Precursor Protein Levels\/Metabolism","volume":"2018","author":"Alasmari","year":"2018","journal-title":"BioMed Res. Int."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1016\/j.bbamem.2007.02.014","article-title":"Amyloid beta-protein and lipid metabolism","volume":"1768","author":"Zinser","year":"2007","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1111\/jnc.13411","article-title":"The contribution of neuroinflammation to amyloid toxicity in Alzheimer\u2019s disease","volume":"136","author":"Minter","year":"2016","journal-title":"J. Neurochem."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"16012","DOI":"10.1038\/npjamd.2016.12","article-title":"Amyloid proteotoxicity initiates an inflammatory response blocked by cannabinoids","volume":"2","author":"Currais","year":"2016","journal-title":"NPJ Aging Mech. Dis."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1111\/bpa.12704","article-title":"Iron accumulation in microglia triggers a cascade of events that leads to altered metabolism and compromised function in APP\/PS1 mice","volume":"29","author":"McIntosh","year":"2019","journal-title":"Brain Pathol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"632","DOI":"10.3389\/fnins.2018.00632","article-title":"Iron and Alzheimer\u2019s Disease: From Pathogenesis to Therapeutic Implications","volume":"12","author":"Liu","year":"2018","journal-title":"Front. Neurosci."},{"key":"ref_46","first-page":"1141","article-title":"Tau protein in neurodegenerative diseases\u2014A review","volume":"58","author":"Pirici","year":"2017","journal-title":"Rom. J. Morphol. Embryol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.ejmech.2017.07.070","article-title":"Tau protein aggregation in Alzheimer\u2019s disease: An attractive target for the development of novel therapeutic agents","volume":"139","author":"Jouanne","year":"2017","journal-title":"Eur. J. Med. Chem."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"809","DOI":"10.3389\/fneur.2018.00809","article-title":"Tau Pathology in Parkinson\u2019s Disease","volume":"9","author":"Zhang","year":"2018","journal-title":"Front. Neurol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.neulet.2019.04.022","article-title":"The complexity of tau in Alzheimer\u2019s disease","volume":"705","author":"Naseri","year":"2019","journal-title":"Neurosci. Lett."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1111\/j.1365-2567.2009.03225.x","article-title":"Inflammation in neurodegenerative diseases","volume":"129","author":"Amor","year":"2010","journal-title":"Immunology"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"3577","DOI":"10.1172\/JCI90609","article-title":"CNS inflammation and neurodegeneration","volume":"127","author":"Chitnis","year":"2017","journal-title":"J. Clin. Investig."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.molmed.2009.12.001","article-title":"Complement in neuroprotection and neurodegeneration","volume":"16","author":"Yanamadala","year":"2010","journal-title":"Trends Mol. Med."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1038\/s41582-020-0400-0","article-title":"Complement in neurological disorders and emerging complement-targeted therapeutics","volume":"16","author":"Dalakas","year":"2020","journal-title":"Nat. Rev. Neurol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1186\/s12974-020-02024-8","article-title":"The good, the bad, and the opportunities of the complement system in neurodegenerative disease","volume":"17","author":"Schartz","year":"2020","journal-title":"J. Neuroinflamm."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1002\/path.2104","article-title":"Immunosenescence of ageing","volume":"211","author":"Gruver","year":"2007","journal-title":"J. Pathol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"72","DOI":"10.3389\/fncel.2018.00072","article-title":"An Inflammation-Centric View of Neurological Disease: Beyond the Neuron","volume":"12","author":"Skaper","year":"2018","journal-title":"Front. Cell. Neurosci."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"624919","DOI":"10.3389\/fimmu.2021.624919","article-title":"Unraveling the Link Between Mitochondrial Dynamics and Neuroinflammation","volume":"12","author":"Angelo","year":"2021","journal-title":"Front. Immunol."},{"key":"ref_58","first-page":"49","article-title":"Neurotransmitter signaling in the pathophysiology of microglia","volume":"7","author":"Domercq","year":"2013","journal-title":"Front. Cell. Neurosci."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/1742-2094-11-48","article-title":"Microglia receptors and their implications in the response to amyloid \u03b2 for Alzheimer\u2019s disease pathogenesis","volume":"11","author":"Doens","year":"2014","journal-title":"J. Neuroinflamm."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"488","DOI":"10.3389\/fncel.2018.00488","article-title":"Microglia in Neurological Diseases: A Road Map to Brain-Disease Dependent-Inflammatory Response","volume":"12","author":"Bachiller","year":"2018","journal-title":"Front. Cell. Neurosci."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"156","DOI":"10.2174\/187152710791012071","article-title":"Microglia and inflammation in Alzheimer\u2019s disease","volume":"9","author":"Landreth","year":"2010","journal-title":"CNS Neurol. Disord. Drug Targets"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1038\/nri3086","article-title":"Microglial cell origin and phenotypes in health and disease","volume":"11","author":"Saijo","year":"2011","journal-title":"Nat. Rev. Immunol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1002\/dneu.22576","article-title":"Microglial interactions with the neurovascular system in physiology and pathology","volume":"78","author":"Zhao","year":"2018","journal-title":"Dev. Neurobiol."},{"key":"ref_64","first-page":"124","article-title":"Microglial cell dysregulation in brain aging and neurodegeneration","volume":"7","year":"2015","journal-title":"Front. Aging Neurosci."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1016\/j.bcp.2014.01.008","article-title":"Microglial dysfunction in brain aging and Alzheimer\u2019s disease","volume":"88","author":"Mosher","year":"2014","journal-title":"Biochem. Pharmacol."},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Mputhia, Z., Hone, E., Tripathi, T., Sargeant, T., Martins, R., and Bharadwaj, P. (2019). Autophagy Modulation as a Treatment of Amyloid Diseases. Molecules, 24.","DOI":"10.3390\/molecules24183372"},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Edler, M.K., Mhatre-Winters, I., and Richardson, J.R. (2021). Microglia in Aging and Alzheimer\u2019s Disease: A Comparative Species Review. Cells, 10.","DOI":"10.3390\/cells10051138"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/s13024-017-0192-x","article-title":"Glial contributions to neurodegeneration in tauopathies","volume":"12","author":"Leyns","year":"2017","journal-title":"Mol. Neurodegener."},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Perea, J.R., Bol\u00f3s, M., and Avila, J. (2020). Microglia in Alzheimer\u2019s Disease in the Context of Tau Pathology. Biomolecules, 10.","DOI":"10.3390\/biom10101439"},{"key":"ref_70","first-page":"59","article-title":"Inflammatory process in Alzheimer\u2019s Disease","volume":"7","year":"2013","journal-title":"Front. Integr. Neurosci."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1016\/j.bbamcr.2011.01.034","article-title":"The pro- and anti-inflammatory properties of the cytokine interleukin-6","volume":"1813","author":"Scheller","year":"2011","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1093\/cvr\/cvq076","article-title":"The nuclear factor-\u03baB\u2013interleukin-6 signalling pathway mediating vascular inflammation","volume":"86","author":"Brasier","year":"2010","journal-title":"Cardiovasc. Res."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"619","DOI":"10.3233\/JAD-200711","article-title":"Therapeutic Potential of TNF- \u03b1 Inhibition for Alzheimer\u2019s Disease Prevention","volume":"78","author":"Isaacson","year":"2020","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"412","DOI":"10.2174\/1567205013666160930110551","article-title":"Targeting Tumor Necrosis Factor Alpha for Alzheimer\u2019s Disease","volume":"14","author":"Decourt","year":"2017","journal-title":"Curr. Alzheimer Res."},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Steeland, S., Libert, C., and Vandenbroucke, R.E. (2018). A New Venue of TNF Targeting. Int. J. Mol. Sci., 19.","DOI":"10.20944\/preprints201804.0015.v1"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"e305","DOI":"10.18295\/squmj.2015.15.03.002","article-title":"The Role of Inflammatory Mediators in the Pathogenesis of Alzheimer\u2019s Disease","volume":"15","author":"Azizi","year":"2015","journal-title":"Sultan Qaboos Univ. Med. J."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1161\/CIRCRESAHA.118.313563","article-title":"Getting to the Heart of Alzheimer Disease","volume":"124","author":"Tublin","year":"2019","journal-title":"Circ. Res."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"S18","DOI":"10.1038\/nrn1434","article-title":"Oxidative stress in neurodegeneration: Cause or consequence?","volume":"10","author":"Andersen","year":"2004","journal-title":"Nat. Med."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/s12264-013-1423-y","article-title":"Oxidative stress in Alzheimer\u2019s disease","volume":"30","author":"Chen","year":"2014","journal-title":"Neurosci. Bull."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"65","DOI":"10.2174\/157015909787602823","article-title":"Oxidative stress and neurodegenerative diseases: A review of upstream and downstream antioxidant therapeutic options","volume":"7","author":"Uttara","year":"2009","journal-title":"Curr. Neuropharmacol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"519","DOI":"10.3892\/br.2016.630","article-title":"Role of oxidative stress in Alzheimer\u2019s disease","volume":"4","author":"Huang","year":"2016","journal-title":"Biomed. Rep."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1124\/jpet.116.237503","article-title":"Oxidative Stress and the Central Nervous System","volume":"360","author":"Salim","year":"2017","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1590\/S0074-02762005000900002","article-title":"Nitric oxide as a regulator of inflammatory processes","volume":"100","author":"Wallace","year":"2005","journal-title":"Mem. Inst. Oswaldo Cruz."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1007\/s10787-007-0013-x","article-title":"Role of nitric oxide in inflammatory diseases","volume":"15","author":"Sharma","year":"2007","journal-title":"Inflammopharmacology"},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"Zhu, H.-Y., Hong, F.-F., and Yang, S.-L. (2021). The Roles of Nitric Oxide Synthase\/Nitric Oxide Pathway in the Pathology of Vascular Dementia and Related Therapeutic Approaches. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22094540"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1111\/j.1574-695X.2007.00329.x","article-title":"The role of nitric oxide in inflammatory reactions","volume":"51","author":"Tripathi","year":"2007","journal-title":"FEMS Immunol. Med. Microbiol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1385\/MN:27:3:325","article-title":"Inflammatory neurodegeneration mediated by nitric oxide, glutamate, and mitochondria","volume":"27","author":"Brown","year":"2003","journal-title":"Mol. Neurobiol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1179\/016164104225016236","article-title":"Nitric oxide pathways in Alzheimer\u2019s disease and other neurodegenerative dementias","volume":"26","author":"Togo","year":"2004","journal-title":"Neurol. Res."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1038\/nrn2214","article-title":"Nitric oxide in the central nervous system: Neuroprotection versus neurotoxicity","volume":"8","author":"Calabrese","year":"2007","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"555409","DOI":"10.3389\/fcell.2020.555409","article-title":"Natural Compounds and Autophagy: Allies Against Neurodegeneration","volume":"8","author":"Stacchiotti","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"398483","DOI":"10.1155\/2015\/398483","article-title":"Cellular and Molecular Connections between Autophagy and Inflammation","volume":"2015","author":"Lapaquette","year":"2015","journal-title":"Mediat. Inflamm."},{"key":"ref_92","first-page":"116","article-title":"Autophagy as a molecular target for cancer treatment","volume":"134","author":"Kocaturk","year":"2019","journal-title":"Eur. J. Pharm. Sci. Off. J. Eur. Fed. Pharm. Sci."},{"key":"ref_93","doi-asserted-by":"crossref","unstructured":"Eshraghi, M., Adlimoghaddam, A., Mahmoodzadeh, A., Sharifzad, F., Yasavoli-Sharahi, H., Lorzadeh, S., Albensi, B.C., and Ghavami, S. (2021). Alzheimer\u2019s Disease Pathogenesis: Role of Autophagy and Mitophagy Focusing in Microglia. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22073330"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1007\/s00018-020-03667-9","article-title":"Selective autophagy as a therapeutic target for neurological diseases","volume":"78","author":"Xu","year":"2021","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"140443","DOI":"10.1016\/j.bbapap.2020.140443","article-title":"The aging lysosome: An essential catalyst for late-onset neurodegenerative diseases","volume":"1868","author":"Nixon","year":"2020","journal-title":"Biochim. Biophys. Acta Proteins Proteom."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/s13197-011-0269-4","article-title":"Role of nutraceuticals in human health","volume":"49","author":"Das","year":"2012","journal-title":"J. Food Sci. Technol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.3389\/fnins.2020.612757","article-title":"Defective Autophagy and Mitophagy in Aging and Alzheimer\u2019s Disease","volume":"14","author":"Tran","year":"2021","journal-title":"Front. Neurosci."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1111\/1440-1681.13500","article-title":"Targeting autophagy in neurodegenerative diseases: From molecular mechanisms to clinical therapeutics","volume":"48","author":"Ajoolabady","year":"2021","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"ref_99","doi-asserted-by":"crossref","unstructured":"Cai, Q., and Jeong, Y.Y. (2020). Mitophagy in Alzheimer\u2019s Disease and Other Age-Related Neurodegenerative Diseases. Cells, 9.","DOI":"10.3390\/cells9010150"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"117253","DOI":"10.1016\/j.jns.2020.117253","article-title":"Role of mitochondrial dysfunction, oxidative stress and autophagy in progression of Alzheimer\u2019s disease","volume":"421","author":"Bhatia","year":"2021","journal-title":"J. Neurol. Sci."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/s40035-020-00221-2","article-title":"Neuroinflammation in neurodegenerative disorders: The roles of microglia and astrocytes","volume":"9","author":"Kwon","year":"2020","journal-title":"Transl. Neurodegener."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.3389\/fimmu.2017.01805","article-title":"Nuclear Factor-Kappa B and Alzheimer Disease, Unifying Genetic and Environmental Risk Factors from Cell to Humans","volume":"8","author":"Jones","year":"2017","journal-title":"Front. Immunol."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1159\/000067426","article-title":"The Role of Mitogen-Activated Protein Kinase Pathways in Alzheimer\u2019s Disease","volume":"11","author":"Zhu","year":"2002","journal-title":"Neurosignals"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"101","DOI":"10.3390\/genes4020101","article-title":"The Role of Mitogen-Activated Protein Kinase-Activated Protein Kinases (MAPKAPKs) in Inflammation","volume":"4","author":"Moens","year":"2013","journal-title":"Genes"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"629","DOI":"10.3389\/fnins.2019.00629","article-title":"Altered Insulin Signaling in Alzheimer\u2019s Disease Brain\u2014Special Emphasis on PI3K-Akt Pathway","volume":"13","author":"Gabbouj","year":"2019","journal-title":"Front. Neurosci."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1007\/s12192-021-01231-3","article-title":"The PI3K\/Akt signaling axis in Alzheimer\u2019s disease: A valuable target to stimulate or suppress?","volume":"26","author":"Razani","year":"2021","journal-title":"Cell Stress Chaperones"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"115444","DOI":"10.1016\/j.taap.2021.115444","article-title":"Health disparities: Intracellular consequences of social determinants of health","volume":"416","author":"Emeny","year":"2021","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1016\/j.jalz.2019.08.192","article-title":"A research framework for cognitive aging and Alzheimer\u2019s disease among diverse US Latinos: Design and implementation of the Hispanic Community Health Study\/Study of Latinos-Investigation of Neurocognitive Aging (SOL-INCA)","volume":"15","author":"Tarraf","year":"2019","journal-title":"Alzheimers Dement."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/j.nicl.2017.09.014","article-title":"Beta-amyloid and Cortical Thickness Reveal Racial Disparities in Preclinical Alzheimer\u2019s Disease","volume":"16","author":"McDonough","year":"2017","journal-title":"NeuroImage Clin."},{"key":"ref_110","first-page":"207","article-title":"The weathering hypothesis and the health of African-American women and infants: Evidence and speculations","volume":"2","author":"Geronimus","year":"1992","journal-title":"Ethn. Dis."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"e207559","DOI":"10.1001\/jamanetworkopen.2020.7559","article-title":"Association of Neighborhood-Level Disadvantage With Alzheimer Disease Neuropathology","volume":"3","author":"Powell","year":"2020","journal-title":"JAMA Netw. Open"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"2268","DOI":"10.1212\/WNL.0000000000004025","article-title":"Racial disparities in neurologic health care access and utilization in the United States","volume":"88","author":"Saadi","year":"2017","journal-title":"Neurology"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1002\/alz.12060","article-title":"Complex interactions underlie racial disparity in the risk of developing Alzheimer\u2019s disease dementia","volume":"16","author":"Xiong","year":"2020","journal-title":"Alzheimers Dement."},{"key":"ref_114","first-page":"1014","article-title":"Sex Differences in Neurodegenerative Diseases","volume":"3","year":"2017","journal-title":"SM J. Neurol. Disord. Stroke"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.jsbmb.2015.09.039","article-title":"Sex differences in neurodevelopmental and neurodegenerative disorders: Focus on microglial function and neuroinflammation during development","volume":"160","author":"Hanamsagar","year":"2016","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"ref_116","doi-asserted-by":"crossref","unstructured":"Andrew, M.K., and Tierney, M.C. (2018). The puzzle of sex, gender and Alzheimer\u2019s disease: Why are women more often affected than men?. Women\u2019s Health, 14.","DOI":"10.1177\/1745506518817995"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"54","DOI":"10.5498\/wjp.v6.i1.54","article-title":"Sex differences in cognitive impairment in Alzheimer\u2019s disease","volume":"6","author":"Laws","year":"2016","journal-title":"World J. Psychiatry"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.yfrne.2014.01.002","article-title":"Sex differences in cognitive impairment and Alzheimer\u2019s disease","volume":"35","author":"Li","year":"2014","journal-title":"Front. Neuroendocrinol."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"e106","DOI":"10.1016\/S2468-2667(20)30258-9","article-title":"Sex differences and the role of education in cognitive ageing: Analysis of two UK-based prospective cohort studies","volume":"6","author":"Bloomberg","year":"2021","journal-title":"Lancet Public Health"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1210\/er.2016-1007","article-title":"Estrogens, Neuroinflammation, and Neurodegeneration","volume":"37","author":"Villa","year":"2016","journal-title":"Endocr. Rev."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"bvaa120","DOI":"10.1210\/jendso\/bvaa120","article-title":"Androgen Therapy in Neurodegenerative Diseases","volume":"4","author":"Bianchi","year":"2020","journal-title":"J. Endocr. Soc."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"011509","DOI":"10.1063\/5.0035610","article-title":"Sex differences in the blood\u2013brain barrier and neurodegenerative diseases","volume":"5","author":"Weber","year":"2021","journal-title":"APL Bioeng."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"124","DOI":"10.3389\/fnagi.2018.00124","article-title":"Mitochondria, Estrogen and Female Brain Aging","volume":"10","author":"Lejri","year":"2018","journal-title":"Front. Aging Neurosci."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"430","DOI":"10.3389\/fnagi.2017.00430","article-title":"Role of Estrogen and Other Sex Hormones in Brain Aging. Neuroprotection and DNA Repair","volume":"9","author":"Stevnsner","year":"2017","journal-title":"Front. Aging Neurosci."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1093\/gerona\/gls068","article-title":"The role of androgens and estrogens on healthy aging and longevity","volume":"67","author":"Horstman","year":"2012","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.biopsych.2021.01.002","article-title":"Sex Differences in Neurodegeneration: The Role of the Immune System in Humans","volume":"91","author":"Kodama","year":"2022","journal-title":"Biol. Psychiatry"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/j.molmed.2019.05.001","article-title":"Do Microglial Sex Differences Contribute to Sex Differences in Neurodegenerative Diseases?","volume":"25","author":"Kodama","year":"2019","journal-title":"Trends Mol. Med."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/s13195-016-0207-9","article-title":"Drug development in Alzheimer\u2019s disease: The path to 2025","volume":"8","author":"Cummings","year":"2016","journal-title":"Alzheimers Res. Ther."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1111\/j.1541-4337.2004.tb00063.x","article-title":"Inflammatory Process and Molecular Targets for Antiinflammatory Nutraceuticals","volume":"3","author":"Huang","year":"2004","journal-title":"Compr. Rev. Food Sci. Food Saf."},{"key":"ref_130","first-page":"70","article-title":"Importance of Phytochemicals in Nutraceuticals","volume":"1","author":"Prof","year":"2012","journal-title":"J. Chin. Med. Res. Dev."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"2986796","DOI":"10.1155\/2016\/2986796","article-title":"Mechanisms of Neuroprotection by Quercetin: Counteracting Oxidative Stress and More","volume":"2016","author":"Costa","year":"2016","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.ejmech.2017.09.001","article-title":"Anti-inflammatory effects of flavonoids in neurodegenerative disorders","volume":"153","author":"Spagnuolo","year":"2018","journal-title":"Eur. J. Med. Chem."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.foodres.2009.01.007","article-title":"Medicinal and therapeutic potentialities of tea (Camellia sinensis L.)\u2014A review","volume":"42","author":"Sharangi","year":"2009","journal-title":"Food Res. Int."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.biopha.2015.12.013","article-title":"Protective role of epigallocatechin-3-gallate in health and disease: A perspective","volume":"78","author":"Chowdhury","year":"2016","journal-title":"Biomed. Pharmacother."},{"key":"ref_135","doi-asserted-by":"crossref","unstructured":"Teixeira, A.M., and Sousa, C. (2021). A Review on the Biological Activity of Camellia Species. Molecules, 26.","DOI":"10.3390\/molecules26082178"},{"key":"ref_136","doi-asserted-by":"crossref","unstructured":"Gao, J., Hu, J., Hu, D., and Yang, X. (2019). A Role of Gallic Acid in Oxidative Damage Diseases: A Comprehensive Review. Nat. Prod. Commun., 14.","DOI":"10.1177\/1934578X19874174"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"1700699","DOI":"10.1002\/mnfr.201700699","article-title":"Gallic Acid and Gallates in Human Health and Disease: Do Mitochondria Hold the Key to Success?","volume":"62","author":"Kosuru","year":"2018","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"16251","DOI":"10.1074\/jbc.RA119.012330","article-title":"Gallic acid is a dual \u03b1\/\u03b2-secretase modulator that reverses cognitive impairment and remediates pathology in Alzheimer mice","volume":"295","author":"Mori","year":"2020","journal-title":"J. Biol. Chem."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"109022","DOI":"10.1016\/j.abb.2021.109022","article-title":"Influence of in vitro neuronal membranes on the anti-amyloidogenic activity of gallic acid: Implication for the therapy of Alzheimer\u2019s disease","volume":"711","author":"Andrade","year":"2021","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"115596","DOI":"10.1016\/j.bmc.2020.115596","article-title":"Amide derivatives of Gallic acid: Design, synthesis and evaluation of inhibitory activities against in vitro \u03b1-synuclein aggregation","volume":"28","author":"Chen","year":"2020","journal-title":"Bioorg. Med. Chem."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1016\/j.bbapap.2014.04.013","article-title":"Gallic acid interacts with \u03b1-synuclein to prevent the structural collapse necessary for its aggregation","volume":"1844","author":"Liu","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_142","doi-asserted-by":"crossref","unstructured":"Xu, Y., Tang, G., Zhang, C., Wang, N., and Feng, Y. (2021). Gallic Acid and Diabetes Mellitus: Its Association with Oxidative Stress. Molecules, 26.","DOI":"10.3390\/molecules26237115"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1007\/s12035-019-01759-7","article-title":"Gallic Acid Attenuated LPS-Induced Neuroinflammation: Protein Aggregation and Necroptosis","volume":"57","author":"Liu","year":"2020","journal-title":"Mol. Neurobiol."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.freeradbiomed.2021.12.009","article-title":"Dietary protein and amino acid restriction: Roles in metabolic health and aging-related diseases","volume":"178","author":"Wang","year":"2022","journal-title":"Free Radic. Biol. Med."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s00424-021-02640-0","article-title":"(\u2212)-Epicatechin and cardiometabolic risk factors: A focus on potential mechanisms of action","volume":"474","author":"Hid","year":"2022","journal-title":"Pflug. Arch."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"108505","DOI":"10.1016\/j.abb.2020.108505","article-title":"(\u2212)-Epicatechin and the comorbidities of obesity","volume":"690","author":"Cremonini","year":"2020","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"e3160","DOI":"10.1038\/cddis.2017.563","article-title":"A new molecular mechanism underlying the EGCG-mediated autophagic modulation of AFP in HepG2 cells","volume":"8","author":"Zhao","year":"2017","journal-title":"Cell Death Dis."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.fct.2017.04.021","article-title":"Galloylation of polyphenols alters their biological activity","volume":"105","author":"Karas","year":"2017","journal-title":"Food Chem. Toxicol."},{"key":"ref_149","doi-asserted-by":"crossref","unstructured":"Zwolak, I. (2021). Epigallocatechin Gallate for Management of Heavy Metal-Induced Oxidative Stress: Mechanisms of Action, Efficacy, and Concerns. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22084027"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"23712","DOI":"10.1074\/jbc.M114.556159","article-title":"Effects of a disrupted blood-brain barrier on cholesterol homeostasis in the brain","volume":"289","author":"Saeed","year":"2014","journal-title":"J. Biol. Chem."},{"key":"ref_151","doi-asserted-by":"crossref","unstructured":"Cai, Z.Y., Li, X.M., Liang, J.P., Xiang, L.P., Wang, K.R., Shi, Y.L., Yang, R., Shi, M., Ye, J.H., and Lu, J.L. (2018). Bioavailability of Tea Catechins and Its Improvement. Molecules, 23.","DOI":"10.3390\/molecules23092346"},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"103732","DOI":"10.1016\/j.jff.2019.103732","article-title":"Bioavailability enhancement of EGCG by structural modification and nano-delivery: A review","volume":"65","author":"Dai","year":"2020","journal-title":"J. Funct. Foods"},{"key":"ref_153","doi-asserted-by":"crossref","unstructured":"Pervin, M., Unno, K., Takagaki, A., Isemura, M., and Nakamura, Y. (2019). Function of Green Tea Catechins in the Brain: Epigallocatechin Gallate and its Metabolites. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20153630"},{"key":"ref_154","doi-asserted-by":"crossref","unstructured":"Liu, B., Kang, Z., and Yan, W. (2021). Synthesis, Stability, and Antidiabetic Activity Evaluation of (\u2212)-Epigallocatechin Gallate (EGCG) Palmitate Derived from Natural Tea Polyphenols. Molecules, 26.","DOI":"10.3390\/molecules26020393"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"e02020","DOI":"10.1016\/j.heliyon.2019.e02020","article-title":"EGCG intestinal absorption and oral bioavailability enhancement using folic acid-functionalized nanostructured lipid carriers","volume":"5","author":"Granja","year":"2019","journal-title":"Heliyon"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"447","DOI":"10.3389\/fbioe.2019.00447","article-title":"Nanodelivery of Natural Antioxidants: An Anti-aging Perspective","volume":"7","author":"Vaiserman","year":"2019","journal-title":"Front. Bioeng. Biotechnol."},{"key":"ref_157","doi-asserted-by":"crossref","unstructured":"Sneideris, T., Sakalauskas, A., Sternke-Hoffmann, R., Peduzzo, A., Ziaunys, M., Buell, A.K., and Smirnovas, V. (2019). The Environment Is a Key Factor in Determining the Anti-Amyloid Efficacy of EGCG. Biomolecules, 9.","DOI":"10.3390\/biom9120855"},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"718188","DOI":"10.3389\/fnins.2021.718188","article-title":"Green Tea Polyphenol Epigallocatechin-Gallate in Amyloid Aggregation and Neurodegenerative Diseases","volume":"15","author":"Fernandes","year":"2021","journal-title":"Front. Neurosci."},{"key":"ref_159","doi-asserted-by":"crossref","unstructured":"Gon\u00e7alves, P.B., Sodero, A.C.R., and Cordeiro, Y. (2021). Green Tea Epigallocatechin-3-gallate (EGCG) Targeting Protein Misfolding in Drug Discovery for Neurodegenerative Diseases. Biomolecules, 11.","DOI":"10.3390\/biom11050767"},{"key":"ref_160","first-page":"52","article-title":"Camellia Sinensis (Green Tea): A Review","volume":"6","author":"Namita","year":"2012","journal-title":"Glob. J. Pharmacol."},{"key":"ref_161","doi-asserted-by":"crossref","unstructured":"Prasanth, M.I., Sivamaruthi, B.S., Chaiyasut, C., and Tencomnao, T. (2019). A Review of the Role of Green Tea (Camellia sinensis) in Antiphotoaging, Stress Resistance, Neuroprotection, and Autophagy. Nutrients, 11.","DOI":"10.3390\/nu11020474"},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1007\/s12640-019-00143-6","article-title":"Protective Effect of (\u2212)Epigallocatechin-3-gallate on Rotenone-Induced Parkinsonism-like Symptoms in Rats","volume":"37","author":"Tseng","year":"2020","journal-title":"Neurotox. Res."},{"key":"ref_163","first-page":"218","article-title":"Epigallocatechin 3-Gallate as an Inhibitor of Tau Phosphorylation and Aggregation: A Molecular and Structural Insight","volume":"4","author":"Fleau","year":"2017","journal-title":"J. Prev. Alzheimers Dis."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"e12381","DOI":"10.7717\/peerj.12381","article-title":"Interplay between epigallocatechin-3-gallate and ionic strength during amyloid aggregation","volume":"9","author":"Ziaunys","year":"2021","journal-title":"PeerJ"},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"12579","DOI":"10.1038\/s41598-020-69429-6","article-title":"EGCG impedes human Tau aggregation and interacts with Tau","volume":"10","author":"Sonawane","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_166","doi-asserted-by":"crossref","unstructured":"Kim, S.N., Kwon, H.J., Akindehin, S., Jeong, H.W., and Lee, Y.H. (2017). Effects of Epigallocatechin-3-Gallate on Autophagic Lipolysis in Adipocytes. Nutrients, 9.","DOI":"10.3390\/nu9070680"},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"200","DOI":"10.21037\/atm.2020.01.92","article-title":"EGCG protects vascular endothelial cells from oxidative stress-induced damage by targeting the autophagy-dependent PI3K-AKT-mTOR pathway","volume":"8","author":"Meng","year":"2020","journal-title":"Ann. Transl. Med."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"6721530","DOI":"10.1155\/2018\/6721530","article-title":"Epigallocatechin-3-Gallate (EGCG) Promotes Autophagy-Dependent Survival via Influencing the Balance of mTOR-AMPK Pathways upon Endoplasmic Reticulum Stress","volume":"2018","author":"Holczer","year":"2018","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1080\/15592294.2016.1144007","article-title":"Aging is associated with hypermethylation of autophagy genes in macrophages","volume":"11","author":"Khalil","year":"2016","journal-title":"Epigenetics"},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.phrs.2018.11.001","article-title":"Molecular pharmacology of inflammation: Medicinal plants as anti-inflammatory agents","volume":"139","author":"Tasneem","year":"2019","journal-title":"Pharmacol. Res."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"152768","DOI":"10.1016\/j.phymed.2018.11.028","article-title":"(\u2212)-Epigallocatechin-3-gallate suppresses cigarette smoke-induced inflammation in human cardiomyocytes via ROS-mediated MAPK and NF-\u03baB pathways","volume":"58","author":"Liang","year":"2019","journal-title":"Phytomedicine"},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"118260","DOI":"10.1016\/j.lfs.2020.118260","article-title":"Epigallocatechin gallate diminishes cigarette smoke-induced oxidative stress, lipid peroxidation, and inflammation in human bronchial epithelial cells","volume":"259","author":"Lakshmi","year":"2020","journal-title":"Life Sci."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.bbrc.2021.02.132","article-title":"Epigallocatechin-3-gallate exhibits immunomodulatory effects in human primary T cells","volume":"550","author":"Huang","year":"2021","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"106872","DOI":"10.1016\/j.intimp.2020.106872","article-title":"Blockade of RANKL\/RANK signaling pathway by epigallocatechin gallate alleviates mast cell-mediated inflammatory reactions","volume":"88","author":"Kim","year":"2020","journal-title":"Int. Immunopharmacol."},{"key":"ref_175","first-page":"317","article-title":"Epigallocatechin 3-gallate attenuates arthritis by regulating Nrf2, HO-1, and cytokine levels in an experimental arthritis model","volume":"67","author":"Karatas","year":"2020","journal-title":"Biotechnol. Appl. Biochem."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"2618","DOI":"10.1016\/j.fct.2011.07.006","article-title":"Epigallocatechin-3-gallate protects rat brain mitochondria against cadmium-induced damage","volume":"49","author":"Abib","year":"2011","journal-title":"Food Chem. Toxicol."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1177\/0960327110392087","article-title":"Protective effects of epigallocatechin-3-gallate against lead-induced oxidative damage","volume":"30","author":"Wei","year":"2011","journal-title":"Hum. Exp. Toxicol."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.taap.2011.10.018","article-title":"Epigallocatechin-3-gallate (EGCG) protects against chromate-induced toxicity in vitro","volume":"258","author":"Wu","year":"2012","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.fct.2016.07.030","article-title":"Epigallocatechin-3-gallate attenuates cadmium-induced chronic renal injury and fibrosis","volume":"96","author":"Chen","year":"2016","journal-title":"Food Chem. Toxicol."},{"key":"ref_180","first-page":"112","article-title":"Vascular pathology: Cause or effect in Alzheimer disease?","volume":"33","author":"Tormos","year":"2018","journal-title":"Neurologia"},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"H83","DOI":"10.1530\/VB-19-0023","article-title":"The crosstalk between the cardiovascular and the immune system","volume":"1","author":"Tona","year":"2019","journal-title":"Vasc. Biol."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2019\/7092151","article-title":"Vascular Inflammation and Oxidative Stress: Major Triggers for Cardiovascular Disease","volume":"2019","author":"Steven","year":"2019","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1172\/JCI97509","article-title":"Blood will out: Vascular contributions to Alzheimer\u2019s disease","volume":"128","author":"Strickland","year":"2018","journal-title":"J. Clin. Investig."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1159\/000505625","article-title":"An Integrated View on Vascular Dysfunction in Alzheimer\u2019s Disease","volume":"19","author":"Klohs","year":"2019","journal-title":"Neurodegener. Dis."},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.lfs.2013.07.006","article-title":"Potential benefits of green tea polyphenol EGCG in the prevention and treatment of vascular inflammation in rheumatoid arthritis","volume":"93","author":"Riegsecker","year":"2013","journal-title":"Life Sci."},{"key":"ref_186","doi-asserted-by":"crossref","unstructured":"Adinew, G.M., Taka, E., Mendonca, P., Messeha, S.S., and Soliman, K.F.A. (2021). The Anticancer Effects of Flavonoids through miRNAs Modulations in Triple-Negative Breast Cancer. Nutrients, 13.","DOI":"10.3390\/nu13041212"},{"key":"ref_187","doi-asserted-by":"crossref","unstructured":"Lee, C.Y., Ryu, I.S., Ryu, J.H., and Cho, H.J. (2021). miRNAs as Therapeutic Tools in Alzheimer\u2019s Disease. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms222313012"},{"key":"ref_188","doi-asserted-by":"crossref","unstructured":"Kou, X., and Chen, N. (2017). Resveratrol as a Natural Autophagy Regulator for Prevention and Treatment of Alzheimer\u2019s Disease. Nutrients, 9.","DOI":"10.3390\/nu9090927"},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"160","DOI":"10.3389\/fnmol.2020.00160","article-title":"MicroRNAs in Alzheimer\u2019s Disease: Function and Potential Applications as Diagnostic Biomarkers","volume":"13","author":"Wei","year":"2020","journal-title":"Front. Mol. Neurosci."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"687973","DOI":"10.3389\/fnins.2021.687973","article-title":"Alzheimer\u2019s Disease and microRNA-132: A Widespread Pathological Factor and Potential Therapeutic Target","volume":"15","author":"Zhang","year":"2021","journal-title":"Front. Neurosci."},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"113688","DOI":"10.1016\/j.bcp.2019.113688","article-title":"Targeting miRNAs by polyphenols: Novel therapeutic strategy for aging","volume":"173","author":"Majidinia","year":"2020","journal-title":"Biochem. Pharmacol."},{"key":"ref_192","doi-asserted-by":"crossref","unstructured":"Cione, E., La Torre, C., Cannataro, R., Caroleo, M.C., Plastina, P., and Gallelli, L. (2019). Quercetin, Epigallocatechin Gallate, Curcumin, and Resveratrol: From Dietary Sources to Human MicroRNA Modulation. Molecules, 25.","DOI":"10.3390\/molecules25010063"},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.3233\/JAD-170156","article-title":"Identification of Circulating miR-125b as a Potential Biomarker of Alzheimer\u2019s Disease in APP\/PS1 Transgenic Mouse","volume":"59","author":"Hong","year":"2017","journal-title":"J. Alzheimers Dis."},{"key":"ref_194","doi-asserted-by":"crossref","unstructured":"Gruendler, R., Hippe, B., Sendula Jengic, V., Peterlin, B., and Haslberger, A.G. (2020). Nutraceutical Approaches of Autophagy and Neuroinflammation in Alzheimer\u2019s Disease: A Systematic Review. Molecules, 25.","DOI":"10.3390\/molecules25246018"},{"key":"ref_195","doi-asserted-by":"crossref","unstructured":"Tzou, F.Y., Wen, J.K., Yeh, J.Y., Huang, S.Y., Chen, G.C., and Chan, C.C. (2021). Drosophila as a model to study autophagy in neurodegenerative diseases and digestive tract. IUBMB Life, in press.","DOI":"10.1002\/iub.2583"},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1007\/s11064-016-2093-8","article-title":"Epigallocatechin Gallate Attenuates \u03b2-Amyloid Generation and Oxidative Stress Involvement of PPAR\u03b3 in N2a\/APP695 Cells","volume":"42","author":"Zhang","year":"2017","journal-title":"Neurochem. Res."},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.1016\/j.biotechadv.2017.12.001","article-title":"Regulation of autophagy by polyphenols: Paving the road for treatment of neurodegeneration","volume":"36","author":"Nabavi","year":"2018","journal-title":"Biotechnol. Adv."},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"105024","DOI":"10.1016\/j.chemphyslip.2020.105024","article-title":"Green tea extract EGCG plays a dual role in A\u03b2(42) protofibril disruption and membrane protection: A molecular dynamic study","volume":"234","author":"Dong","year":"2021","journal-title":"Chem. Phys. Lipids"},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.bpj.2020.05.033","article-title":"The Effect of (\u2212)-Epigallocatechin-3-Gallate on the Amyloid-\u03b2 Secondary Structure","volume":"119","author":"Acharya","year":"2020","journal-title":"Biophys. J."},{"key":"ref_200","doi-asserted-by":"crossref","unstructured":"Mao, L., Hochstetter, D., Yao, L., Zhao, Y., Zhou, J., Wang, Y., and Xu, P. (2019). Green Tea Polyphenol (\u2212)-Epigallocatechin Gallate (EGCG) Attenuates Neuroinflammation in Palmitic Acid-Stimulated BV-2 Microglia and High-Fat Diet-Induced Obese Mice. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20205081"},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"107412","DOI":"10.1016\/j.intimp.2021.107412","article-title":"Epigallocatechin-3-gallate prevents inflammation and diabetes-induced glucose tolerance through inhibition of NLRP3 inflammasome activation","volume":"93","author":"Zhang","year":"2021","journal-title":"Int. Immunopharmacol."},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1111\/jpn.12276","article-title":"Effects of epigallocatechin gallate on lipid metabolism and its underlying molecular mechanism in broiler chickens","volume":"99","author":"Huang","year":"2015","journal-title":"J. Anim. Physiol. Anim. Nutr."},{"key":"ref_203","doi-asserted-by":"crossref","unstructured":"Unno, K., and Nakamura, Y. (2021). Green Tea Suppresses Brain Aging. Molecules, 26.","DOI":"10.3390\/molecules26164897"},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"705304","DOI":"10.3389\/fnagi.2021.705304","article-title":"Cerebral Cortex Apoptosis in Early Aged Hypertension: Effects of Epigallocatechin-3-Gallate","volume":"13","author":"Hsieh","year":"2021","journal-title":"Front. Aging Neurosci."},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/s10522-018-9785-1","article-title":"Epigallocatechin gallate suppresses premature senescence of preadipocytes by inhibition of PI3K\/Akt\/mTOR pathway and induces senescent cell death by regulation of Bax\/Bcl-2 pathway","volume":"20","author":"Kumar","year":"2019","journal-title":"Biogerontology"},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"282","DOI":"10.3389\/fphys.2014.00282","article-title":"Mitochondrial and cellular mechanisms for managing lipid excess","volume":"5","author":"Aon","year":"2014","journal-title":"Front. Physiol."},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1007\/s10522-017-9710-z","article-title":"Lipid (per) oxidation in mitochondria: An emerging target in the ageing process?","volume":"18","author":"Ademowo","year":"2017","journal-title":"Biogerontology"},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"S121","DOI":"10.1038\/sj.ejcn.1601033","article-title":"Lipid metabolism in the elderly","volume":"54","author":"Toth","year":"2000","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.yclnex.2018.05.001","article-title":"Lipids: An insight into the neurodegenerative disorders","volume":"20","author":"Shamim","year":"2018","journal-title":"Clin. Nutr. Exp."},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"556","DOI":"10.3389\/fnins.2019.00556","article-title":"A Crosstalk Between Brain Cholesterol Oxidation and Glucose Metabolism in Alzheimer\u2019s Disease","volume":"13","author":"Gamba","year":"2019","journal-title":"Front. Neurosci."},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"292598","DOI":"10.1155\/2012\/292598","article-title":"Cholesterol: Its Regulation and Role in Central Nervous System Disorders","volume":"2012","author":"Orth","year":"2012","journal-title":"Cholesterol"},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"105876","DOI":"10.1016\/j.biocel.2020.105876","article-title":"Cholesterol metabolism: At the cross road between cancer cells and immune environment","volume":"129","author":"Kopecka","year":"2020","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1161\/01.ATV.0000120374.59826.1b","article-title":"Brain cholesterol: Long secret life behind a barrier","volume":"24","author":"Meaney","year":"2004","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.15252\/embr.201439225","article-title":"Cholesterol in brain disease: Sometimes determinant and frequently implicated","volume":"15","author":"Pfrieger","year":"2014","journal-title":"EMBO Rep."},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.arr.2016.03.008","article-title":"Cholesterol metabolism: A review of how ageing disrupts the biological mechanisms responsible for its regulation","volume":"27","author":"Morgan","year":"2016","journal-title":"Ageing Res. Rev."},{"key":"ref_216","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1007\/s11011-017-0021-5","article-title":"The beneficial effects of HMG-CoA reductase inhibitors in the processes of neurodegeneration","volume":"32","author":"Arefidoust","year":"2017","journal-title":"Metab. Brain Dis."},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1002\/biof.1597","article-title":"The effects of statins on microglial cells to protect against neurodegenerative disorders: A mechanistic review","volume":"46","author":"Bagheri","year":"2020","journal-title":"Biofactors"},{"key":"ref_218","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1006\/scdb.1998.0273","article-title":"The role of TNF alpha in adipocyte metabolism","volume":"10","author":"Sethi","year":"1999","journal-title":"Semin. Cell Dev. Biol."},{"key":"ref_219","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1002\/cbf.1596","article-title":"TNF-alpha, a potent lipid metabolism regulator","volume":"27","author":"Chen","year":"2009","journal-title":"Cell Biochem. Funct."},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"393","DOI":"10.3389\/fphys.2020.00393","article-title":"Lipid and Lipoprotein Metabolism in Microglia","volume":"11","author":"Loving","year":"2020","journal-title":"Front. Physiol."},{"key":"ref_221","doi-asserted-by":"crossref","first-page":"174","DOI":"10.3389\/fnagi.2019.00174","article-title":"Liver Dysfunction as a Novel Player in Alzheimer\u2019s Progression: Looking Outside the Brain","volume":"11","author":"Estrada","year":"2019","journal-title":"Front. Aging Neurosci."},{"key":"ref_222","doi-asserted-by":"crossref","unstructured":"Zhou, J., Farah, B.L., Sinha, R.A., Wu, Y., Singh, B.K., Bay, B.H., Yang, C.S., and Yen, P.M. (2014). Epigallocatechin-3-gallate (EGCG), a green tea polyphenol, stimulates hepatic autophagy and lipid clearance. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0087161"},{"key":"ref_223","doi-asserted-by":"crossref","first-page":"1479164120966998","DOI":"10.1177\/1479164120966998","article-title":"Epigallocatechin-3-gallate ameliorates glucolipid metabolism and oxidative stress in type 2 diabetic rats","volume":"17","author":"Li","year":"2020","journal-title":"Diabetes Vasc. Dis. Res."},{"key":"ref_224","doi-asserted-by":"crossref","unstructured":"Rothenberg, D.O., Zhou, C., and Zhang, L. (2018). A Review on the Weight-Loss Effects of Oxidized Tea Polyphenols. Molecules, 23.","DOI":"10.3390\/molecules23051176"},{"key":"ref_225","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1016\/j.immuni.2019.03.016","article-title":"Immune Signaling in Neurodegeneration","volume":"50","author":"Hammond","year":"2019","journal-title":"Immunity"}],"container-title":["Biomolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2218-273X\/12\/3\/371\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T22:27:53Z","timestamp":1760135273000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2218-273X\/12\/3\/371"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,25]]},"references-count":225,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2022,3]]}},"alternative-id":["biom12030371"],"URL":"https:\/\/doi.org\/10.3390\/biom12030371","relation":{},"ISSN":["2218-273X"],"issn-type":[{"value":"2218-273X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,25]]}}}