{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T07:09:28Z","timestamp":1768892968106,"version":"3.49.0"},"reference-count":45,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2022,3,16]],"date-time":"2022-03-16T00:00:00Z","timestamp":1647388800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Projects of the Slovak Research and Development Agency ,  Grant Agency of The Ministry of Education, Science, Research, and Sport of the Slovak Republic","award":["APVV-15-0565, APVV- APVV-19-0154, VEGA 2\/0111\/19"],"award-info":[{"award-number":["APVV-15-0565, APVV- APVV-19-0154, VEGA 2\/0111\/19"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>The objective of this study was to investigate the vasoregulatory role of perivascular adipose tissue (PVAT) and its mutual interaction with endogenous and exogenous H2S in the thoracic aorta (TA) of adult normotensive Wistar rats and spontaneously hypertensive rats (SHRs). In SHRs, hypertension was associated with cardiac hypertrophy and increased contractility. Regardless of the strain, PVAT revealed an anticontractile effect; however, PVAT worsened endothelial-dependent vasorelaxation. Since H2S produced by both the vascular wall and PVAT had a pro-contractile effect in SHRs, H2S decreased the sensitivity of adrenergic receptors to noradrenaline in Wistar rats. While H2S had no contribution to endothelium-dependent relaxation in Wistar rats, in SHRs, H2S produced by the vascular wall had a pro-relaxant effect. We observed a larger vasorelaxation induced by exogenous H2S donor in SHRs than in Wistar rats. Additionally, in the presence of PVAT, this effect was potentiated. We demonstrated that PVAT of the TA aggravated endothelial function in SHRs. However, H2S produced by the TA vascular wall had a pro-relaxation effect, and PVAT revealed anti-contractile activity mediated by the release of an unknown factor and potentiated the vasorelaxation induced by exogenous H2S. All these actions could represent a form of compensatory mechanism to balance impaired vascular tone regulation.<\/jats:p>","DOI":"10.3390\/biom12030457","type":"journal-article","created":{"date-parts":[[2022,3,16]],"date-time":"2022-03-16T03:34:13Z","timestamp":1647401653000},"page":"457","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["The Vasoactive Effect of Perivascular Adipose Tissue and Hydrogen Sulfide in Thoracic Aortas of Normotensive and Spontaneously Hypertensive Rats"],"prefix":"10.3390","volume":"12","author":[{"given":"Samuel","family":"Golas","sequence":"first","affiliation":[{"name":"Center of Experimental Medicine, Institute of Normal and Pathological Physiology, Slovak Academy of Sciences, 84104 Bratislava, Slovakia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Berenyiova","sequence":"additional","affiliation":[{"name":"Center of Experimental Medicine, Institute of Normal and Pathological Physiology, Slovak Academy of Sciences, 84104 Bratislava, Slovakia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8748-4279","authenticated-orcid":false,"given":"Miroslava","family":"Majzunova","sequence":"additional","affiliation":[{"name":"Center of Experimental Medicine, Institute of Normal and Pathological Physiology, Slovak Academy of Sciences, 84104 Bratislava, Slovakia"},{"name":"Department of Animal Physiology and Ethology, Faculty of Natural Sciences, Comenius University, 81108 Bratislava, Slovakia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magdalena","family":"Drobna","sequence":"additional","affiliation":[{"name":"Center of Experimental Medicine, Institute of Normal and Pathological Physiology, Slovak Academy of Sciences, 84104 Bratislava, Slovakia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muobarak J.","family":"Tuorkey","sequence":"additional","affiliation":[{"name":"Zoology Department, Division of Physiology, Faculty of Science, Damanhour University, Damanhour 22514, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sona","family":"Cacanyiova","sequence":"additional","affiliation":[{"name":"Center of Experimental Medicine, Institute of Normal and Pathological Physiology, Slovak Academy of Sciences, 84104 Bratislava, Slovakia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,3,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1159\/000356380","article-title":"Perivascular Adipose Tissue, Vascular Reactivity and Hypertension","volume":"24","author":"Oriowo","year":"2015","journal-title":"Med. 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