{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:56:39Z","timestamp":1792788999068,"version":"4.5.0"},"reference-count":91,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2022,4,14]],"date-time":"2022-04-14T00:00:00Z","timestamp":1649894400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"European Regional Development Fund\u2014Project ENOCH","award":["CZ.02.1.01\/0.0\/0.0\/16_019\/0000868"],"award-info":[{"award-number":["CZ.02.1.01\/0.0\/0.0\/16_019\/0000868"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>Alternanthera philoxeroides (Mart.) Griseb., commonly known as \u201cAlligator weed\u201d in English, and \u201cMalancha\u201d in Bengali, is a leafy vegetable from the family Amaranthaceae A. L. de Jussieu. This species is native to China, particularly to the provinces around the Yangtze River, other Far East and South-East Asian countries, and countries from other continents (e.g., South America). This plant also grows in certain areas in Australia, New Zealand, and the USA. While in Bangladesh the leaves of this plant are consumed as a vegetable, in China, this plant has been used widely as a traditional remedy for the treatment of various viral diseases (e.g., measles, influenza, and haemorrhagic fever). Flavonoids and saponins are the two largest groups of phytochemicals produced by this plant, and the antiviral property of this plant and its compounds has been studied extensively. This review article reviews all published literature on this plant and critically appraises its phytochemical profile linking to biomolecular interactions and therapeutic potential, particularly, against viral diseases.<\/jats:p>","DOI":"10.3390\/biom12040582","type":"journal-article","created":{"date-parts":[[2022,4,14]],"date-time":"2022-04-14T21:44:06Z","timestamp":1649972646000},"page":"582","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["\u201cMalancha\u201d [Alternanthera philoxeroides (Mart.) Griseb.]: A Potential Therapeutic Option against Viral Diseases"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1157-2405","authenticated-orcid":false,"given":"Lutfun","family":"Nahar","sequence":"first","affiliation":[{"name":"Laboratory of Growth Regulators, Institute of Experimental Botany ASCR & Palack\u00fd University, \u0160lechtitel\u016f 27, 78371 Olomouc, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sushmita","family":"Nath","sequence":"additional","affiliation":[{"name":"Centre for Natural Products Discovery (CNPD), School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, James Parsons Building, Byrom Street, Liverpool L3 3AF, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4038-0514","authenticated-orcid":false,"given":"Satyajit D.","family":"Sarker","sequence":"additional","affiliation":[{"name":"Centre for Natural Products Discovery (CNPD), School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, James Parsons Building, Byrom Street, Liverpool L3 3AF, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,4,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"95","DOI":"10.3329\/bjpt.v20i1.15469","article-title":"Taxonomy of the leafy vegetables in Bangladesh","volume":"20","author":"Khatun","year":"2013","journal-title":"Bangladesh J. Plant Taxon."},{"key":"ref_2","first-page":"416","article-title":"In Vitro cytotoxicity of ethanolic leaf extract of Alternanthera sessilis (L.) R. Br. Ex. DC and Alternanthera philoxeroides (Mart.) Griseb. Against human osteosarcoma cell line MG-63","volume":"3","author":"Sunmathi","year":"2016","journal-title":"Eur. J. Biomed. Pharm. Sci."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"83","DOI":"10.26651\/allelo.j\/2021-53-1-1329","article-title":"Antibacterial activity of Alternanthera philoxeroides (Mart.) Griseb. against bacterial phytopathogens: Erwinia carotovora, Ralstonia solanacearum and Xanthomonas axonopodis","volume":"53","author":"Akbar","year":"2021","journal-title":"Allelopath. J."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"3633","DOI":"10.1016\/0031-9422(88)80781-7","article-title":"Alternanthin, a glycosylated flavonoid from Alternanthera philoxeroides","volume":"27","author":"Zhou","year":"1988","journal-title":"Phytochemistry"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1080\/10286020600782231","article-title":"Antitumor constituents from Alternanthera Philoxeroides","volume":"9","author":"Fang","year":"2007","journal-title":"J. Asian Nat. Prod. Res."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2199","DOI":"10.1080\/14786419.2014.930857","article-title":"Isolation and characterisation of methanol-soluble fraction of Alternanthera philoxeroides (Mart.) evaluation of their antioxidant, \u03b1-glucosidase inhibitory and antimicrobial activity in vitro systems","volume":"28","author":"Bhattacharjee","year":"2014","journal-title":"Nat. Prod. Res."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1590\/2236-8906-26\/2016","article-title":"Potential allelopathic and antibacterial activity from Alternanthera Philoxeroides","volume":"43","author":"Kleinowski","year":"2016","journal-title":"Hoehnea"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1080\/10286020802684656","article-title":"Cytotoxic triterpene saponins from Alternanthera philoxeroides","volume":"11","author":"Fang","year":"2009","journal-title":"J. Asian Nat. Prod. Res."},{"key":"ref_9","first-page":"2473","article-title":"Constituents from Alternanthera philoxeroides and their antitumour activity","volume":"34","author":"Fang","year":"2009","journal-title":"Zhongguo Zhong Yao Za Zhi China J. Chin. Mater. Med."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Li, B., Guo, Q.-L., Tian, Y., Liu, S.-J., Wang, Q., Li, C., and Dong, J.-X. (2016). New anti-HBV C-boivinopyranosyl flavones from Alternanthera philoxeroides. Molecules, 21.","DOI":"10.3390\/molecules21030336"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Khamphukdee, C., Monthakantirat, O., Chulikhit, Y., Buttachon, S., Lee, M., Silva, A.M.S., Sekeroglu, N., and Kijioa, A. (2018). Chemical constituents and antidepressant-like effects in ovariectomized mice of the ethanol extract of Alternanthera philoxeroides. Molecules, 23.","DOI":"10.3390\/molecules23092202"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"112","DOI":"10.3724\/SP.J.1009.2008.00112","article-title":"Chemical constituents of Alternanthera philoxeroides","volume":"6","author":"Fan","year":"2008","journal-title":"Chin. J. Nat. Med."},{"key":"ref_13","first-page":"113","article-title":"Immunomodulatory activity of chikusetsusaponin Iva from Alternanthera philoxeroides","volume":"4","author":"Rattanathongkom","year":"2008","journal-title":"Isan J. Pharm. Sci."},{"key":"ref_14","first-page":"1072","article-title":"Chemical constituents from herb of Alternanthera philoxeroides","volume":"31","author":"Fang","year":"2006","journal-title":"Zhongguo Zhong Yao Za Zhi China J. Chin. Mater. Med."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"S568","DOI":"10.1016\/S1995-7645(14)60291-1","article-title":"Antioxidant capacity and total phenolic contents in hydrophilic extracts of selected Bangladeshi medicinal plants","volume":"7","author":"Tukun","year":"2014","journal-title":"Asian Pac. J. Trop. Med."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"341","DOI":"10.5582\/ddt.2018.01070","article-title":"Quantitation of \u03b2-carboline and quercetin in alligator weed (Alternanthera philoxeroides (Mart.) Griseb.) by LC-MS\/MS and evaluation of cardioprotective effects of the methanol extracts","volume":"12","author":"Zhang","year":"2018","journal-title":"Drug Discov. Ther."},{"key":"ref_17","first-page":"3834","article-title":"In-vitro antibacterial potential of Alternanthera philoxeroides (Mart.) Griseb. against multi-drug resistant uropathogens","volume":"11","author":"Pulipati","year":"2020","journal-title":"Int. J. Pharm. Sci. Res."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.25303\/168rjbt0121","article-title":"Antioxidant and Antibacterial Activities of Phytochemicals in Methanolic Extracts of Five Underutilized Leafy Vegetables","volume":"16","author":"Raj","year":"2021","journal-title":"Res. J. Biotechnol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1093\/nutrit\/nuy036","article-title":"Food sources and biomolecular targets of tyramine","volume":"77","author":"Andersen","year":"2019","journal-title":"Nutr. Rev."},{"key":"ref_20","first-page":"1","article-title":"Monoamine oxidase inhibitors: A review concerning dietary tyramine and drug interactions","volume":"1","author":"Gillman","year":"2016","journal-title":"Psychotr. Comment."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"479","DOI":"10.2174\/092986707779940998","article-title":"\u03b2-Carboline alkaloids: Biochemical and pharmacological functions","volume":"14","author":"Cao","year":"2007","journal-title":"Curr. Med. Chem."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/S2221-1691(12)60116-6","article-title":"A review on medicinal importance, pharmacological activity and bioanalytical aspects of \u03b2-carboline alkaloid \u201charmine\u201d","volume":"2","author":"Patel","year":"2012","journal-title":"Asian J. Trop. Biomed."},{"key":"ref_23","unstructured":"Nahar, L., and Sarker, S.D. (2019). Chemistry for Pharmacy Students\u2014General, Organic and Natural Product Chemistry, Wiley & Sons. [2nd ed.]."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"152848","DOI":"10.1016\/j.phymed.2019.152848","article-title":"2-Hydroxy-3-methylanthraquinone inhibits lung carcinoma cells through modulation of IL-6-induced JAK2\/STAT3 pathway","volume":"61","author":"Sun","year":"2019","journal-title":"Phytomedicine"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Bussmann, R.W., Henning, L., Giannis, A., Ortwein, J., Kutchan, T.M., and Feng, X. (2013). Anthraquinone content in Noni (Morinda citrifolia L.). Evid.-Based Complement. Altern. Med.","DOI":"10.1155\/2013\/208378"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"4527","DOI":"10.2147\/DDDT.S338548","article-title":"Chemistry, biosynthesis, physicochemical and biological properties of rubiadin: A promising natural anthraquinone for new drug discovery and development","volume":"15","author":"Watroly","year":"2021","journal-title":"Drug Des. Dev. Ther."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.toxrep.2017.12.024","article-title":"Interaction of anthraquinones of Cassia occidentalis with DNA and glutathione","volume":"5","author":"Panigrahi","year":"2018","journal-title":"Toxicol. Rep."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1080\/073911012010525031","article-title":"Molecular dynamics of anthraquinone DNA intercalators with polyethylene glycol side chains","volume":"19","author":"Beckford","year":"2012","journal-title":"J. Biomol. Struct. Dyn."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"S494","DOI":"10.5530\/ijper.51.3s.73","article-title":"Potential of Alternanthera philoxeroides on improvement of anxiety-like behavior induced by ovariectomized mice model","volume":"51","author":"Khamphukdee","year":"2017","journal-title":"Indian J. Pharm. Educ. Res."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Kumar, S., and Pandey, A.K. (2013). Chemistry and biological activities of flavonoids: An overview. Sci. World J., 162750.","DOI":"10.1155\/2013\/162750"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Batiha, G.E., Beshbishy, A.M., Ikram, M., Mulla, Z.S., El-Hack, M.E.A., Taha, A.E., Algammal, A.M., and Elewa, Y.H.A. (2020). The pharmacological activity, biochemical properties and pharmacokinetics of the major natural polyphenolic flavonoid: Quercetin. Foods, 9.","DOI":"10.3390\/foods9030374"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1080\/14786419.2018.1493588","article-title":"Flavonoids: Biological activities and therapeutic potential","volume":"34","author":"Juca","year":"2020","journal-title":"Nat. Prod. Res."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.freeradbiomed.2007.04.009","article-title":"Inhibition of the peroxidation of linoleic acid by the flavonoid quercetin within their complex with human serum albumin","volume":"43","author":"Dufour","year":"2007","journal-title":"Free Radic. Biol. Med."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/S0006-291X(02)02667-0","article-title":"The interaction of quercetin with human serum albumin: A fluorescence spectroscopic study","volume":"299","author":"Sengupta","year":"2002","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_35","first-page":"1019","article-title":"Comparative binding affinities of flavonoid phytochemicals with bovine serum albumin","volume":"13","author":"Liu","year":"2014","journal-title":"Iran. J. Pharm. Res."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Navarro-Retamal, C., and Caballero, J. (2016). Flavonoids as CDK1 inhibitors: Insights in their binding orientations and structure activity relationships. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0161111"},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Attrahimovich, D., Avni, D., and Khatib, S. (2021). Flavonoids-macromolecules interactions in human diseases with focus on Alzheimers, atherosclerosis and cancer. Antioxidants, 10.","DOI":"10.3390\/antiox10030423"},{"key":"ref_38","first-page":"1817","article-title":"Structural basis for great protein-binding potential of flavonoids: A case study of quercetin","volume":"12","author":"Gao","year":"2017","journal-title":"Nat. Prod. Commun."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1080\/10575639908045437","article-title":"Biologically active blumenol A from the leaves of Annona glabra","volume":"14","author":"Liu","year":"1999","journal-title":"Nat. Prod. Lett."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1080\/10286020.2018.1509313","article-title":"Bioactive megastigmane glucosides and monoterpenes from Lyonia ovalifolia","volume":"21","author":"Lv","year":"2019","journal-title":"J. Asian Nat. Prod. Res."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Ha, T.K.Q., Lee, B.W., Nguyen, N.H., Cho, H.M., Venkatesan, T., Doan, T.P., Kim, E., and Oh, W.K. (2020). Antiviral activities of compounds isolated from Pinus densiflora (Pine Tree) against the unfluenza A virus. Biomolecules, 10.","DOI":"10.3390\/biom10050711"},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Chen, Y.-C., Chia, Y.-C., and Huang, B.-M. (2021). Phytochemicals from Polyalthia species: Potential and implication on antioxidant, anti-inflammatory, anticancer and chemopreventive activities. Molecules, 26.","DOI":"10.3390\/molecules26175369"},{"key":"ref_43","first-page":"488","article-title":"Extraction of effective parts of Alternanthera philoxeroides (Mart.) Griseb. And its antiviral effect","volume":"14","author":"Yang","year":"1989","journal-title":"Zhongguo Zhong Yao Za Zhi China J. Chin. Mater. Med."},{"key":"ref_44","first-page":"454","article-title":"Effects of Alternanthera philoxeroides Griseb. against dengue virus in vitro","volume":"25","author":"Jiang","year":"2005","journal-title":"Di Yi Jun Yi Da Xue Xue Bao"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"4228","DOI":"10.1021\/jf0480290","article-title":"Binding of selected phenolic compounds to proteins","volume":"53","author":"Rawel","year":"2005","journal-title":"J. Agric. Food Chem."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Schefer, S., Oest, M., and Rohn, S. (2021). Interactions between phenolic acids, proteins and carbohydrates\u2014Influence on dough and bread properties. Foods, 10.","DOI":"10.3390\/foods10112798"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1017\/S095442241300019X","article-title":"Interaction of plant phenols with food macronutrients: Characterisation and nutritional-physiological consequences","volume":"27","author":"Zhang","year":"2014","journal-title":"Nutr. Res. Rev."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"14631","DOI":"10.1074\/jbc.M111.325456","article-title":"Phenolic compounds prevent amyloid b-protein oligomerisation and synaptic dysfunction by site-specific binding","volume":"287","author":"Ono","year":"2012","journal-title":"J. Biol. Chem."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1515\/DMDI.2000.17.1-4.211","article-title":"The bioactivity of saponins: Triterpenoid and steroidal glycosides","volume":"17","author":"Rao","year":"2000","journal-title":"Drug Metab. Drug Interact."},{"key":"ref_50","first-page":"5","article-title":"Saponin from Alternanthera philoxeroides (Mart.) Griseb","volume":"3","author":"Dogra","year":"1978","journal-title":"Comp. Physiol. Ecol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1055\/s-0029-1185436","article-title":"Evaluation of chikusetsusaponin Iva isolated from Alternanthera philoxeroides for its potency against viral replication","volume":"75","author":"Rattanathongkom","year":"2009","journal-title":"Planta Med."},{"key":"ref_52","first-page":"428","article-title":"Triterpenoid saponins of Alternanthera philoxeroides (Mart.) Griseb","volume":"46","author":"Guo","year":"2011","journal-title":"Yaoxue Xuebao Acta Pharm. Sin."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1021\/jf00032a023","article-title":"Protein-saponin interaction and its influence on blood lipids","volume":"41","author":"Potter","year":"1993","journal-title":"J. Agric. Food Chem."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"576887","DOI":"10.3389\/fphar.2020.576887","article-title":"Lipid membranes as key targets for the pharmacological actions of ginsenosides","volume":"11","author":"Verstraeten","year":"2020","journal-title":"Front. Pharmacol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"250","DOI":"10.3390\/pathophysiology28020017","article-title":"Saponins in cancer treatment: Current progress and future prospects","volume":"28","author":"Ilekofehinti","year":"2021","journal-title":"Pathophysiology"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1024\/0300-9831.73.2.127","article-title":"Non-nutritive bioactive constituents of plants: Phytosterols","volume":"73","author":"Miettinen","year":"2003","journal-title":"Int. J. Vitam. Nutr. Res."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1002\/mnfr.201100722","article-title":"Effects of plant sterols and stanols on intestinal cholesterol metabolism: Suggested mechanisms from past to present","volume":"56","author":"Mensink","year":"2012","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1177\/2047487314554864","article-title":"Intake of phytosterols from natural sources and risk of cardiovascular disease in the European perspective investigation into cancer and nutrition\u2014The Netherland\u2019s (epic-nl) population","volume":"22","author":"Ras","year":"2015","journal-title":"Eur. J. Prev. Cardiol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"599959","DOI":"10.3389\/fphar.2020.599959","article-title":"Phytosterols: From preclinical evidence to potential clinical applications","volume":"11","author":"Salehi","year":"2020","journal-title":"Front. Pharmacol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.atherosclerosis.2008.06.026","article-title":"New insights into the molecular actions of plant sterols and stanols in cholesterol metabolism","volume":"203","year":"2009","journal-title":"Atherosclerosis"},{"key":"ref_61","first-page":"1213","article-title":"Isolation of cycloeucalenol from Boophone disticha and evaluation of its cytotoxicity","volume":"8","author":"Adewusi","year":"2013","journal-title":"Nat. Prod. Commun."},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Ayleso, T.B., Matumba, M.G., and Mukwevho, E. (2017). Oleanolic acid and its derivatives: Biological activities and therapeutic potential in chronic diseases. Molecules, 22.","DOI":"10.3390\/molecules22111915"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"620472","DOI":"10.1155\/2015\/620472","article-title":"Antimicrobial activity of oleanolic and ursolic acid: An update","volume":"2015","author":"Jesus","year":"2015","journal-title":"Evid.-Based Complement. Altern. Med."},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Mlala, S., Oyedeji, A.O., Gondwe, M., and Oyedeji, O.O. (2019). Ursolic acid and its derivatives as bioactive agents. Molecules, 24.","DOI":"10.3390\/molecules24152751"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"eaau8408","DOI":"10.1126\/sciadv.aau8408","article-title":"Triterpenoids manipulate a broad range of virus-host fusion via wrapping the HR2 domain prevalent in viral envelop","volume":"4","author":"Si","year":"2018","journal-title":"Sci. Adv."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.jmgm.2015.08.010","article-title":"Sterols and triterpenoids as potential anti-inflammatories: Molecular docking studies for binding to some enzymes involved in inflammatory pathways","volume":"62","author":"Salazar","year":"2015","journal-title":"J. Mol. Graph. Model."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"473","DOI":"10.14719\/pst.2021.8.3.1100","article-title":"Evaluation of vitamin C of ethno-wild edible plants in Northeast India","volume":"8","author":"Nakhuru","year":"2021","journal-title":"Plant. Sci. Today"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"27","DOI":"10.2165\/00044011-199500102-00005","article-title":"Pharmacological properties of azelaic acid","volume":"10","author":"Breathnach","year":"1995","journal-title":"Clin. Drug Investig."},{"key":"ref_69","first-page":"181","article-title":"Azelaic acid: A promising agent for dermatological applications","volume":"15","author":"Kumar","year":"2020","journal-title":"Curr. Drug Ther."},{"key":"ref_70","first-page":"128","article-title":"Bioavailability and bioactivity of vitamin C\u2014A review","volume":"13","author":"Subroto","year":"2021","journal-title":"Int. J. Pharm. Res."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1007\/s12539-016-0186-3","article-title":"Molecular recognition of azelaic acid and related molecules with DNA polymerase I investigated by molecular modeling calculations","volume":"10","author":"Shawon","year":"2018","journal-title":"Interdiscip. Sci."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"20","DOI":"10.7897\/2230-8407.07545","article-title":"Physicochemical and antioxidant assay of Ayurvedic formulations of Alternanthera philoxeroides","volume":"7","author":"Majumder","year":"2016","journal-title":"Int. Res. J. Pharm."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"S71","DOI":"10.1016\/S2221-1691(11)60127-5","article-title":"Evaluation of antimicrobial properties of four extracts against human pathogens","volume":"1","author":"Rawani","year":"2011","journal-title":"Asian Pac. J. Trop. Biomed."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s00284-009-9501-0","article-title":"Antibacterial activity of phenolic compounds against the phytopathogenic Xylella Fastidiosa","volume":"60","author":"Maddox","year":"2010","journal-title":"Curr. Microbiol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"829","DOI":"10.3389\/fmicb.2019.00829","article-title":"Antibacterial properties of polyphenols: Characterisation and QSAR (quantitative- structure-activity relationship) models","volume":"10","author":"Forquet","year":"2019","journal-title":"Front. Microbiol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1080\/17458080.2017.1407042","article-title":"Green synthesis and characterisation of antioxidant-tagged gold nanoparticles (X-GNP) and studies on its potent antimicrobial activity","volume":"13","author":"Bhattacharjee","year":"2018","journal-title":"J. Exp. Nanosci."},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Chang, D., Liu, J., Bilinski, K., Xu, L., Steiner, G.Z., Seto, S.W., and Bensoussan, A. (2016). Herbal medicine for the treatment of vascular dementia: An overview of scientific evidence. Evid.-Based Complement. Altern. Med.","DOI":"10.1155\/2016\/7293626"},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Khamphukdee, C., Monthakantirat, O., Chulikhit, Y., Boonyarat, C., Daodee, S., Aon-im, P., Maneenet, J., Chotritthirong, Y., Luecha, P., and Sekeroglu, N. (2021). Antidementia effects of Alternanthera philoxeroides in ovariectomized mice supported by NMR-based metabolomic analysis. Molecules, 26.","DOI":"10.3390\/molecules26092789"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1924","DOI":"10.2174\/1568026616666160204121039","article-title":"A Systematic review of plant-derived natural compounds for anxiety disorders","volume":"16","author":"Mohammad","year":"2016","journal-title":"Curr. Top. Med. Chem."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1097\/FBP.0000000000000290","article-title":"The anxiolytic-like effect of rutin in rats involves GABAA receptors in the bAPolateral amygdala","volume":"28","year":"2017","journal-title":"Behav. Pharmacol."},{"key":"ref_81","first-page":"583","article-title":"Evaluation of antinociceptive and antihyperglycemic activities in methanol extracts of whole plants of Alternanthera philoxeroides (Mart.) Griseb. (Amaranthaceae) in mice","volume":"25","author":"Khatun","year":"2012","journal-title":"Pak. J. Pharm. Sci."},{"key":"ref_82","first-page":"317","article-title":"Occurrence of plant virus inhibitors om 5 species of Caryophylales 2. Alternanthera amoena, Alternanthera brasiliana, Alternanthera philoxeroides, Iresine herbstii and Talinum paniculatum","volume":"8","author":"Noronha","year":"1983","journal-title":"Fitopatologia Brasileira"},{"key":"ref_83","first-page":"29","article-title":"A study of the preventative and therapeutic effects of Alternanthera philoxeroides on influenza","volume":"6","author":"Niu","year":"1988","journal-title":"Chin. J. Mod. Dev. Tradit. Med."},{"key":"ref_84","first-page":"861","article-title":"Inhibitor against the human immunodeficiency virus in aqueous extracts of Alternanthera philoxeroides","volume":"101","author":"Zhang","year":"1988","journal-title":"Chin. Med. J."},{"key":"ref_85","first-page":"304","article-title":"Alternanthera philoxeroides (Mavt.) Griseb protection against fetal epidemic hemorrhagic fever virus infection in suckling mice","volume":"18","author":"Qu","year":"1993","journal-title":"Zhongguo Zhong Yao Za Zhi China J. Chin. Mater. Med."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"A90","DOI":"10.1016\/S0166-3542(97)83316-5","article-title":"Studies on antiviral effect of extract from Alternanthera philoxeroides Griseb. on epidemic hemorrhagic fever virus in vivo","volume":"34","author":"Peng","year":"1997","journal-title":"Antivir. Res."},{"key":"ref_87","first-page":"62","article-title":"Effects of Alternanthera philoxeroides Griseb. against respiratory syncytial virus infection in mice","volume":"27","author":"Jiang","year":"2007","journal-title":"Nan Fang Yi Ke Da Xue Bao J. South. Med. Univ."},{"key":"ref_88","first-page":"700","article-title":"Antiviral effect of Alternanthera philoxeroides microemulsion on coxsackie virus group-3 in vitro","volume":"26","author":"Wang","year":"2005","journal-title":"Wuhan Daxue Xuebao Yixue Ban"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1007\/s11418-013-0767-y","article-title":"Potential anti-dengue medicinal plants: A review","volume":"67","author":"Yaakob","year":"2013","journal-title":"J. Nat. Med."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/20587384211002621","article-title":"A review: Mechanisms of action of antiviral drugs","volume":"35","author":"Kausar","year":"2021","journal-title":"Int. J. Immunopathol. Pharmacol."},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Resende, F.A., de Oliveira, A.P.S., de Camargo, M.S., Vilegas, W., and Varanda, E.A. (2013). Evaluation of estrogenic potential of flavonoids using a recombinant yeast strain and MCF7\/BUS cell proliferation assay. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0074881"}],"container-title":["Biomolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2218-273X\/12\/4\/582\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T22:54:13Z","timestamp":1760136853000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2218-273X\/12\/4\/582"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,14]]},"references-count":91,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2022,4]]}},"alternative-id":["biom12040582"],"URL":"https:\/\/doi.org\/10.3390\/biom12040582","relation":{},"ISSN":["2218-273X"],"issn-type":[{"value":"2218-273X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,14]]}}}