{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T13:53:03Z","timestamp":1790689983459,"version":"4.1.0"},"reference-count":111,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2022,5,6]],"date-time":"2022-05-06T00:00:00Z","timestamp":1651795200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"LA CaTS Pilot Grant","award":["U54 GM104940"],"award-info":[{"award-number":["U54 GM104940"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>The transcription factor EB (TFEB) is a master regulator of lysosomal function and autophagy. Mechanistic target of rapamycin (mTOR)-mediated phosphorylation on TFEB is known to regulate TFEB subcellular localization and activity at the lysosomal surface. Recent studies have shown that TFEB also plays a critical role in physiological processes such as lipid metabolism, and dysfunction of TFEB has been observed in the pathogenesis of several diseases. Owing to its ability to improve disease status in murine models, TFEB has attracted attention as a therapeutic target for diseases. In this review, we will present the regulation of TFEB and its role in the pathogenesis of liver diseases, particularly non-alcoholic fatty liver disease (NAFLD).<\/jats:p>","DOI":"10.3390\/biom12050672","type":"journal-article","created":{"date-parts":[[2022,5,6]],"date-time":"2022-05-06T14:49:38Z","timestamp":1651848578000},"page":"672","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Role of TFEB in Autophagy and the Pathogenesis of Liver Diseases"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4012-9557","authenticated-orcid":false,"given":"Shengmin","family":"Yan","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Tulane University School of Medicine, New Orleans, LA 70112, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,5,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2475","DOI":"10.1242\/jcs.146365","article-title":"TFEB at a glance","volume":"129","author":"Napolitano","year":"2016","journal-title":"J. Cell Sci."},{"key":"ref_2","first-page":"1641","article-title":"The important role of TFEB in autophagy-lysosomal pathway and autophagy-related diseases: A systematic review","volume":"25","author":"Song","year":"2021","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"117418","DOI":"10.1016\/j.lfs.2020.117418","article-title":"The regulation of TFEB in lipid homeostasis of non-alcoholic fatty liver disease: Molecular mechanism and promising therapeutic targets","volume":"246","author":"Yu","year":"2020","journal-title":"Life Sci."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1126\/science.1204592","article-title":"TFEB links autophagy to lysosomal biogenesis","volume":"332","author":"Settembre","year":"2011","journal-title":"Science"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1126\/science.1174447","article-title":"A gene network regulating lysosomal biogenesis and function","volume":"325","author":"Sardiello","year":"2009","journal-title":"Science"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"3852","DOI":"10.1093\/hmg\/ddr306","article-title":"Characterization of the CLEAR network reveals an integrated control of cellular clearance pathways","volume":"20","author":"Palmieri","year":"2011","journal-title":"Hum. Mol. Genet."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"108371","DOI":"10.1016\/j.celrep.2020.108371","article-title":"TFEB Transcriptional Responses Reveal Negative Feedback by BHLHE40 and BHLHE41","volume":"33","author":"Carey","year":"2020","journal-title":"Cell Rep."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1038\/ncb2718","article-title":"TFEB controls cellular lipid metabolism through a starvation-induced autoregulatory loop","volume":"15","author":"Settembre","year":"2013","journal-title":"Nat. Cell Biol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.nbd.2018.05.012","article-title":"TFEB dysregulation as a driver of autophagy dysfunction in neurodegenerative disease: Molecular mechanisms, cellular processes, and emerging therapeutic opportunities","volume":"122","author":"Cortes","year":"2019","journal-title":"Neurobiol. Dis."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1038\/s41419-020-2322-6","article-title":"Pharmacological enhancement of TFEB-mediated autophagy alleviated neuronal death in oxidative stress-induced Parkinson\u2019s disease models","volume":"11","author":"Zhuang","year":"2020","journal-title":"Cell Death Dis."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"3833","DOI":"10.1080\/15548627.2021.1886720","article-title":"Electroacupuncture ameliorates beta-amyloid pathology and cognitive impairment in Alzheimer disease via a novel mechanism involving activation of TFEB (transcription factor EB)","volume":"17","author":"Zheng","year":"2021","journal-title":"Autophagy"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2267","DOI":"10.1038\/ncomms3267","article-title":"The TFEB orthologue HLH-30 regulates autophagy and modulates longevity in Caenorhabditis elegans","volume":"4","author":"Lapierre","year":"2013","journal-title":"Nat. Commun."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1038\/s41420-020-0265-4","article-title":"Regulation of TFEB activity and its potential as a therapeutic target against kidney diseases","volume":"6","author":"Zhang","year":"2020","journal-title":"Cell Death Discov."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1002\/stem.3144","article-title":"Mesenchymal stem cells elicit macrophages into M2 phenotype via improving transcription factor EB-mediated autophagy to alleviate diabetic nephropathy","volume":"38","author":"Yuan","year":"2020","journal-title":"Stem Cells"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"5829","DOI":"10.7150\/thno.44051","article-title":"Activation of TFEB-mediated autophagy by trehalose attenuates mitochondrial dysfunction in cisplatin-induced acute kidney injury","volume":"10","author":"Zhu","year":"2020","journal-title":"Theranostics"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1954","DOI":"10.1080\/15548627.2019.1596486","article-title":"Impaired TFEB-mediated lysosomal biogenesis promotes the development of pancreatitis in mice and is associated with human pancreatitis","volume":"15","author":"Wang","year":"2019","journal-title":"Autophagy"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.jcmgh.2020.01.008","article-title":"Critical Role of TFEB-Mediated Lysosomal Biogenesis in Alcohol-Induced Pancreatitis in Mice and Humans","volume":"10","author":"Wang","year":"2020","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1080\/15548627.2019.1689770","article-title":"Restriction of intracellular Salmonella replication by restoring TFEB-mediated xenophagy","volume":"16","author":"Ammanathan","year":"2020","journal-title":"Autophagy"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"2149","DOI":"10.1002\/mc.23105","article-title":"YY1 cooperates with TFEB to regulate autophagy and lysosomal biogenesis in melanoma","volume":"58","author":"Du","year":"2019","journal-title":"Mol. Carcinog."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1002\/1878-0261.12867","article-title":"Multifaceted activities of transcription factor EB in cancer onset and progression","volume":"15","author":"Astanina","year":"2021","journal-title":"Mol. Oncol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"640061","DOI":"10.3389\/fphys.2021.640061","article-title":"The Oncogene Transcription Factor EB Regulates Vascular Functions","volume":"12","author":"Doronzo","year":"2021","journal-title":"Front. Physiol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"10309","DOI":"10.1074\/jbc.M114.610659","article-title":"Activation of peroxisome proliferator-activated receptor alpha induces lysosomal biogenesis in brain cells: Implications for lysosomal storage disorders","volume":"290","author":"Ghosh","year":"2015","journal-title":"J. Biol. Chem."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"7896","DOI":"10.1096\/fj.201802528R","article-title":"Regulation of hepatic autophagy by stress-sensing transcription factor CREBH","volume":"33","author":"Kim","year":"2019","journal-title":"FASEB J."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"e94229","DOI":"10.1172\/JCI94229","article-title":"Macrophage SR-BI modulates autophagy via VPS34 complex and PPARalpha transcription of Tfeb in atherosclerosis","volume":"131","author":"Tao","year":"2021","journal-title":"J. Clin. Investig."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1038\/s41418-020-00646-2","article-title":"Programmed cell death 4 modulates lysosomal function by inhibiting TFEB translation","volume":"28","author":"Chen","year":"2021","journal-title":"Cell Death Differ."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"3776","DOI":"10.1080\/15548627.2021.1897961","article-title":"TP53\/p53-FBXO22-TFEB controls basal autophagy to govern hormesis","volume":"17","author":"Suzuki","year":"2021","journal-title":"Autophagy"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"3623","DOI":"10.1038\/s41467-019-11568-0","article-title":"MYC competes with MiT\/TFE in regulating lysosomal biogenesis and autophagy through an epigenetic rheostat","volume":"10","author":"Annunziata","year":"2019","journal-title":"Nat. Commun."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.1080\/15548627.2020.1788889","article-title":"The unfolded protein response regulates hepatic autophagy by sXBP1-mediated activation of TFEB","volume":"17","author":"Zhang","year":"2021","journal-title":"Autophagy"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1016\/j.cell.2017.02.004","article-title":"mTOR Signaling in Growth, Metabolism, and Disease","volume":"168","author":"Saxton","year":"2017","journal-title":"Cell"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"903","DOI":"10.4161\/auto.19653","article-title":"MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB","volume":"8","author":"Martina","year":"2012","journal-title":"Autophagy"},{"key":"ref_31","first-page":"ra42","article-title":"The transcription factor TFEB links mTORC1 signaling to transcriptional control of lysosome homeostasis","volume":"5","author":"Petit","year":"2012","journal-title":"Sci. Signal."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1080\/15548627.2019.1569928","article-title":"YWHA\/14-3-3 proteins recognize phosphorylated TFEB by a noncanonical mode for controlling TFEB cytoplasmic localization","volume":"15","author":"Xu","year":"2019","journal-title":"Autophagy"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1038\/emboj.2012.32","article-title":"A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB","volume":"31","author":"Settembre","year":"2012","journal-title":"EMBO J."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1083\/jcb.201209135","article-title":"Rag GTPases mediate amino acid-dependent recruitment of TFEB and MITF to lysosomes","volume":"200","author":"Martina","year":"2013","journal-title":"J. Cell Biol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1038\/s41586-020-2444-0","article-title":"A substrate-specific mTORC1 pathway underlies Birt-Hogg-Dube syndrome","volume":"585","author":"Napolitano","year":"2020","journal-title":"Nature"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"3312","DOI":"10.1038\/s41467-018-05862-6","article-title":"mTOR-dependent phosphorylation controls TFEB nuclear export","volume":"9","author":"Napolitano","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"700","DOI":"10.15252\/embr.201439496","article-title":"RIP1 negatively regulates basal autophagic flux through TFEB to control sensitivity to apoptosis","volume":"16","author":"Yonekawa","year":"2015","journal-title":"EMBO Rep."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1038\/s41467-018-03340-7","article-title":"MAP4K3 mediates amino acid-dependent regulation of autophagy via phosphorylation of TFEB","volume":"9","author":"Hsu","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"14338","DOI":"10.1038\/ncomms14338","article-title":"mTORC1-independent TFEB activation via Akt inhibition promotes cellular clearance in neurodegenerative storage diseases","volume":"8","author":"Palmieri","year":"2017","journal-title":"Nat. Commun."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1101\/gad.213827.113","article-title":"A RANKL-PKCbeta-TFEB signaling cascade is necessary for lysosomal biogenesis in osteoclasts","volume":"27","author":"Ferron","year":"2013","journal-title":"Genes Dev."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"3957","DOI":"10.1080\/15548627.2021.1898748","article-title":"AMPK-dependent phosphorylation is required for transcriptional activation of TFEB and TFE3","volume":"17","author":"Paquette","year":"2021","journal-title":"Autophagy"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1038\/nature18014","article-title":"AMPK-SKP2-CARM1 signalling cascade in transcriptional regulation of autophagy","volume":"534","author":"Shin","year":"2016","journal-title":"Nature"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"e48335","DOI":"10.15252\/embr.201948335","article-title":"Acetyltransferase GCN5 regulates autophagy and lysosome biogenesis by targeting TFEB","volume":"21","author":"Wang","year":"2020","journal-title":"EMBO Rep."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1007\/s13238-016-0269-2","article-title":"Deacetylation of TFEB promotes fibrillar Abeta degradation by upregulating lysosomal biogenesis in microglia","volume":"7","author":"Bao","year":"2016","journal-title":"Protein Cell"},{"key":"ref_45","first-page":"1043","article-title":"Importance of TFEB acetylation in control of its transcriptional activity and lysosomal function in response to histone deacetylase inhibitors","volume":"14","author":"Zhang","year":"2018","journal-title":"Autophagy"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"2544","DOI":"10.15252\/embj.201796699","article-title":"STUB1 regulates TFEB-induced autophagy-lysosome pathway","volume":"36","author":"Sha","year":"2017","journal-title":"EMBO J."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"12109","DOI":"10.1038\/ncomms12109","article-title":"MCOLN1 is a ROS sensor in lysosomes that regulates autophagy","volume":"7","author":"Zhang","year":"2016","journal-title":"Nat Commun."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1038\/ncb3114","article-title":"Lysosomal calcium signalling regulates autophagy through calcineurin and TFEB","volume":"17","author":"Medina","year":"2015","journal-title":"Nat. Cell Biol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"3924","DOI":"10.1080\/15548627.2021.1896925","article-title":"Coxsackievirus B3 targets TFEB to disrupt lysosomal function","volume":"17","author":"Mohamud","year":"2021","journal-title":"Autophagy"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"101445","DOI":"10.1016\/j.redox.2020.101445","article-title":"A stress response p38 MAP kinase inhibitor SB202190 promoted TFEB\/TFE3-dependent autophagy and lysosomal biogenesis independent of p38","volume":"32","author":"Yang","year":"2020","journal-title":"Redox Biol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1038\/cr.2017.45","article-title":"Fasting-induced hormonal regulation of lysosomal function","volume":"27","author":"Chen","year":"2017","journal-title":"Cell Res."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.devcel.2011.07.016","article-title":"Transcriptional activation of lysosomal exocytosis promotes cellular clearance","volume":"21","author":"Medina","year":"2011","journal-title":"Dev. Cell"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1038\/s41580-020-0272-6","article-title":"The nucleolus as a multiphase liquid condensate","volume":"22","author":"Lafontaine","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1016\/j.devcel.2020.10.010","article-title":"Inositol Polyphosphate Multikinase Inhibits Liquid-Liquid Phase Separation of TFEB to Negatively Regulate Autophagy Activity","volume":"55","author":"Chen","year":"2020","journal-title":"Dev. Cell"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1038\/s41418-020-0602-4","article-title":"Nuclear miR-30b-5p suppresses TFEB-mediated lysosomal biogenesis and autophagy","volume":"28","author":"Guo","year":"2021","journal-title":"Cell Death Differ."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.cell.2018.09.048","article-title":"Biological Functions of Autophagy Genes: A Disease Perspective","volume":"176","author":"Levine","year":"2019","journal-title":"Cell"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/j.jhep.2019.01.026","article-title":"Autophagy in liver diseases: Time for translation?","volume":"70","author":"Allaire","year":"2019","journal-title":"J. Hepatol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1682","DOI":"10.1016\/j.cell.2019.05.026","article-title":"Autophagy-Independent Functions of the Autophagy Machinery","volume":"177","author":"Galluzzi","year":"2019","journal-title":"Cell"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1038\/nrgastro.2016.185","article-title":"Autophagy in the liver: Functions in health and disease","volume":"14","author":"Ueno","year":"2017","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1083\/jcb.201501002","article-title":"MiT\/TFE transcription factors are activated during mitophagy downstream of Parkin and Atg5","volume":"210","author":"Nezich","year":"2015","journal-title":"J. Cell Biol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1038\/s41556-020-00583-9","article-title":"LC3 lipidation is essential for TFEB activation during the lysosomal damage response to kidney injury","volume":"22","author":"Nakamura","year":"2020","journal-title":"Nat. Cell Biol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1161\/CIRCRESAHA.119.316007","article-title":"The Calcineurin-TFEB-p62 Pathway Mediates the Activation of Cardiac Macroautophagy by Proteasomal Malfunction","volume":"127","author":"Pan","year":"2020","journal-title":"Circ. Res."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"e101347","DOI":"10.15252\/embj.2018101347","article-title":"Nutrient-sensitive transcription factors TFEB and TFE3 couple autophagy and metabolism to the peripheral clock","volume":"38","author":"Pastore","year":"2019","journal-title":"EMBO J."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"E1817","DOI":"10.1073\/pnas.1305623110","article-title":"TFEB-mediated autophagy rescues midbrain dopamine neurons from alpha-synuclein toxicity","volume":"110","author":"Decressac","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"3740","DOI":"10.1080\/15548627.2021.1896906","article-title":"Trehalose causes low-grade lysosomal stress to activate TFEB and the autophagy-lysosome biogenesis response","volume":"17","author":"Jeong","year":"2021","journal-title":"Autophagy"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1080\/15548627.2018.1535292","article-title":"Trehalose induces autophagy via lysosomal-mediated TFEB activation in models of motoneuron degeneration","volume":"15","author":"Rusmini","year":"2019","journal-title":"Autophagy"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1007\/s00726-017-2429-y","article-title":"Relevance of autophagy to fatty liver diseases and potential therapeutic applications","volume":"49","author":"Yan","year":"2017","journal-title":"Amino Acids"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1055\/s-0038-1669939","article-title":"Homeostatic Role of Autophagy in Hepatocytes","volume":"38","author":"Khambu","year":"2018","journal-title":"Semin. Liver Dis."},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Yan, S., Khambu, B., Hong, H., Liu, G., Huda, N., and Yin, X.M. (2019). Autophagy, Metabolism, and Alcohol-Related Liver Disease: Novel Modulators and Functions. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20205029"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1740","DOI":"10.1053\/j.gastro.2010.07.041","article-title":"Autophagy reduces acute ethanol-induced hepatotoxicity and steatosis in mice","volume":"139","author":"Ding","year":"2010","journal-title":"Gastroenterology"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1016\/j.jhep.2013.01.011","article-title":"Pharmacological promotion of autophagy alleviates steatosis and injury in alcoholic and non-alcoholic fatty liver conditions in mice","volume":"58","author":"Lin","year":"2013","journal-title":"J. Hepatol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"2354","DOI":"10.1111\/acer.12904","article-title":"Acute and Chronic Ethanol Administration Differentially Modulate Hepatic Autophagy and Transcription Factor EB","volume":"39","author":"Thomes","year":"2015","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1053\/j.gastro.2018.05.027","article-title":"Impaired TFEB-Mediated Lysosome Biogenesis and Autophagy Promote Chronic Ethanol-Induced Liver Injury and Steatosis in Mice","volume":"155","author":"Chao","year":"2018","journal-title":"Gastroenterology"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"G509","DOI":"10.1152\/ajpgi.00376.2018","article-title":"Ethanol withdrawal mitigates fatty liver by normalizing lipid catabolism","volume":"316","author":"Thomes","year":"2019","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1950","DOI":"10.1111\/acer.14695","article-title":"Trehalose activates hepatic transcription factor EB (TFEB) but fails to ameliorate alcohol-impaired TFEB and liver injury in mice","volume":"45","author":"Chao","year":"2021","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.4161\/auto.24469","article-title":"Autophagy master regulator TFEB induces clearance of toxic SERPINA1\/alpha-1-antitrypsin polymers","volume":"9","author":"Pastore","year":"2013","journal-title":"Autophagy"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1002\/emmm.201202046","article-title":"Gene transfer of master autophagy regulator TFEB results in clearance of toxic protein and correction of hepatic disease in alpha-1-anti-trypsin deficiency","volume":"5","author":"Pastore","year":"2013","journal-title":"EMBO Mol. Med."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"101751","DOI":"10.1016\/j.redox.2020.101751","article-title":"Diclofenac impairs autophagic flux via oxidative stress and lysosomal dysfunction: Implications for hepatotoxicity","volume":"37","author":"Jung","year":"2020","journal-title":"Redox Biol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1038\/s41419-018-1112-x","article-title":"Carbon monoxide-induced TFEB nuclear translocation enhances mitophagy\/mitochondrial biogenesis in hepatocytes and ameliorates inflammatory liver injury","volume":"9","author":"Kim","year":"2018","journal-title":"Cell Death Dis."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"2461","DOI":"10.1038\/s41467-020-16300-x","article-title":"TFEB regulates murine liver cell fate during development and regeneration","volume":"11","author":"Pastore","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.ajpath.2021.10.004","article-title":"Loss of Hepatic Transcription Factor EB Attenuates Alcohol-Associated Liver Carcinogenesis","volume":"192","author":"Chao","year":"2022","journal-title":"Am. J. Pathol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1038\/nrm3565","article-title":"Signals from the lysosome: A control centre for cellular clearance and energy metabolism","volume":"14","author":"Settembre","year":"2013","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1038\/s41467-020-14384-z","article-title":"Fasting-induced FGF21 signaling activates hepatic autophagy and lipid degradation via JMJD3 histone demethylase","volume":"11","author":"Byun","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1038\/ncb2741","article-title":"MXL-3 and HLH-30 transcriptionally link lipolysis and autophagy to nutrient availability","volume":"15","author":"Ruvkun","year":"2013","journal-title":"Nat. Cell Biol."},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"Evans, T.D., Zhang, X., Jeong, S.J., He, A., Song, E., Bhattacharya, S., Holloway, K.B., Lodhi, I.J., and Razani, B. (2019). TFEB drives PGC-1alpha expression in adipocytes to protect against diet-induced metabolic dysfunction. Sci. Signal., 12.","DOI":"10.1126\/scisignal.aau2281"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"2685","DOI":"10.1038\/s41467-018-04849-7","article-title":"A TFEB nuclear export signal integrates amino acid supply and glucose availability","volume":"9","author":"Li","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1161\/ATVBAHA.120.315310","article-title":"Endothelial TFEB (Transcription Factor EB) Improves Glucose Tolerance via Upregulation of IRS (Insulin Receptor Substrate) 1 and IRS2","volume":"41","author":"Sun","year":"2021","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_88","doi-asserted-by":"crossref","unstructured":"Lu, H., Fan, Y., Qiao, C., Liang, W., Hu, W., Zhu, T., Zhang, J., and Chen, Y.E. (2017). TFEB inhibits endothelial cell inflammation and reduces atherosclerosis. Sci. Signal., 10.","DOI":"10.1126\/scisignal.aah4214"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.cmet.2016.11.003","article-title":"Transcription Factor EB Controls Metabolic Flexibility during Exercise","volume":"25","author":"Mansueto","year":"2017","journal-title":"Cell Metab."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"2985","DOI":"10.1016\/j.jacc.2013.11.004","article-title":"2013 AHA\/ACC\/TOS Guideline for the Management of Overweight and Obesity in Adults","volume":"63","author":"Jensen","year":"2014","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1126\/science.1204265","article-title":"Human fatty liver disease: Old questions and new insights","volume":"332","author":"Cohen","year":"2011","journal-title":"Science"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"w822","DOI":"10.1377\/hlthaff.28.5.w822","article-title":"Annual medical spending attributable to obesity: Payer-and service-specific estimates","volume":"28","author":"Finkelstein","year":"2009","journal-title":"Health Aff."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1136\/gutjnl-2017-313884","article-title":"Non-alcoholic fatty liver disease and its relationship with cardiovascular disease and other extrahepatic diseases","volume":"66","author":"Adams","year":"2017","journal-title":"Gut"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.jhepr.2019.02.004","article-title":"Macrophages in obesity and non-alcoholic fatty liver disease: Crosstalk with metabolism","volume":"1","author":"Lefere","year":"2019","journal-title":"JHEP Rep."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1038\/s41575-018-0082-x","article-title":"The role of macrophages in nonalcoholic fatty liver disease and nonalcoholic steatohepatitis","volume":"16","author":"Kazankov","year":"2019","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"S47","DOI":"10.1016\/j.jhep.2014.12.012","article-title":"NAFLD: A multisystem disease","volume":"62","author":"Byrne","year":"2015","journal-title":"J. Hepatol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/j.tips.2019.05.002","article-title":"Genetic Insights for Drug Development in NAFLD","volume":"40","author":"Eslam","year":"2019","journal-title":"Trends Pharmacol. Sci."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1016\/j.jacc.2018.11.050","article-title":"Nonalcoholic Fatty Liver Disease and the Heart: JACC State-of-the-Art Review","volume":"73","author":"Stahl","year":"2019","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1002\/cld.721","article-title":"The Association between Nonalcoholic Fatty Liver Disease and Cardiovascular Disease Outcomes","volume":"12","author":"Wong","year":"2018","journal-title":"Clin. Liver Dis."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1080\/15548627.2018.1490850","article-title":"Dynamic MTORC1-TFEB feedback signaling regulates hepatic autophagy, steatosis and liver injury in long-term nutrient oversupply","volume":"14","author":"Zhang","year":"2018","journal-title":"Autophagy"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"3612","DOI":"10.1038\/s41467-020-17363-6","article-title":"An FGF15\/19-TFEB regulatory loop controls hepatic cholesterol and bile acid homeostasis","volume":"11","author":"Wang","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1038\/nature13949","article-title":"Transcriptional regulation of autophagy by an FXR-CREB axis","volume":"516","author":"Seok","year":"2014","journal-title":"Nature"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"2270","DOI":"10.1038\/s41467-017-02332-3","article-title":"Small-molecule TFEB pathway agonists that ameliorate metabolic syndrome in mice and extend C. elegans lifespan","volume":"8","author":"Wang","year":"2017","journal-title":"Nat. Commun."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1038\/s41467-018-03939-w","article-title":"A novel autophagy enhancer as a therapeutic agent against metabolic syndrome and diabetes","volume":"9","author":"Lim","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1080\/15548627.2017.1356977","article-title":"Ezetimibe ameliorates steatohepatitis via AMP activated protein kinase-TFEB-mediated activation of autophagy and NLRP3 inflammasome inhibition","volume":"13","author":"Kim","year":"2017","journal-title":"Autophagy"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.freeradbiomed.2018.08.024","article-title":"Procyanidin B2 ameliorates free fatty acids-induced hepatic steatosis through regulating TFEB-mediated lysosomal pathway and redox state","volume":"126","author":"Su","year":"2018","journal-title":"Free Radic. Biol. Med."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"108214","DOI":"10.1016\/j.jnutbio.2019.07.005","article-title":"Formononetin alleviates hepatic steatosis by facilitating TFEB-mediated lysosome biogenesis and lipophagy","volume":"73","author":"Wang","year":"2019","journal-title":"J. Nutr. Biochem."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"602574","DOI":"10.3389\/fcell.2020.602574","article-title":"Liraglutide Alleviates Hepatic Steatosis by Activating the TFEB-Regulated Autophagy-Lysosomal Pathway","volume":"8","author":"Fang","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"154798","DOI":"10.1016\/j.metabol.2021.154798","article-title":"Fenofibrate, a PPARalpha agonist, reduces hepatic fat accumulation through the upregulation of TFEB-mediated lipophagy","volume":"120","author":"Yoo","year":"2021","journal-title":"Metabolism"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"689111","DOI":"10.3389\/fphar.2021.689111","article-title":"Metformin Alleviates Hepatic Steatosis and Insulin Resistance in a Mouse Model of High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease by Promoting Transcription Factor EB-Dependent Autophagy","volume":"12","author":"Zhang","year":"2021","journal-title":"Front. Pharmacol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"3997","DOI":"10.2147\/DDDT.S315724","article-title":"Non-Alcoholic Steatohepatitis (NASH)\u2014A Review of a Crowded Clinical Landscape, Driven by a Complex Disease","volume":"15","author":"Fraile","year":"2021","journal-title":"Drug Des. Dev. Ther."}],"container-title":["Biomolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2218-273X\/12\/5\/672\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T23:06:54Z","timestamp":1760137614000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2218-273X\/12\/5\/672"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,6]]},"references-count":111,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2022,5]]}},"alternative-id":["biom12050672"],"URL":"https:\/\/doi.org\/10.3390\/biom12050672","relation":{},"ISSN":["2218-273X"],"issn-type":[{"value":"2218-273X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,6]]}}}