{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T16:55:19Z","timestamp":1787849719863,"version":"build-2784847793"},"reference-count":188,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2022,5,12]],"date-time":"2022-05-12T00:00:00Z","timestamp":1652313600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>Neurodegenerative disorders including Parkinson\u2019s disease (PD), Huntington\u2019s disease (HD) and the most frequent, Alzheimer\u2019s disease (AD), represent one of the most urgent medical needs worldwide. Despite a significantly developed understanding of disease development and pathology, treatments that stop AD progression are not yet available. The recent approval of sodium oligomannate (GV-971) for AD treatment in China emphasized the potential value of natural products for the treatment of neurodegenerative disorders. Many current clinical studies include the administration of a natural compound as a single and combination treatment. The most prominent mechanisms of action are anti-inflammatory and anti-oxidative activities, thus preserving cellular survival. Here, we review current natural products that are either approved or are in testing for a treatment of neurodegeneration in AD. In addition to the most important compounds of plant origin, we also put special emphasis on compounds from algae, given their neuroprotective activity and their underlying mechanisms of neuroprotection.<\/jats:p>","DOI":"10.3390\/biom12050694","type":"journal-article","created":{"date-parts":[[2022,5,12]],"date-time":"2022-05-12T21:46:53Z","timestamp":1652392013000},"page":"694","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Natural Products from Plants and Algae for Treatment of Alzheimer\u2019s Disease: A Review"],"prefix":"10.3390","volume":"12","author":[{"given":"Jana","family":"Klose","sequence":"first","affiliation":[{"name":"Faculty of Applied Biosciences and Process Technology, Anhalt University of Applied Sciences, Bernburger Stra\u00dfe 55, 06366 Koethen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3496-0299","authenticated-orcid":false,"given":"Carola","family":"Griehl","sequence":"additional","affiliation":[{"name":"Faculty of Applied Biosciences and Process Technology, Anhalt University of Applied Sciences, Bernburger Stra\u00dfe 55, 06366 Koethen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steffen","family":"Ro\u00dfner","sequence":"additional","affiliation":[{"name":"Paul Flechsig Institute for Brain Research, University of Leipzig, Liebigstra\u00dfe 19, 04103 Leipzig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Schilling","sequence":"additional","affiliation":[{"name":"Faculty of Applied Biosciences and Process Technology, Anhalt University of Applied Sciences, Bernburger Stra\u00dfe 55, 06366 Koethen, Germany"},{"name":"Fraunhofer Institute for Cell Therapy and Immunology, Weinbergweg 22, 06120 Halle, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,5,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1007\/s00018-009-0182-4","article-title":"Cerebral amyloidosis: Amyloid subunits, mutants and phenotypes","volume":"67","author":"Rostagno","year":"2009","journal-title":"Cell. 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