{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T12:31:08Z","timestamp":1783341068705,"version":"3.54.6"},"reference-count":23,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2022,5,17]],"date-time":"2022-05-17T00:00:00Z","timestamp":1652745600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005297","name":"Medical University of Bialystok","doi-asserted-by":"publisher","award":["SUB\/1\/DN\/20\/003\/1153"],"award-info":[{"award-number":["SUB\/1\/DN\/20\/003\/1153"]}],"id":[{"id":"10.13039\/501100005297","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005297","name":"Medical University of Bialystok","doi-asserted-by":"publisher","award":["W\/UB\/DSP\/1640\/UMBIA\u0141YSTOK\/2017"],"award-info":[{"award-number":["W\/UB\/DSP\/1640\/UMBIA\u0141YSTOK\/2017"]}],"id":[{"id":"10.13039\/501100005297","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Municipal Office in Bialystok","award":["SUB\/1\/DN\/20\/003\/1153"],"award-info":[{"award-number":["SUB\/1\/DN\/20\/003\/1153"]}]},{"name":"Municipal Office in Bialystok","award":["W\/UB\/DSP\/1640\/UMBIA\u0141YSTOK\/2017"],"award-info":[{"award-number":["W\/UB\/DSP\/1640\/UMBIA\u0141YSTOK\/2017"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>The aim of our study was to evaluate the importance of insulin-like growth-factor-binding protein 7 (IGFBP-7) as a potential marker of symptomatic peripheral artery disease (PAD) occurrence. The study group consisted of 145 patients with diagnosed PAD, who qualified for the invasive treatment. The control group consisted of 67 individuals representing the local population and an ischemic heart disease (IHD) group of 88 patients after myocardial infarction or percutaneous coronary intervention. Patients with PAD had significantly higher IGFBP-7 concentrations than control group (1.80 \u00b1 1.62 vs. 1.41 \u00b1 0.45 ng\/mL, p = 0.04). No significant differences between PAD patients and IHD patients were found (1.80 \u00b1 1.62 vs. 1.76 \u00b1 1.04 ng\/mL, p = 0.783). Patients with multilevel PAD presented significantly higher IGFBP-7 concentrations than patients with aortoiliac PAD\u2014median 1.18 (IQR 0.48\u20132.23) vs. 1.42 ng\/mL (0.71\u20132.63), p = 0.035. In the group of patients who died or had a major adverse cardiovascular event (MACE) during six months of follow-up, a statistically significant higher IGFBP-7 concentration was found (median 2.66 (IQR 1.80\u20134.93) vs. 1.36 ng\/mL (IQR 0.65\u20132.34), p = 0.004). It seems that IGFBP-7 is elevated in patients with atherosclerotic lesions\u2014regardless of their locations. Further research should be conducted to verify IGFBP-7 usefulness as a predictor of MACE or death.<\/jats:p>","DOI":"10.3390\/biom12050712","type":"journal-article","created":{"date-parts":[[2022,5,17]],"date-time":"2022-05-17T04:04:19Z","timestamp":1652760259000},"page":"712","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Insulin-Like Growth Factor-Binding Protein 7 (IGFBP-7)\u2014New Diagnostic and Prognostic Marker in Symptomatic Peripheral Arterial Disease?\u2014Pilot Study"],"prefix":"10.3390","volume":"12","author":[{"given":"Anna","family":"Szyszkowska","sequence":"first","affiliation":[{"name":"Department of Cardiology, Medical University of Bialystok, 15-276 Bialystok, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylwia","family":"Bara\u0144ska","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery and Transplantation, Medical University of Bialystok, 15-276 Bialystok, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Sawicki","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Medical University of Bialystok, 15-276 Bialystok, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewa","family":"Tarasiuk","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Medical University of Bialystok, 15-276 Bialystok, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5977-0745","authenticated-orcid":false,"given":"Marlena","family":"Dubat\u00f3wka","sequence":"additional","affiliation":[{"name":"Department of Population Medicine and Lifestyle Diseases Prevention, Medical University of Bialystok, 15-276 Bialystok, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcin","family":"Kondraciuk","sequence":"additional","affiliation":[{"name":"Department of Population Medicine and Lifestyle Diseases Prevention, Medical University of Bialystok, 15-276 Bialystok, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8306-1882","authenticated-orcid":false,"given":"Emilia","family":"Sawicka-\u015amiarowska","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Medical University of Bialystok, 15-276 Bialystok, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ma\u0142gorzata","family":"Knapp","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Medical University of Bialystok, 15-276 Bialystok, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0058-8081","authenticated-orcid":false,"given":"Jerzy","family":"G\u0142owi\u0144ski","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery and Transplantation, Medical University of Bialystok, 15-276 Bialystok, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9465-2581","authenticated-orcid":false,"given":"Karol","family":"Kami\u0144ski","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Medical University of Bialystok, 15-276 Bialystok, Poland"},{"name":"Department of Population Medicine and Lifestyle Diseases Prevention, Medical University of Bialystok, 15-276 Bialystok, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Lisowska","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Medical University of Bialystok, 15-276 Bialystok, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,5,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1161\/CIRCRESAHA.116.303849","article-title":"Epidemiology of peripheral artery disease","volume":"24","author":"Criqui","year":"2015","journal-title":"Circ. 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