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Regulatory T cells (Treg) residing within skeletal muscle comprise a distinct and special cell population that modifies the inflammatory environment by secreting cytokines and amphiregulin, an epidermal growth factor receptor (EGFR) ligand that acts directly upon satellite cells, promoting tissue regeneration. This systematic review summarizes the current knowledge regarding the role of Treg in muscle repair and discusses their therapeutic potential in skeletal muscle injuries. A bibliographic search was carried out using the terms Treg and muscle regeneration and repair, covering all articles up to April 2021 indexed in the PubMed and EMBASE databases. The search included only published original research in human and experimental animal models, with further data analysis based on the PICO methodology, following PRISMA definitions and Cochrane guidelines.<\/jats:p>","DOI":"10.3390\/biom12060817","type":"journal-article","created":{"date-parts":[[2022,6,11]],"date-time":"2022-06-11T09:33:26Z","timestamp":1654940006000},"page":"817","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Role of Regulatory T Cells in Skeletal Muscle Regeneration: A Systematic Review"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3945-8644","authenticated-orcid":false,"given":"Jaciara F. G.","family":"Gama","sequence":"first","affiliation":[{"name":"Laborat\u00f3rio de Imunopatologia, Departamento de Imunobiologia, Universidade Federal Fluminense, Niter\u00f3i, Rio de Janeiro 24210-201, Brazil"},{"name":"Laborat\u00f3rio de Comunica\u00e7\u00e3o Celular, Funda\u00e7\u00e3o Oswaldo Cruz (FIOCRUZ), Instituto Oswaldo Cruz (IOC), Rio de Janeiro 21040-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rayza D.","family":"Romualdo","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Imunopatologia, Departamento de Imunobiologia, Universidade Federal Fluminense, Niter\u00f3i, Rio de Janeiro 24210-201, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7028-6847","authenticated-orcid":false,"given":"Mayara L.","family":"de Assis","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Imunopatologia, Departamento de Imunobiologia, Universidade Federal Fluminense, Niter\u00f3i, Rio de Janeiro 24210-201, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luana M.","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Imunopatologia, Departamento de Imunobiologia, Universidade Federal Fluminense, Niter\u00f3i, Rio de Janeiro 24210-201, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thereza","family":"Qu\u00edrico-Santos","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Imunopatologia, Departamento de Imunobiologia, Universidade Federal Fluminense, Niter\u00f3i, Rio de Janeiro 24210-201, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz A.","family":"Alves","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Comunica\u00e7\u00e3o Celular, Funda\u00e7\u00e3o Oswaldo Cruz (FIOCRUZ), Instituto Oswaldo Cruz (IOC), Rio de Janeiro 21040-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6573-561X","authenticated-orcid":false,"given":"Jussara","family":"Lagrota-Candido","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Imunopatologia, Departamento de Imunobiologia, Universidade Federal Fluminense, Niter\u00f3i, Rio de Janeiro 24210-201, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,6,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/s00223-014-9915-y","article-title":"Skeletal Muscle: A Brief Review of Structure and Function","volume":"96","author":"Frontera","year":"2015","journal-title":"Calcif. 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