{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T19:32:26Z","timestamp":1772307146444,"version":"3.50.1"},"reference-count":45,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2022,6,23]],"date-time":"2022-06-23T00:00:00Z","timestamp":1655942400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"JSPS KAKENHI","award":["JP21K06777"],"award-info":[{"award-number":["JP21K06777"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>Perivascular adipose tissue (PVAT) enhances vascular relaxation of mesenteric arteries in SHRSP.Z-Leprfa\/IzmDmcr rats (SPZF), a metabolic syndrome model. We investigated and compared the effects of PVAT on the renal artery in SPZF with those on SHR\/NDmcr-cp rats (CP). Renal arteries with and without PVAT were isolated from 23-week-old SPZF and CP. The effects of PVAT on acetylcholine- and nitroprusside-induced relaxation were examined using bioassays with phenylephrine-contracted arterial rings. Acetylcholine-induced relaxations without PVAT in SPZF and CP were 0.7- and 0.5-times lower in females than in males, respectively. In the presence of PVAT, acetylcholine-induced relaxations increased 1.4- and 2-times in male and female CP, respectively, but did not differ in SPZF. Nitroprusside-induced relaxation with and without PVAT was 0.7-times lower in female than in male SPZF but did not differ in CP. Angiotensin-II type-1 receptor (AT1R)\/AT1R-associated protein mRNA ratios were lower in CP than in the SPZF and negatively correlated with the difference in arterial relaxation with and without PVAT. The effects of renal artery PVAT differed between the SPZF and CP groups. Higher levels of enhanced AT1R activity in SPZF PVAT may drive these differences by impairing the vascular smooth muscle responses to nitric oxide.<\/jats:p>","DOI":"10.3390\/biom12070870","type":"journal-article","created":{"date-parts":[[2022,6,23]],"date-time":"2022-06-23T01:59:47Z","timestamp":1655949587000},"page":"870","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Modulation of Vasomotor Function by Perivascular Adipose Tissue of Renal Artery Depends on Severity of Arterial Dysfunction to Nitric Oxide and Severity of Metabolic Parameters"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2044-5552","authenticated-orcid":false,"given":"Satomi","family":"Kagota","sequence":"first","affiliation":[{"name":"Department of Pharmacology, School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women\u2019s University, Nishinomiya 663 8179, Japan"},{"name":"Institute for Bioscience, Mukogawa Women\u2019s University, Nishinomiya 663 8179, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Risa","family":"Futokoro","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women\u2019s University, Nishinomiya 663 8179, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0302-3884","authenticated-orcid":false,"given":"John J.","family":"McGuire","sequence":"additional","affiliation":[{"name":"Departments of Medical Biophysics, Physiology & Pharmacology, Schulich School of Medicine & Dentistry, Western University, London, ON N6A 5C1, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kana","family":"Maruyama-Fumoto","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women\u2019s University, Nishinomiya 663 8179, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazumasa","family":"Shinozuka","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women\u2019s University, Nishinomiya 663 8179, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,6,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"101040","DOI":"10.1016\/j.arr.2020.101040","article-title":"Perivascular adipose tissue in age-related vascular disease","volume":"59","author":"Queiroz","year":"2020","journal-title":"Ageing Res. 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