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Baldwin Breast Cancer Fund","award":["R35GM139584"],"award-info":[{"award-number":["R35GM139584"]}]},{"name":"SUNY Upstate Medical University, Upstate Foundation","award":["R35GM139584"],"award-info":[{"award-number":["R35GM139584"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>Heat shock protein-90 (Hsp90) is an ATP-dependent molecular chaperone that is tightly regulated by a group of proteins termed co-chaperones. This chaperone system is essential for the stabilization and activation of many key signaling proteins. Recent identification of the co-chaperones FNIP1, FNIP2, and Tsc1 has broadened the spectrum of Hsp90 regulators. These new co-chaperones mediate the stability of critical tumor suppressors FLCN and Tsc2 as well as the various classes of Hsp90 kinase and non-kinase clients. Many early observations of the roles of FNIP1, FNIP2, and Tsc1 suggested functions independent of FLCN and Tsc2 but have not been fully delineated. Given the broad cellular impact of Hsp90-dependent signaling, it is possible to explain the cellular activities of these new co-chaperones by their influence on Hsp90 function. Here, we review the literature on FNIP1, FNIP2, and Tsc1 as co-chaperones and discuss the potential downstream impact of this regulation on normal cellular function and in human diseases.<\/jats:p>","DOI":"10.3390\/biom12070928","type":"journal-article","created":{"date-parts":[[2022,7,2]],"date-time":"2022-07-02T11:12:35Z","timestamp":1656760355000},"page":"928","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Emerging Link between Tsc1 and FNIP Co-Chaperones of Hsp90 and Cancer"],"prefix":"10.3390","volume":"12","author":[{"given":"Sarah J.","family":"Backe","sequence":"first","affiliation":[{"name":"Department of Urology, SUNY Upstate Medical University, Syracuse, NY 13210, USA"},{"name":"Upstate Cancer Center, Upstate University Hospital, Syracuse, NY 13210, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca A.","family":"Sager","sequence":"additional","affiliation":[{"name":"Department of Urology, SUNY Upstate Medical University, Syracuse, NY 13210, USA"},{"name":"Upstate Cancer Center, Upstate University Hospital, Syracuse, NY 13210, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katherine A.","family":"Meluni","sequence":"additional","affiliation":[{"name":"Department of Urology, SUNY Upstate Medical University, Syracuse, NY 13210, USA"},{"name":"Upstate Cancer Center, Upstate University Hospital, Syracuse, NY 13210, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6737-2832","authenticated-orcid":false,"given":"Mark R.","family":"Woodford","sequence":"additional","affiliation":[{"name":"Department of Urology, SUNY Upstate Medical University, Syracuse, NY 13210, USA"},{"name":"Upstate Cancer Center, Upstate University Hospital, Syracuse, NY 13210, USA"},{"name":"Department of Biochemistry and Molecular Biology, SUNY Upstate Medical University, Syracuse, NY 13210, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8567-2775","authenticated-orcid":false,"given":"Dimitra","family":"Bourboulia","sequence":"additional","affiliation":[{"name":"Department of Urology, SUNY Upstate Medical University, Syracuse, NY 13210, USA"},{"name":"Upstate Cancer Center, Upstate University Hospital, Syracuse, NY 13210, USA"},{"name":"Department of Biochemistry and Molecular Biology, SUNY Upstate Medical University, Syracuse, NY 13210, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2144-1361","authenticated-orcid":false,"given":"Mehdi","family":"Mollapour","sequence":"additional","affiliation":[{"name":"Department of Urology, SUNY Upstate Medical University, Syracuse, NY 13210, USA"},{"name":"Upstate Cancer Center, Upstate University Hospital, Syracuse, NY 13210, USA"},{"name":"Department of Biochemistry and Molecular Biology, SUNY Upstate Medical University, Syracuse, NY 13210, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,7,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0092-8674(00)80314-1","article-title":"Identification and structural characterization of the ATP\/ADP-binding site in the Hsp90 molecular chaperone","volume":"90","author":"Prodromou","year":"1997","journal-title":"Cell"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"39303","DOI":"10.1074\/jbc.M305751200","article-title":"Dissection of the contribution of individual domains to the ATPase mechanism of Hsp90","volume":"278","author":"Wegele","year":"2003","journal-title":"J. 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