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Zinc plays an important role in many physiological and pathological processes in normal mammalian brain development, especially in the development of the central nervous system. Zinc deficiency can lead to neurodegenerative diseases, mental abnormalities, sleep disorders, tumors, vascular diseases, and other pathological conditions, which can cause cognitive impairment and premature aging. This study aimed to review the important effects of zinc and zinc-associated proteins in cognitive impairment and aging, to reveal its molecular mechanism, and to highlight potential interventions for zinc-associated aging and cognitive impairments.<\/jats:p>","DOI":"10.3390\/biom12071000","type":"journal-article","created":{"date-parts":[[2022,7,18]],"date-time":"2022-07-18T11:32:23Z","timestamp":1658143943000},"page":"1000","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":61,"title":["Zinc in Cognitive Impairment and Aging"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5303-6002","authenticated-orcid":false,"given":"Ruize","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Neurology, Shengjing Hospital of China Medical University, 36 Sanhao St., Shenyang 110004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jue","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Shengjing Hospital of China Medical University, 36 Sanhao St., Shenyang 110004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Neurology, Shengjing Hospital of China Medical University, 36 Sanhao St., Shenyang 110004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Neurology, Shengjing Hospital of China Medical University, 36 Sanhao St., Shenyang 110004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,7,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.pedneo.2018.06.006","article-title":"Effects of oral zinc supplementation on zinc status and catch-up growth during the first 2 years of life in children with non-organic failure to thrive born preterm and at term","volume":"60","author":"Min","year":"2019","journal-title":"J. Pediatr. Neonatol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1111\/j.1651-2227.2011.02336.x","article-title":"Placental IGF-I, IGFBP-1, zinc, and iron, and maternal and infant anthropometry at birth","volume":"100","year":"2011","journal-title":"Acta Paediatr."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.jtemb.2014.08.007","article-title":"The effect of adding zinc to vitamin A on IGF-1, bone age and linear growth in stunted children","volume":"28","author":"Merryana","year":"2014","journal-title":"J. Trace Elem. Med. Biol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1007\/s10534-016-9922-8","article-title":"Possible role of metal ionophore against zinc induced cognitive dysfunction in D-galactose senescent mice","volume":"29","author":"Kanchan","year":"2016","journal-title":"Biometals"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"8941","DOI":"10.3390\/ijms21238941","article-title":"Zinc in the Brain: Friend or Foe?","volume":"21","author":"Seunghyuk","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.pneurobio.2005.04.005","article-title":"Brain, aging and neurodegeneration, Role of zinc ion availability","volume":"75","author":"Mocchegiani","year":"2004","journal-title":"Prog. Neurobiol."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Portbury, S.D., and Adlard, P.A. (2017). Zinc Signal in Brain Diseases. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18122506"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"22067","DOI":"10.3390\/ijms141122067","article-title":"The molecular mechanisms of zinc neurotoxicity and the pathogenesis of vascular type senile dementia","volume":"14","author":"Mizuno","year":"2013","journal-title":"Int. J. Mol. Sci."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1021\/pr050361j","article-title":"Counting the zinc-proteins encoded in the human genome","volume":"5","author":"Claudia","year":"2006","journal-title":"J. Proteome. Res."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.3390\/biom10081164","article-title":"Zinc Therapy in Early Alzheimer\u2019s Disease: Safety and Potential Therapeutic Efficacy","volume":"10","author":"Rosanna","year":"2020","journal-title":"Biomolecules"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1037\/pag0000070","article-title":"Sex differences in cognitive trajectories in clinically normal older adults","volume":"31","author":"McCarrey","year":"2016","journal-title":"Psychol. Aging"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1007\/s13311-019-00766-9","article-title":"The Role of Estrogen in Brain and Cognitive Aging","volume":"16","author":"Russell","year":"2019","journal-title":"Neurotherapeutics"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.freeradbiomed.2016.04.200","article-title":"Energy metabolism and inflammation in brain aging and Alzheimer\u2019s disease","volume":"100","author":"Yin","year":"2016","journal-title":"Free Radic. Biol. Med."},{"key":"ref_14","first-page":"1105","article-title":"Oxidative Stress, Synaptic Dysfunction, and Alzheimer\u2019s Disease","volume":"57","author":"Trushina","year":"2017","journal-title":"J. Alzheimer\u2019s Dis. JAD"},{"key":"ref_15","first-page":"536","article-title":"Intravenous human interleukin-1alpha impairs memory processing in mice: Dependence on blood-brain barrier transport into posterior division of the septum","volume":"299","author":"Banks","year":"2001","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Hossain, Z., Qasem, W.A., Friel, J.K., and Omri, A. (2021). Effects of Total Enteral Nutrition on Early Growth, Immunity, and Neuronal Development of Preterm Infants. Nutrients, 13.","DOI":"10.3390\/nu13082755"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1038\/s41372-020-0658-5","article-title":"\u201cExtrauterine growth restriction\u201d and \u201cpostnatal growth failure\u201d are misnomers for preterm infants","volume":"40","author":"Fenton","year":"2020","journal-title":"J. Perinatol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/0031-9384(86)90205-2","article-title":"Learning and memory disabilities in young adult rats from mildly zinc deficient dams","volume":"37","author":"Halas","year":"1986","journal-title":"Physiol. Behav."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.bbi.2011.10.002","article-title":"Prenatal exposure to lipopolysaccharide results in neurodevelopmental damage that is ameliorated by zinc in mice","volume":"26","author":"Manavis","year":"2012","journal-title":"Brain Behav. Immun."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"112247","DOI":"10.1016\/j.bbr.2019.112247","article-title":"Prenatal zinc supplementation attenuates lipopolysaccharide-induced behavioral impairments in maternal immune activation model","volume":"377","author":"Alizadeh","year":"2020","journal-title":"Behav. Brain Res."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1038\/s41436-019-0693-9","article-title":"De novo and inherited variants in ZNF292 underlie a neurodevelopmental disorder with features of autism spectrum disorder","volume":"22","author":"Mirzaa","year":"2020","journal-title":"Genet. Med."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1186\/s13041-021-00809-3","article-title":"In vitro zinc supplementation alters synaptic deficits caused by autism spectrum disorder-associated Shank2 point mutations in hippocampal neurons","volume":"14","author":"Yukti","year":"2021","journal-title":"Mol. Brain"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"32","DOI":"10.3389\/fneur.2020.00032","article-title":"CH-Type Zinc Finger Proteins in Brain Development, Neurodevelopmental, and Other Neuropsychiatric Disorders: Systematic Literature-Based Analysis","volume":"11","author":"Njoud","year":"2020","journal-title":"Front. Neurol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"11","DOI":"10.3233\/JAD-131004","article-title":"Hippocampal neurogenesis in Alzheimer\u2019s disease: Is there a role for dietary modulation?","volume":"38","author":"Maruszak","year":"2014","journal-title":"Alzheimers Dis."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"6512","DOI":"10.1093\/hmg\/ddu370","article-title":"Deficiency of patched 1-induced Gli1 signal transduction results in astrogenesis in Swedish mutated APP transgenic mice","volume":"23","author":"Ping","year":"2014","journal-title":"Hum. Mol. Genet."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"5971","DOI":"10.1038\/s41598-020-62912-0","article-title":"CXXC5 as an unmethylated CpG dinucleotide binding protein contributes to estrogen-mediated cellular proliferation","volume":"10","author":"Gamze","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1016\/j.neuroscience.2016.10.035","article-title":"Zinc plus cyclo-(His-Pro) promotes hippocampal neurogenesis in rats","volume":"339","author":"Young","year":"2016","journal-title":"Neuroscience"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Choi, B.Y., Kim, I.Y., Kim, J.H., Lee, B.E., Lee, S.H., Kho, A.R., Sohn, M., and Suh, S.W. (2017). Administration of Zinc plus Cyclo-(His-Pro) Increases Hippocampal Neurogenesis in Rats during the Early Phase of Streptozotocin-Induced Diabetes. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18010073"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.jtemb.2014.07.007","article-title":"Zinc chelation reduces traumatic brain injury-induced neurogenesis in the subgranular zone of the hippocampal dentate gyrus","volume":"28","author":"Choi","year":"2014","journal-title":"J. Trace Elem. Med. Biol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"11667","DOI":"10.1038\/s41598-017-12054-7","article-title":"The cancer chemotherapeutic agent paclitaxel (Taxol) reduces hippocampal neurogenesis via down-regulation of vesicular zinc","volume":"7","author":"Lee","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"3149","DOI":"10.1007\/s11064-017-2353-2","article-title":"Differential Effects of Low- and High-dose Zinc Supplementation on Synaptic Plasticity and Neurogenesis in the Hippocampus of Control and High-fat Diet-fed Mice","volume":"42","author":"Nam","year":"2017","journal-title":"Neurochem. Res."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1002\/stem.3194","article-title":"Zinc transporter 3 modulates cell proliferation and neuronal differentiation in the adult hippocampus","volume":"38","author":"Choi","year":"2020","journal-title":"Stem Cells"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1002\/biof.1005","article-title":"Copper excess, zinc deficiency, and cognition loss in Alzheimer\u2019s disease","volume":"38","author":"George","year":"2012","journal-title":"Biofactors"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.jtemb.2014.07.019","article-title":"Zinc: An antioxidant and anti-inflammatory agent: Role of zinc in degenerative disorders of aging","volume":"28","year":"2014","journal-title":"J. Trace Elem. Med. Biol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"BSR20182378","DOI":"10.1042\/BSR20182378","article-title":"Emodin inhibits zinc-induced neurotoxicity in neuroblastoma SH-SY5Y cells","volume":"39","author":"Liu","year":"2019","journal-title":"Biosci. Rep."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"110951","DOI":"10.1016\/j.exger.2020.110951","article-title":"DNA methylation of the RE-1 silencing transcription factor in peripheral blood mononuclear cells and gene expression of antioxidant enzyme in patients with late-onset Alzheimer disease","volume":"136","author":"Fleury","year":"2020","journal-title":"Exp. Gerontol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"2728","DOI":"10.1038\/s41380-020-0800-y","article-title":"Alzheimer risk factors age and female sex induce cortical A\u03b2 aggregation by raising extracellular zinc","volume":"25","author":"Datki","year":"2020","journal-title":"Mol. Psychiatry"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1016\/j.ijbiomac.2016.12.003","article-title":"Antioxidant, antibacterial and anti-aging activities of intracellular zinc polysaccharides from Grifola frondosa SH-05","volume":"95","author":"Zhang","year":"2017","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.exger.2016.09.013","article-title":"Aging amplifies multiple phenotypic defects in mice with zinc transporter Zip14 (Slc39a14) deletion","volume":"85","author":"Aydemir","year":"2016","journal-title":"Exp. Gerontol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/s10534-020-00279-5","article-title":"Effects of zinc status on age-related T cell dysfunction and chronic inflammation","volume":"34","author":"Wong","year":"2021","journal-title":"Biometals"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"104771","DOI":"10.1016\/j.nbd.2020.104771","article-title":"Role of zinc dyshomeostasis in inflammasome formation in cultured cortical cells following lipopolysaccharide or oxygen-glucose deprivation\/reperfusion exposure","volume":"137","author":"Heui","year":"2020","journal-title":"Neurobiol. Dis."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"8320","DOI":"10.18632\/aging.202642","article-title":"Celecoxib alleviates zinc deficiency-promoted colon tumorigenesis through suppressing inflammation","volume":"13","author":"Yin","year":"2021","journal-title":"Aging"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"101462","DOI":"10.1016\/j.psj.2021.101462","article-title":"Effect of zinc supplementation on growth performance, intestinal development, and intestinal barrier function in Pekin ducks with lipopolysaccharide challenge","volume":"100","author":"Xie","year":"2021","journal-title":"Poult. Sci."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/s40478-017-0441-9","article-title":"Identification and description of three families with familial Alzheimer disease that segregate variants in the SORL1 gene","volume":"5","author":"Thonberg","year":"2017","journal-title":"Acta Neuropathol. Commun."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1038\/s41583-018-0067-3","article-title":"Imaging the evolution and pathophysiology of Alzheimer disease","volume":"19","author":"Jagust","year":"2018","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Jung, S.J., Jung, E.S., Ha, K.C., Baek, H.I., Park, Y.K., Han, S.K., Chae, S.W., Lee, S.O., and Chung, Y.C. (2021). Efficacy and Safety of Sesame Oil Cake Extract on Memory Function Improvement: A 12-Week, Randomized, Double-Blind, Placebo-Controlled Pilot Study. Nutrients, 13.","DOI":"10.3390\/nu13082606"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.3233\/JAD-210007","article-title":"Effects of Peroral Omega-3 Fatty Acid Supplementation on Cerebrospinal Fluid Biomarkers in Patients with Alzheimer\u2019s Disease: A Randomized Controlled Trial-The OmegAD Study","volume":"83","author":"Tofiq","year":"2021","journal-title":"J. Alzheimers Dis."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"661","DOI":"10.3233\/JAD-210158","article-title":"The Association of Essential Metals with APOE Genotype in Alzheimer\u2019s Disease","volume":"82","author":"Orct","year":"2021","journal-title":"J. Alzheimers Dis."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"4568","DOI":"10.1074\/jbc.M705957200","article-title":"Selective intracellular release of copper and zinc ions from bis(thiosemicarbazonato) complexes reduces levels of Alzheimer disease amyloid-beta peptide","volume":"283","author":"Donnelly","year":"2008","journal-title":"J. Biol. Chem."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.3233\/JAD-210448","article-title":"Porphyromonas gingivalis Outer Membrane Vesicles as the Major Driver of and Explanation for Neuropathogenesis, the Cholinergic Hypothesis, Iron Dyshomeostasis, and Salivary Lactoferrin in Alzheimer\u2019s Disease","volume":"82","author":"Nara","year":"2021","journal-title":"J. Alzheimers Dis."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1161\/ATVBAHA.120.311911","article-title":"Vascular Hypothesis of Alzheimer Disease: Topical Review of Mouse Models","volume":"41","author":"Scheffer","year":"2021","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"a024539","DOI":"10.1101\/cshperspect.a024539","article-title":"Genetics of \u03b2-Amyloid Precursor Protein in Alzheimer\u2019s Disease","volume":"7","author":"Tcw","year":"2017","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1007\/s00775-019-01684-z","article-title":"Is brain iron trafficking part of the physiology of the amyloid precursor protein?","volume":"24","author":"Bailey","year":"2019","journal-title":"J. Biol. Inorg. Chem."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.neuropharm.2016.08.035","article-title":"Isoflurane anesthesia exacerbates learning and memory impairment in zinc-deficient APP\/PS1 transgenic mice","volume":"111","author":"Feng","year":"2016","journal-title":"Neuropharmacology"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"3751","DOI":"10.1074\/jbc.M116.754101","article-title":"Zinc and Copper Differentially Modulate Amyloid Precursor Protein Processing by \u03b3-Secretase and Amyloid-\u03b2 Peptide Production","volume":"292","author":"Gerber","year":"2017","journal-title":"J. Biol. Chem."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1111\/jnc.14716","article-title":"Copper and zinc ions govern the transdirected dimerization of APP family members in multiple ways","volume":"151","author":"August","year":"2019","journal-title":"J. Neurochem."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.3233\/JAD-200128","article-title":"Upregulation of Alzheimer\u2019s Disease Amyloid-\u03b2 Protein Precursor in Astrocytes Both in vitro and in vivo","volume":"76","author":"Liang","year":"2020","journal-title":"J. Alzheimers Dis."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"9650","DOI":"10.1074\/jbc.RA119.012386","article-title":"Amyloidogenic processing of amyloid \u03b2 protein precursor (APP) is enhanced in the brains of alcadein \u03b1-deficient mice","volume":"295","author":"Gotoh","year":"2020","journal-title":"J. Biol. Chem."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.1007\/s12011-020-02280-y","article-title":"Effects of Fish Oil Combined with Selenium and Zinc on Learning and Memory Impairment in Aging Mice and Amyloid Precursor Protein Processing","volume":"199","author":"Fu","year":"2021","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"681","DOI":"10.2131\/jts.44.681","article-title":"Long-term administration of excess zinc impairs learning and memory in aged mice","volume":"44","author":"Yoshida","year":"2019","journal-title":"J. Toxicol. Sci."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1016\/j.neurobiolaging.2007.10.018","article-title":"CSF Mg and Ca as diagnostic markers for dementia with Lewy bodies","volume":"30","author":"Hansson","year":"2009","journal-title":"Neurobiol. Aging"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1016\/j.tips.2018.10.001","article-title":"Copper and Zinc Dysregulation in Alzheimer\u2019s Disease","volume":"39","author":"Sensi","year":"2018","journal-title":"Trends Pharmacol. Sci."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.3233\/JAD-170662","article-title":"Metals and Alzheimer\u2019s Disease: How Far Have We Come in the Clinic?","volume":"62","author":"Adlard","year":"2018","journal-title":"J. Alzheimers Dis."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.neuro.2020.07.003","article-title":"Multifunctional roles of zinc in Alzheimer\u2019s disease","volume":"80","author":"Xie","year":"2020","journal-title":"Neurotoxicology"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1212\/01.wnl.0000223644.08653.b5","article-title":"Elevated cortical zinc in Alzheimer disease","volume":"67","author":"Religa","year":"2006","journal-title":"Neurology"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"43542","DOI":"10.1007\/s11356-020-10477-w","article-title":"Molecular mechanism of zinc neurotoxicity in Alzheimer\u2019s disease","volume":"27","author":"Narayanan","year":"2020","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1001\/jama.2015.9677","article-title":"Effect of Omega-3 Fatty Acids, Lutein\/Zeaxanthin, or Other Nutrient Supplementation on Cognitive Function: The AREDS2 Randomized Clinical Trial","volume":"314","author":"Chew","year":"2015","journal-title":"JAMA"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"3228","DOI":"10.1016\/j.neurobiolaging.2015.09.006","article-title":"The zinc ionophore clioquinol reverses autophagy arrest in chloroquine-treated ARPE-19 cells and in APP\/mutant presenilin-1-transfected Chinese hamster ovary cells","volume":"36","author":"Seo","year":"2015","journal-title":"Neurobiol. Aging"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"2753","DOI":"10.1021\/acschemneuro.0c00392","article-title":"The S100B Alarmin Is a Dual-Function Chaperone Suppressing Amyloid-\u03b2 Oligomerization through Combined Zinc Chelation and Inhibition of Protein Aggregation","volume":"11","author":"Figueira","year":"2020","journal-title":"ACS Chem. Neurosci."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.bbadis.2016.11.022","article-title":"Pathological concentration of zinc dramatically accelerates abnormal aggregation of full-length human Tau and thereby significantly increases Tau toxicity in neuronal cells","volume":"1863","author":"Hu","year":"2017","journal-title":"Biochim. Biophys Acta Mol. Basis Dis."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"4098","DOI":"10.1021\/acschemneuro.0c00278","article-title":"His-Rich Domain of Selenoprotein P Ameliorates Neuropathology and Cognitive Deficits by Regulating TrkB Pathway and Zinc Homeostasis in an Alzheimer Model of Mice","volume":"11","author":"Yue","year":"2020","journal-title":"ACS Chem. Neurosci."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1097\/NEN.0b013e3182417387","article-title":"Alteration of the cerebral zinc pool in a mouse model of Alzheimer disease","volume":"71","author":"Lee","year":"2012","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.jphs.2021.11.007","article-title":"Zinc transporters as potential therapeutic targets: An updated review","volume":"148","author":"Hara","year":"2022","journal-title":"J Pharmacol. Sci."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.jtemb.2017.12.006","article-title":"Reduced plaque size and inflammation in the APP23 mouse model for Alzheimer\u2019s disease after chronic application of polymeric nanoparticles for CNS targeted zinc delivery","volume":"49","author":"Vilella","year":"2018","journal-title":"J. Trace Elem. Med. Biol."},{"key":"ref_75","first-page":"375391","article-title":"Prophylactic Subacute Administration of Zinc Increases CCL2, CCR2, FGF2, and IGF-1 Expression and Prevents the Long-Term Memory Loss in a Rat Model of Cerebral Hypoxia-Ischemia","volume":"2015","author":"Brambila","year":"2015","journal-title":"Neural. Plast."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1002\/biof.1247","article-title":"Effect of ZIP2 Gln\/Arg\/Leu (rs2234632) polymorphism on zinc homeostasis and inflammatory response following zinc supplementation","volume":"41","author":"Giacconi","year":"2015","journal-title":"Biofactors"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"26","DOI":"10.3389\/fnagi.2014.00026","article-title":"Cognitive decline due to excess synaptic Zn(2+) signaling in the hippocampus","volume":"6","author":"Takeda","year":"2014","journal-title":"Front. Aging Neurosci."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.3233\/JAD-191092","article-title":"The Prevalence of Dementia: A Systematic Review and Meta-Analysis","volume":"73","author":"Cao","year":"2020","journal-title":"J. Alzheimers Dis."},{"key":"ref_79","first-page":"680","article-title":"Effect of Global Brain Ischemia on Amyloid Precursor Protein Metabolism and Expression of Amyloid-Degrading Enzymes in Rat Cortex: Role in Pathogenesis of Alzheimer\u2019s Disease","volume":"86","author":"Babusikova","year":"2021","journal-title":"Biochemistry"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1111\/acel.12537","article-title":"Chelation of hippocampal zinc enhances long-term potentiation and synaptic tagging\/capture in CA1 pyramidal neurons of aged rats: Implications to aging and memory","volume":"16","author":"Shetty","year":"2017","journal-title":"Aging Cell"},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Higashi, Y., Aratake, T., Shimizu, T., Shimizu, S., and Saito, M. (2021). Protective Role of Glutathione in the Hippocampus after Brain Ischemia. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22157765"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1177\/1099800420951633","article-title":"Effect of Obesity on Cognitive Impairment in Vascular Dementia Rat Model via BDNF-ERK-CREB Pathway","volume":"23","author":"Kim","year":"2021","journal-title":"Biol. Res. Nurs."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.3233\/JAD-201256","article-title":"Variation in VKORC1 Is Associated with Vascular Dementia","volume":"80","author":"Mur","year":"2021","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"3122","DOI":"10.1007\/s11606-021-06954-8","article-title":"Atrial Fibrillation Is Associated with Cognitive Impairment, All-Cause Dementia, Vascular Dementia, and Alzheimer\u2019s Disease: A Systematic Review and Meta-Analysis","volume":"36","author":"Papanastasiou","year":"2021","journal-title":"J. Gen. Intern. Med."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.3233\/JAD-200656","article-title":"Cerebrospinal Fluid Metals and the Association with Cerebral Small Vessel Disease","volume":"78","author":"Shams","year":"2020","journal-title":"J. Alzheimers Dis."},{"key":"ref_86","doi-asserted-by":"crossref","unstructured":"Kawahara, M., Tanaka, K.-I., and Kato-Negishi, M. (2021). Copper as a Collaborative Partner of Zinc-Induced Neurotoxicity in the Pathogenesis of Vascular Dementia. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22147242"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"58","DOI":"10.3389\/fnins.2017.00058","article-title":"Copper Enhances Zinc-Induced Neurotoxicity and the Endoplasmic Reticulum Stress Response in a Neuronal Model of Vascular Dementia","volume":"11","author":"Tanaka","year":"2017","journal-title":"Front. Neurosci."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"135774","DOI":"10.1016\/j.neulet.2021.135774","article-title":"Differentially expressed genes accompanying neurobehavioral deficits in a modified rat model of vascular dementia","volume":"750","author":"Hu","year":"2021","journal-title":"Neurosci. Lett."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1089\/scd.2018.0138","article-title":"Sublethal Doses of Zinc Protect Rat Neural Stem Cells Against Hypoxia Through Activation of the PI3K Pathway","volume":"28","author":"Choi","year":"2019","journal-title":"Stem. Cells Dev."},{"key":"ref_90","doi-asserted-by":"crossref","unstructured":"Kawahara, M., Sadakane, Y., Mizuno, K., Kato-Negishi, M., and Tanaka, K.I. (2020). Carnosine as a Possible Drug for Zinc-Induced Neurotoxicity and Vascular Dementia. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21072570"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1111\/cns.13032","article-title":"Intracerebroventricular streptozotocin-induced Alzheimer\u2019s disease-like sleep disorders in rats: Role of the GABAergic system in the parabrachial complex","volume":"24","author":"Cui","year":"2018","journal-title":"CNS Neurosci. Ther."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"615838","DOI":"10.3389\/fnagi.2020.615838","article-title":"Sleep Disturbance is Associated with Higher Plasma A\u03b2 Levels in Cognitively Normal Adults-A Population-Based Cross-Sectional Study","volume":"12","author":"Gao","year":"2020","journal-title":"Front Aging Neurosci."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1007\/s11064-019-02719-2","article-title":"Chronic Sleep Restriction Induces A\u03b2 Accumulation by Disrupting the Balance of A\u03b2 Production and Clearance in Rats","volume":"44","author":"Zhao","year":"2019","journal-title":"Neurochem. Res."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1111\/j.1532-5415.2010.03232.x","article-title":"The effect of melatonin, magnesium, and zinc on primary insomnia in long-term care facility residents in Italy: A double-blind, placebo-controlled clinical trial","volume":"59","author":"Rondanelli","year":"2011","journal-title":"J. Am. Geriatr. Soc."},{"key":"ref_95","first-page":"1431","article-title":"Serum levels of leptin, zinc and tryptophan in obese subjects with sleep deficits","volume":"30","author":"Samad","year":"2017","journal-title":"Pak. J. Pharm. Sci."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"571","DOI":"10.3233\/JAD-150138","article-title":"The Synergistic Relationship between Alzheimer\u2019s Disease and Sleep Disorders: An Update","volume":"46","author":"Villa","year":"2015","journal-title":"J. Alzheimers Dis."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.5665\/sleep.6158","article-title":"Periodic Limb Movements in Sleep are Associated with Greater Cognitive Decline in Older Men without Dementia","volume":"39","author":"Leng","year":"2016","journal-title":"Sleep"},{"key":"ref_98","first-page":"613","article-title":"Sleep-disordered breathing, hypoxia, and risk of mild cognitive impairment and dementia in older women","volume":"306","author":"Yaffe","year":"2011","journal-title":"JAMA"},{"key":"ref_99","doi-asserted-by":"crossref","unstructured":"Chen, T.-I., Chen, M., and Yu, C. (2016). Zinc Is Indispensable in Exercise-Induced Cardioprotection against Intermittent Hypoxia-Induced Left Ventricular Function Impairment in Rats. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0168600"},{"key":"ref_100","doi-asserted-by":"crossref","unstructured":"Levenson, C.W., and Tassabehji, N.M. (2007). Role and Regulation of Copper and Zinc Transport Proteins in the Central Nervous System. Handbook of Neurochemistry and Molecular Neurobiology, Springer.","DOI":"10.1007\/978-0-387-30380-2_13"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1038\/308734a0","article-title":"Release of endogenous Zn2+ from brain tissue during activity","volume":"308","author":"Assaf","year":"1984","journal-title":"Nature"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1038\/nrn1671","article-title":"The neurobiology of zinc in health and disease","volume":"6","author":"Frederickson","year":"2005","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1152\/physrev.00035.2014","article-title":"The Physiological, Biochemical, and Molecular Roles of Zinc Transporters in Zinc Homeostasis and Metabolism","volume":"95","author":"Kambe","year":"2014","journal-title":"Physiol. Rev."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1007\/BF03033884","article-title":"Alterations in zinc transporter protein-1 (ZnT-1) in the brain of subjects with mild cognitive impairment, early, and late-stage alzheimer\u2019s disease","volume":"7","author":"Lovell","year":"2004","journal-title":"Neurotox. Res."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1107\/S2059798319003814","article-title":"A structural overview of the zinc transporters in the cation diffusion facilitator family","volume":"75","author":"Cotrim","year":"2019","journal-title":"Acta Crystallogr. Sect. D Struct. Biol."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1002\/gene.20067","article-title":"Mousezinc transporter 1 gene provides an essential function during early embryonic development","volume":"40","author":"Andrews","year":"2003","journal-title":"Genesis"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1002\/j.1460-2075.1995.tb07042.x","article-title":"Cloning and functional characterization of a mammalian zinc transporter that confers resistance to zinc","volume":"14","author":"Palmiter","year":"1995","journal-title":"EMBO J."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1007\/s00109-006-0062-4","article-title":"Silencing of ZnT-1 expression enhances heavy metal influx and toxicity","volume":"84","author":"Ohana","year":"2006","journal-title":"J. Mol. Med."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0165-3806(02)00437-6","article-title":"Postnatal regulation of ZnT-1 expression in the mouse brain","volume":"137","author":"Nitzan","year":"2002","journal-title":"Dev. Brain Res."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1002\/cne.10224","article-title":"Distribution of the zinc transporter ZnT-1 in comparison with chelatable zinc in the mouse brain","volume":"447","author":"Sekler","year":"2002","journal-title":"J. Comp. Neurol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/1756-6606-7-16","article-title":"Zinc transporter-1 concentrates at the postsynaptic density of hippocampal synapses","volume":"7","author":"Sindreu","year":"2013","journal-title":"Mol. Brain"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1523\/JNEUROSCI.4604-08.2009","article-title":"Intracellular Zn2+ Accumulation Contributes to Synaptic Failure, Mitochondrial Depolarization, and Cell Death in an Acute Slice Oxygen-Glucose Deprivation Model of Ischemia","volume":"29","author":"Medvedeva","year":"2008","journal-title":"J. Neurosci."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1002\/glia.20065","article-title":"ZnT-1 expression in astroglial cells protects against zinc toxicity and slows the accumulation of intracellular zinc","volume":"48","author":"Nolte","year":"2003","journal-title":"Glia"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1097\/01.jnen.0000229237.98124.91","article-title":"Elevated Zinc Transporter-6 in Mild Cognitive Impairment, Alzheimer Disease, and Pick Disease","volume":"65","author":"Lovell","year":"2006","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/S0969-9961(03)00123-2","article-title":"Functional \u03b3-secretase complex assembly in Golgi\/trans-Golgi network: Interactions among presenilin, nicastrin, Aph1, Pen-2, and \u03b3-secretase substrates","volume":"14","author":"Baulac","year":"2002","journal-title":"Neurobiol. Dis."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1046\/j.1471-4159.2003.01616.x","article-title":"Localization of presenilin-nicastrin complexes and \u03b3-secretase activity to the trans-Golgi network","volume":"84","author":"Siman","year":"2002","journal-title":"J. Neurochem."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"1921","DOI":"10.1126\/science.268.5219.1921","article-title":"Response: Zinc and Alzheimer\u2019s Disease","volume":"268","author":"Bush","year":"1995","journal-title":"Science"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1016\/j.neuron.2022.02.008","article-title":"Colocalization of different neurotransmitter transporters on synaptic vesicles is sparse except for VGLUT1 and ZnT3","volume":"110","author":"Upmanyu","year":"2021","journal-title":"Neuron"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"4806","DOI":"10.1038\/s41467-019-12761-x","article-title":"Sub-nanomolar sensitive GZnP3 reveals TRPML1-mediated neuronal Zn2+ signals","volume":"10","author":"Minckley","year":"2019","journal-title":"Nat. Commun."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"9411","DOI":"10.1038\/s41598-019-45844-2","article-title":"Intracellular Zn2+ transients modulate global gene expression in dissociated rat hippocampal neurons","volume":"9","author":"Sanford","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_121","doi-asserted-by":"crossref","unstructured":"Kawahara, M., Midori, K.-N., and Tanaka, K. (2019). Amyloids: Regulators of Metal Homeostasis in the Synapse. Molecules, 25.","DOI":"10.3390\/molecules25061441"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/j.chembiol.2018.05.004","article-title":"A Proposed Mechanism for Neurodegeneration in Movement Disorders Characterized by Metal Dyshomeostasis and Oxidative Stress","volume":"25","author":"Trist","year":"2018","journal-title":"Cell Chem. Biol."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"3366","DOI":"10.1073\/pnas.1019166108","article-title":"Zinc transporter ZnT-3 regulates pre-synaptic Erk1\/2 signaling and hippocampus-dependent memory","volume":"108","author":"Sindreu","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1038\/s41398-021-01693-0","article-title":"Synaptic Zn2+ potentiates the effects of cocaine on striatal dopamine neurotransmission and behavior","volume":"11","author":"Gomez","year":"2021","journal-title":"Transl. Psychiatry"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1523\/JNEUROSCI.5255-09.2010","article-title":"Cognitive loss in zinctransporter-3 knock-out mice: A phenocopy for the synaptic and memory deficits of Alzheimer\u2019s disease?","volume":"30","author":"Adlard","year":"2010","journal-title":"J. Neurosci."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"e838","DOI":"10.1038\/tp.2016.83","article-title":"Obesity and age-related alterations in the gene expression of zinc-transporter proteins in the human brain","volume":"6","author":"Olesen","year":"2016","journal-title":"Transl. Psychiatry"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.neurobiolaging.2008.02.018","article-title":"Altered expression and distribution of zinc transporters in APP\/PS1 transgenic mouse brain","volume":"31","author":"Zhang","year":"2010","journal-title":"Neurobiol. Aging"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.ejphar.2003.08.067","article-title":"Zn2+ transporters and Zn2+ homeostasis in neurons","volume":"479","author":"Colvin","year":"2003","journal-title":"Eur. J. Pharmacol."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1007\/s12011-010-8793-z","article-title":"Effects of forced running exercise on cognitive function and its relation to zinc homeostasis-related gene expression in rat hippocampus","volume":"142","author":"Hong","year":"2011","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"863","DOI":"10.3233\/JAD-2012-112105","article-title":"Zinc transporter mRNA levels in Alzheimer\u2019s disease postmortem brain","volume":"29","author":"Beyer","year":"2012","journal-title":"J. Alzheimer\u2019s Dis. JAD"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1016\/S0002-9440(10)64463-X","article-title":"Intraneuronal Alzheimer abeta42 accumulates in multivesicular bodies and is associated with synaptic pathology","volume":"161","author":"Takahashi","year":"2002","journal-title":"Am. J. Pathol."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/S0304-3940(01)01876-6","article-title":"Intraneuronal Abeta accumulation precedes plaque formation in beta-amyloid precursor protein and presenilin-1 double-transgenic mice","volume":"306","author":"Wirths","year":"2001","journal-title":"Neurosci. Lett."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1097\/00001756-200301200-00023","article-title":"Early intraneuronal Abeta deposition in the hippocampus of APP transgenic mice","volume":"14","author":"Shie","year":"2003","journal-title":"Neuroreport"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1016\/j.neuroscience.2006.02.049","article-title":"Altered expression of zinc transporters-4 and -6 in mild cognitive impairment, early and late Alzheimer\u2019s disease brain","volume":"140","author":"Smith","year":"2006","journal-title":"Neuroscience"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1177\/0271678X20926787","article-title":"MicroRNA-30a regulates acute cerebral ischemia-induced blood-brain barrier damage through ZnT4\/zinc pathway","volume":"41","author":"Wang","year":"2021","journal-title":"J. Cereb. Blood Flow Metab. Off. J. Int. Soc. Cereb. Blood Flow Metab."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"C948","DOI":"10.1152\/ajpcell.00020.2022","article-title":"Early secretory pathway-resident Zn transporter proteins contribute to cellular sphingolipid metabolism through activation of sphingomyelin phosphodiesterase 1","volume":"322","author":"Ueda","year":"2022","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"26389","DOI":"10.1074\/jbc.M200462200","article-title":"Functional characterization of a novel mammalian zinc transporter, ZnT6","volume":"277","author":"Huang","year":"2002","journal-title":"J. Biol. Chem."},{"key":"ref_138","doi-asserted-by":"crossref","unstructured":"Fukuda, T., and Kambe, T. (2014). Molecular aspects of zinc signals. Zinc Signals in Cellular Functions and Disorders, Springer.","DOI":"10.1007\/978-4-431-55114-0"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.jtemb.2016.03.003","article-title":"Significance of synaptic Zn2+ signaling in zincergic and non-zincergic synapses in the hippocampus in cognition","volume":"38","author":"Tamano","year":"2016","journal-title":"J. Trace. Elem. Med. Biol."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1007\/s00775-011-0799-2","article-title":"Chemistry and biology of mammalian metallothioneins","volume":"16","author":"Vasak","year":"2011","journal-title":"J. Biol. Inorg. Chem."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1039\/C5MT00305A","article-title":"Zinc sensing by metal-responsive transcription factor 1 (MTF1) controls metallothionein and ZnT1 expression to buffer the sensitivity of the transcriptome response to zinc","volume":"8","author":"Hardyman","year":"2016","journal-title":"Metallomics"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1039\/c3mt00123g","article-title":"Mammalian MT1 and MT2 metallothioneins differ in their metal binding abilities","volume":"5","author":"Artells","year":"2013","journal-title":"Metallomics"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"5828056","DOI":"10.1155\/2017\/5828056","article-title":"Metallothionein in Brain Disorders","volume":"2017","author":"Rios","year":"2017","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"2316","DOI":"10.1002\/glia.23465","article-title":"Cognitive Function and Ageing Neuropathology Study Group. Metallothionein-I\/II expression associates with the astrocyte DNA damage response and not Alzheimer-type pathology in the aging brain","volume":"66","author":"Waller","year":"2018","journal-title":"Glia"},{"key":"ref_145","first-page":"L856","article-title":"Overexpression of metallothionein decreases sensitivity of pulmonary endothelial cells to oxidant injury","volume":"273","author":"Pitt","year":"1997","journal-title":"Am. J. Physiol."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1007\/s00204-012-0927-y","article-title":"Metallothionein blocks oxidative DNA damage in vitro","volume":"87","author":"Qu","year":"2013","journal-title":"Arch. Toxicol."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1111\/j.1471-4159.2012.07725.x","article-title":"Amyloid neurotoxicity is attenuated by metallothionein: Dual mechanisms at work","volume":"121","author":"Nam","year":"2012","journal-title":"J. Neurochem."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1177\/153537020623100902","article-title":"Expression of metallothionein-I, -II, and -III in Alzheimer disease and animal models of neuroinflammation","volume":"231","author":"Hidalgo","year":"2006","journal-title":"Exp. Biol. Med."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.biocel.2006.07.001","article-title":"Free radicals and antioxidants in normal physiological functions and human disease","volume":"39","author":"Valko","year":"2007","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.brainres.2007.11.038","article-title":"Metallothionein I,II deficient mice do not exhibit significantly worse long-term behavioral outcomes following neonatal hypoxia-ischemia: MT-I,II deficient mice have inherent behavioral impairments","volume":"1190","author":"McAuliffe","year":"2008","journal-title":"Brain Res."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"5003","DOI":"10.1016\/j.febslet.2007.09.046","article-title":"Protective effects of metallothionein against dopamine quinone-induced dopaminergic neurotoxicity","volume":"581","author":"Miyazaki","year":"2007","journal-title":"FEBS Lett."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.1111\/j.1742-4658.2006.05207.x","article-title":"Metallothioneins are multipurpose neuroprotectants during brain pathology","volume":"273","author":"Penkowa","year":"2006","journal-title":"FEBS J."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/0896-6273(91)90272-2","article-title":"The growth inhibitory factor that is deficient in the Alzheimer\u2019s disease brain is a 68 amino acid metallothionein-like protein","volume":"7","author":"Uchida","year":"1991","journal-title":"Neuron"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"4843","DOI":"10.1002\/j.1460-2075.1992.tb05590.x","article-title":"Molecular cloning of human growth inhibitory factor cDNA and its down-regulation in Alzheimer\u2019s disease","volume":"11","author":"Tsuji","year":"1992","journal-title":"EMBO J."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0006-8993(00)03196-6","article-title":"Metallothionein III is reduced in Alzheimer\u2019s disease","volume":"894","author":"Yu","year":"2001","journal-title":"Brain Res."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/BF02898066","article-title":"Metallothioneins and brain injury: What transgenic mice tell us","volume":"9","author":"Hidalgo","year":"2004","journal-title":"Environ. Health Prev. Med."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/S0006-8993(02)03891-X","article-title":"Anti-amyloid beta activity of metallothionein-III is different from its neuronal growth inhibitory activity: Structure-activity studies","volume":"960","author":"Yoshifumi","year":"2003","journal-title":"Brain Res."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0304-3940(00)01488-9","article-title":"Expression of metallothionein-III mRNA and its regulation by levodopa in the basal ganglia of hemi-parkinsonian rats","volume":"293","author":"Miyazaki","year":"2000","journal-title":"Neurosci. Lett."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"32353","DOI":"10.1074\/jbc.M111263200","article-title":"Growth inhibitory factor prevents neurite extension and the death of cortical neurons caused by high oxygen exposure through hydroxyl radical scavenging","volume":"277","author":"Uchida","year":"2002","journal-title":"J. Biol. Chem."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/s12929-016-0269-9","article-title":"Zinc finger proteins in cancer progression","volume":"23","author":"Jen","year":"2016","journal-title":"J. Biomed. Sci."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1146\/annurev.biophys.29.1.183","article-title":"DNA recognition by Cys2His2 zinc finger proteins","volume":"29","author":"Wolfe","year":"2000","journal-title":"Annu. Rev. Biophys. Biomol. Struct."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"2643","DOI":"10.1021\/ar500182d","article-title":"Structural metal sites in nonclassical zinc finger proteins involved in transcriptional and translational regulation","volume":"47","author":"Lee","year":"2014","journal-title":"Acc. Chem. Res."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"12619","DOI":"10.1039\/c1dt11071c","article-title":"Cysteine and histidine shuffling: Mixing and matching cysteine and histidine residues in zinc finger proteins to afford different folds and function","volume":"40","author":"Michalek","year":"2011","journal-title":"Dalton Trans."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1042\/bst0300945","article-title":"Tristetraprolin and other CCCH tandem zinc-finger proteins in the regulation of mRNA turnover","volume":"30","author":"Blackshear","year":"2002","journal-title":"Biochem. Soc. Trans."},{"key":"ref_165","doi-asserted-by":"crossref","unstructured":"Andreini, C., Bertini, I., and Cavallaro, G. (2011). Minimal functional sites allow a classification of zinc sites in proteins. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0026325"},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1039\/c0mt00024h","article-title":"Zinc proteomes, phylogenetics and evolution","volume":"2","author":"Decaria","year":"2010","journal-title":"Met. Integr. Biomet. Sci."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"7697","DOI":"10.1021\/acs.inorgchem.0c03808","article-title":"Cadmium Exchange with Zinc in the Non-Classical Zinc Finger Protein Tristetraprolin","volume":"60","author":"Brandis","year":"2021","journal-title":"Inorg. Chem."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S0959-440X(00)00167-6","article-title":"Zinc finger proteins: New insights into structural and functional diversity","volume":"11","author":"Laity","year":"2001","journal-title":"Curr. Opin. Struct. Biol."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"20190333","DOI":"10.1098\/rstb.2019.0333","article-title":"Widespread correlation of KRAB zinc finger protein binding with brain-developmental gene expression patterns","volume":"375","author":"Farmiloe","year":"2020","journal-title":"Philos. Trans. R. Soc. Lond. B Biol."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"760567","DOI":"10.3389\/fnins.2021.760567","article-title":"Zinc Finger Proteins in Neuro-Related Diseases Progression","volume":"15","author":"Bu","year":"2021","journal-title":"Front. Neurosci."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.ajhg.2014.01.002","article-title":"NR2F1 mutations cause optic atrophy with intellectual disability","volume":"94","author":"Bosch","year":"2014","journal-title":"Am. J. Hum. Genet."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1006\/bbrc.1999.1516","article-title":"Cloning and characterization of a novel p21(Cip1\/Waf1)-interacting zinc finger protein, ciz1","volume":"264","author":"Mitsui","year":"1999","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1242\/jcs.01599","article-title":"Ciz1 promotes mammalian DNA replication","volume":"118","author":"Coverley","year":"2005","journal-title":"J. Cell Sci."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.neurobiolaging.2017.10.014","article-title":"DNA damage and neurodegenerative phenotypes in aged Ciz1 null mice","volume":"62","author":"Khan","year":"2018","journal-title":"Neurobiol. Aging."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/1750-1326-5-60","article-title":"DNA damage and cell cycle events implicate cerebellar dentate nucleus neurons as targets of Alzheimer\u2019s disease","volume":"5","author":"Chen","year":"2010","journal-title":"Mol. Neurodegener."},{"key":"ref_176","doi-asserted-by":"crossref","unstructured":"Silva, A.R., Santos, A.C., Farfel, J.M., Grinberg, L.T., Ferretti, R.E., Campos, A.H., Cunha, I.W., Begnami, M.D., Rocha, R.M., and Carraro, D.M. (2014). Repair of oxidative DNA damage, cell-cycle regulation and neuronal death may influence the clinical manifestation of Alzheimer\u2019s disease. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0099897"},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.mcn.2008.05.007","article-title":"Altered splicing in exon 8 of the DNA replication factor CIZ1 affects subnuclear distribution and is associated with Alzheimer\u2019s disease","volume":"38","author":"Dahmcke","year":"2008","journal-title":"Mol. Cell. Neurosci."},{"key":"ref_178","doi-asserted-by":"crossref","unstructured":"Avet-Rochex, A., Carvajal, N., Christoforou, C.P., Yeung, K., Maierbrugger, K.T., Hobbs, C., Lalli, G., Cagin, U., Plachot, C., and McNeill, H. (2014). Unkempt is negatively regulated by mTOR and uncouples neuronal differentiation from growth control. PLoS Genet., 10.","DOI":"10.1371\/journal.pgen.1004624"},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"e1058684","DOI":"10.1080\/23262133.2015.1058684","article-title":"Mechanistic insights into the role of mTOR signaling in neuronal differentiation","volume":"2","author":"Bateman","year":"2015","journal-title":"Neurogenesis"},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/j.celrep.2018.12.086","article-title":"Headcase and Unkempt Regulate Tissue Growth and Cell Cycle Progression in Response to Nutrient Restriction","volume":"26","author":"Li","year":"2019","journal-title":"Cell Rep."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.ydbio.2020.01.006","article-title":"The mTOR pathway component Unkempt regulates neural stem cell and neural progenitor cell cycle in the Drosophila central nervous system","volume":"461","author":"Maierbrugger","year":"2020","journal-title":"Dev. Biol."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"16299","DOI":"10.1038\/s41598-021-95286-y","article-title":"The zinc finger\/RING domain protein Unkempt regulates cognitive flexibility","volume":"11","author":"Vinsland","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"13836","DOI":"10.1523\/JNEUROSCI.2656-15.2015","article-title":"Dysregulation of Mammalian Target of Rapamycin Signaling in Mouse Models of Autism","volume":"35","author":"Huber","year":"2015","journal-title":"J. Neurosci."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1038\/nsmb.3140","article-title":"Recognition of distinct RNA motifs by the clustered CCCH zinc fingers of neuronal protein Unkempt","volume":"23","author":"Murn","year":"2016","journal-title":"Nat. Struct. Mol. Biol."},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.neuroscience.2012.06.054","article-title":"Chronic inhibition of mammalian target of rapamycin by rapamycin modulates cognitive and non-cognitive components of behavior throughout lifespan in mice","volume":"223","author":"Halloran","year":"2012","journal-title":"Neuroscience"},{"key":"ref_186","doi-asserted-by":"crossref","unstructured":"Teng, L.L., Lu, G.L., Chiou, L.C., Lin, W.S., Cheng, Y.Y., Hsueh, T.E., Huang, Y.C., Hwang, N.H., Yeh, J.W., and Liao, R.M. (2019). Serotonin receptor HTR6-mediated mTORC1 signaling regulates dietary restriction-induced memory enhancement. PLoS Biol., 17.","DOI":"10.1371\/journal.pbio.2007097"},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1038\/msb.2011.79","article-title":"Modularity and hormone sensitivity of the Drosophila melanogaster insulin receptor\/target of rapamycin interaction proteome","volume":"7","author":"Glatter","year":"2011","journal-title":"Mol. Syst. Biol."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"2603","DOI":"10.1093\/brain\/awq192","article-title":"Genetic variation influences glutamate concentrations in brains of patients with multiple sclerosis","volume":"133","author":"Baranzini","year":"2010","journal-title":"Brain"},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.biopsych.2016.08.038","article-title":"Psychosis Risk Candidate ZNF804A Localizes to Synapses and Regulates Neurite Formation and Dendritic Spine Structure","volume":"82","author":"Deans","year":"2017","journal-title":"Biol. Psychiatry"},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1002\/ajmg.b.32284","article-title":"Bioinformatic analyses and conceptual synthesis of evidence linking ZNF804A to risk for schizophrenia and bipolar disorder","volume":"168B","author":"Hess","year":"2015","journal-title":"Am. J. Med. Genetics. Part B Neuropsychiatr. Genet. Off. Publ. Int. Soc. Psychiatr. Genet."},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1001\/jamapsychiatry.2014.1079","article-title":"Expression of ZNF804A in human brain and alterations in schizophrenia, bipolar disorder, and major depressive disorder: A novel transcript fetally regulated by the psychosis risk variant rs1344706","volume":"71","author":"Tao","year":"2014","journal-title":"JAMA Psychiatry"},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.schres.2015.06.023","article-title":"Postnatal neurodevelopmental expression and glutamate-dependent regulation of the ZNF804A rodent homologue","volume":"168","author":"Chang","year":"2015","journal-title":"Schizophr. Res."},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1038\/mp.2017.166","article-title":"Interactome analysis reveals ZNF804A, a schizophrenia risk gene, as a novel component of protein translational machinery critical for embryonic neurodevelopment","volume":"23","author":"Zhou","year":"2018","journal-title":"Mol. Psychiatry"},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1038\/nature10523","article-title":"Spatio-temporal transcriptome of the human brain","volume":"478","author":"Kang","year":"2011","journal-title":"Nature"},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1093\/hmg\/ddr532","article-title":"Knockdown of the psychosis susceptibility gene ZNF804A alters expression of genes involved in cell adhesion","volume":"21","author":"Hill","year":"2012","journal-title":"Hum. Mol. Genet."},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.neuron.2015.11.023","article-title":"Mice with Shank3 Mutations Associated with ASD and Schizophrenia Display Both Shared and Distinct Defects","volume":"89","author":"Zhou","year":"2016","journal-title":"Neuron"},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1001\/jamapsychiatry.2014.1582","article-title":"Prefrontal cortical dendritic spine pathology in schizophrenia and bipolar disorder","volume":"71","author":"Konopaske","year":"2014","journal-title":"JAMA Psychiatry"},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.nbd.2018.12.011","article-title":"Brain proteome changes in female Brd1+\/- mice unmask dendritic spine pathology and show enrichment for schizophrenia risk","volume":"124","author":"Paternoster","year":"2019","journal-title":"Neurobiol. Dis."},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/s11910-010-0104-8","article-title":"Synapse pathology in psychiatric and neurologic disease","volume":"10","author":"Hoogenraad","year":"2010","journal-title":"Curr. Neurol. Neurosci. Rep."},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s13041-021-00729-2","article-title":"Schizophrenia risk ZNF804A interacts with its associated proteins to modulate dendritic morphology and synaptic development","volume":"14","author":"Dong","year":"2021","journal-title":"Mol. Brain"},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"2514","DOI":"10.1038\/s41380-020-00972-4","article-title":"ZFP804A mutant mice display sex-dependent schizophrenia-like behaviors","volume":"26","author":"Huang","year":"2021","journal-title":"Mol. Psychiatry"},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"e136","DOI":"10.1038\/tp.2012.62","article-title":"Evidence for the involvement of ZNF804A in cognitive processes of relevance to reading and spelling","volume":"2","author":"Becker","year":"2012","journal-title":"Transl. Psychiatry"},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1002\/ajmg.b.31107","article-title":"The refinement of the critical region for the 2q31.2q32.3 deletion syndrome indicates candidate genes for mental retardation and speech impairment","volume":"153B","author":"Cocchella","year":"2010","journal-title":"Am. J. Med. Genet. Part B Neuropsychiatr. Genet. Off. Publ. Int. Soc. Psychiatr. Genet."},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1046\/j.0021-9630.2003.00305.x","article-title":"Specific reading disability (dyslexia): What have we learned in the past four decades?","volume":"45","author":"Vellutino","year":"2004","journal-title":"J. Child Psychol. Psychiatry Allied Discip."},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"126636","DOI":"10.1016\/j.jtemb.2020.126636","article-title":"Interplay Between Autophagy and Zinc","volume":"62","author":"Liuzzi","year":"2020","journal-title":"J. Trace Elem. Med. Biol."},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1152\/physrev.00030.2009","article-title":"Rubinsztein Regulation of mammalian autophagy in physiology and pathophysiology","volume":"90","author":"Ravikumar","year":"2010","journal-title":"Physiol. Rev."},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1023\/A:1012993017026","article-title":"The role of zinc in caspase activation and apoptotic cell death","volume":"14","author":"Carter","year":"2001","journal-title":"Biometals"},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"C2175","DOI":"10.1152\/ajpcell.00256.2006","article-title":"Zinc deficiency depresses p21 gene expression: Inhibition of cell cycle progression is independent of the decrease in p21 protein level in HepG2 cells","volume":"292","author":"Wong","year":"2007","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/1756-6606-3-30","article-title":"Roles of zinc and metallothionein-3 in oxidative stress-induced lysosomal dysfunction, cell death, and autophagy in neurons and astrocytes","volume":"3","author":"Lee","year":"2010","journal-title":"Mol. Brain"},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1007\/s12011-013-9816-3","article-title":"Role of zinc in the regulation of autophagy during ethanol exposure in human hepatoma cells","volume":"156","author":"Liuzzi","year":"2013","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1007\/s10534-010-9346-9","article-title":"Zinc(II) ion mediates tamoxifen-induced autophagy and cell death in MCF-7 breast cancer cell line","volume":"23","author":"Hwang","year":"2010","journal-title":"Biometals"},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1007\/s10565-013-9261-2","article-title":"Dopamine- and zinc-induced autophagosome formation facilitates PC12 cell survival","volume":"29","author":"Hung","year":"2013","journal-title":"Cell Biol. Toxicol."},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.jnutbio.2007.12.008","article-title":"Aranda Assessment of iron and Zn intake and related biochemical parameters in an adult Mediterranean population from southern Spain: Influence of lifestyle factors","volume":"20","author":"Planells","year":"2009","journal-title":"J. Nutr. Biochem."},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.molmed.2009.03.004","article-title":"Regulation of the aging process by autophagy","volume":"15","author":"Salminen","year":"2009","journal-title":"Trends Mol. Med."},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.arr.2017.09.005","article-title":"Autophagy, its mechanisms and regulation: Implications in neurodegenerative diseases","volume":"40","author":"Moloudizargari","year":"2017","journal-title":"Ageing Res. Rev."},{"key":"ref_216","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1016\/j.neuron.2017.01.022","article-title":"Rubinsztein Autophagy and neurodegeneration: Pathogenic mechanisms and therapeutic opportunities","volume":"93","author":"Menzies","year":"2017","journal-title":"Neuron"},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"8177","DOI":"10.1523\/JNEUROSCI.20-21-08177.2000","article-title":"Activation of ERK\/MAP kinase in the amygdala is required for memory consolidation of pavlovian fear conditioning","volume":"20","author":"Schafe","year":"2000","journal-title":"J. Neurosci. Off. J. Soc. Neurosci."},{"key":"ref_218","doi-asserted-by":"crossref","first-page":"2411","DOI":"10.1097\/00001756-199908020-00035","article-title":"Activation of neuronal extracellular receptor kinase (ERK) in Alzheimer disease links oxidative stress to abnormal phosphorylation","volume":"10","author":"Perry","year":"1999","journal-title":"Neuroreport"},{"key":"ref_219","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0169-328X(02)00488-6","article-title":"Up-regulation of mitogen-activated protein kinases ERK1\/2 and MEK1\/2 is associated with the progression of neurofibrillary degeneration in Alzheimer\u2019s disease. Brain research","volume":"109","author":"Pei","year":"2002","journal-title":"Mol. Brain Res."},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/S0002-9440(10)63445-1","article-title":"Okadaic-acid-induced inhibition of protein phosphatase 2A produces activation of mitogen-activated protein kinases ERK1\/2, MEK1\/2, and p70 S6, similar to that in Alzheimer\u2019s disease","volume":"163","author":"Pei","year":"2003","journal-title":"Am. J. Pathol."},{"key":"ref_221","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1080\/10715762.2017.1414949","article-title":"Zinc prevents mitochondrial superoxide generation by inducing mitophagy in the setting of hypoxia\/reoxygenation in cardiac cells","volume":"52","author":"Bian","year":"2018","journal-title":"Free Radic. Res."},{"key":"ref_222","doi-asserted-by":"crossref","first-page":"12003","DOI":"10.1128\/JVI.01434-12","article-title":"Porcine circovirus type 2 induces autophagy via the AMPK\/ERK\/TSC2\/mTOR signaling pathway in PK-15 cells","volume":"86","author":"Zhu","year":"2012","journal-title":"J. Virol."},{"key":"ref_223","doi-asserted-by":"crossref","first-page":"21412","DOI":"10.1074\/jbc.M109.026013","article-title":"A non-canonical MEK\/ERK signaling pathway regulates autophagy via regulating Beclin 1","volume":"284","author":"Wang","year":"2009","journal-title":"J. Biol. Chem."},{"key":"ref_224","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1007\/s12640-011-9291-6","article-title":"Zinc and the ERK kinases in the developing brain","volume":"21","author":"Nuttall","year":"2012","journal-title":"Neurotox. Res."},{"key":"ref_225","doi-asserted-by":"crossref","first-page":"67","DOI":"10.4161\/auto.2.2.2458","article-title":"Autophagy signaling and the cogwheels of cancer","volume":"2","author":"Botti","year":"2006","journal-title":"Autophagy"},{"key":"ref_226","doi-asserted-by":"crossref","unstructured":"Gonnella, R., Guttieri, L., Gilardini Montani, M.S., Santarelli, R., Bassetti, E., D\u2019Orazi, G., and Cirone, M. (2022). Zinc Supplementation Enhances the Pro-Death Function of UPR in Lymphoma Cells Exposed to Radiation. Biology, 11.","DOI":"10.3390\/biology11010132"},{"key":"ref_227","first-page":"647","article-title":"The metal transcription factor MTF-1: Biological facts and medical implications","volume":"131","author":"Lichtlen","year":"2001","journal-title":"Swiss Med. Wkly."},{"key":"ref_228","doi-asserted-by":"crossref","unstructured":"Xiao, W., Wang, J., Wang, X., Cai, S., Guo, Y., Ye, L., Li, D., Hu, A., Jin, S., and Yuan, B. (2022). Therapeutic targeting of the USP2-E2F4 axis inhibits autophagic machinery essential for zinc homeostasis in cancer progression. Autophagy, 1\u201321.","DOI":"10.1080\/15548627.2022.2044651"},{"key":"ref_229","doi-asserted-by":"crossref","first-page":"jkab366","DOI":"10.1093\/g3journal\/jkab366","article-title":"Natural variation in the transcriptional response of Drosophila melanogaster to oxidative stress","volume":"12","author":"Ramnarine","year":"2022","journal-title":"G3"},{"key":"ref_230","doi-asserted-by":"crossref","unstructured":"Actis, C., Muzio, G., and Autelli, R. (2021). Autophagy Triggers Tamoxifen Resistance in Human Breast Cancer Cells by Preventing Drug-Induced Lysosomal Damage. Cancers, 13.","DOI":"10.3390\/cancers13061252"},{"key":"ref_231","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.1038\/s41598-020-58237-7","article-title":"A role of metallothionein-3 in radiation-induced autophagy in glioma cells","volume":"10","author":"Cho","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_232","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.mrfmmm.2011.08.009","article-title":"The role of zinc in genomic stability","volume":"733","author":"Sharif","year":"2012","journal-title":"Mutat. Res."},{"key":"ref_233","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1515\/hsz-2020-0265","article-title":"RNA secondary structure dependence in METTL3-METTL14 mRNA methylation is modulated by the N-terminal domain of METTL3","volume":"402","author":"Meiser","year":"2020","journal-title":"Biol. Chem."},{"key":"ref_234","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1038\/cr.2017.15","article-title":"YTHDF3 facilitates translation and decay of N6-methyladenosine-modified RNA","volume":"27","author":"Shi","year":"2017","journal-title":"Cell Res."},{"key":"ref_235","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1038\/cr.2017.10","article-title":"Cytoplasmic m6A reader YTHDF3 promotes mRNA translation","volume":"27","author":"Li","year":"2017","journal-title":"Cell Res."},{"key":"ref_236","doi-asserted-by":"crossref","first-page":"83","DOI":"10.21037\/atm-21-6857","article-title":"YTHDF3 facilitates triple-negative breast cancer progression and metastasis by stabilizing ZEB1 mRNA in an m6A-dependent manner","volume":"10","author":"Lin","year":"2022","journal-title":"Ann. Transl. Med."},{"key":"ref_237","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1038\/s41467-022-28753-3","article-title":"Two zinc finger proteins with functions in m6A writing interact with HAKAI","volume":"13","author":"Zhang","year":"2022","journal-title":"Nat. Commun."},{"key":"ref_238","doi-asserted-by":"crossref","first-page":"48","DOI":"10.3389\/fpls.2012.00048","article-title":"Adenosine Methylation in Arabidopsis mRNA is Associated with the 3\u2019 End and Reduced Levels Cause Developmental Defects","volume":"3","author":"Bodi","year":"2012","journal-title":"Front. Plant Sci."},{"key":"ref_239","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1105\/tpc.108.058883","article-title":"MTA is an Arabidopsis messenger RNA adenosine methylase and interacts with a homolog of a sex-specific splicing factor","volume":"20","author":"Zhong","year":"2008","journal-title":"Plant Cell"},{"key":"ref_240","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1111\/nph.14586","article-title":"Identification of factors required for m6A mRNA methylation in Arabidopsis reveals a role for the conserved E3 ubiquitin ligase HAKAI","volume":"215","author":"Zhang","year":"2017","journal-title":"New Phytol."},{"key":"ref_241","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1016\/j.tig.2008.10.002","article-title":"Autophagy and aging: Keeping that old broom working","volume":"24","author":"Cuervo","year":"2008","journal-title":"Trends Genet. TIG"},{"key":"ref_242","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.tiv.2017.08.006","article-title":"Autophagy plays a positive role in zinc-induced apoptosis in intestinal porcine epithelial cells","volume":"44","author":"Zhou","year":"2017","journal-title":"Toxicol. Vitro"},{"key":"ref_243","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.nbd.2011.01.009","article-title":"Hwang Clioquinol induces autophagy in cultured astrocytes and neurons by acting as a zinc ionophore","volume":"42","author":"Park","year":"2011","journal-title":"Neurobiol. Dis."},{"key":"ref_244","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1097\/JTO.0b013e3182208fac","article-title":"The zinc ionophore PCI-5002 radiosensitizes non-small cell lung cancer cells by enhancing autophagic cell death","volume":"6","author":"Kim","year":"2011","journal-title":"J. Thorac. Oncol."},{"key":"ref_245","doi-asserted-by":"crossref","first-page":"5344","DOI":"10.1167\/iovs.12-9827","article-title":"Induction of autophagy and cell death by tamoxifen in cultured retinal pigment epithelial and photoreceptor cells","volume":"53","author":"Cho","year":"2012","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_246","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1002\/glia.20854","article-title":"Oxidative injury triggers autophagy in astrocytes: The role of endogenous zinc","volume":"57","author":"Lee","year":"2009","journal-title":"Glia"},{"key":"ref_247","doi-asserted-by":"crossref","first-page":"2433","DOI":"10.1007\/s12031-021-01859-x","article-title":"Protective Effects of Zinc on Spinal Cord Injury","volume":"71","author":"Wen","year":"2021","journal-title":"J. Mol. Neurosci. MN"},{"key":"ref_248","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/978-981-13-3681-2_5","article-title":"Ageing and Cognition","volume":"91","author":"Juan","year":"2019","journal-title":"Subcell. Biochem."},{"key":"ref_249","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.neuroscience.2008.01.061","article-title":"Zinc at glutamatergic synapses","volume":"158","author":"Paoletti","year":"2009","journal-title":"Neuroscience"},{"key":"ref_250","doi-asserted-by":"crossref","first-page":"7705","DOI":"10.1073\/pnas.092034699","article-title":"Contribution by synaptic zinc to the gender-disparate plaque formation in human Swedish mutant APP transgenic mice","volume":"99","author":"Lee","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_251","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1016\/j.neurobiolaging.2004.01.005","article-title":"The lipophilic metal chelator DP-109 reduces amyloid pathology in brains of human beta-amyloid precursor protein transgenic mice","volume":"25","author":"Lee","year":"2004","journal-title":"Neurobiol. Aging"},{"key":"ref_252","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.canlet.2008.06.011","article-title":"Zinc-binding compounds induce cancer cell death via distinct modes of action","volume":"271","author":"Ding","year":"2008","journal-title":"Cancer Lett."},{"key":"ref_253","doi-asserted-by":"crossref","first-page":"C726","DOI":"10.1152\/ajpcell.00541.2007","article-title":"Insights into Zn2+ homeostasis in neurons from experimental and modeling studies","volume":"294","author":"Colvin","year":"2008","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_254","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/S0896-6273(01)00317-8","article-title":"Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer\u2019s disease transgenic mice","volume":"30","author":"Cherny","year":"2001","journal-title":"Neuron"},{"key":"ref_255","doi-asserted-by":"crossref","first-page":"14934","DOI":"10.1073\/pnas.93.25.14934","article-title":"ZnT-3, a putative transporter of zinc into synaptic vesicles","volume":"93","author":"Palmiter","year":"1996","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_256","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1369\/jhc.6A7035.2007","article-title":"Evidence that the ZNT3 protein controls the total amount of elemental zinc in synaptic vesicles","volume":"56","author":"Linkous","year":"2008","journal-title":"J. Histochem. Cytochem."},{"key":"ref_257","doi-asserted-by":"crossref","first-page":"1716","DOI":"10.1073\/pnas.96.4.1716","article-title":"Elimination of zinc from synaptic vesicles in the intact mouse brain by disruption of the ZnT3 gene","volume":"96","author":"Cole","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_258","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1111\/acel.12178","article-title":"A novel approach to rapidly prevent age-related cognitive decline","volume":"13","author":"Adlard","year":"2014","journal-title":"Aging Cell"},{"key":"ref_259","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.nbd.2014.12.012","article-title":"Metal chaperones prevent zinc-mediated cognitive decline","volume":"81","author":"Adlard","year":"2015","journal-title":"Neurobiol. Dis."},{"key":"ref_260","doi-asserted-by":"crossref","first-page":"509","DOI":"10.3233\/JAD-2010-1390","article-title":"PBT2 rapidly improves cognition in Alzheimer\u2019s disease: Additional phase II analyses","volume":"20","author":"Faux","year":"2010","journal-title":"J. Alzheimers Dis."},{"key":"ref_261","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/S1474-4422(08)70167-4","article-title":"Safety, efficacy, and biomarker findings of PBT2 in targeting Abeta as a modifying therapy for Alzheimer\u2019s disease: A phase IIa, double-blind, randomised, placebo-controlled trial","volume":"7","author":"Lannfelt","year":"2008","journal-title":"Lancet Neurol."},{"key":"ref_262","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1016\/j.cell.2017.02.004","article-title":"mTOR Signaling in Growth, Metabolism, and Disease","volume":"168","author":"Saxton","year":"2017","journal-title":"Cell"},{"key":"ref_263","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s40035-018-0133-9","article-title":"Intranasal rapamycin ameliorates Alzheimer-like cognitive decline in a mouse model of Down syndrome","volume":"7","author":"Tramutola","year":"2018","journal-title":"Transl. Neurodegener."},{"key":"ref_264","doi-asserted-by":"crossref","first-page":"941","DOI":"10.2741\/s310","article-title":"The role of mTOR signaling in Alzheimer disease","volume":"4","author":"Oddo","year":"2012","journal-title":"Front. Biosci."},{"key":"ref_265","doi-asserted-by":"crossref","first-page":"2525","DOI":"10.1111\/j.1582-4934.2008.00509.x","article-title":"mTOR-dependent signalling in Alzheimer\u2019s disease","volume":"12","author":"Pei","year":"2008","journal-title":"J. Cell. Mol. Med."},{"key":"ref_266","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.freeradbiomed.2021.04.025","article-title":"mTOR in Alzheimer disease and its earlier stages: Links to oxidative damage in the progression of this dementing disorder","volume":"169","author":"Perluigi","year":"2021","journal-title":"Free Radic. Biol. Med."},{"key":"ref_267","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/S0002-9440(10)63687-5","article-title":"Up-regulation of phosphorylated\/activated p70 S6 kinase and its relationship to neurofibrillary pathology in Alzheimer\u2019s disease","volume":"163","author":"An","year":"2003","journal-title":"Am. J. Pathol."},{"key":"ref_268","doi-asserted-by":"crossref","first-page":"15556","DOI":"10.1074\/jbc.M112.435123","article-title":"Mammalian target of rapamycin (mTor) mediates tau protein dyshomeostasis: Implication for Alzheimer disease","volume":"288","author":"Tang","year":"2013","journal-title":"J. Biol. Chem."},{"key":"ref_269","doi-asserted-by":"crossref","first-page":"782434","DOI":"10.3389\/fimmu.2022.782434","article-title":"Rapamycin Attenuated Zinc-Induced Tau Phosphorylation and Oxidative Stress in Rats: Involvement of Dual mTOR\/p70S6K and Nrf2\/HO-1 Pathways","volume":"13","author":"Lai","year":"2022","journal-title":"Front. Immunol."},{"key":"ref_270","doi-asserted-by":"crossref","first-page":"434","DOI":"10.2174\/1570159X14666161228122115","article-title":"Melatonin: Pharmacology, Functions and Therapeutic Benefits","volume":"15","author":"Tordjman","year":"2017","journal-title":"Curr. Neuropharmacol."},{"key":"ref_271","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1038\/hr.2013.29","article-title":"Should melatonin be used to lower blood pressure?","volume":"36","author":"Grossman","year":"2013","journal-title":"Hypertens. Res. Off. J. Jpn. Soc. Hypertens."},{"key":"ref_272","doi-asserted-by":"crossref","first-page":"110887","DOI":"10.1016\/j.biopha.2020.110887","article-title":"Melatonin regulates A\u03b2 production\/clearance balance and A\u03b2 neurotoxicity: A potential therapeutic molecule for Alzheimer\u2019s disease","volume":"132","author":"Li","year":"2020","journal-title":"Biomed. Pharmacother. = Biomed. Pharmacother."},{"key":"ref_273","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.phrs.2015.03.010","article-title":"Glycogen synthase kinase-3 beta (GSK-3\u03b2) signaling: Implications for Parkinson\u2019s disease","volume":"97","author":"Golpich","year":"2015","journal-title":"Pharmacol. Res."},{"key":"ref_274","doi-asserted-by":"crossref","first-page":"227","DOI":"10.3389\/fncel.2019.00227","article-title":"Wnt Signaling Deregulation in the Aging and Alzheimer\u2019s Brain","volume":"13","author":"Palomer","year":"2019","journal-title":"Front. Cell. Neurosci."},{"key":"ref_275","first-page":"61","article-title":"The downregulation of Wnt\/\u03b2-catenin signaling pathway is associated with zinc deficiency-induced proliferative deficit of C17","volume":"1615","author":"Zhao","year":"2015","journal-title":"2 neural stem cells. Brain Res."}],"container-title":["Biomolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2218-273X\/12\/7\/1000\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T23:53:07Z","timestamp":1760140387000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2218-273X\/12\/7\/1000"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,18]]},"references-count":275,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2022,7]]}},"alternative-id":["biom12071000"],"URL":"https:\/\/doi.org\/10.3390\/biom12071000","relation":{},"ISSN":["2218-273X"],"issn-type":[{"value":"2218-273X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,18]]}}}