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GJJ218104"],"award-info":[{"award-number":["NO. GJJ218104"]}]},{"name":"Natural Science Foundation of Jiangxi Province","award":["NO. 81660151"],"award-info":[{"award-number":["NO. 81660151"]}]},{"name":"Natural Science Foundation of Jiangxi Province","award":["NO. 2021BAB206092"],"award-info":[{"award-number":["NO. 2021BAB206092"]}]},{"name":"Natural Science Foundation of Jiangxi Province","award":["NO. 82060661"],"award-info":[{"award-number":["NO. 82060661"]}]},{"name":"Natural Science Foundation of Jiangxi Province","award":["NO. 81660751"],"award-info":[{"award-number":["NO. 81660751"]}]},{"name":"Natural Science Foundation of Jiangxi Province","award":["NO. GJJ218104"],"award-info":[{"award-number":["NO. GJJ218104"]}]},{"name":"National Natural Science Foundation of China","award":["NO. 81660151"],"award-info":[{"award-number":["NO. 81660151"]}]},{"name":"National Natural Science Foundation of China","award":["NO. 2021BAB206092"],"award-info":[{"award-number":["NO. 2021BAB206092"]}]},{"name":"National Natural Science Foundation of China","award":["NO. 82060661"],"award-info":[{"award-number":["NO. 82060661"]}]},{"name":"National Natural Science Foundation of China","award":["NO. 81660751"],"award-info":[{"award-number":["NO. 81660751"]}]},{"name":"National Natural Science Foundation of China","award":["NO. GJJ218104"],"award-info":[{"award-number":["NO. GJJ218104"]}]},{"name":"Key project of Jiangxi Provincial Department of Education","award":["NO. 81660151"],"award-info":[{"award-number":["NO. 81660151"]}]},{"name":"Key project of Jiangxi Provincial Department of Education","award":["NO. 2021BAB206092"],"award-info":[{"award-number":["NO. 2021BAB206092"]}]},{"name":"Key project of Jiangxi Provincial Department of Education","award":["NO. 82060661"],"award-info":[{"award-number":["NO. 82060661"]}]},{"name":"Key project of Jiangxi Provincial Department of Education","award":["NO. 81660751"],"award-info":[{"award-number":["NO. 81660751"]}]},{"name":"Key project of Jiangxi Provincial Department of Education","award":["NO. GJJ218104"],"award-info":[{"award-number":["NO. GJJ218104"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>Rheumatoid arthritis, a chronic autoimmune disease with complex etiology, is characterized by excessive proliferation of synovial cells, massive production of inflammatory cells and cartilage destruction. Studies have shown that mitochondrial dysfunction plays an important role in promoting the occurrence of RA. Mitochondria with normal structure and function are essential for the normal survival of chondrocytes and synovial cells. Once mitochondrial function is destroyed, it will affect the survival, activation and differentiation of immune cells and non-immune cells involved in the pathogenesis of RA, thus leading to the occurrence of RA. However, the mechanism of mitochondrial dysfunction in RA remains unclear. This article reviews the method of mitochondrial dysfunction leading to RA, the effects of mitochondrial dysfunction on immune cells, the etiology of mitochondrial dysfunction in RA, and the pathology of mitochondrial dysfunction in RA. We also outline some drugs that can exert therapeutic effects on RA which are associated with modulating mitochondrial activity. The understanding and summary of mitochondrial dysfunction in RA may provide new research directions for pathological intervention and prevention of RA.<\/jats:p>","DOI":"10.3390\/biom12091216","type":"journal-article","created":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T21:27:17Z","timestamp":1662067637000},"page":"1216","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":72,"title":["Mitochondrial Dysfunction in Rheumatoid Arthritis"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6380-0043","authenticated-orcid":false,"given":"Chen","family":"Ma","sequence":"first","affiliation":[{"name":"Experimental Center of Pathogen Biology, College of Medicine, Nanchang University, Nanchang 330006, China"},{"name":"Queen Mary School, College of Medicine, Nanchang University, Nanchang 330006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7716-1302","authenticated-orcid":false,"given":"Jie","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Graduate, Shandong First Medical University, Shandong Academy of Medical Sciences, Jinan 250117, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6440-1311","authenticated-orcid":false,"given":"Fenfang","family":"Hong","sequence":"additional","affiliation":[{"name":"Experimental Center of Pathogen Biology, College of Medicine, Nanchang University, Nanchang 330006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shulong","family":"Yang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Chronic Diseases, Fuzhou Medical College, Nanchang University, Fuzhou 344099, China"},{"name":"Department of Physiology, Fuzhou Medical College, Nanchang University, Fuzhou 344099, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"673916","DOI":"10.3389\/fimmu.2021.673916","article-title":"Mitochondria as Key Players in the Pathogenesis and Treatment of Rheumatoid Arthritis","volume":"12","author":"Clayton","year":"2021","journal-title":"Front. 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