{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T03:38:36Z","timestamp":1784864316605,"version":"3.55.0"},"reference-count":134,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2022,9,8]],"date-time":"2022-09-08T00:00:00Z","timestamp":1662595200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Faculty Resources Grant, University of Cagliari","award":["2019.1440"],"award-info":[{"award-number":["2019.1440"]}]},{"name":"Faculty Resources Grant, University of Cagliari","award":["2021.0504"],"award-info":[{"award-number":["2021.0504"]}]},{"DOI":"10.13039\/100014810","name":"Fondazione di Sardegna","doi-asserted-by":"publisher","award":["2019.1440"],"award-info":[{"award-number":["2019.1440"]}],"id":[{"id":"10.13039\/100014810","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014810","name":"Fondazione di Sardegna","doi-asserted-by":"publisher","award":["2021.0504"],"award-info":[{"award-number":["2021.0504"]}],"id":[{"id":"10.13039\/100014810","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>The neuroactive steroid allopregnanolone ((3\u03b1,5\u03b1)-3-hydroxypregnan-20-one or 3\u03b1,5\u03b1-THP) plays a key role in the response to stress, by normalizing hypothalamic-pituitary-adrenal (HPA) axis function to restore homeostasis. Most studies have been conducted on male rats, and little is known about the allopregnanolone response to stress in females, despite that women are more susceptible than men to develop emotional and stress-related disorders. Here, we provide an overview of animal and human studies examining the allopregnanolone responses to acute stress in females in the context of stress-related neuropsychiatric diseases and under the different conditions that characterize the female lifespan associated with the reproductive function. The blunted allopregnanolone response to acute stress, often observed in female rats and women, may represent one of the mechanisms that contribute to the increased vulnerability to stress and affective disorders in women under the different hormonal fluctuations that occur throughout their lifespan. These studies highlight the importance of targeting neuroactive steroids as a therapeutic approach for stress-related disorders in women.<\/jats:p>","DOI":"10.3390\/biom12091262","type":"journal-article","created":{"date-parts":[[2022,9,8]],"date-time":"2022-09-08T07:05:56Z","timestamp":1662620756000},"page":"1262","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["The Allopregnanolone Response to Acute Stress in Females: Preclinical and Clinical Studies"],"prefix":"10.3390","volume":"12","author":[{"given":"Maria Giuseppina","family":"Pisu","sequence":"first","affiliation":[{"name":"Neuroscience Institute, National Research Council of Italy (CNR), 09042 Cagliari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2921-3128","authenticated-orcid":false,"given":"Luca","family":"Concas","sequence":"additional","affiliation":[{"name":"Department of Life and Environment Sciences, Section of Neuroscience and Anthropology, University of Cagliari, 09042 Cagliari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1042-3993","authenticated-orcid":false,"given":"Carlotta","family":"Siddi","sequence":"additional","affiliation":[{"name":"Department of Life and Environment Sciences, Section of Neuroscience and Anthropology, University of Cagliari, 09042 Cagliari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariangela","family":"Serra","sequence":"additional","affiliation":[{"name":"Department of Life and Environment Sciences, Section of Neuroscience and Anthropology, University of Cagliari, 09042 Cagliari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0848-7258","authenticated-orcid":false,"given":"Patrizia","family":"Porcu","sequence":"additional","affiliation":[{"name":"Neuroscience Institute, National Research Council of Italy (CNR), 09042 Cagliari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,8]]},"reference":[{"key":"ref_1","first-page":"162","article-title":"Anxiety disorders among women: A female lifespan approach","volume":"15","author":"Hantsoo","year":"2017","journal-title":"Focus (Am. 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