{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T01:39:30Z","timestamp":1792805970594,"version":"4.5.0"},"reference-count":88,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2022,9,9]],"date-time":"2022-09-09T00:00:00Z","timestamp":1662681600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Field project Foundation of Ningxia Medical University","award":["XT2020022"],"award-info":[{"award-number":["XT2020022"]}],"id":[{"id":"https:\/\/ror.org\/02h8a1848","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Field project Foundation of Ningxia Medical University","award":["2021BEB04060"],"award-info":[{"award-number":["2021BEB04060"]}],"id":[{"id":"https:\/\/ror.org\/02h8a1848","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Field project Foundation of the Ningxia Hui Autonomous Region","award":["XT2020022"],"award-info":[{"award-number":["XT2020022"]}]},{"name":"Field project Foundation of the Ningxia Hui Autonomous Region","award":["2021BEB04060"],"award-info":[{"award-number":["2021BEB04060"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>Infectious diseases caused by bacteria and fungi are threatening human health all over the world. It is an increasingly serious problem that the efficacies of some antibacterial and antifungal agents have been weakened by the drug resistance of some bacteria and fungi, which makes a great need for new antibiotics. Sesquiterpenoids, with abundant structural skeleton types and a wide range of bioactivities, are considered as good candidates to be antibacterial and antifungal agents. In the past decades, many sesquiterpenoids were isolated from plants and fungi that exhibited good antibacterial and antifungal activities. In this review, the names, source, structures, antibacterial and antifungal degrees, and mechanisms of sesquiterpenoids with antibacterial and antifungal activity from 2012 to 2022 are summarized, and the structure-activity relationship of these sesquiterpenoids against bacteria and fungi is also discussed.<\/jats:p>","DOI":"10.3390\/biom12091271","type":"journal-article","created":{"date-parts":[[2022,9,12]],"date-time":"2022-09-12T20:52:25Z","timestamp":1663015945000},"page":"1271","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":83,"title":["Antibacterial and Antifungal Sesquiterpenoids: Chemistry, Resource, and Activity"],"prefix":"10.3390","volume":"12","author":[{"given":"Hang-Ying","family":"Li","sequence":"first","affiliation":[{"name":"College of Pharmacy, Ningxia Medical University, Yinchuan 750004, China"},{"name":"Ningxia Research Center of Modern Hui Medicine Engineering and Technology, Ningxia Medical University, Yinchuan 750004, China"},{"name":"Key Laboratory of Ningxia Ethnomedicine Modernization, Ministry of Education, Ningxia Medical University, Yinchuan 750004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Qian","family":"Yang","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Ningxia Medical University, Yinchuan 750004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin-Zhu","family":"Zhou","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Ningxia Medical University, Yinchuan 750004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Shao","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Ningxia Medical University, Yinchuan 750004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Shen","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Ningxia Medical University, Yinchuan 750004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-Ying","family":"Guan","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Ningxia Medical University, Yinchuan 750004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Zheng","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Ningxia Medical University, Yinchuan 750004, China"},{"name":"Ningxia Research Center of Modern Hui Medicine Engineering and Technology, Ningxia Medical University, Yinchuan 750004, China"},{"name":"Key Laboratory of Ningxia Ethnomedicine Modernization, Ministry of Education, Ningxia Medical University, Yinchuan 750004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Ming","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Ningxia Medical University, Yinchuan 750004, China"},{"name":"Ningxia Research Center of Modern Hui Medicine Engineering and Technology, Ningxia Medical University, Yinchuan 750004, China"},{"name":"Key Laboratory of Ningxia Ethnomedicine Modernization, Ministry of Education, Ningxia Medical University, Yinchuan 750004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2475067","DOI":"10.1155\/2016\/2475067","article-title":"Mechanisms of Antimicrobial Resistance in ESKAPE Pathogens","volume":"2016","author":"Santajit","year":"2016","journal-title":"Biomed. 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