{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T20:30:41Z","timestamp":1790800241270,"version":"4.1.0"},"reference-count":157,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2022,9,21]],"date-time":"2022-09-21T00:00:00Z","timestamp":1663718400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"R\u00e9gion Centre-Val de Loire (ARD Biom\u00e9dicaments)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>Liver and kidney diseases are the most frequently encountered problems around the globe. Damage to the liver and kidney may occur as a result of exposure to various drugs, chemicals, toxins, and pathogens, leading to severe disease conditions such as cirrhosis, fibrosis, hepatitis, acute kidney injury, and liver and renal failure. In this regard, the use of nanoparticles (NPs) such as silver nanoparticles (AgNPs), gold nanoparticles (AuNPs), and zinc oxide nanoparticles (ZnONPs) has emerged as a rapidly developing field of study in terms of safe delivery of various medications to target organs with minimal side effects. Due to their physical characteristics, NPs have inherent pharmacological effects, and an accidental buildup can have a significant impact on the structure and function of the liver and kidney. By suppressing the expression of the proinflammatory cytokines iNOS and COX-2, NPs are known to possess anti-inflammatory effects. Additionally, NPs have demonstrated their ability to operate as an antioxidant, squelching the generation of ROS caused by substances that cause oxidative stress. Finally, because of their pro-oxidant properties, they are also known to increase the level of ROS, which causes malignant liver and kidney cells to undergo apoptosis. As a result, NPs can be regarded as a double-edged sword whose inherent therapeutic benefits can be refined as we work to comprehend them in terms of their toxicity.<\/jats:p>","DOI":"10.3390\/biom12101337","type":"journal-article","created":{"date-parts":[[2022,9,21]],"date-time":"2022-09-21T21:22:23Z","timestamp":1663795343000},"page":"1337","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Implication of Nanoparticles to Combat Chronic Liver and Kidney Diseases: Progress and Perspectives"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-2795-2140","authenticated-orcid":false,"given":"Mariam","family":"Hashim","sequence":"first","affiliation":[{"name":"Department of Biotechnology, Kinnaird College for Women, Jail Road, Lahore 54000, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huma","family":"Mujahid","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Biotechnology, University of Veterinary and Animal Sciences, Lahore 54000, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samina","family":"Hassan","sequence":"additional","affiliation":[{"name":"Department of Botany, Kinnaird College for Women, Jail Road, Lahore 54000, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanila","family":"Bukhari","sequence":"additional","affiliation":[{"name":"Department of Botany, Kinnaird College for Women, Jail Road, Lahore 54000, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9015-3179","authenticated-orcid":false,"given":"Iram","family":"Anjum","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Kinnaird College for Women, Jail Road, Lahore 54000, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9938-0151","authenticated-orcid":false,"given":"Christophe","family":"Hano","sequence":"additional","affiliation":[{"name":"Department of Biological Chemistry, University of Orleans, Eure & Loir Campus, 28000 Chartres, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6529-2134","authenticated-orcid":false,"given":"Bilal Haider","family":"Abbasi","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Quaid-i-Azam University, Islamabad 15320, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2276-8785","authenticated-orcid":false,"given":"Sumaira","family":"Anjum","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Kinnaird College for Women, Jail Road, Lahore 54000, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,21]]},"reference":[{"key":"ref_1","first-page":"116","article-title":"Hepatoprotective activity of methanol extract of some medicinal plants against carbon tetrachloride induced hepatotoxicity in albino rats","volume":"3","author":"Ahsan","year":"2009","journal-title":"Glob. J. Pharmacol."},{"key":"ref_2","first-page":"64","article-title":"Antihepatotoxic activity of some ayurvedic prepartions","volume":"55","author":"Reddy","year":"1993","journal-title":"Indian J. Pharm. Sci."},{"key":"ref_3","unstructured":"Pandey, G.P. (1990). Hepatogenic Effect of Some Indigenous Drugs on Experimental Liver Damage. [Ph.D. Thesis, College of Veterinary Science & Animal Husbandry]."},{"key":"ref_4","unstructured":"Pandey, G.P. (1980). Pharmacological Studies of Livol (R) with Special Reference to Liver Function. [MVSc & AH Thesis, Jawaharlal Nehru Krishi Vishwavidyalaya]."},{"key":"ref_5","first-page":"501","article-title":"A review on hepatoprotective activity of medicinal plants","volume":"2","author":"Kumar","year":"2011","journal-title":"Int. J. Pharm. Sci. Res."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.cbi.2019.02.022","article-title":"Protective effects of anthocyanins from bilberry extract in rats exposed to nephrotoxic effects of carbon tetrachloride","volume":"304","author":"Zarubica","year":"2019","journal-title":"Chem. Biol. Interact."},{"key":"ref_7","unstructured":"Cleveland, C.J. (2007). Encyclopedia of Earth, National Council for Science and the Environment."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"213","DOI":"10.4062\/biomolther.2019.214","article-title":"Fyn kinase: A potential therapeutic target in acute kidney injury","volume":"28","author":"Uddin","year":"2020","journal-title":"Biomol. Ther."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"2474831","DOI":"10.1155\/2018\/2474831","article-title":"Nephroprotective effect of Zingerone against CCl4-induced renal toxicity in Swiss albino mice: Molecular mechanism","volume":"2018","author":"Safhi","year":"2018","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Akter, T., Rahman, M.A., Moni, A., Apu, M.A.I., Fariha, A., Hannan, M.A., and Uddin, M.J. (2021). Prospects for Protective Potential of Moringa oleifera against Kidney Diseases. Plants, 10.","DOI":"10.3390\/plants10122818"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"3041","DOI":"10.2174\/092986709788803097","article-title":"Current concepts of mechanisms in drug-induced hepatotoxicity","volume":"16","author":"Russmann","year":"2009","journal-title":"Curr. Med. Chem."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"817974","DOI":"10.3389\/fgene.2021.817974","article-title":"Role of Nanotechnology and Their Perspectives in the Treatment of Kidney Diseases","volume":"12","author":"Merlin","year":"2021","journal-title":"Front. Genet."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1056\/NEJMra052270","article-title":"Drug-related hepatotoxicity","volume":"354","author":"Navarro","year":"2006","journal-title":"N. Engl. J. Med."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1001\/jama.1971.03190160088021","article-title":"Acetaminophen-induced hepatic necrosis and renal failure","volume":"218","author":"Boyer","year":"1971","journal-title":"Jama"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1007\/BF03160941","article-title":"Acetaminophen-induced nephrotoxicity: Pathophysiology, clinical manifestations, and management","volume":"4","author":"Mazer","year":"2008","journal-title":"J. Med. Toxicol."},{"key":"ref_16","first-page":"135","article-title":"Studying the protective effect of gamma-irradiated basil (Ocimum basilicum L.) against methotrexate-induced liver and renal toxicity in rats","volume":"51","year":"2017","journal-title":"Indian J. Anim. Res."},{"key":"ref_17","first-page":"85","article-title":"Methotrexate-induced hepatic and renal toxicity: Role of L-carnitine in treatment","volume":"2","author":"Tousson","year":"2014","journal-title":"Biomed. Biotechnol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"2490","DOI":"10.3390\/toxins2112490","article-title":"Ramesh g and Reeves WB: Mechanisms of cisplatin nephrotoxicity","volume":"2","author":"Miller","year":"2010","journal-title":"Toxins"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.biopha.2008.08.004","article-title":"Role of glutathione S-transferase Pi in cisplatin-induced nephrotoxicity","volume":"63","author":"Townsend","year":"2009","journal-title":"Biomed. Pharmacother."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1615\/CritRevTherDrugCarrierSyst.v25.i1.10","article-title":"Engineered nanocarriers of doxorubicin: A current update","volume":"25","author":"Patil","year":"2008","journal-title":"Crit. Rev. Ther. Drug Carr. Syst."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1177\/0748233713483203","article-title":"The protective effects of \u03c9-3 fatty acids on doxorubicin-induced hepatotoxicity and nephrotoxicity in rats","volume":"31","author":"Tulubas","year":"2015","journal-title":"Toxicol. Ind. Health"},{"key":"ref_22","first-page":"981461","article-title":"Effect of coenzyme-Q10 on doxorubicin-induced nephrotoxicity in rats","volume":"2012","author":"Morsy","year":"2012","journal-title":"Adv. Pharmacol. Sci."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.bbrc.2012.04.150","article-title":"ARD1 binding to RIP1 mediates doxorubicin-induced NF-\u03baB activation","volume":"422","author":"Park","year":"2012","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1007\/s00005-009-0051-8","article-title":"Cardiomyocyte death in doxorubicin-induced cardiotoxicity","volume":"57","author":"Zhang","year":"2009","journal-title":"Arch. Immunol. Ther. Exp."},{"key":"ref_25","unstructured":"Center for Substance Abuse Treatment (2011). Addressing Viral Hepatitis in People with Substance Use Disorders, Report No.: (SMA) 11-4656."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1016\/S0140-6736(08)60383-9","article-title":"Liver cirrhosis","volume":"371","author":"Schuppan","year":"2008","journal-title":"Lancet"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1038\/ki.2011.380","article-title":"Treatment of chronic kidney disease","volume":"81","author":"Turner","year":"2012","journal-title":"Kidney Int."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"101762","DOI":"10.1016\/j.bpg.2021.101762","article-title":"Adverse effects of immunosuppression after liver transplantation","volume":"54","author":"Noble","year":"2021","journal-title":"Best Pract. Res. Clin. Gastroenterol."},{"key":"ref_29","first-page":"19","article-title":"Evaluation of the green synthesis, characterization and antibacterial activity of silver nanoparticles from corm extract of Crocus sativus var. Haussknechtii","volume":"4","author":"Zivyar","year":"2021","journal-title":"J. Hortic. Postharvest Res."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1007\/s12668-020-00766-6","article-title":"Effective Dose of Herbal Gold Nanoparticles for Protection of Acetaminophen-Induced Hepatotoxicity in Male Albino Rats","volume":"10","author":"Mitra","year":"2020","journal-title":"BioNanoScience"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1007\/s00210-020-01888-0","article-title":"Curcumin nanoparticles ameliorate hepatotoxicity and nephrotoxicity induced by cisplatin in rats","volume":"393","author":"Hosny","year":"2020","journal-title":"Naunyn-Schmiedeberg's Arch. Pharmacol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.copbio.2007.01.006","article-title":"Nanotechnological applications in medicine","volume":"18","author":"Caruthers","year":"2007","journal-title":"Curr. Opin. Biotechnol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1038\/nmat3877","article-title":"A targeted approach to cancer imaging and therapy","volume":"13","author":"Li","year":"2014","journal-title":"Nat. Mater."},{"key":"ref_34","first-page":"9","article-title":"Hepatoprotective effect of Foeniculum vulgare essential oil: A carbon-tetrachloride induced liver fibrosis model in rats","volume":"31","author":"Ugras","year":"2004","journal-title":"Scand. J. Lab. Anim. Sci."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Bayda, S., Adeel, M., Tuccinardi, T., Cordani, M., and Rizzolio, F. (2019). The history of nanoscience and nanotechnology: From chemical\u2013physical applications to nanomedicine. Molecules, 25.","DOI":"10.3390\/molecules25010112"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.3762\/bjnano.9.98","article-title":"Review on nanoparticles and nanostructured materials: History, sources, toxicity and regulations","volume":"9","author":"Jeevanandam","year":"2018","journal-title":"Beilstein J. Nanotechnol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1038\/nbt.3330","article-title":"Principles of nanoparticle design for overcoming biological barriers to drug delivery","volume":"33","author":"Blanco","year":"2015","journal-title":"Nat. Biotechnol."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Gheorghe, D.C., Niculescu, A.-G., B\u00eerc\u0103, A.C., and Grumezescu, A.M. (2021). Nanoparticles for the treatment of inner ear infections. Nanomaterials, 11.","DOI":"10.3390\/nano11051311"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1039\/B514191E","article-title":"Why gold nanoparticles are more precious than pretty gold: Noble metal surface plasmon resonance and its enhancement of the radiative and nonradiative properties of nanocrystals of different shapes","volume":"35","author":"Eustis","year":"2006","journal-title":"Chem. Soc. Rev."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Clogston, J.D., and Patri, A.K. (2011). Zeta potential measurement. Characterization of Nanoparticles Intended for Drug Delivery, Springer.","DOI":"10.1007\/978-1-60327-198-1_6"},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Kumar, N., and Sinha Ray, S. (2018). Synthesis and functionalization of nanomaterials. Processing of Polymer-Based Nanocomposites, Springer.","DOI":"10.1007\/978-3-319-97779-9_2"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"4559","DOI":"10.2174\/092986710794183024","article-title":"Nanoparticles: Functionalization and multifunctional applications in biomedical sciences","volume":"17","author":"Subbiah","year":"2010","journal-title":"Curr. Med. Chem."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"14618","DOI":"10.1039\/C7NJ03295A","article-title":"Ionic liquid-assisted synthesis of Ag\/Ag2 Te nanocrystals via a hydrothermal route for enhanced photocatalytic performance","volume":"41","author":"Kumar","year":"2017","journal-title":"New J. Chem."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1002\/cplu.201600047","article-title":"Ionic-Liquid-Functionalized Copper Oxide Nanorods for Photocatalytic Splitting of Water","volume":"81","author":"Gusain","year":"2016","journal-title":"ChemPlusChem"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/1743-8977-4-10","article-title":"Kupffer cells are central in the removal of nanoparticles from the organism","volume":"4","author":"Sadauskas","year":"2007","journal-title":"Part. Fibre Toxicol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1038\/nmat4718","article-title":"Mechanism of hard-nanomaterial clearance by the liver","volume":"15","author":"Tsoi","year":"2016","journal-title":"Nat. Mater."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"8350","DOI":"10.1016\/j.biomaterials.2010.07.045","article-title":"The kinetics of the tissue distribution of silver nanoparticles of different sizes","volume":"31","author":"Lankveld","year":"2010","journal-title":"Biomaterials"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"2000153","DOI":"10.1002\/smll.202000153","article-title":"All roads lead to the liver: Metal nanoparticles and their implications for liver health","volume":"16","author":"Boey","year":"2020","journal-title":"Small"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1681\/ASN.2007101138","article-title":"Glomerular endothelial cells form diaphragms during development and pathologic conditions","volume":"19","author":"Ichimura","year":"2008","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"F1512","DOI":"10.1152\/ajprenal.00215.2007","article-title":"Delayed recovery of renal regional blood flow in diabetic mice subjected to acute ischemic kidney injury","volume":"293","author":"Shi","year":"2007","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"851","DOI":"10.3892\/ijmm.2017.2902","article-title":"Albumin-based nanoparticles as methylprednisolone carriers for targeted delivery towards the neonatal Fc receptor in glomerular podocytes","volume":"39","author":"Wu","year":"2017","journal-title":"Int. J. Mol. Med."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"2532","DOI":"10.1021\/acs.molpharmaceut.9b00132","article-title":"Salinomycin-loaded gold nanoparticles for treating cancer stem cells by ferroptosis-induced cell death","volume":"16","author":"Zhao","year":"2019","journal-title":"Mol. Pharm."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1517\/17460441.2015.1033394","article-title":"Designing drugs that combat kidney damage","volume":"10","author":"Ramos","year":"2015","journal-title":"Expert Opin. Drug Discov."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1038\/nrneph.2014.246","article-title":"Diverse origins of the myofibroblast\u2014implications for kidney fibrosis","volume":"11","author":"Falke","year":"2015","journal-title":"Nat. Rev. Nephrol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"6341","DOI":"10.1016\/j.biomaterials.2009.08.008","article-title":"Antiangiogenic properties of silver nanoparticles","volume":"30","author":"Gurunathan","year":"2009","journal-title":"Biomaterials"},{"key":"ref_56","first-page":"1129","article-title":"Further evidence of the anti-inflammatory effects of silver nanoparticles","volume":"4","author":"Wong","year":"2009","journal-title":"ChemMedChem Chem. Enabling Drug Discov."},{"key":"ref_57","first-page":"32","article-title":"In vitro evaluation of antioxidant and anticancer potential of Morinda pubescens synthesized silver nanoparticles","volume":"6","author":"Inbathamizh","year":"2013","journal-title":"J. Pharm. Res."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.yrtph.2017.08.011","article-title":"Silver nanoparticles protect acetaminophen induced acute hepatotoxicity: A biochemical and histopathological approach","volume":"90","author":"Reshi","year":"2017","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"e22968","DOI":"10.1002\/jbt.22968","article-title":"Biomimetic synthesis of silver nanoparticles for treatment of N-Nitrosodiethylamine-induced hepatotoxicity","volume":"36","author":"Singh","year":"2022","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.msec.2018.08.027","article-title":"Effect of silver nanoparticles in the induction of apoptosis on human hepatocellular carcinoma (HepG2) cell line","volume":"93","author":"Ahmadian","year":"2018","journal-title":"Mater. Sci. Eng. C"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.jphotobiol.2018.10.015","article-title":"Ameliorative effect of berberine coated bio-active nanoparticles in acetaminophen induced hepato-renal damage in diabetic rats","volume":"189","author":"Wu","year":"2018","journal-title":"J. Photochem. Photobiol. B Biol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.fct.2012.11.022","article-title":"Antioxidant and hepatoprotective effects of Schisandra chinensis pollen extract on CCl4-induced acute liver damage in mice","volume":"55","author":"Cheng","year":"2013","journal-title":"Food Chem. Toxicol."},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Manna, P., Sinha, M., and Sil, P.C. (2006). Aqueous extract of Terminalia arjuna prevents carbon tetrachloride induced hepatic and renal disorders. BMC Complement. Altern. Med., 6.","DOI":"10.1186\/1472-6882-6-33"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.cbi.2008.08.006","article-title":"Pleurotus ostreatus, an oyster mushroom, decreases the oxidative stress induced by carbon tetrachloride in rat kidneys, heart and brain","volume":"176","author":"Jayakumar","year":"2008","journal-title":"Chem. Biol. Interact."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"3517","DOI":"10.2147\/IJN.S198895","article-title":"Hepatoprotective effect of silver nanoparticles synthesized using aqueous leaf extract of Rhizophora apiculata","volume":"14","author":"Zhang","year":"2019","journal-title":"Int. J. Nanomed."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.colsurfb.2012.06.039","article-title":"Hepatocurative activity of biosynthesized silver nanoparticles fabricated using Andrographis paniculata","volume":"102","author":"Suriyakalaa","year":"2013","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"101587","DOI":"10.1016\/j.jksus.2021.101587","article-title":"Rumex hastatus derived silver nanoparticles development and their potential applications as hepatic-protection agent along with antimicrobial activity","volume":"33","author":"Gul","year":"2021","journal-title":"J. King Saud Univ.-Sci."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"381","DOI":"10.52547\/nbr.7.4.381","article-title":"Hepatoprotective activity of Silver Nanoparticles synthesized using aqueous leaf extract of Punica granatum against induced hepatotoxicity in rats","volume":"7","author":"Kumar","year":"2021","journal-title":"Nova Biol. Reper."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.serj.2017.04.003","article-title":"A novel green synthesis of silver nanoparticles and their catalytic action in reduction of Methylene Blue dye","volume":"27","author":"Saha","year":"2017","journal-title":"Sustain. Environ. Res."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.ijpharm.2018.01.034","article-title":"Inorganic nanoparticles: A potential cancer therapy for human welfare","volume":"539","author":"Pugazhendhi","year":"2018","journal-title":"Int. J. Pharm."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"10164","DOI":"10.1007\/s11356-017-9912-6","article-title":"New insights on the green synthesis of metallic nanoparticles using plant and waste biomaterials: Current knowledge, their agricultural and environmental applications","volume":"25","author":"Saratale","year":"2018","journal-title":"Environ. Sci. Pollut. Res."},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"BEGUM, Q., and Mahboob, T. Silver Nanoparticles Protects Streptozotocin-Induced Hepatotoxicity: A Biochemical and Histopathological Approach. Res. Square., 2020.","DOI":"10.21203\/rs.3.rs-45335\/v1"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"103602","DOI":"10.1016\/j.arabjc.2021.103602","article-title":"Green formulation of Ag nanoparticles by Hibiscus rosa-sinensis: Introducing a navel chemotherapeutic drug for the treatment of liver cancer","volume":"15","author":"Lu","year":"2022","journal-title":"Arab. J. Chem."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1007\/s00449-021-02666-9","article-title":"Green synthesis of silver nanoparticles using Rhodiola imbricata and Withania somnifera root extract and their potential catalytic, antioxidant, cytotoxic and growth-promoting activities","volume":"45","author":"Kapoor","year":"2022","journal-title":"Bioprocess Biosyst. Eng."},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Al-Khedhairy, A.A., and Wahab, R. (2022). Silver nanoparticles: An instantaneous solution for anticancer activity against human liver (HepG2) and breast (MCF-7) cancer cells. Metals, 12.","DOI":"10.3390\/met12010148"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1093\/toxres\/tfaa040","article-title":"Acetaminophen-induced renal toxicity: Preventive effect of silver nanoparticles","volume":"9","author":"Reshi","year":"2020","journal-title":"Toxicol. Res."},{"key":"ref_77","first-page":"305","article-title":"Assessment of hepatoprotective role of phenolic extract of Urticadioica and silver nanoparticles in male rat induced by carbon tetra-chloride","volume":"10","author":"Kadhim","year":"2017","journal-title":"Ras\u0101yan J. Chem."},{"key":"ref_78","first-page":"151","article-title":"Role of Salvia officinalis Silver Nanoparticles in Attenuation Renal Damage in Rabbits Exposed to Methotrexate","volume":"77","author":"Saud","year":"2022","journal-title":"Arch. Razi Inst."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/s40097-015-0178-6","article-title":"Synthesis and characterization of Solanum nigrum-mediated silver nanoparticles and its protective effect on alloxan-induced diabetic rats","volume":"6","author":"Sengottaiyan","year":"2016","journal-title":"J. Nanostruct. Chem."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"131642","DOI":"10.1016\/j.matlet.2021.131642","article-title":"Evaluation of hepato and renal protective effect of synthesized nanoparticles using Tinospora cordifolia leaf extract","volume":"312","author":"Biruntha","year":"2022","journal-title":"Mater. Lett."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1007\/s12668-020-00774-6","article-title":"A review on green synthesis of zinc oxide nanoparticles using plant extracts and its biomedical applications","volume":"10","author":"Akintelu","year":"2020","journal-title":"BioNanoScience"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1016\/j.drudis.2017.08.006","article-title":"Zinc oxide nanoparticles: A promising nanomaterial for biomedical applications","volume":"22","author":"Mishra","year":"2017","journal-title":"Drug Discov. Today"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"3101","DOI":"10.3390\/ma8063101","article-title":"Photoluminescent ZnO nanoparticles and their biological applications","volume":"8","author":"Zhang","year":"2015","journal-title":"Materials"},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"Kim, S., Lee, S.Y., and Cho, H.-J. (2017). Doxorubicin-wrapped zinc oxide nanoclusters for the therapy of colorectal adenocarcinoma. Nanomaterials, 7.","DOI":"10.3390\/nano7110354"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"5329","DOI":"10.1002\/adma.201301732","article-title":"ZnO nanoparticles applied to bioimaging and drug delivery","volume":"25","author":"Xiong","year":"2013","journal-title":"Adv. Mater."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"4973","DOI":"10.1039\/D0TB00739K","article-title":"Zinc oxide nanoparticles for therapeutic purposes in cancer medicine","volume":"8","author":"Wiesmann","year":"2020","journal-title":"J. Mater. Chem. B"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.saa.2012.01.006","article-title":"Novel microbial route to synthesize ZnO nanoparticles using Aeromonas hydrophila and their activity against pathogenic bacteria and fungi","volume":"90","author":"Jayaseelan","year":"2012","journal-title":"Spectrochim. Acta Part A Mol. Biomol. Spectrosc."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.1007\/s13204-021-02006-z","article-title":"Synthesis, characterization and protective effect of green tea-mediated zinc oxide nanoparticles against ochratoxin A induced hepatotoxicity and nephrotoxicity in albino rats","volume":"11","author":"Hassan","year":"2021","journal-title":"Appl. Nanosci."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0300-483X(90)90064-N","article-title":"Role of metabolism in dimethylnitrosamine-induced immunosuppression: A review","volume":"63","author":"Haggerty","year":"1990","journal-title":"Toxicology"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.cbi.2017.10.009","article-title":"Zinc oxide nanoparticles inhibit dimethylnitrosamine induced liver injury in rat","volume":"295","author":"Rani","year":"2018","journal-title":"Chem.-Biol. Interact."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1007\/s12010-021-03689-4","article-title":"Zinc Oxide Nanoparticles Ameliorate Dimethylnitrosamine-Induced Renal Toxicity in Rat","volume":"194","author":"Rani","year":"2022","journal-title":"Appl. Biochem. Biotechnol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"9966","DOI":"10.1007\/s11356-019-04443-4","article-title":"Ameliorative effect of zinc oxide nanoparticles against potassium bromate-mediated toxicity in Swiss albino rats","volume":"26","author":"Hassan","year":"2019","journal-title":"Environ. Sci. Pollut. Res."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1039\/C7MT00024C","article-title":"Complex effect of zinc oxide nanoparticles on cadmium chloride-induced hepatotoxicity in mice: Protective role of metallothionein","volume":"9","author":"Gao","year":"2017","journal-title":"Metallomics"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.pathophys.2007.08.001","article-title":"Hepatocytes are protected by herb Phyllanthus niruri protein isolate against thioacetamide toxicity","volume":"14","author":"Sarkar","year":"2007","journal-title":"Pathophysiology"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.tox.2009.12.018","article-title":"Investigation of antioxidant, anti-inflammatory and DNA-protective properties of eugenol in thioacetamide-induced liver injury in rats","volume":"268","author":"Yogalakshmi","year":"2010","journal-title":"Toxicology"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1139\/cjpp-2017-0247","article-title":"Role of zinc oxide nanoparticles in alleviating hepatic fibrosis and nephrotoxicity induced by thioacetamide in rats","volume":"96","author":"Bashandy","year":"2018","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.3390\/nano5031317","article-title":"An investigation of the cytotoxicity and caspase-mediated apoptotic effect of green synthesized zinc oxide nanoparticles using Eclipta prostrata on human liver carcinoma cells","volume":"5","author":"Chung","year":"2015","journal-title":"Nanomaterials"},{"key":"ref_98","first-page":"108","article-title":"Efficacy of zinc oxide nanoparticles on hepatocellular carcinomainduced biochemical and trace element alterations in rats","volume":"11","author":"Bashandy","year":"2021","journal-title":"J. Appl. Pharm. Sci"},{"key":"ref_99","first-page":"1034","article-title":"Effect of Zinc Oxide Nanoparticles on Liver Cirrhosis Induced by Carbon Tetrachloride in Albino Rats","volume":"14","author":"Afzal","year":"2020","journal-title":"Pak. J. Med. Health Sci."},{"key":"ref_100","first-page":"27","article-title":"Methotrexate Induced Serum Biochemical Alteration and Its Amelioration by Zinc Oxide Nanoparticles in Wistar Albino Rats","volume":"8","author":"Akshata","year":"2019","journal-title":"Front. J. Vet. Anim. Sci."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"118503","DOI":"10.1016\/j.lfs.2020.118503","article-title":"Protective role of zinc oxide nanoparticles in kidney injury induced by cisplatin in rats","volume":"262","author":"Barakat","year":"2020","journal-title":"Life Sci."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1049\/nbt2.12026","article-title":"Alleviation of diabetic nephropathy by zinc oxide nanoparticles in streptozotocin-induced type 1 diabetes in rats","volume":"15","author":"Alomari","year":"2021","journal-title":"IET Nanobiotechnol."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ab.2011.05.027","article-title":"Gold nanoparticle-based signal amplification for biosensing","volume":"417","author":"Cao","year":"2011","journal-title":"Anal. Biochem."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1021\/ar200061q","article-title":"Gold nanocages: From synthesis to theranostic applications","volume":"44","author":"Xia","year":"2011","journal-title":"Acc. Chem. Res."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.jconrel.2009.12.006","article-title":"The forthcoming applications of gold nanoparticles in drug and gene delivery systems","volume":"149","author":"Pissuwan","year":"2011","journal-title":"J. Control. Release"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.aca.2011.12.008","article-title":"Functionalized gold nanoparticle supported sensory mechanisms applied in detection of chemical and biological threat agents: A review","volume":"715","author":"Upadhyayula","year":"2012","journal-title":"Anal. Chim. Acta"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.etp.2017.01.009","article-title":"Gold nanoparticles ameliorate acetaminophen induced hepato-renal injury in rats","volume":"69","author":"Reshi","year":"2017","journal-title":"Exp. Toxicol. Pathol."},{"key":"ref_108","doi-asserted-by":"crossref","unstructured":"Mitra, M., Mitra, S., and Nandi, D.K. In-Vivo Study of Green Synthesised Gold Nanoparticles on Inflammatory Cytokines as Diagnostic Biomarker in Acetaminophen Induced Immunotoxicity in Rat Model. Res. Sq., 2021.","DOI":"10.21203\/rs.3.rs-629788\/v1"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"111117","DOI":"10.1016\/j.msec.2020.111117","article-title":"Hepatoprotective effects of silymarin coated gold nanoparticles in experimental cholestasis","volume":"115","author":"Clichici","year":"2020","journal-title":"Mater. Sci. Eng. C"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"1000190","DOI":"10.4172\/2161-1025.1000190","article-title":"Hepatoprotective efficacy of gold nanoparticle synthesized by green method using Trigonella foenum-graecum seed extract","volume":"6","author":"Ghosh","year":"2016","journal-title":"Transl. Med."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1111\/adb.12476","article-title":"Methamphetamine self-administration reduces alcohol consumption and preference in alcohol-preferring P rats","volume":"23","author":"Winkler","year":"2018","journal-title":"Addict. Biol."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/1747-597X-2-33","article-title":"Mono-versus polydrug abuse patterns among publicly funded clients","volume":"2","author":"Kedia","year":"2007","journal-title":"Subst. Abus. Treat. Prev. Policy"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ijpharm.2018.06.008","article-title":"Spherical neutral gold nanoparticles improve anti-inflammatory response, oxidative stress and fibrosis in alcohol-methamphetamine-induced liver injury in rats","volume":"548","author":"Garcia","year":"2018","journal-title":"Int. J. Pharm."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"9012","DOI":"10.1039\/C3RA46093B","article-title":"Silymarin coated gold nanoparticles ameliorates CCl 4-induced hepatic injury and cirrhosis through down regulation of hepatic stellate cells and attenuation of Kupffer cells","volume":"4","author":"Kabir","year":"2014","journal-title":"RSC Adv."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/s12291-015-0520-2","article-title":"Exploring the potential role of chemopreventive agent, hesperetin conjugated pegylated gold nanoparticles in diethylnitrosamine-induced hepatocellular carcinoma in male wistar albino rats","volume":"31","author":"Gokuladhas","year":"2016","journal-title":"Indian J. Clin. Biochem."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.colsurfb.2014.09.051","article-title":"Apoptosis in liver cancer (HepG2) cells induced by functionalized gold nanoparticles","volume":"123","author":"Ashokkumar","year":"2014","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.2147\/IJN.S26650","article-title":"Biochemical analysis of Cassia fistula aqueous extract and phytochemically synthesized gold nanoparticles as hypoglycemic treatment for diabetes mellitus","volume":"7","author":"Daisy","year":"2012","journal-title":"Int. J. Nanomed."},{"key":"ref_118","first-page":"113","article-title":"Protective effect of royal jelly against the liver toxicity caused by aluminum chloride (AlCl3) in adult male rats","volume":"10","year":"2016","journal-title":"Adv Env. Biol"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"293","DOI":"10.5897\/AJB2015.15037","article-title":"Protective effect of Haloxylon salicornicum on hepatic and renal functions of Wistar rats exposed to aluminium","volume":"15","author":"Tahari","year":"2016","journal-title":"Afr. J. Biotechnol."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"4007","DOI":"10.2147\/IJN.S43691","article-title":"Effect of selenium nanoparticles with different sizes in primary cultured intestinal epithelial cells of crucian carp, Carassius auratus gibelio","volume":"8","author":"Wang","year":"2013","journal-title":"Int. J. Nanomed."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1007\/s10695-018-0556-3","article-title":"Dietary supplementation of selenium nanoparticles modulated systemic and mucosal immune status and stress resistance of red sea bream (Pagrus major)","volume":"45","author":"Dawood","year":"2019","journal-title":"Fish Physiol. Biochem."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1016\/j.biopha.2018.12.146","article-title":"Therapeutic applications of selenium nanoparticles","volume":"111","author":"Khurana","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40104-022-00722-2","article-title":"Toxicological effects of nanoselenium in animals","volume":"13","author":"Bano","year":"2022","journal-title":"J. Anim. Sci. Biotechnol."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1016\/j.ijbiomac.2021.09.156","article-title":"Protective effect of starch-stabilized selenium nanoparticles against melamine-induced hepato-renal toxicity in male albino rats","volume":"191","author":"Ahmed","year":"2021","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1007\/s12011-016-0748-6","article-title":"Antioxidant and hepatoprotective efficiency of selenium nanoparticles against acetaminophen-induced hepatic damage","volume":"175","author":"Amin","year":"2017","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_126","first-page":"6741","article-title":"Anti-hyperglycemic activity of selenium nanoparticles in streptozotocin-induced diabetic rats","volume":"10","author":"Dkhil","year":"2015","journal-title":"Int. J. Nanomed."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"F502","DOI":"10.1152\/ajprenal.00546.2016","article-title":"Inhibition of HDAC6 protects against rhabdomyolysis-induced acute kidney injury","volume":"312","author":"Shi","year":"2017","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1124\/jpet.111.190249","article-title":"Recovery from glycerol-induced acute kidney injury is accelerated by suramin","volume":"341","author":"Korrapati","year":"2012","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S1734-1140(12)70728-4","article-title":"Animal models of acute renal failure","volume":"64","author":"Singh","year":"2012","journal-title":"Pharmacol. Rep."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1007\/s12011-019-01793-5","article-title":"Nephroprotective role of selenium nanoparticles against glycerol-induced acute kidney injury in rats","volume":"194","author":"AlBasher","year":"2020","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.ijcard.2004.04.006","article-title":"Health outcomes in decompensated congestive heart failure: A comparison of tertiary hospitals in Brazil and United States","volume":"102","author":"Rohde","year":"2005","journal-title":"Int. J. Cardiol."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.procbio.2011.10.036","article-title":"Protective effect of chitosan oligosaccharides against Fc\u025bRI-mediated RBL-2H3 mast cell activation","volume":"47","author":"Vo","year":"2012","journal-title":"Process Biochem."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.intimp.2011.12.027","article-title":"Anti-inflammatory effects of low-molecular weight chitosan oligosaccharides in IgE\u2013antigen complex-stimulated RBL-2H3 cells and asthma model mice","volume":"12","author":"Chung","year":"2012","journal-title":"Int. Immunopharmacol."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"237","DOI":"10.2174\/157341305774642939","article-title":"Nanoparticle formulation increases oral bioavailability of poorly soluble drugs: Approaches, experimental evidences and theory","volume":"1","author":"Jia","year":"2005","journal-title":"Curr. Nanosci."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"81","DOI":"10.4103\/2231-4040.82950","article-title":"Nanosuspension: An approach to enhance solubility of drugs","volume":"2","author":"Patel","year":"2011","journal-title":"J. Adv. Pharm. Technol. Res."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"36","DOI":"10.4236\/snl.2015.52005","article-title":"Possible Synergistic Effect and Antioxidant Properties of Chitosan Nanoparticles and Quercetin against Carbon Tetrachloride-Induce Hepatotoxicity in Rats","volume":"5","author":"Aljawish","year":"2015","journal-title":"Soft Nanosci. Lett."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1016\/j.freeradbiomed.2011.06.006","article-title":"Neuroprotective mechanisms of cerium oxide nanoparticles in a mouse hippocampal brain slice model of ischemia","volume":"51","author":"Estevez","year":"2011","journal-title":"Free Radic. Biol. Med."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1124\/jpet.111.179978","article-title":"Cerium oxide nanoparticles inhibits oxidative stress and nuclear factor-\u03baB activation in H9c2 cardiomyocytes exposed to cigarette smoke extract","volume":"338","author":"Niu","year":"2011","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.jhep.2015.10.020","article-title":"Cerium oxide nanoparticles reduce steatosis, portal hypertension and display anti-inflammatory properties in rats with liver fibrosis","volume":"64","author":"Yudina","year":"2016","journal-title":"J. Hepatol."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1016\/j.sjbs.2020.03.009","article-title":"Curcumin-loaded cockle shell-derived calcium carbonate nanoparticles: A novel strategy for the treatment of lead-induced hepato-renal toxicity in rats","volume":"27","author":"Mailafiya","year":"2020","journal-title":"Saudi J. Biol. Sci."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1111\/j.1574-695X.2007.00329.x","article-title":"The role of nitric oxide in inflammatory reactions","volume":"51","author":"Tripathi","year":"2007","journal-title":"FEMS Immunol. Med. Microbiol."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"763","DOI":"10.2174\/1566524043359908","article-title":"The role of iNOS in chronic inflammatory processes in vivo: Is it damage-promoting, protective, or active at all?","volume":"4","author":"Suschek","year":"2004","journal-title":"Curr. Mol. Med."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"a021709","DOI":"10.1101\/cshperspect.a021709","article-title":"Associative learning in invertebrates","volume":"7","author":"Hawkins","year":"2015","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"103423","DOI":"10.1016\/j.bioorg.2019.103423","article-title":"A review on anti-inflammatory activity of green synthesized zinc oxide nanoparticle: Mechanism-based approach","volume":"94","author":"Agarwal","year":"2020","journal-title":"Bioorg. Chem."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/s12951-017-0252-y","article-title":"Selenium nanoparticles decorated with Ulva lactuca polysaccharide potentially attenuate colitis by inhibiting NF-\u03baB mediated hyper inflammation","volume":"15","author":"Zhu","year":"2017","journal-title":"J. Nanobiotechnol."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"109274","DOI":"10.1016\/j.inoche.2022.109274","article-title":"Zingiber officinale driven bioproduction of ZnO nanoparticles and their anti-inflammatory, anti-diabetic, anti-Alzheimer, anti-oxidant, and anti-microbial applications","volume":"140","author":"Faisal","year":"2022","journal-title":"Inorg. Chem. Commun."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"104992","DOI":"10.1016\/j.neuint.2021.104992","article-title":"Nanogold induces anti-inflammation against oxidative stress induced in human neural stem cells exposed to amyloid-beta peptide","volume":"145","author":"Chiang","year":"2021","journal-title":"Neurochem. Int."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"101917","DOI":"10.1016\/j.jddst.2020.101917","article-title":"Nanotechnological interventions for the treatment of renal diseases: Current scenario and future prospects","volume":"59","author":"Acharya","year":"2020","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"105927","DOI":"10.1016\/j.bioorg.2022.105927","article-title":"Nanotechnology applications for treatment of hepatic infections via modulating Hepatic histopathological and DNA alterations","volume":"127","author":"Gad","year":"2022","journal-title":"Bioorganic Chem."},{"key":"ref_150","doi-asserted-by":"crossref","unstructured":"Song, W.-J., Jeong, M.-S., Choi, D.-M., Kim, K.-N., and Wie, M.-B. (2019). Zinc oxide nanoparticles induce autophagy and apoptosis via oxidative injury and pro-inflammatory cytokines in primary astrocyte cultures. Nanomaterials, 9.","DOI":"10.3390\/nano9071043"},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"931","DOI":"10.3389\/fmicb.2019.00931","article-title":"Phytofabrication of selenium nanoparticles from Emblica officinalis fruit extract and exploring its biopotential applications: Antioxidant, antimicrobial, and biocompatibility","volume":"10","author":"Gunti","year":"2019","journal-title":"Front. Microbiol."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.scitotenv.2008.06.042","article-title":"Manufactured nanoparticles: An overview of their chemistry, interactions and potential environmental implications","volume":"400","author":"Lead","year":"2008","journal-title":"Sci. Total Environ."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12951-019-0516-9","article-title":"Synthesis and biomedical applications of nanoceria, a redox active nanoparticle","volume":"17","author":"Thakur","year":"2019","journal-title":"J. Nanobiotechnol."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1007\/s12011-021-02773-4","article-title":"The prospective ameliorative role of zinc oxide nanoparticles in STZ-induced diabetic nephropathy in rats: Mechanistic targeting of autophagy and regulating Nrf2\/TXNIP\/NLRP3 inflammasome signaling","volume":"200","author":"Ragab","year":"2022","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_155","doi-asserted-by":"crossref","unstructured":"Abd El-Baset, S.A., Mazen, N.F., Abdul-Maksoud, R.S., and Kattaia, A.A. (2022). The therapeutic prospect of zinc oxide nanoparticles in experimentally induced diabetic nephropathy. Tissue Barriers, 2069966.","DOI":"10.1080\/21688370.2022.2069966"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/j.etap.2013.07.005","article-title":"Green synthesis of silver nanoparticles: An approach to overcome toxicity","volume":"36","author":"Roy","year":"2013","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"1","DOI":"10.15761\/FNN.1000189","article-title":"Selenium nanoparticles: An insight on its Pro-oxidant and antioxidant properties","volume":"6","author":"Kondaparthi","year":"2019","journal-title":"Front. Nanosci. Nanotechnol."}],"container-title":["Biomolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2218-273X\/12\/10\/1337\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:36:45Z","timestamp":1760143005000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2218-273X\/12\/10\/1337"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,21]]},"references-count":157,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2022,10]]}},"alternative-id":["biom12101337"],"URL":"https:\/\/doi.org\/10.3390\/biom12101337","relation":{},"ISSN":["2218-273X"],"issn-type":[{"value":"2218-273X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,21]]}}}