{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T15:44:40Z","timestamp":1791215080449,"version":"4.1.0"},"reference-count":181,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2022,9,27]],"date-time":"2022-09-27T00:00:00Z","timestamp":1664236800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82272450"],"award-info":[{"award-number":["82272450"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81902182"],"award-info":[{"award-number":["81902182"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82071591"],"award-info":[{"award-number":["82071591"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2021GMFY06"],"award-info":[{"award-number":["2021GMFY06"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Natural Science Foundation Incubation Program of The Second Hospital of Anhui Medical University","award":["82272450"],"award-info":[{"award-number":["82272450"]}]},{"name":"Natural Science Foundation Incubation Program of The Second Hospital of Anhui Medical University","award":["81902182"],"award-info":[{"award-number":["81902182"]}]},{"name":"Natural Science Foundation Incubation Program of The Second Hospital of Anhui Medical University","award":["82071591"],"award-info":[{"award-number":["82071591"]}]},{"name":"Natural Science Foundation Incubation Program of The Second Hospital of Anhui Medical University","award":["2021GMFY06"],"award-info":[{"award-number":["2021GMFY06"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>Rheumatoid arthritis is a common autoimmune disease that results from the deposition of antibodies\u2013autoantigens in the joints, leading to long-lasting inflammation. The main features of RA include cartilage damage, synovial invasion and flare-ups of intra-articular inflammation, and these pathological processes significantly reduce patients\u2019 quality of life. To date, there is still no drug target that can act in rheumatoid arthritis. Therefore, the search for novel drug targets has become urgent. Due to their unique physicochemical properties, calcium ions play an important role in all cellular activities and the body has evolved a rigorous calcium signaling system. Calcium-permeable channels, as the main operators of calcium signaling, are widely distributed in cell membranes, endoplasmic reticulum membranes and mitochondrial membranes, and mediate the efflux and entry of Ca2+. Over the last century, more and more calcium-permeable channels have been identified in human cells, and the role of this large family of calcium-permeable channels in rheumatoid arthritis has gradually become clear. In this review, we briefly introduce the major calcium-permeable channels involved in the pathogenesis of RA (e.g., acid-sensitive ion channel (ASIC), transient receptor potential (TRP) channel and P2X receptor) and explain the specific roles and mechanisms of these calcium-permeable channels in the pathogenesis of RA, providing more comprehensive ideas and targets for the treatment of RA.<\/jats:p>","DOI":"10.3390\/biom12101383","type":"journal-article","created":{"date-parts":[[2022,9,27]],"date-time":"2022-09-27T21:23:27Z","timestamp":1664313807000},"page":"1383","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Calcium-Permeable Channels Cooperation for Rheumatoid Arthritis: Therapeutic Opportunities"],"prefix":"10.3390","volume":"12","author":[{"given":"Hong-Yu","family":"Liang","sequence":"first","affiliation":[{"name":"The Second School of Clinical Medicine, Anhui Medical University, Hefei 230032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan-Xin","family":"Yin","sequence":"additional","affiliation":[{"name":"The Second School of Clinical Medicine, Anhui Medical University, Hefei 230032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu-Fang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology, The Second Hospital of Anhui Medical University, Hefei 230601, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3520-1991","authenticated-orcid":false,"given":"Yong","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology, The Second Hospital of Anhui Medical University, Hefei 230601, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9892-3732","authenticated-orcid":false,"given":"Ying-Jie","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology, The Second Hospital of Anhui Medical University, Hefei 230601, China"},{"name":"The Key Laboratory of Anti-Inflammatory and Immune Medicine, Anhui Medical University, Hefei 230032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology, The Second Hospital of Anhui Medical University, Hefei 230601, China"},{"name":"The Key Laboratory of Anti-Inflammatory and Immune Medicine, Anhui Medical University, Hefei 230032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren-Peng","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology, The Second Hospital of Anhui Medical University, Hefei 230601, China"},{"name":"The Key Laboratory of Anti-Inflammatory and Immune Medicine, Anhui Medical University, Hefei 230032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1016\/S0140-6736(01)06075-5","article-title":"Rheumatoid arthritis","volume":"358","author":"Lee","year":"2001","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1136\/ard.57.6.350","article-title":"Magnetic resonance imaging of the wrist in early rheumatoid arthritis reveals a high prevalence of erosions at four months after symptom onset","volume":"57","author":"McQueen","year":"1998","journal-title":"Ann. 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