{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T05:13:18Z","timestamp":1790399598204,"version":"4.1.0"},"reference-count":95,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2022,9,30]],"date-time":"2022-09-30T00:00:00Z","timestamp":1664496000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Natural Science Foundation of China","award":["31871157"],"award-info":[{"award-number":["31871157"]}]},{"name":"National Natural Science Foundation of China","award":["81830001"],"award-info":[{"award-number":["81830001"]}]},{"name":"National Natural Science Foundation of China","award":["82170046"],"award-info":[{"award-number":["82170046"]}]},{"name":"National Natural Science Foundation of China","award":["2019HXFH042"],"award-info":[{"award-number":["2019HXFH042"]}]},{"name":"the 1\u20223\u20225 Project for Disciplines of Excellence at West China Hospital of Sichuan University","award":["31871157"],"award-info":[{"award-number":["31871157"]}]},{"name":"the 1\u20223\u20225 Project for Disciplines of Excellence at West China Hospital of Sichuan University","award":["81830001"],"award-info":[{"award-number":["81830001"]}]},{"name":"the 1\u20223\u20225 Project for Disciplines of Excellence at West China Hospital of Sichuan University","award":["82170046"],"award-info":[{"award-number":["82170046"]}]},{"name":"the 1\u20223\u20225 Project for Disciplines of Excellence at West China Hospital of Sichuan University","award":["2019HXFH042"],"award-info":[{"award-number":["2019HXFH042"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>The usefulness of serum angiotensin-converting enzyme (sACE) for diagnosing sarcoidosis and determining the active status of sarcoidosis has been reported with varying outcomes. On the basis of the majority of published data, we conducted a meta-analysis to calculate the overall predictive accuracy of sACE in sarcoidosis disease and the active status of sarcoidosis. The inclusion of related research listed in Web of Science, PubMed, Scopus, and other literature databases was assessed. SROC curves were generated to characterize the overall test results after data on sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), and diagnostic odds ratio (DOR) were combined. Publication bias was identified using Deeks\u2019 funnel plot. Thirty-five publications with 8645 subjects met the inclusion criteria. The following are summary estimates of sACE diagnostic performance for sarcoidosis: sensitivity, 60% (95% confidence interval (CI), 52\u201368%); specificity, 93% (95% CI, 88\u201396%); PLR, 8.4 (95% CI, 5.3\u201313.3); NLR, 0.43 (95% CI, 0.36\u20130.52); and DOR, 19 (95% CI, 12\u201331). The area under the SROC curve (AUC) was 0.84 (95% CI, 0.80\u20130.87). Summary estimates for predicting the active status of sarcoidosis were as follows: sensitivity, 0.76 (95% CI, 0.61\u20130.87); specificity, 0.80 (95% CI, 0.64\u20130.90); PLR, 3.9 (95% CI, 2.1\u20137.3); NLR, 0.29 (95% CI, 0.17\u20130.49); and DOR, 13 (95% CI, 6\u201331). The AUC was 0.85 (95% CI, 0.82\u20130.88). There was no evidence of publication bias. Our meta-analysis suggests that measuring the sACE may assist in the diagnosis of sarcoidosis and predicting the active status of sarcoidosis, but the interpretation of the sACE results should be with caution. Future studies should validate our results.<\/jats:p>","DOI":"10.3390\/biom12101400","type":"journal-article","created":{"date-parts":[[2022,10,8]],"date-time":"2022-10-08T00:07:43Z","timestamp":1665187663000},"page":"1400","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Performance of Serum Angiotensin-Converting Enzyme in Diagnosing Sarcoidosis and Predicting the Active Status of Sarcoidosis: A Meta-Analysis"],"prefix":"10.3390","volume":"12","author":[{"given":"Xueru","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, West China Hospital of Sichuan University and Division of Pulmonary Diseases, State Key Laboratory of Biotherapy of China, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zou","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, West China Hospital of Sichuan University, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuyan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, West China Hospital of Sichuan University and Division of Pulmonary Diseases, State Key Laboratory of Biotherapy of China, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, West China Hospital of Sichuan University and Division of Pulmonary Diseases, State Key Laboratory of Biotherapy of China, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, West China Hospital of Sichuan University and Division of Pulmonary Diseases, State Key Laboratory of Biotherapy of China, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8142-1792","authenticated-orcid":false,"given":"Yongchun","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, West China Hospital of Sichuan University and Division of Pulmonary Diseases, State Key Laboratory of Biotherapy of China, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, West China Hospital of Sichuan University and Division of Pulmonary Diseases, State Key Laboratory of Biotherapy of China, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.mcna.2018.12.011","article-title":"Sarcoidosis","volume":"103","author":"Llanos","year":"2019","journal-title":"Med. 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