{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T12:08:34Z","timestamp":1791461314118,"version":"4.3.4"},"reference-count":235,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2022,10,6]],"date-time":"2022-10-06T00:00:00Z","timestamp":1665014400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>Brain neurodegenerative diseases (BND) are debilitating conditions that are especially characteristic of a certain period of life and considered major threats to human health. Current treatments are limited, meaning that there is a challenge in developing new options that can efficiently tackle the different components and pathophysiological processes of these conditions. The renin-angiotensin-aldosterone system (RAS) is an endocrine axis with important peripheral physiological functions such as blood pressure and cardiovascular homeostasis, as well as water and sodium balance and systemic vascular resistance\u2014functions which are well-documented. However, recent work has highlighted the paracrine and autocrine functions of RAS in different tissues, including the central nervous system (CNS). It is known that RAS hyperactivation has pro-inflammatory and pro-oxidant effects, thus suggesting that its pharmacological modulation could be used in the management of these conditions. The present paper underlines the involvement of RAS and its components in the pathophysiology of BNDs such as Parkinson\u2019s disease (PD), Alzheimer\u2019s disease (AD), multiple sclerosis (MS), Huntington\u2019s disease (HD), motor neuron disease (MND), and prion disease (PRD), as well as the identification of drugs and pharmacologically active substances that act upon RAS, which could alleviate their symptomatology or evolution, and thus, contribute to novel therapeutic approaches.<\/jats:p>","DOI":"10.3390\/biom12101429","type":"journal-article","created":{"date-parts":[[2022,10,8]],"date-time":"2022-10-08T00:07:43Z","timestamp":1665187663000},"page":"1429","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Impact of the Renin-Angiotensin System on the Pathogeny and Pharmacotherapeutics of Neurodegenerative Diseases"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4923-8020","authenticated-orcid":false,"given":"Walther","family":"Bild","sequence":"first","affiliation":[{"name":"Department of Physiology, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, 700115 Iasi, Romania"},{"name":"Center of Biomedical Research of the Romanian Academy, 700506 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3948-6496","authenticated-orcid":false,"given":"Alexandru","family":"Vasincu","sequence":"additional","affiliation":[{"name":"Department of Pharmacodynamics and Clinical Pharmacy, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u0103zvan-Nicolae","family":"Rusu","sequence":"additional","affiliation":[{"name":"Department of Pharmacodynamics and Clinical Pharmacy, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5568-2123","authenticated-orcid":false,"given":"Daniela-Carmen","family":"Ababei","sequence":"additional","affiliation":[{"name":"Department of Pharmacodynamics and Clinical Pharmacy, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aurelian Bogdan","family":"Stana","sequence":"additional","affiliation":[{"name":"Department of Physiology, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4440-9628","authenticated-orcid":false,"given":"Gabriela Dumitri\u021ba","family":"Stanciu","sequence":"additional","affiliation":[{"name":"Center for Advanced Research and Development in Experimental Medicine (CEMEX), \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bogdan","family":"Savu","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronica","family":"Bild","sequence":"additional","affiliation":[{"name":"Center of Biomedical Research of the Romanian Academy, 700506 Iasi, Romania"},{"name":"Department of Pharmacodynamics and Clinical Pharmacy, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, 700115 Iasi, Romania"},{"name":"Center for Advanced Research and Development in Experimental Medicine (CEMEX), \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/nrd.2018.168","article-title":"Drug repurposing: Progress, challenges and recommendations","volume":"18","author":"Pushpakom","year":"2019","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_2","first-page":"127","article-title":"Chapter 10\u2014Translational bioinformatics methods for drug discovery and drug repurposing","volume":"Volume 13","author":"Raza","year":"2021","journal-title":"Translational Bioinformatics in Healthcare and Medicine"},{"key":"ref_3","unstructured":"Fountain, J.H., and Lappin, S.L. (2021). Physiology, Renin Angiotensin System, StatPearls Publishing."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"101612","DOI":"10.1016\/j.arr.2022.101612","article-title":"Targeting brain Renin-Angiotensin System for the prevention and treatment of Alzheimer\u2019s disease: Past, present and future","volume":"77","author":"Gouveia","year":"2022","journal-title":"Ageing Res. Rev."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Jackson, L., Eldahshan, W., Fagan, S.C., and Ergul, A. (2018). Within the Brain: The Renin Angiotensin System. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19030876"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.biopha.2017.07.091","article-title":"Renin-angiotensin-aldosterone (RAAS): The ubiquitous system for homeostasis and pathologies","volume":"94","author":"Patel","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"107680","DOI":"10.1016\/j.exer.2019.05.020","article-title":"The renin-angiotensin-aldosterone system and its therapeutic targets","volume":"186","author":"Colafella","year":"2019","journal-title":"Exp. Eye Res."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1007\/s00424-014-1668-y","article-title":"Salt feedback on the renin-angiotensin-aldosterone system","volume":"467","author":"Schweda","year":"2015","journal-title":"Pflug. Arch.-Eur. J. Physiol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/j.sjbs.2020.01.026","article-title":"Role of brain renin angiotensin system in neurodegeneration: An update","volume":"27","author":"Abiodun","year":"2020","journal-title":"Saudi J. Biol. Sci."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.endinu.2021.05.012","article-title":"Renin-angiotensin system: Basic and clinical aspects\u2014A general perspective","volume":"69","author":"Vargas","year":"2022","journal-title":"Endocrinol. Diabetes Y Nutr."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Saravi, B., Li, Z., Lang, C.N., Schmid, B., Lang, F.K., Grad, S., Alini, M., Richards, R.G., Schmal, H., and S\u00fcdkamp, N. (2021). The Tissue Renin-Angiotensin System and Its Role in the Pathogenesis of Major Human Diseases: Quo Vadis?. Cells, 10.","DOI":"10.3390\/cells10030650"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"121","DOI":"10.3317\/jraas.2005.018","article-title":"Angiotensin peptides and their pleiotropic actions","volume":"6","author":"Haulica","year":"2005","journal-title":"J. Renin. Angiotensin Aldosterone Syst."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"102602","DOI":"10.1155\/2013\/102602","article-title":"Renin angiotensin system in cognitive function and dementia","volume":"2013","author":"Bodiga","year":"2013","journal-title":"Asian J. Neurosci."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"129","DOI":"10.3389\/fnagi.2017.00129","article-title":"Brain Renin-Angiotensin System and Microglial Polarization: Implications for Aging and Neurodegeneration","volume":"9","author":"Lanciego","year":"2017","journal-title":"Front. Aging Neurosci."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"268","DOI":"10.37349\/emed.2021.00046","article-title":"Angiotensin-(1-7) and Mas receptor in the brain","volume":"2","author":"Pineda","year":"2021","journal-title":"Explor. Med."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.pneurobio.2007.10.009","article-title":"Angiotensin receptor subtype mediated physiologies and behaviors: New discoveries and clinical targets","volume":"84","author":"Wright","year":"2008","journal-title":"Prog. Neurobiol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"109809","DOI":"10.1016\/j.cellsig.2020.109809","article-title":"The counter regulatory axis of the renin angiotensin system in the brain and ischaemic stroke: Insight from preclinical stroke studies and therapeutic potential","volume":"76","author":"McFall","year":"2020","journal-title":"Cell. Signal."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/s00424-012-1102-2","article-title":"The brain renin\u2013angiotensin system: A diversity of functions and implications for CNS diseases","volume":"465","author":"Wright","year":"2012","journal-title":"Pfl\u00fcgers Arch.-Eur. J. Physiol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1161\/HYPERTENSIONAHA.117.08550","article-title":"How Is the Brain Renin-Angiotensin System Regulated?","volume":"70","author":"Nakagawa","year":"2017","journal-title":"Hypertension"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"a020412","DOI":"10.1101\/cshperspect.a020412","article-title":"The Blood\u2013Brain Barrier","volume":"7","author":"Daneman","year":"2015","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Spohr, T. (2020). Astrocytes in Pathogenesis of Multiple Sclerosis and Potential Translation into Clinic. Glia in Health and Disease, IntechOpen.","DOI":"10.5772\/intechopen.82593"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1002\/glia.1078","article-title":"Angiotensin receptor-like immunoreactivity in adult brain white matter astrocytes and oligodendrocytes","volume":"35","author":"Fogarty","year":"2001","journal-title":"Glia"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1002\/glia.22443","article-title":"The astrocyte in multiple sclerosis revisited","volume":"61","author":"Brosnan","year":"2013","journal-title":"Glia"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"9032","DOI":"10.1523\/JNEUROSCI.2088-07.2007","article-title":"Angiotensin II Controls Occludin Function and Is Required for Blood Brain Barrier Maintenance: Relevance to Multiple Sclerosis","volume":"27","author":"Wosik","year":"2007","journal-title":"J. Neurosci."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"586314","DOI":"10.3389\/fnins.2020.586314","article-title":"Brain Renin\u2013Angiotensin System at the Intersect of Physical and Cognitive Frailty","volume":"14","author":"Cosarderelioglu","year":"2020","journal-title":"Front. Neurosci."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1152\/physiol.00002.2008","article-title":"An Intracellular Renin-Angiotensin System in Neurons: Fact, Hypothesis, or Fantasy","volume":"23","author":"Grobe","year":"2008","journal-title":"Physiology"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1210\/edrv-13-2-329","article-title":"Brain and pituitary angiotensin","volume":"13","author":"Saavedra","year":"1992","journal-title":"Endocr. Rev."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1113\/expphysiol.2011.058578","article-title":"Cerebroprotection by angiotensin-(1-7) in endothelin-1-induced ischaemic stroke","volume":"96","author":"Mecca","year":"2011","journal-title":"Exp. Physiol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.pneurobio.2011.07.001","article-title":"Brain renin-angiotensin\u2014A new look at an old system","volume":"95","author":"Wright","year":"2011","journal-title":"Prog. Neurobiol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"5847","DOI":"10.1007\/s12035-017-0805-y","article-title":"Paracrine and Intracrine Angiotensin 1-7\/Mas Receptor Axis in the Substantia Nigra of Rodents, Monkeys, and Humans","volume":"55","author":"Valenzuela","year":"2018","journal-title":"Mol. Neurobiol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"e2427","DOI":"10.1038\/cddis.2016.327","article-title":"Mitochondrial angiotensin receptors in dopaminergic neurons. Role in cell protection and aging-related vulnerability to neurodegeneration","volume":"7","author":"Valenzuela","year":"2016","journal-title":"Cell Death Dis."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1016\/S1357-2725(02)00306-0","article-title":"The brain renin-angiotensin system: Location and physiological roles","volume":"35","author":"McKinley","year":"2003","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s40478-015-0189-z","article-title":"Loss of angiotensin II receptor expression in dopamine neurons in Parkinson\u2019s disease correlates with pathological progression and is accompanied by increases in Nox4- and 8-OH guanosine-related nucleic acid oxidation and caspase-3 activation","volume":"3","author":"Zawada","year":"2015","journal-title":"Acta Neuropathol. Commun."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"2218","DOI":"10.1172\/JCI16980","article-title":"Altered blood pressure responses and normal cardiac phenotype in ACE2-null mice","volume":"116","author":"Gurley","year":"2006","journal-title":"J. Clin. Investig."},{"key":"ref_35","first-page":"129","article-title":"Brain Aminopeptidases and Hypertension","volume":"7","author":"Banegas","year":"2006","journal-title":"JRAAS"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.lfs.2017.11.022","article-title":"Divergent profile between hypothalamic and plasmatic aminopeptidase activities in WKY and SHR. Influence of beta-adrenergic blockade","volume":"192","author":"Prieto","year":"2018","journal-title":"Life Sci."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.kisu.2021.11.002","article-title":"The renin-angiotensin system biomolecular cascade: A 2022 update of newer insights and concepts","volume":"12","author":"Ferrario","year":"2022","journal-title":"Kidney Int. Suppl."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/j.exger.2013.03.002","article-title":"Plasma renin\u2013angiotensin system-regulating aminopeptidase activities are modified in early stage Alzheimer\u2019s disease and show gender differences but are not related to apolipoprotein E genotype","volume":"48","author":"Puertas","year":"2013","journal-title":"Exp. Gerontol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"107684","DOI":"10.1016\/j.pharmthera.2020.107684","article-title":"The role of the brain renin-angiotensin system (RAS) in mild traumatic brain injury (TBI)","volume":"218","author":"Vadhan","year":"2021","journal-title":"Pharmacol. Ther."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1016\/j.yjmcc.2012.03.013","article-title":"Neuronal nitric oxide synthase is up-regulated by angiotensin II and attenuates NADPH oxidase activity and facilitates relaxation in murine left ventricular myocytes","volume":"52","author":"Jin","year":"2012","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"655","DOI":"10.3233\/JAD-170944","article-title":"Associations of Angiotensin Converting Enzyme-1 and Angiotensin II Blood Levels and Cognitive Function","volume":"63","author":"Yasar","year":"2018","journal-title":"J. Alzheimers Dis."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/j.tins.2009.07.006","article-title":"Angiotensins in Alzheimer\u2019s disease\u2014friend or foe?","volume":"32","author":"Kehoe","year":"2009","journal-title":"Trends Neurosci."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"170775","DOI":"10.1016\/j.peptides.2022.170775","article-title":"Angiotensin-(1-7), a protective peptide against vascular aging","volume":"152","author":"Valencia","year":"2022","journal-title":"Peptides"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.cca.2021.10.029","article-title":"Angiotensin converting enzyme (ACE)","volume":"524","author":"Khurana","year":"2022","journal-title":"Clin. Chim. Acta"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"4222","DOI":"10.1111\/bph.12770","article-title":"Angiotensin-(1\u20137) induces cerebral ischaemic tolerance by promoting brain angiogenesis in a Mas\/eNOS-dependent pathway","volume":"171","author":"Jiang","year":"2014","journal-title":"Br. J. Pharmacol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1152\/physrev.00023.2016","article-title":"The ACE2\/Angiotensin-(1-7)\/MAS Axis of the Renin-Angiotensin System: Focus on Angiotensin-(1-7)","volume":"98","author":"Santos","year":"2018","journal-title":"Physiol. Rev."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"104644","DOI":"10.1016\/j.nbd.2019.104644","article-title":"Memory and cerebrovascular deficits recovered following angiotensin IV intervention in a mouse model of Alzheimer\u2019s disease","volume":"134","author":"Royea","year":"2020","journal-title":"Neurobiol. Dis."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.exger.2017.01.006","article-title":"Changes of renin-angiotensin system-related aminopeptidases in early stage Alzheimer\u2019s disease","volume":"89","author":"Gard","year":"2017","journal-title":"Exp. Gerontol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"2283","DOI":"10.1093\/brain\/114.5.2283","article-title":"Ageing and Parkinson\u2019s disease: Substantia nigra regional selectivity","volume":"114","year":"1991","journal-title":"Brain"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"17013","DOI":"10.1038\/nrdp.2017.13","article-title":"Parkinson disease","volume":"3","author":"Poewe","year":"2017","journal-title":"Nat. Rev. Dis. Primers"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3389\/fnmol.2016.00007","article-title":"Expression of Tgf\u03b21 and Inflammatory Markers in the 6-hydroxydopamine Mouse Model of Parkinson\u2019s Disease","volume":"9","author":"Haas","year":"2016","journal-title":"Front. Mol. Neurosci."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1152\/physrev.00038.2017","article-title":"Angiotensin II signal transduction: An update on mechanisms of physiology and pathophysiology","volume":"98","author":"Forrester","year":"2018","journal-title":"Physiol. Rev."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jocn.2017.08.055","article-title":"The renin angiotensin system and the brain: New developments","volume":"46","author":"Farag","year":"2017","journal-title":"J. Clin. Neurosci."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"24099","DOI":"10.18632\/oncotarget.15732","article-title":"Azilsartan ameliorates apoptosis of dopaminergic neurons and rescues characteristic parkinsonian behaviors in a rat model of Parkinson\u2019s disease","volume":"8","author":"Gao","year":"2017","journal-title":"Oncotarget"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1007\/s11357-011-9284-7","article-title":"Mitochondrial ATP-sensitive potassium channels enhance angiotensin-induced oxidative damage and dopaminergic neuron degeneration. Relevance for aging-associated susceptibility to Parkinson\u2019s disease","volume":"34","author":"Parga","year":"2012","journal-title":"Age"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"170713","DOI":"10.1016\/j.peptides.2021.170713","article-title":"Parkinson disease: Protective role and function of neuropeptides","volume":"151","author":"Tabikh","year":"2021","journal-title":"Peptides"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"S140","DOI":"10.1016\/j.jval.2021.11.676","article-title":"POSC203 Preventive Effects of Renin-Angiotensin System Inhibitors on Parkinson\u2019s Disease: A Population-Based Retrospective Cohort Study","volume":"25","author":"Jo","year":"2022","journal-title":"Value Health"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.jns.2016.07.031","article-title":"Peripheral levels of angiotensins are associated with depressive symptoms in Parkinson\u2019s disease","volume":"368","author":"Rocha","year":"2016","journal-title":"J. Neurol. Sci."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1111\/j.1460-9568.2010.07448.x","article-title":"Nigral and striatal regulation of angiotensin receptor expression by dopamine and angiotensin in rodents: Implications for progression of Parkinson\u2019s disease","volume":"32","author":"Valenzuela","year":"2010","journal-title":"Eur. J. Neurosci."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"837890","DOI":"10.3389\/fphar.2022.837890","article-title":"Protective Effect of Renin-Angiotensin System Inhibitors on Parkinson\u2019s Disease: A Nationwide Cohort Study","volume":"13","author":"Jo","year":"2022","journal-title":"Front. Pharmacol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/j.jalz.2016.02.010","article-title":"Neuroinflammation in Alzheimer\u2019s disease: Current evidence and future directions","volume":"12","author":"Calsolaro","year":"2016","journal-title":"Alzheimers Dement"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"712","DOI":"10.2174\/1567205012666150701103107","article-title":"Neurobiology of Alzheimer\u2019s Disease: Integrated Molecular, Physiological, Anatomical, Biomarker, and Cognitive Dimensions","volume":"12","author":"Raskin","year":"2015","journal-title":"Curr. Alzheimer Res."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.neurobiolaging.2020.12.011","article-title":"Associations between brain amyloid accumulation and the use of angiotensin-converting enzyme inhibitors versus angiotensin receptor blockers","volume":"100","author":"Ouk","year":"2021","journal-title":"Neurobiol. Aging"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"209","DOI":"10.2174\/1570159X11311020007","article-title":"ACE2-Ang-(1-7)-Mas Axis in Brain: A Potential Target for Prevention and Treatment of Ischemic Stroke","volume":"11","author":"Jiang","year":"2013","journal-title":"Curr. Neuropharmacol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"105515","DOI":"10.1016\/j.phrs.2021.105515","article-title":"Association between renin-angiotensin-aldosterone system inhibitors and risk of dementia: A meta-analysis","volume":"166","author":"Scotti","year":"2021","journal-title":"Pharmacol. Res."},{"key":"ref_66","first-page":"Cd009096","article-title":"Angiotensin converting enzyme (ACE) inhibitors versus angiotensin receptor blockers for primary hypertension","volume":"2014","author":"Li","year":"2014","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1042\/CS20120078","article-title":"Angiotensin II AT1 receptor blockers as treatments for inflammatory brain disorders","volume":"123","author":"Saavedra","year":"2012","journal-title":"Clin. Sci."},{"key":"ref_68","first-page":"26822027","article-title":"An integrative genome-wide transcriptome reveals that candesartan is neuroprotective and a candidate therapeutic for Alzheimer\u2019s disease","volume":"8","author":"Elkahloun","year":"2016","journal-title":"Alzheimer\u2019s Res. Ther."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.phrs.2017.06.017","article-title":"Beneficial effects of Angiotensin II receptor blockers in brain disorders","volume":"125","author":"Saavedra","year":"2017","journal-title":"Pharmacol. Res."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"806","DOI":"10.3389\/fphys.2018.00806","article-title":"Oxidative Stress: A Major Player in Cerebrovascular Alterations Associated to Neurodegenerative Events","volume":"9","author":"Carvalho","year":"2018","journal-title":"Front. Physiol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"5282","DOI":"10.1007\/s12035-017-0754-5","article-title":"Angiotensin Receptor Blockade by Inhibiting Glial Activation Promotes Hippocampal Neurogenesis Via Activation of Wnt\/\u03b2-Catenin Signaling in Hypertension","volume":"55","author":"Bhat","year":"2018","journal-title":"Mol. Neurobiol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"104230","DOI":"10.1016\/j.phrs.2019.04.014","article-title":"Improvements of symptoms of Alzheimer\u2019s disease by inhibition of the angiotensin system","volume":"154","author":"Quitterer","year":"2020","journal-title":"Pharmacol. Res."},{"key":"ref_73","first-page":"95","article-title":"Direct angiotensin type 2 receptor (AT2R) stimulation attenuates T-cell and microglia activation and prevents demyelination in experimental autoimmune encephalomyelitis in mice","volume":"128","author":"Lucht","year":"2014","journal-title":"Clin. Sci."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1001\/archneur.1997.00550200068012","article-title":"Serum Angiotensin-Converting Enzyme in Multiple Sclerosis","volume":"54","author":"Constantinescu","year":"1997","journal-title":"Arch. Neurol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.pneurobio.2014.11.004","article-title":"The development of small molecule angiotensin IV analogs to treat Alzheimer\u2019s and Parkinson\u2019s diseases","volume":"125","author":"Wright","year":"2015","journal-title":"Prog. Neurobiol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1016\/B978-0-12-820472-6.00160-2","article-title":"4.24\u2014Renin-Angiotensin-Aldosterone System","volume":"4","author":"Speth","year":"2022","journal-title":"Compr. Pharmacol."},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Sun, X., Deng, Y., Fu, X., Wang, S., Duan, R., and Zhang, Y. (2021). AngIV-Analog Dihexa Rescues Cognitive Impairment and Recovers Memory in the APP\/PS1 Mouse via the PI3K\/AKT Signaling Pathway. Brain Sci., 11.","DOI":"10.3390\/brainsci11111487"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1172\/JCI7451","article-title":"Angiotensin II regulates cellular immune responses through a calcineurin-dependent pathway","volume":"104","author":"Nataraj","year":"1999","journal-title":"J. Clin. Investig."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1007\/s10571-011-9754-6","article-title":"Angiotensin II AT(1) receptor blockers ameliorate inflammatory stress: A beneficial effect for the treatment of brain disorders","volume":"32","author":"Saavedra","year":"2012","journal-title":"Cell Mol. Neurobiol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"14942","DOI":"10.1073\/pnas.0903602106","article-title":"Role of the renin-angiotensin system in autoimmune inflammation of the central nervous system","volume":"106","author":"Stegbauer","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.neuropharm.2013.05.025","article-title":"Telmisartan attenuates MPTP induced dopaminergic degeneration and motor dysfunction through regulation of alpha-synuclein and neurotrophic factors (BDNF and GDNF) expression in C57BL\/6J mice","volume":"73","author":"Sathiya","year":"2013","journal-title":"Neuropharmacology"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.ejphar.2016.02.042","article-title":"Inhibition of endoplasmic reticulum stress-activated IRE1alpha-TRAF2-caspase-12 apoptotic pathway is involved in the neuroprotective effects of telmisartan in the rotenone rat model of Parkinson\u2019s disease","volume":"776","author":"Tong","year":"2016","journal-title":"Eur. J. Pharmacol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1089\/rej.2009.0944","article-title":"Protective effects of intranasal losartan in the APP\/PS1 transgenic mouse model of Alzheimer disease","volume":"13","author":"Danielyan","year":"2010","journal-title":"Rejuvenation Res."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"3393","DOI":"10.1172\/JCI31547","article-title":"Valsartan lowers brain beta-amyloid protein levels and improves spatial learning in a mouse model of Alzheimer disease","volume":"117","author":"Wang","year":"2007","journal-title":"J. Clin. Investig."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"111441","DOI":"10.1016\/j.fct.2020.111441","article-title":"The anti-Alzheimer effect of telmisartan in a hyperglycemic ovariectomized rat model; role of central angiotensin and estrogen receptors","volume":"142","author":"Khallaf","year":"2020","journal-title":"Food Chem. Toxicol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.expneurol.2009.09.012","article-title":"The brain RAS and Alzheimer\u2019s disease","volume":"223","author":"Wright","year":"2010","journal-title":"Exp. Neurol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.jocn.2016.02.036","article-title":"The association of renin-angiotensin system blockade use with the risks of cognitive impairment of aging and Alzheimer\u2019s disease: A meta-analysis","volume":"33","author":"Zhuang","year":"2016","journal-title":"J. Clin. Neurosci."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"123","DOI":"10.3233\/JAD-2011-0010","article-title":"Effects of Hypoperfusion in Alzheimer\u2019s Disease","volume":"26","author":"Austin","year":"2011","journal-title":"J. Alzheimers Dis."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1002\/glia.22765","article-title":"Interaction between NADPH-oxidase and Rho-kinase in angiotensin II-induced microglial activation","volume":"63","author":"Borrajo","year":"2015","journal-title":"Glia"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1007\/s11064-013-1058-4","article-title":"Telmisartan ameliorates neurotrophic support and oxidative stress in the retina of streptozotocin-induced diabetic rats","volume":"38","author":"Ola","year":"2013","journal-title":"Neurochem. Res."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1016\/j.amjmed.2022.04.029","article-title":"Association of angiotensin receptor blockers with incident Parkinson\u2019s disease in patients with hypertension: A retrospective cohort study","volume":"135","author":"Lin","year":"2022","journal-title":"Am. J. Med."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"1892","DOI":"10.1681\/ASN.V1291892","article-title":"Increased tyrosine nitration of the brain in chronic renal insufficiency: Reversal by antioxidant therapy and angiotensin-converting enzyme inhibition","volume":"12","author":"Deng","year":"2001","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"43107","DOI":"10.1038\/srep43107","article-title":"Renin-angiotensin system acting on reactive oxygen species in paraventricular nucleus induces sympathetic activation via AT1R\/PKC\u03b3\/Rac1 pathway in salt-induced hypertension","volume":"7","author":"Su","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"18300","DOI":"10.1038\/srep18300","article-title":"Attrition of Hepatic Damage Inflicted by Angiotensin II with alpha-Tocopherol and beta-Carotene in Experimental Apolipoprotein E Knock-out Mice","volume":"5","author":"Gopal","year":"2015","journal-title":"Sci. Rep."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"971","DOI":"10.2147\/VHRM.S3215","article-title":"The renin angiotensin system in the development of cardiovascular disease: Role of aliskiren in risk reduction","volume":"4","author":"Verdecchia","year":"2008","journal-title":"Vasc. Health Risk Manag."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1161\/HYPERTENSIONAHA.111.173534","article-title":"Attenuation of brain damage and cognitive impairment by direct renin inhibition in mice with chronic cerebral hypoperfusion","volume":"58","author":"Dong","year":"2011","journal-title":"Hypertension"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.neuint.2012.05.012","article-title":"Renin inhibitor aliskiren exerts neuroprotection against amyloid beta-peptide toxicity in rat cortical neurons","volume":"61","author":"Chen","year":"2012","journal-title":"Neurochem. Int."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1007\/s11481-016-9703-8","article-title":"Angiotensin Converting Enzyme Inhibitors Ameliorate Brain Inflammation Associated with Microglial Activation: Possible Implications for Alzheimer\u2019s Disease","volume":"11","author":"Torika","year":"2016","journal-title":"J. Neuroimmune Pharmacol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"a028936","DOI":"10.1101\/cshperspect.a028936","article-title":"Multiple Sclerosis Pathology","volume":"Volume 8","author":"Weiner","year":"2018","journal-title":"Cold Spring Harbor Perspectives in Medicine"},{"key":"ref_100","doi-asserted-by":"crossref","unstructured":"Hussain, R., Zubair, H., Pursell, S., and Shahab, M. (2018). Neurodegenerative Diseases: Regenerative Mechanisms and Novel Therapeutic Approaches. Brain Sci., 8.","DOI":"10.3390\/brainsci8090177"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.jns.2005.03.002","article-title":"Cannabinoids and neuroprotection in CNS inflammatory disease","volume":"233","author":"Jackson","year":"2005","journal-title":"J. Neurol. Sci."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1016\/j.amjmed.2020.05.049","article-title":"Treatment of Multiple Sclerosis: A Review","volume":"133","author":"Hauser","year":"2020","journal-title":"Am. J. Med."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1097\/WCO.0000000000000206","article-title":"Classification, diagnosis, and differential diagnosis of multiple sclerosis","volume":"28","year":"2015","journal-title":"Curr. Opin. Neurol."},{"key":"ref_104","first-page":"1003","article-title":"Neuroinflammation Induces Neurodegeneration","volume":"1","author":"Kempuraj","year":"2016","journal-title":"J. Neurol. Neurosurg. Spine"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1126\/science.aaf6260","article-title":"Inflammatory neuroprotection following traumatic brain injury","volume":"353","author":"Russo","year":"2016","journal-title":"Science"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1084\/jem.194.5.669","article-title":"A Pathogenic Role for Myelin-specific CD8+ T Cells in a Model for Multiple Sclerosis","volume":"194","author":"Huseby","year":"2001","journal-title":"J. Exp. Med."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/j.bbi.2010.01.014","article-title":"Infiltration of Th1 and Th17 cells and activation of microglia in the CNS during the course of experimental autoimmune encephalomyelitis","volume":"24","author":"Murphy","year":"2010","journal-title":"Brain Behav. Immun."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/j.autrev.2016.07.008","article-title":"B cells and antibodies in progressive multiple sclerosis: Contribution to neurodegeneration and progression","volume":"15","author":"Fraussen","year":"2016","journal-title":"Autoimmun. Rev."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1038\/s41582-022-00624-x","article-title":"The role of glial cells in multiple sclerosis disease progression","volume":"18","author":"Healy","year":"2022","journal-title":"Nat. Rev. Neurol."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"180","DOI":"10.3389\/fneur.2015.00180","article-title":"The Role of Astrocytes in Multiple Sclerosis Progression","volume":"6","author":"Correale","year":"2015","journal-title":"Front. Neurol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"H404","DOI":"10.1152\/ajpheart.00247.2015","article-title":"Cross talk between AT1 receptors and Toll-like receptor 4 in microglia contributes to angiotensin II-derived ROS production in the hypothalamic paraventricular nucleus","volume":"310","author":"Biancardi","year":"2016","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/1750-1326-9-49","article-title":"Increase of angiotensin II type 1 receptor auto-antibodies in Huntington\u2019s disease","volume":"9","author":"Lee","year":"2014","journal-title":"Mol. Neurodegener."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1111\/cei.12467","article-title":"Angiotensin II in inflammation, immunity and rheumatoid arthritis","volume":"179","author":"Chang","year":"2015","journal-title":"Clin. Exp. Immunol."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1161\/01.HYP.0000075082.06183.4E","article-title":"Imbalance of T-cell subsets in angiotensin II-infused hypertensive rats with kidney injury","volume":"42","author":"Shao","year":"2003","journal-title":"Hypertension"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1177\/1352458507085760","article-title":"Reduction of angiotensin II in the cerebrospinal fluid of patients with multiple sclerosis","volume":"14","author":"Kawajiri","year":"2008","journal-title":"Mult. Scler. J."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1177\/1352458508097923","article-title":"Angiotensin-converting enzyme (ACE) and ACE2 levels in the cerebrospinal fluid of patients with multiple sclerosis","volume":"15","author":"Kawajiri","year":"2009","journal-title":"Mult. Scler."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.jneuroim.2018.07.001","article-title":"Age-adjusted CSF \u03b22-microglobulin and lactate are increased and ACE is decreased in patients with multiple sclerosis, but only lactate correlates with clinical disease duration and severity","volume":"323","author":"Haarmann","year":"2018","journal-title":"J. Neuroimmunol."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"471","DOI":"10.3109\/08923979509016382","article-title":"Effects Of The Angiotensin Converting Enzyme Inhibitor Captopril On Experimental Autoimmune Encephalomyelitis","volume":"17","author":"Constantinescu","year":"1995","journal-title":"Immunopharmacol. Immunotoxicol."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1016\/j.jprot.2010.01.004","article-title":"Multiple sclerosis: Identification and clinical evaluation of novel CSF biomarkers","volume":"73","author":"Ottervald","year":"2010","journal-title":"J. Proteom."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1007\/s11062-019-09760-5","article-title":"Serum Angiotensin-Converting Enzyme in Patients Suffering from Multiple Sclerosis and Healthy Controls: A Pilot Study","volume":"50","author":"Razazian","year":"2019","journal-title":"Neurophysiology"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"14948","DOI":"10.1073\/pnas.0903958106","article-title":"Blocking angiotensin-converting enzyme induces potent regulatory T cells and modulates TH1- and TH17-mediated autoimmunity","volume":"106","author":"Platten","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"2782","DOI":"10.1172\/JCI41709","article-title":"Angiotensin II sustains brain inflammation in mice via TGF-\u03b2","volume":"120","author":"Lanz","year":"2010","journal-title":"J. Clin. Investig."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"3306","DOI":"10.1172\/JCI31763","article-title":"Glia-dependent TGF-beta signaling, acting independently of the TH17 pathway, is critical for initiation of murine autoimmune encephalomyelitis","volume":"117","author":"Luo","year":"2007","journal-title":"J. Clin. Investig."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"195","DOI":"10.2147\/EB.S54131","article-title":"Optic neuritis as an early sign of multiple sclerosis","volume":"8","author":"Kale","year":"2016","journal-title":"Eye Brain"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"2876","DOI":"10.1016\/j.ajpath.2017.08.012","article-title":"The Renin-Angiotensin System Regulates Neurodegeneration in a Mouse Model of Optic Neuritis","volume":"187","author":"Guo","year":"2017","journal-title":"Am. J. Pathol."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1111\/j.1471-4159.2009.05999.x","article-title":"The inflammatory response in the MPTP model of Parkinson\u2019s disease is mediated by brain angiotensin: Relevance to progression of the disease","volume":"109","author":"Joglar","year":"2009","journal-title":"J. Neurochem."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.pbb.2015.04.002","article-title":"Hypertension exacerbates predisposition to neurodegeneration and memory impairment in the presence of a neuroinflammatory stimulus: Protection by angiotensin converting enzyme inhibition","volume":"133","author":"Goel","year":"2015","journal-title":"Pharmacol. Biochem. Behav."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1179\/016164103101201382","article-title":"Temocapril prevents motor neuron damage and upregulation of cyclooxygenase-II in glutamate-induced neurotoxicity","volume":"25","author":"Iwasaki","year":"2003","journal-title":"Neurol. Res."},{"key":"ref_129","first-page":"367","article-title":"Neuroprotective effect of ACE inhibitors in glutamate\u2014induced neurotoxicity: Rat neuron culture study","volume":"21","author":"Sengul","year":"2011","journal-title":"Turk. Neurosurg."},{"key":"ref_130","doi-asserted-by":"crossref","unstructured":"Goniotaki, D., Lakkaraju, A.K.K., Shrivastava, A.N., Bakirci, P., Sorce, S., Senatore, A., Marpakwar, R., Hornemann, S., Gasparini, F., and Triller, A. (2017). Inhibition of group-I metabotropic glutamate receptors protects against prion toxicity. PLoS Pathog., 13.","DOI":"10.1371\/journal.ppat.1006733"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1002\/sctm.16-0382","article-title":"Angiotensin II Causes Apoptosis of Adult Hippocampal Neural Stem Cells and Memory Impairment Through the Action on AMPK-PGC1alpha Signaling in Heart Failure","volume":"6","author":"Kim","year":"2017","journal-title":"Stem Cells Transl. Med."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"117108","DOI":"10.1016\/j.lfs.2019.117108","article-title":"Telmisartan inhibits oxalate and calcium oxalate crystal-induced epithelial-mesenchymal transformation via PPAR-\u03b3-AKT\/STAT3\/p38 MAPK-Snail pathway","volume":"241","author":"Liu","year":"2020","journal-title":"Life Sci."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"795","DOI":"10.2741\/4517","article-title":"Role of JNK isoforms in the kainic acid experimental model of epilepsy and neurodegeneration","volume":"22","author":"Auladell","year":"2017","journal-title":"Front. Biosci."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1038\/icb.2009.100","article-title":"PPAR-gamma agonist inhibits Ang II-induced activation of dendritic cells via the MAPK and NF-kappaB pathways","volume":"88","author":"Hui","year":"2010","journal-title":"Immunol. Cell Biol."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.neuropharm.2006.03.004","article-title":"Reduction of dopaminergic degeneration and oxidative stress by inhibition of angiotensin converting enzyme in a MPTP model of parkinsonism","volume":"51","author":"Rey","year":"2006","journal-title":"Neuropharmacology"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1750-1326-2-1","article-title":"Angiotensin type 1 receptor antagonist losartan, reduces MPTP-induced degeneration of dopaminergic neurons in substantia nigra","volume":"2","author":"Grammatopoulos","year":"2007","journal-title":"Mol. Neurodegener."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"15005","DOI":"10.1038\/nrdp.2015.5","article-title":"Huntington disease","volume":"1","author":"Bates","year":"2015","journal-title":"Nat. Reviews. Dis. Primers"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1016\/j.neuron.2016.02.003","article-title":"The Biology of Huntingtin","volume":"89","author":"Saudou","year":"2016","journal-title":"Neuron"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"201","DOI":"10.3233\/JHD-180290","article-title":"Cancer: From Wild-Type to Mutant Huntingtin","volume":"7","author":"Thion","year":"2018","journal-title":"J. Huntingt. Dis."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"aww165","DOI":"10.1093\/brain\/aww165","article-title":"George Huntington: A legacy of inquiry, empathy and hope","volume":"139","author":"Wexler","year":"2016","journal-title":"Brain"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"329","DOI":"10.3389\/fnmol.2018.00329","article-title":"A Mitochondria-Associated Oxidative Stress Perspective on Huntington\u2019s Disease","volume":"11","author":"Zheng","year":"2018","journal-title":"Front. Mol. Neurosci."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/978-3-319-71779-1_3","article-title":"Mitochondrial Dysfunction in Huntington\u2019s Disease","volume":"1049","author":"Carmo","year":"2018","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1155\/2013\/408362","article-title":"The role of dopamine and glutamate modulation in Huntington disease","volume":"26","author":"Mittal","year":"2013","journal-title":"Behav. Neurol."},{"key":"ref_144","unstructured":"Ajitkumar, A., and De Jesus, O. (2022). Huntington Disease. StatPearls, StatPearls Publishing."},{"key":"ref_145","unstructured":"Adam, M.P., Mirzaa, G.M., Pagon, R.A., Wallace, S.E., Bean, L.J.H., Gripp, K.W., and Amemiya, A. (1993). Huntington Disease. GeneReviews(\u00ae), University of Washington, Seattle."},{"key":"ref_146","first-page":"376","article-title":"Huntington\u2019s disease: Managing neuropsychiatric symptoms in Huntington\u2019s disease","volume":"26","author":"Loi","year":"2018","journal-title":"Australas. Psychiatry Bull. R. Aust. N. Z. Coll. Psychiatr."},{"key":"ref_147","unstructured":"Merical, B., and S\u00e1nchez-Manso, J.C. (2022). Chorea. StatPearls, StatPearls Publishing."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"594945","DOI":"10.3389\/fnins.2020.594945","article-title":"Peripheral Levels of Renin-Angiotensin System Components Are Associated With Cognitive Performance in Huntington\u2019s Disease","volume":"14","author":"Rocha","year":"2020","journal-title":"Front. Neurosci."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1177\/1470320313515038","article-title":"Beneficial effect of candesartan and lisinopril against haloperidol-induced tardive dyskinesia in rat","volume":"16","author":"Thakur","year":"2015","journal-title":"J. Renin Angiotensin Aldosterone Syst."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.pnpbp.2012.12.009","article-title":"Inhibition of central angiotensin II enhances memory function and reduces oxidative stress status in rat hippocampus","volume":"43","author":"Bild","year":"2013","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"109","DOI":"10.2478\/v10011-011-0009-3","article-title":"Inhibition of central angiotensin converting enzyme exerts anxiolytic effects by decreasing brain oxidative stress","volume":"30","author":"Ciobica","year":"2011","journal-title":"J. Med. Biochem."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.neuro.2014.10.004","article-title":"Potential of protease inhibitor in 3-nitropropionic acid induced Huntington\u2019s disease like symptoms: Mitochondrial dysfunction and neurodegeneration","volume":"45","author":"Hariharan","year":"2014","journal-title":"Neurotoxicology"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"456","DOI":"10.2174\/0929866527666200110154523","article-title":"The Renin-Angiotensin System in Huntington\u2019s Disease: Villain or Hero?","volume":"27","author":"Machado","year":"2020","journal-title":"Protein Pept. Lett."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"33861","DOI":"10.1038\/srep33861","article-title":"Identification of hepta-histidine as a candidate drug for Huntington\u2019s disease by in silico-in vitro- in vivo-integrated screens of chemical libraries","volume":"6","author":"Imamura","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1002\/mds.27976","article-title":"Hypertension, Antihypertensive Use and the Delayed-Onset of Huntington\u2019s Disease","volume":"35","author":"Steventon","year":"2020","journal-title":"Mov. Disord. Off. J. Mov. Disord. Soc."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1177\/003693300004500102","article-title":"Motor neuron disease\u2014A review","volume":"45","author":"Pritchard","year":"2000","journal-title":"Scott. Med. J."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"493","DOI":"10.3109\/17482968.2012.656652","article-title":"A systematic review of behavioural changes in motor neuron disease","volume":"13","author":"Raaphorst","year":"2012","journal-title":"Amyotroph. Lateral Scler."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1007\/BF02940251","article-title":"Motor neuron disease: Etiology, pathogenesis and treatment\u2014A review","volume":"165","author":"Donohoe","year":"1996","journal-title":"Ir. J. Med. Sci."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1111\/j.1600-0404.2008.01099.x","article-title":"Reduced angiotensin II levels in the cerebrospinal fluid of patients with amyotrophic lateral sclerosis","volume":"119","author":"Kawajiri","year":"2009","journal-title":"Acta Neurol. Scand."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1001\/jamaneurol.2014.3367","article-title":"Angiotensin-converting enzyme inhibitors and amyotrophic lateral sclerosis risk: A total population-based case-control study","volume":"72","author":"Lin","year":"2015","journal-title":"JAMA Neurol."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1212\/01.WNL.0000140705.23869.E9","article-title":"Effects of brain-penetrating ACE inhibitors on Alzheimer disease progression","volume":"63","author":"Ohrui","year":"2004","journal-title":"Neurology"},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1111\/j.1532-5415.2004.52178_7.x","article-title":"Angiotensin-converting enzyme inhibitors and incidence of Alzheimer\u2019s disease in Japan","volume":"52","author":"Ohrui","year":"2004","journal-title":"J. Am. Geriatr. Soc."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"e002881","DOI":"10.1136\/bmjopen-2013-002881","article-title":"Effects of centrally acting ACE inhibitors on the rate of cognitive decline in dementia","volume":"3","author":"Gao","year":"2013","journal-title":"BMJ Open"},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"16917","DOI":"10.3390\/ijms140816917","article-title":"ACE inhibition with captopril retards the development of signs of neurodegeneration in an animal model of Alzheimer\u2019s disease","volume":"14","author":"AbdAlla","year":"2013","journal-title":"Int. J. Mol. Sci."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1111\/j.1445-5994.2000.tb01054.x","article-title":"The angiotensin converting enzyme (ACE) inhibitor, perindopril, modifies the clinical features of Parkinson\u2019s disease","volume":"30","author":"Reardon","year":"2000","journal-title":"Aust. N. Z. J. Med."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"22082","DOI":"10.1038\/s41598-020-79096-2","article-title":"Chronically infused angiotensin II induces depressive-like behavior via microglia activation","volume":"10","author":"Park","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"107902","DOI":"10.1016\/j.exer.2019.107902","article-title":"Angiotensin II and aldosterone activate retinal microglia","volume":"191","author":"Rana","year":"2020","journal-title":"Exp. Eye Res."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1002\/clc.20324","article-title":"A comparison of the aldosterone-blocking agents eplerenone and spironolactone","volume":"31","author":"Struthers","year":"2008","journal-title":"Clin. Cardiol."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1038\/hr.2011.38","article-title":"Angiotensin II and aldosterone-induced neuronal damage in neurons through an astrocyte-dependent mechanism","volume":"34","author":"Min","year":"2011","journal-title":"Hypertens. Res."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1007\/s12035-017-0450-5","article-title":"Angiotensin II Receptor Blockers Attenuate Lipopolysaccharide-Induced Memory Impairment by Modulation of NF-\u03baB-Mediated BDNF\/CREB Expression and Apoptosis in Spontaneously Hypertensive Rats","volume":"55","author":"Goel","year":"2018","journal-title":"Mol. Neurobiol."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-1-4939-7571-6_1","article-title":"Neurotrophic Factors: An Overview","volume":"1727","author":"Skaper","year":"2018","journal-title":"Methods Mol. Biol."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1007\/s12035-015-9675-3","article-title":"Brain-Derived Neurotrophic Factor Knockdown Blocks the Angiogenic and Protective Effects of Angiotensin Modulation After Experimental Stroke","volume":"54","author":"Fouda","year":"2017","journal-title":"Mol. Neurobiol."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1139\/Y11-011","article-title":"Regulation of L-type inward calcium channel activity by captopril and angiotensin II via the phosphatidyl inositol 3-kinase pathway in cardiomyocytes from volume-overload hypertrophied rat hearts","volume":"89","author":"Alvin","year":"2011","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"4192","DOI":"10.1007\/s12035-018-1370-8","article-title":"Inhibition of Autophagy by Captopril Attenuates Prion Peptide-Mediated Neuronal Apoptosis via AMPK Activation","volume":"56","author":"Moon","year":"2019","journal-title":"Mol. Neurobiol."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1179\/016164102101200357","article-title":"Trophic effect of olmesartan, a novel AT1R antagonist, on spinal motor neurons in vitro and in vivo","volume":"24","author":"Iwasaki","year":"2002","journal-title":"Neurol. Res."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1023\/A:1023768811842","article-title":"c-Met: Structure, functions and potential for therapeutic inhibition","volume":"22","author":"Ma","year":"2003","journal-title":"Cancer Metastasis Rev."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"48623","DOI":"10.1074\/jbc.C100512200","article-title":"Evidence that the angiotensin IV (AT(4)) receptor is the enzyme insulin-regulated aminopeptidase","volume":"276","author":"Albiston","year":"2001","journal-title":"J. Biol. Chem."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1111\/j.1476-5381.2011.01402.x","article-title":"Identification and development of specific inhibitors for insulin-regulated aminopeptidase as a new class of cognitive enhancers","volume":"164","author":"Albiston","year":"2011","journal-title":"Br. J. Pharmacol."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"385","DOI":"10.3109\/21678421.2016.1143515","article-title":"Angiotensin-converting enzyme inhibitors and motor neuron disease: An unconfirmed association","volume":"17","author":"Franchi","year":"2016","journal-title":"Amyotroph. Lateral Scler. Front. Degener."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1080\/21678421.2019.1682613","article-title":"Identifying potential targets for prevention and treatment of amyotrophic lateral sclerosis based on a screen of medicare prescription drugs","volume":"21","author":"Pfeiffer","year":"2020","journal-title":"Amyotroph. Lateral Scler. Front. Degener."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1186\/s13023-016-0531-y","article-title":"Gene expression profiles and protein-protein interaction networks in amyotrophic lateral sclerosis patients with C9orf72 mutation","volume":"11","author":"Kotni","year":"2016","journal-title":"Orphanet J. Rare Dis."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1093\/bib\/bbaa285","article-title":"Bioinformatic analysis of SMN1-ACE\/ACE2 interactions hinted at a potential protective effect of spinal muscular atrophy against COVID-19-induced lung injury","volume":"22","author":"Li","year":"2021","journal-title":"Brief. Bioinform."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1016\/j.yjmcc.2012.01.005","article-title":"Partial restoration of cardio-vascular defects in a rescued severe model of spinal muscular atrophy","volume":"52","author":"Shababi","year":"2012","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1126\/science.6801762","article-title":"Novel proteinaceous infectious particles cause scrapie","volume":"216","author":"Prusiner","year":"1982","journal-title":"Science"},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/S0140-6736(82)90519-0","article-title":"Research on scrapie","volume":"2","author":"Prusiner","year":"1982","journal-title":"Lancet"},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1096\/fasebj.2018.32.1_supplement.794.8","article-title":"PrPc: The Normal Prion","volume":"32","author":"Wright","year":"2018","journal-title":"FASEB J."},{"key":"ref_187","doi-asserted-by":"crossref","unstructured":"Miranzadeh Mahabadi, H., and Taghibiglou, C. (2020). Cellular Prion Protein (PrPc): Putative Interacting Partners and Consequences of the Interaction. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21197058"},{"key":"ref_188","first-page":"741","article-title":"Functions of prion protein PrPc","volume":"23","author":"Cazaubon","year":"2007","journal-title":"Med. Sci."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"19","DOI":"10.3389\/fmolb.2017.00019","article-title":"Physiological Functions of the Cellular Prion Protein","volume":"4","author":"Castle","year":"2017","journal-title":"Front. Mol. Biosci."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"36542","DOI":"10.1074\/jbc.M110.157263","article-title":"Role of alpha7 nicotinic acetylcholine receptor in calcium signaling induced by prion protein interaction with stress-inducible protein 1","volume":"285","author":"Beraldo","year":"2010","journal-title":"J. Biol. Chem."},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/s13024-019-0329-1","article-title":"Alpha-synuclein structure and Parkinson\u2019s disease\u2014lessons and emerging principles","volume":"14","author":"Meade","year":"2019","journal-title":"Mol. Neurodegener."},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1038\/42166","article-title":"Alpha-synuclein in Lewy bodies","volume":"388","author":"Spillantini","year":"1997","journal-title":"Nature"},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.tcb.2015.08.007","article-title":"Cell Biology of Prions and Prionoids: A Status Report","volume":"26","author":"Aguzzi","year":"2016","journal-title":"Trends Cell Biol."},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1038\/s41582-020-0333-7","article-title":"Protein transmission in neurodegenerative disease","volume":"16","author":"Peng","year":"2020","journal-title":"Nat. Reviews. Neurol."},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"2635","DOI":"10.1084\/jem.20160833","article-title":"Unique pathological tau conformers from Alzheimer\u2019s brains transmit tau pathology in nontransgenic mice","volume":"213","author":"Guo","year":"2016","journal-title":"J. Exp. Med."},{"key":"ref_196","first-page":"510","article-title":"Rapidly Progressive Dementia","volume":"22","author":"Geschwind","year":"2016","journal-title":"Continuum"},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1093\/bmb\/66.1.267","article-title":"Diagnosis of prion diseases","volume":"66","author":"Kubler","year":"2003","journal-title":"Br. Med. Bull."},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"169","DOI":"10.4103\/0972-2327.179979","article-title":"Prions, prion-like prionoids, and neurodegenerative disorders","volume":"19","author":"Verma","year":"2016","journal-title":"Ann. Indian Acad. Neurol."},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"e2009579118","DOI":"10.1073\/pnas.2009579118","article-title":"Inhibition of neuroinflammatory nitric oxide signaling suppresses glycation and prevents neuronal dysfunction in mouse prion disease","volume":"118","author":"Bourgognon","year":"2021","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1134\/S0026893318040106","article-title":"Enalaprilat Inhibits Zinc-Dependent Oligomerization of Metal-Binding Domain of Amyloid-beta Isoforms and Protects Human Neuroblastoma Cells from Toxic Action of these Isoforms","volume":"52","author":"Kozin","year":"2018","journal-title":"Mol. Biol."},{"key":"ref_201","first-page":"415","article-title":"L-AP4, a potent agonist of group III metabotropic glutamate receptor, decreases central action of angiotensin II","volume":"54","author":"Holy","year":"2002","journal-title":"Pol. J. Pharmacol."},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.brainresbull.2021.06.002","article-title":"Angiotensin II induces cognitive decline and anxiety-like behavior via disturbing pattern of theta-gamma oscillations","volume":"174","author":"Gao","year":"2021","journal-title":"Brain Res. Bull."},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1161\/HYPERTENSIONAHA.121.17049","article-title":"Blood-Brain Barrier Crossing Renin-Angiotensin Drugs and Cognition in the Elderly: A Meta-Analysis","volume":"78","author":"Ho","year":"2021","journal-title":"Hypertension"},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"469","DOI":"10.3233\/JAD-181035","article-title":"Contributions by the Brain Renin-Angiotensin System to Memory, Cognition, and Alzheimer\u2019s Disease","volume":"67","author":"Wright","year":"2019","journal-title":"J. Alzheimers Dis."},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"226","DOI":"10.2165\/00002512-199507030-00007","article-title":"Captopril. A review of its pharmacology and therapeutic efficacy after myocardial infarction and in ischaemic heart disease","volume":"7","author":"Plosker","year":"1995","journal-title":"Drugs Aging"},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.expneurol.2013.10.014","article-title":"The angiotensin converting enzyme inhibitor captopril protects nigrostriatal dopamine neurons in animal models of parkinsonism","volume":"250","author":"Sonsalla","year":"2013","journal-title":"Exp. Neurol."},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.vph.2017.08.004","article-title":"Cerebrovascular recovery after stroke with individual and combined losartan and captopril treatment of SHRsp","volume":"96\u201398","author":"Smeda","year":"2017","journal-title":"Vascul. Pharmacol."},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"399","DOI":"10.3233\/JAD-220105","article-title":"COVID-19 and Neurodegenerative Diseases: Prion-Like Spread and Long-Term Consequences","volume":"88","author":"Baazaoui","year":"2022","journal-title":"J. Alzheimers Dis."},{"key":"ref_209","doi-asserted-by":"crossref","unstructured":"Khazaal, S., Harb, J., Rima, M., Annweiler, C., Wu, Y., Cao, Z., Abi Khattar, Z., Legros, C., Kovacic, H., and Fajloun, Z. (2022). The Pathophysiology of Long COVID throughout the Renin-Angiotensin System. Molecules, 27.","DOI":"10.3390\/molecules27092903"},{"key":"ref_210","doi-asserted-by":"crossref","unstructured":"Mungmungpuntipantip, R., and Wiwanitkit, V. (2022). Regarding Oculomotor Palsy After the Administration of the Messenger RNA-1273 Vaccine for SARS-CoV-2: Diplopia After the COVID-19 Vaccine. J. Neuroophthalmol., 1097.","DOI":"10.1097\/WNO.0000000000001558"},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"17024","DOI":"10.1021\/acsomega.2c00154","article-title":"Biophysical Insight into the SARS-CoV2 Spike-ACE2 Interaction and Its Modulation by Hepcidin through a Multifaceted Computational Approach","volume":"7","author":"Hu","year":"2022","journal-title":"ACS Omega"},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1186\/s13195-020-00640-3","article-title":"Immediate and long-term consequences of COVID-19 infections for the development of neurological disease","volume":"12","author":"Heneka","year":"2020","journal-title":"Alzheimers Res. Ther."},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"120061","DOI":"10.1016\/j.jns.2021.120061","article-title":"Neurologic and cognitive sequelae after SARS-CoV2 infection: Different impairment for ICU patients","volume":"432","author":"Mattioli","year":"2022","journal-title":"J. Neurol. Sci."},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1681\/ASN.2020050667","article-title":"Kidney and Lung ACE2 Expression after an ACE Inhibitor or an Ang II Receptor Blocker: Implications for COVID-19","volume":"31","author":"Wysocki","year":"2020","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_215","doi-asserted-by":"crossref","unstructured":"Chandra, A., and Johri, A. (2022). A Peek into Pandora\u2019s Box: COVID-19 and Neurodegeneration. Brain Sci., 12.","DOI":"10.3390\/brainsci12020190"},{"key":"ref_216","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1007\/s13238-022-00905-7","article-title":"SARS-CoV-2 impairs the disassembly of stress granules and promotes ALS-associated amyloid aggregation","volume":"13","author":"Li","year":"2022","journal-title":"Protein Cell"},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"3333","DOI":"10.2174\/0929867325666180226102358","article-title":"RAS in the Central Nervous System: Potential Role in Neuropsychiatric Disorders","volume":"25","author":"Rocha","year":"2018","journal-title":"Curr. Med. Chem."},{"key":"ref_218","doi-asserted-by":"crossref","first-page":"1470320316666750","DOI":"10.1177\/1470320316666750","article-title":"Renin\u2013angiotensin system gene expression and neurodegenerative diseases","volume":"17","author":"Goldstein","year":"2016","journal-title":"J. Renin-Angiotensin-Aldosterone Syst."},{"key":"ref_219","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1023\/A:1015823315983","article-title":"Relative lipophilicities and structural-pharmacological considerations of various angiotensin-converting enzyme (ACE) inhibitors","volume":"9","author":"Ranadive","year":"1992","journal-title":"Pharm. Res."},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.amjhyper.2004.09.004","article-title":"Inhibition of brain angiotensin-converting enzyme by peripheral administration of trandolapril versus lisinopril in Wistar rats","volume":"18","author":"Tan","year":"2005","journal-title":"Am. J. Hypertens."},{"key":"ref_221","first-page":"44","article-title":"Physicochemical and enzyme binding kinetic properties of a new angiotensin-converting enzyme inhibitor ramipril and their clinical implications","volume":"8","author":"Bender","year":"1990","journal-title":"Clin. Physiol. Biochem."},{"key":"ref_222","doi-asserted-by":"crossref","first-page":"S321","DOI":"10.3233\/JAD-132189","article-title":"Brain-penetrating angiotensin-converting enzyme inhibitors and cognitive change in patients with dementia due to Alzheimer\u2019s disease","volume":"42","author":"Bertolucci","year":"2014","journal-title":"J. Alzheimers Dis."},{"key":"ref_223","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/s13195-021-00778-8","article-title":"The use of angiotensin-converting enzyme inhibitors vs. angiotensin receptor blockers and cognitive decline in Alzheimer\u2019s disease: The importance of blood-brain barrier penetration and APOE \u03b54 carrier status","volume":"13","author":"Ouk","year":"2021","journal-title":"Alzheimers Res. Ther."},{"key":"ref_224","doi-asserted-by":"crossref","first-page":"1678","DOI":"10.1007\/s13311-021-01064-z","article-title":"Drug Repurposing: A Network-based Approach to Amyotrophic Lateral Sclerosis","volume":"18","author":"Fiscon","year":"2021","journal-title":"Neurother. J. Am. Soc. Exp. NeuroTherapeutics"},{"key":"ref_225","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.tips.2019.06.003","article-title":"Insights into Computational Drug Repurposing for Neurodegenerative Disease","volume":"40","author":"Paranjpe","year":"2019","journal-title":"Trends Pharmacol. Sci."},{"key":"ref_226","doi-asserted-by":"crossref","first-page":"104841","DOI":"10.1016\/j.neuint.2020.104841","article-title":"Protective role of anticancer drugs in neurodegenerative disorders: A drug repurposing approach","volume":"140","author":"Advani","year":"2020","journal-title":"Neurochem. Int."},{"key":"ref_227","doi-asserted-by":"crossref","first-page":"100022","DOI":"10.1016\/j.crphar.2021.100022","article-title":"Gauging the role and impact of drug interactions and repurposing in neurodegenerative disorders","volume":"2","author":"Khatri","year":"2021","journal-title":"Curr. Res. Pharmacol. Drug Discov."},{"key":"ref_228","doi-asserted-by":"crossref","first-page":"1994","DOI":"10.1016\/j.drudis.2022.04.003","article-title":"Repurposing small-molecule drugs for modulating toxic protein aggregates in neurodegenerative diseases","volume":"27","author":"Liu","year":"2022","journal-title":"Drug Discov. Today"},{"key":"ref_229","unstructured":"Roy, K. (2019). Chapter 4\u2014Computational Drug Repurposing for Neurodegenerative Diseases. Silico Drug Design, Academic Press."},{"key":"ref_230","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.18632\/aging.101249","article-title":"Repurposing ARBs as treatments for breast cancer","volume":"9","author":"George","year":"2017","journal-title":"Aging"},{"key":"ref_231","doi-asserted-by":"crossref","first-page":"113895","DOI":"10.1016\/j.bcp.2020.113895","article-title":"Repurposing of drugs approved for cardiovascular diseases: Opportunity or mirage?","volume":"177","author":"Gelosa","year":"2020","journal-title":"Biochem. Pharmacol."},{"key":"ref_232","doi-asserted-by":"crossref","first-page":"51","DOI":"10.3897\/pharmacia.69.e72548","article-title":"Repurposing\u2014Second life for drugs","volume":"69","author":"Ayyar","year":"2022","journal-title":"Pharmacia"},{"key":"ref_233","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1186\/s12967-016-1031-5","article-title":"Repurposing of approved cardiovascular drugs","volume":"14","author":"Ishida","year":"2016","journal-title":"J. Transl. Med."},{"key":"ref_234","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.brainresbull.2014.11.003","article-title":"Medical genetics-based drug repurposing for Alzheimer\u2019s disease","volume":"110","author":"Zhang","year":"2015","journal-title":"Brain Res. Bull."},{"key":"ref_235","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1093\/ajh\/hpu197","article-title":"Neuroprotective effects of angiotensin receptor blockers","volume":"28","author":"Villapol","year":"2015","journal-title":"Am. J. Hypertens."}],"container-title":["Biomolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2218-273X\/12\/10\/1429\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:47:07Z","timestamp":1760143627000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2218-273X\/12\/10\/1429"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,6]]},"references-count":235,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2022,10]]}},"alternative-id":["biom12101429"],"URL":"https:\/\/doi.org\/10.3390\/biom12101429","relation":{},"ISSN":["2218-273X"],"issn-type":[{"value":"2218-273X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,6]]}}}