{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T04:08:18Z","timestamp":1790654898537,"version":"4.1.0"},"reference-count":115,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2022,10,10]],"date-time":"2022-10-10T00:00:00Z","timestamp":1665360000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"ITMO Fellowship Professorship Program and Goszadanie","award":["2019-1075"],"award-info":[{"award-number":["2019-1075"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>Alzheimer\u2019s disease (AD) is considered a chronic and debilitating neurological illness that is increasingly impacting older-age populations. Some proteins, including clusterin (CLU or apolipoprotein J) transporter, can be linked to AD, causing oxidative stress. Therefore, its activity can affect various functions involving complement system inactivation, lipid transport, chaperone activity, neuronal transmission, and cellular survival pathways. This transporter is known to bind to the amyloid beta (A\u03b2) peptide, which is the major pathogenic factor of AD. On the other hand, this transporter is also active at the blood\u2013brain barrier (BBB), a barrier that prevents harmful substances from entering and exiting the brain. Therefore, in this review, we discuss and emphasize the role of the CLU transporter and CLU-linked molecular mechanisms at the BBB interface in the pathogenesis of AD.<\/jats:p>","DOI":"10.3390\/biom12101452","type":"journal-article","created":{"date-parts":[[2022,10,10]],"date-time":"2022-10-10T21:07:11Z","timestamp":1665436031000},"page":"1452","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["The Role of Clusterin Transporter in the Pathogenesis of Alzheimer\u2019s Disease at the Blood\u2013Brain Barrier Interface: A Systematic Review"],"prefix":"10.3390","volume":"12","author":[{"given":"Muhammad Mazhar","family":"Fareed","sequence":"first","affiliation":[{"name":"Department of Computer Science, School of Science and Engineering, Universit\u00e0 Degli Studi di Verona, Via dell\u2019Artigliere, 8, 37129 Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Qasmi","sequence":"additional","affiliation":[{"name":"Department of Bioinformatics and Biotechnology, Faculty of Life Sciences, Government College University, Faisalabad 38000, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaan","family":"Aziz","sequence":"additional","affiliation":[{"name":"Department of Bioinformatics and Biotechnology, Faculty of Life Sciences, Government College University, Faisalabad 38000, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"V\u00f6lker","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Intensive Care, Emergency and Pain Medicine, W\u00fcrzburg University Hospital, 97070 W\u00fcrzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3878-247X","authenticated-orcid":false,"given":"Carola Yvette","family":"F\u00f6rster","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Intensive Care, Emergency and Pain Medicine, W\u00fcrzburg University Hospital, 97070 W\u00fcrzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6953-9771","authenticated-orcid":false,"given":"Sergey","family":"Shityakov","sequence":"additional","affiliation":[{"name":"Laboratory of Chemoinformatics, Infochemistry Scientific Center, ITMO University, 195251 Saint-Petersburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/j.ncl.2007.03.009","article-title":"Genetics of Alzheimer\u2019s disease: A centennial review","volume":"25","year":"2007","journal-title":"Neurol. 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