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The formation of PAs can induce a variety of clinical diseases. However, there is currently no effective strategy for the prevention and treatment of PAs. Damage to peritoneal mesothelial cells (PMCs) is believed to cause PAs by promoting inflammation, fibrin deposition, and fibrosis formation. In the early stages of PA formation, PMCs undergo mesothelial\u2013mesenchymal transition and have the ability to produce an extracellular matrix. The PMCs may transdifferentiate into myofibroblasts and accelerate the formation of PAs. Therefore, the aim of this review was to understand the mechanism of action of PMCs in PAs, and to offer a theoretical foundation for the treatment and prevention of PAs.<\/jats:p>","DOI":"10.3390\/biom12101498","type":"journal-article","created":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T21:11:51Z","timestamp":1666041111000},"page":"1498","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Mechanisms of Peritoneal Mesothelial Cells in Peritoneal Adhesion"],"prefix":"10.3390","volume":"12","author":[{"given":"Ruipeng","family":"Wang","sequence":"first","affiliation":[{"name":"The First School of Clinical Medical, Gansu University of Chinese Medicine, Lanzhou 730030, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiankang","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Gansu Provincial Hospital, Lanzhou 730030, China"},{"name":"The First School of Clinical Medicine, Lanzhou University, Lanzhou 730030, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junliang","family":"Li","sequence":"additional","affiliation":[{"name":"The First School of Clinical Medical, Gansu University of Chinese Medicine, Lanzhou 730030, China"},{"name":"Department of General Surgery, Gansu Provincial Hospital, Lanzhou 730030, China"},{"name":"The First School of Clinical Medicine, Lanzhou University, Lanzhou 730030, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,17]]},"reference":[{"key":"ref_1","unstructured":"Ferns, G.A., Hassanian, S.M., and Arjmand, M.-H. 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