{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T06:38:31Z","timestamp":1789799911281,"version":"4.0.1"},"reference-count":70,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T00:00:00Z","timestamp":1665964800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006769","name":"Russian Science Foundation","doi-asserted-by":"publisher","award":["21-15-00022"],"award-info":[{"award-number":["21-15-00022"]}],"id":[{"id":"10.13039\/501100006769","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>The pathogenesis of the development of chronic lung diseases assumes the participation of systemic inflammation factors, as well as hormone-like substances produced by adipose tissue. The aim of this study was to evaluate the associations of certain adipokines\/cytokines and chronic bronchitis against the background of abdominal obesity in young people. The study included 1415 people aged 25\u221244. In total, 115 people were selected by the random numbers method, who were divided into two subgroups: those with chronic bronchitis and abdominal obesity and those with chronic bronchitis without abdominal obesity. A control group of patients with comparable gender and age was also selected. In the group of patients with chronic bronchitis, adiponectin, TNFa and GIP levels were 1.4 times higher. The levels of C-peptide, MCP-1 and PP in the group of chronic bronchitis were 1.3 times higher compared to the control. Adipsin, lipocalin-2, IL-6 and resistin were significantly higher in the group with chronic bronchitis. Glucagon, amylin and ghrelin were 2.2, 2.3 and 3.2 times lower, respectively, in the group of patients with chronic bronchitis. Against the background of abdominal obesity, the probability of having chronic bronchitis increased with an increase in the level of lipocalin-2 and GIP and TNFa.<\/jats:p>","DOI":"10.3390\/biom12101502","type":"journal-article","created":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T21:11:51Z","timestamp":1666041111000},"page":"1502","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Blood Adipokines\/Cytokines in Young People with Chronic Bronchitis and Abdominal Obesity"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7875-1566","authenticated-orcid":false,"given":"Alena Dmitrievna","family":"Khudiakova","sequence":"first","affiliation":[{"name":"Research Institute of Internal and Preventive Medicine\u2014Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, B. Bogatkova str., 175\/1, Novosibirsk 630089, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3538-0280","authenticated-orcid":false,"given":"Yana Vladimirovna","family":"Polonskaya","sequence":"additional","affiliation":[{"name":"Research Institute of Internal and Preventive Medicine\u2014Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, B. Bogatkova str., 175\/1, Novosibirsk 630089, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0436-2549","authenticated-orcid":false,"given":"Victoria Sergeevna","family":"Shramko","sequence":"additional","affiliation":[{"name":"Research Institute of Internal and Preventive Medicine\u2014Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, B. Bogatkova str., 175\/1, Novosibirsk 630089, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lilia Valeryevna","family":"Shcherbakova","sequence":"additional","affiliation":[{"name":"Research Institute of Internal and Preventive Medicine\u2014Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, B. Bogatkova str., 175\/1, Novosibirsk 630089, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5316-4664","authenticated-orcid":false,"given":"Evgeniia Vitalievna","family":"Striukova","sequence":"additional","affiliation":[{"name":"Research Institute of Internal and Preventive Medicine\u2014Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, B. Bogatkova str., 175\/1, Novosibirsk 630089, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2268-4186","authenticated-orcid":false,"given":"Elena Vladimirovna","family":"Kashtanova","sequence":"additional","affiliation":[{"name":"Research Institute of Internal and Preventive Medicine\u2014Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, B. Bogatkova str., 175\/1, Novosibirsk 630089, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4936-8362","authenticated-orcid":false,"given":"Yulia Igorevna","family":"Ragino","sequence":"additional","affiliation":[{"name":"Research Institute of Internal and Preventive Medicine\u2014Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, B. Bogatkova str., 175\/1, Novosibirsk 630089, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,17]]},"reference":[{"key":"ref_1","first-page":"577","article-title":"Chronic bronchitis, asthma, and pulmonary emphysema: A statement by the Committee on Diagnostic Standards for Nontuberculous Respiratory Diseases","volume":"152","author":"Bartolome","year":"1995","journal-title":"Am. J. Respir Crit. Care Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1503\/cmaj.051299","article-title":"The effect of obesity on chronic respiratory diseases: Pathophysiology and therapeutic strategies","volume":"174","author":"Poulain","year":"2006","journal-title":"Can. Med. Assoc. 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