{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T12:43:15Z","timestamp":1765888995642,"version":"build-2065373602"},"reference-count":166,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2022,10,28]],"date-time":"2022-10-28T00:00:00Z","timestamp":1666915200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81872557","202201011800"],"award-info":[{"award-number":["81872557","202201011800"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"science and technology projects in Guangzhou","award":["81872557","202201011800"],"award-info":[{"award-number":["81872557","202201011800"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>Circular RNAs (circRNAs) are endogenous, non-coding RNAs, which are derived from host genes that are present in several species and can be involved in the progression of various diseases. circRNAs\u2019 leading role is to act as RNA sponges. In recent years, the other roles of circRNAs have been discovered, such as regulating transcription and translation, regulating host genes, and even being translated into proteins. As some tumor cells are no longer radiosensitive, tumor radioresistance has since become a challenge in treating tumors. In recent years, circRNAs are differentially expressed in tumor cells and can be used as biological markers of tumors. In addition, circRNAs can regulate the radiosensitivity of tumors. Here, we list the mechanisms of circRNAs in glioma, nasopharyngeal carcinoma, and non-small cell lung cancer; further, these studies also provide new ideas for the purposes of eliminating radioresistance in tumors.<\/jats:p>","DOI":"10.3390\/biom12111586","type":"journal-article","created":{"date-parts":[[2022,10,29]],"date-time":"2022-10-29T23:45:00Z","timestamp":1667087100000},"page":"1586","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["CircRNAs in Tumor Radioresistance"],"prefix":"10.3390","volume":"12","author":[{"given":"Yining","family":"Gao","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, School of Basic Medical Science, Southern Medical University and Guangdong Provincial Key Laboratory of Single Cell Technology and Application, Guangzhou 510000, China"},{"name":"Department of Biochemistry and Molecular Biology, School of Basic Medical Science, Southern Medical University and School of Public Health, Southern Medical University, Guangzhou 510000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiawen","family":"Gao","sequence":"additional","affiliation":[{"name":"Division of Spine Surgery, Department of Orthopaedics, Nanfang Hospital, Southern Medical University, Guangzhou 510000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8344-2901","authenticated-orcid":false,"given":"Fei","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, School of Basic Medical Science, Southern Medical University and Guangdong Provincial Key Laboratory of Single Cell Technology and Application, Guangzhou 510000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, School of Basic Medical Science, Southern Medical University and Guangdong Provincial Key Laboratory of Single Cell Technology and Application, Guangzhou 510000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sitong","family":"Huo","sequence":"additional","affiliation":[{"name":"School of Medicine, Tsinghua University, Beijing 100084, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiefang","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Radiology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4567-6525","authenticated-orcid":false,"given":"Qi","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, School of Basic Medical Science, Southern Medical University and Guangdong Provincial Key Laboratory of Single Cell Technology and Application, Guangzhou 510000, China"},{"name":"Department of Biochemistry and Molecular Biology, School of Basic Medical Science, Southern Medical University and School of Public Health, Southern Medical University, Guangzhou 510000, China"},{"name":"Department of Cardiology, the Fifth Affiliated Hospital of Southern Medical University, 1838 Guangzhou Boulevard, Guangzhou 510000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9127-7379","authenticated-orcid":false,"given":"Chao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, School of Basic Medical Science, Southern Medical University and Guangdong Provincial Key Laboratory of Single Cell Technology and Application, Guangzhou 510000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3852","DOI":"10.1073\/pnas.73.11.3852","article-title":"Viroids are single-stranded covalently closed circular RNA molecules existing as highly base-paired rod-like structures","volume":"73","author":"Sanger","year":"1976","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1038\/s41580-020-0243-y","article-title":"The expanding regulatory mechanisms and cellular functions of circular RNAs","volume":"21","author":"Chen","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1038\/nrg.2016.114","article-title":"Detecting circular RNAs: Bioinformatic and experimental challenges","volume":"17","author":"Szabo","year":"2016","journal-title":"Nat. Rev. Genet."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Salzman, J., Gawad, C., Wang, P.L., Lacayo, N., and Brown, P.O. (2012). Circular RNAs are the predominant transcript isoform from hundreds of human genes in diverse cell types. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0030733"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/0092-8674(91)90244-S","article-title":"Scrambled exons","volume":"64","author":"Nigro","year":"1991","journal-title":"Cell"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.molcel.2014.08.019","article-title":"circRNA biogenesis competes with pre-mRNA splicing","volume":"56","author":"Meyer","year":"2014","journal-title":"Mol. Cell"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.celrep.2014.12.002","article-title":"Exon circularization requires canonical splice signals","volume":"10","author":"Starke","year":"2015","journal-title":"Cell Rep."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1038\/543183a","article-title":"Non-coding RNA: More uses for genomic junk","volume":"543","author":"Adelman","year":"2017","journal-title":"Nature"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/nbt.2890","article-title":"Detecting and characterizing circular RNAs","volume":"32","author":"Jeck","year":"2014","journal-title":"Nat. Biotechnol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1186\/s12943-020-01246-x","article-title":"CircRNA inhibits DNA damage repair by interacting with host gene","volume":"19","author":"Xu","year":"2020","journal-title":"Mol. Cancer"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/nature11928","article-title":"Circular RNAs are a large class of animal RNAs with regulatory potency","volume":"495","author":"Memczak","year":"2013","journal-title":"Nature"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1017\/S135583829898061X","article-title":"Circular mRNA can direct translation of extremely long repeating-sequence proteins in vivo","volume":"4","author":"Perriman","year":"1998","journal-title":"RNA"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1038\/s41576-019-0158-7","article-title":"The biogenesis, biology and characterization of circular RNAs","volume":"20","author":"Kristensen","year":"2019","journal-title":"Nat. Rev. Genet."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.tcb.2019.12.004","article-title":"Biogenesis and Functions of Circular RNAs Come into Focus","volume":"30","author":"Xiao","year":"2020","journal-title":"Trends Cell Biol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"e100836","DOI":"10.15252\/embj.2018100836","article-title":"Past, present, and future of circRNAs","volume":"38","author":"Patop","year":"2019","journal-title":"EMBO J."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"2819","DOI":"10.2174\/1381612811319150017","article-title":"Targeted radiosensitization in prostate cancer","volume":"19","author":"Ghotra","year":"2013","journal-title":"Curr. Pharm. Des."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.tips.2017.11.003","article-title":"Cancer Radiosensitizers","volume":"39","author":"Wang","year":"2018","journal-title":"Trends Pharmacol. Sci."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"e28133","DOI":"10.4161\/onci.28133","article-title":"Is tumor (R)ejection by the immune system the \u201c5th R\u201d of radiobiology?","volume":"3","author":"Golden","year":"2014","journal-title":"Oncoimmunology"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1080\/09553008914552491","article-title":"The 5Rs of radiobiology","volume":"56","author":"Steel","year":"1989","journal-title":"Int. J. Radiat. Biol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"2985","DOI":"10.1128\/MCB.17.6.2985","article-title":"Exon skipping and circular RNA formation in transcripts of the human cytochrome P-450 2C18 gene in epidermis and of the rat androgen binding protein gene in testis","volume":"17","author":"Zaphiropoulos","year":"1997","journal-title":"Mol Cell Biol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1093\/hmg\/8.3.493","article-title":"Circular dystrophin RNAs consisting of exons that were skipped by alternative splicing","volume":"8","author":"Surono","year":"1999","journal-title":"Hum. Mol. Genet."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Burd, C.E., Jeck, W.R., Liu, Y., Sanoff, H.K., Wang, Z., and Sharpless, N.E. (2010). Expression of linear and novel circular forms of an INK4\/ARF-associated non-coding RNA correlates with atherosclerosis risk. PLoS Genet., 6.","DOI":"10.1371\/journal.pgen.1001233"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/978-3-030-12668-1_10","article-title":"Circular RNAs as Potential Biomarkers and Therapeutic Targets for Metabolic Diseases","volume":"1134","author":"Zaiou","year":"2019","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1261\/rna.035667.112","article-title":"Circular RNAs are abundant, conserved, and associated with ALU repeats","volume":"19","author":"Jeck","year":"2013","journal-title":"RNA"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1016\/j.molcel.2013.08.017","article-title":"Circular intronic long noncoding RNAs","volume":"51","author":"Zhang","year":"2013","journal-title":"Mol. Cell"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1038\/nsmb.2959","article-title":"Exon-intron circular RNAs regulate transcription in the nucleus","volume":"22","author":"Li","year":"2015","journal-title":"Nat. Struct. Mol. Biol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1016\/0092-8674(93)90279-Y","article-title":"Circular transcripts of the testis-determining gene Sry in adult mouse testis","volume":"73","author":"Capel","year":"1993","journal-title":"Cell"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Wang, P.L., Bao, Y., Yee, M.C., Barrett, S.P., Hogan, G.J., Olsen, M.N., Dinneny, J.R., Brown, P.O., and Salzman, J. (2014). Circular RNA is expressed across the eukaryotic tree of life. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0090859"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"8057","DOI":"10.1038\/srep08057","article-title":"Correlation of circular RNA abundance with proliferation\u2014exemplified with colorectal and ovarian cancer, idiopathic lung fibrosis, and normal human tissues","volume":"5","author":"Reiner","year":"2015","journal-title":"Sci Rep."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1016\/j.cell.2015.02.014","article-title":"The RNA binding protein quaking regulates formation of circRNAs","volume":"160","author":"Conn","year":"2015","journal-title":"Cell"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/j.ymthe.2020.01.010","article-title":"Circular Noncoding RNA NR3C1 Acts as a miR-382-5p Sponge to Protect RPE Functions via Regulating PTEN\/AKT\/mTOR Signaling Pathway","volume":"28","author":"Chen","year":"2020","journal-title":"Mol. Ther."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.3389\/fgene.2019.01171","article-title":"A Novel Long Noncoding RNA, lncR-125b, Promotes the Differentiation of Goat Skeletal Muscle Satellite Cells by Sponging miR-125b","volume":"10","author":"Zhan","year":"2019","journal-title":"Front. Genet."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.biochi.2021.05.004","article-title":"A combinatorial in silico approach for microRNA-target identification: Order out of chaos","volume":"187","author":"Arif","year":"2021","journal-title":"Biochimie"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.cell.2004.12.035","article-title":"Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets","volume":"120","author":"Lewis","year":"2005","journal-title":"Cell"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.cell.2018.03.006","article-title":"Metazoan MicroRNAs","volume":"173","author":"Bartel","year":"2018","journal-title":"Cell"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"402","DOI":"10.3389\/fendo.2018.00402","article-title":"Overview of MicroRNA Biogenesis, Mechanisms of Actions, and Circulation","volume":"9","author":"Hayder","year":"2018","journal-title":"Front. Endocrinol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1080\/15476286.2017.1279788","article-title":"Identification of HuR target circular RNAs uncovers suppression of PABPN1 translation by CircPABPN1","volume":"14","author":"Abdelmohsen","year":"2017","journal-title":"RNA Biol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"12429","DOI":"10.1038\/ncomms12429","article-title":"Circular non-coding RNA ANRIL modulates ribosomal RNA maturation and atherosclerosis in humans","volume":"7","author":"Holdt","year":"2016","journal-title":"Nat. Commun."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.cell.2018.01.011","article-title":"Functional Classification and Experimental Dissection of Long Noncoding RNAs","volume":"172","author":"Kopp","year":"2018","journal-title":"Cell"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1101\/gad.304055.117","article-title":"RNA-binding proteins in neurodegeneration: Mechanisms in aggregate","volume":"31","author":"Conlon","year":"2017","journal-title":"Genes Dev."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"2062","DOI":"10.1016\/j.ymthe.2017.05.022","article-title":"The Circular RNA Interacts with STAT3, Increasing Its Nuclear Translocation and Wound Repair by Modulating Dnmt3a and miR-17 Function","volume":"25","author":"Yang","year":"2017","journal-title":"Mol. Ther."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1038\/cdd.2017.86","article-title":"A circular RNA promotes tumorigenesis by inducing c-myc nuclear translocation","volume":"24","author":"Yang","year":"2017","journal-title":"Cell Death Differ."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1038\/ng.2434","article-title":"Inhibition of RNA lariat debranching enzyme suppresses TDP-43 toxicity in ALS disease models","volume":"44","author":"Armakola","year":"2012","journal-title":"Nat. Genet."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"3842","DOI":"10.7150\/thno.19764","article-title":"A Circular RNA Binds To and Activates AKT Phosphorylation and Nuclear Localization Reducing Apoptosis and Enhancing Cardiac Repair","volume":"7","author":"Zeng","year":"2017","journal-title":"Theranostics"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1186\/s13059-018-1594-y","article-title":"A novel FLI1 exonic circular RNA promotes metastasis in breast cancer by coordinately regulating TET1 and DNMT1","volume":"19","author":"Chen","year":"2018","journal-title":"Genome Biol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"16435","DOI":"10.1038\/srep16435","article-title":"Rolling Circle Translation of Circular RNA in Living Human Cells","volume":"5","author":"Abe","year":"2015","journal-title":"Sci. Rep."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.1016\/j.ymthe.2019.09.001","article-title":"ncRNA-Encoded Peptides or Proteins and Cancer","volume":"27","author":"Wang","year":"2019","journal-title":"Mol. Ther."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1038\/s41388-017-0019-9","article-title":"A novel protein encoded by the circular form of the SHPRH gene suppresses glioma tumorigenesis","volume":"37","author":"Zhang","year":"2018","journal-title":"Oncogene"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"107641","DOI":"10.1016\/j.celrep.2020.107641","article-title":"Modulation of circRNA Metabolism by m(6)A Modification","volume":"31","author":"Dattilo","year":"2020","journal-title":"Cell Rep."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"2629","DOI":"10.1038\/s41467-018-05096-6","article-title":"Engineering circular RNA for potent and stable translation in eukaryotic cells","volume":"9","author":"Wesselhoeft","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1093\/jnci\/djx166","article-title":"Novel Role of FBXW7 Circular RNA in Repressing Glioma Tumorigenesis","volume":"110","author":"Yang","year":"2018","journal-title":"J. Natl. Cancer Inst."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"R125","DOI":"10.1093\/hmg\/dds317","article-title":"Exosomes and microvesicles: Extracellular vesicles for genetic information transfer and gene therapy","volume":"21","author":"Lee","year":"2012","journal-title":"Hum. Mol. Genet."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1021\/acs.chemrev.7b00534","article-title":"New Technologies for Analysis of Extracellular Vesicles","volume":"118","author":"Shao","year":"2018","journal-title":"Chem. Rev."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1038\/ncomms1180","article-title":"Tumour microvesicles contain retrotransposon elements and amplified oncogene sequences","volume":"2","author":"Balaj","year":"2011","journal-title":"Nat. Commun."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s12020-012-9839-0","article-title":"Extracellular vesicles as an emerging mechanism of cell-to-cell communication","volume":"44","author":"Tetta","year":"2013","journal-title":"Endocrine"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1186\/s12943-019-1041-z","article-title":"Exosomal circRNAs: Biogenesis, effect and application in human diseases","volume":"18","author":"Wang","year":"2019","journal-title":"Mol. Cancer"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1038\/cr.2015.82","article-title":"Circular RNA is enriched and stable in exosomes: A promising biomarker for cancer diagnosis","volume":"25","author":"Li","year":"2015","journal-title":"Cell Res."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1186\/s13046-018-0822-3","article-title":"Circular RNA IARS (circ-IARS) secreted by pancreatic cancer cells and located within exosomes regulates endothelial monolayer permeability to promote tumor metastasis","volume":"37","author":"Li","year":"2018","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"9","DOI":"10.3389\/fimmu.2018.00009","article-title":"The Potential Role of circRNA in Tumor Immunity Regulation and Immunotherapy","volume":"9","author":"Xu","year":"2018","journal-title":"Front. Immunol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1038\/nrc2714","article-title":"Environment-mediated drug resistance: A major contributor to minimal residual disease","volume":"9","author":"Meads","year":"2009","journal-title":"Nat. Rev. Cancer"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1038\/nrclinonc.2015.120","article-title":"Opportunities and challenges of radiotherapy for treating cancer","volume":"12","author":"Schaue","year":"2015","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1007\/s12038-021-00198-8","article-title":"Knockdown of circ_0008344 contributes to radiosensitization in glioma via miR-433-3p\/RNF2 axis","volume":"46","author":"Di","year":"2021","journal-title":"J. Biosci."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"e19171","DOI":"10.1097\/MD.0000000000019171","article-title":"The circ_VCAN with radioresistance contributes to the carcinogenesis of glioma by regulating microRNA-1183","volume":"99","author":"Zhu","year":"2020","journal-title":"Medicine"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1186\/s12935-020-01169-z","article-title":"Circular RNA circPITX1 knockdown inhibits glycolysis to enhance radiosensitivity of glioma cells by miR-329-3p\/NEK2 axis","volume":"20","author":"Guan","year":"2020","journal-title":"Cancer Cell Int."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1016\/j.bbrc.2019.03.126","article-title":"CircRNA_000543 knockdown sensitizes nasopharyngeal carcinoma to irradiation by targeting miR-9\/platelet-derived growth factor receptor B axis","volume":"512","author":"Chen","year":"2019","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"3965","DOI":"10.2147\/OTT.S249202","article-title":"High Expression of hsa_circRNA_001387 in Nasopharyngeal Carcinoma and the Effect on Efficacy of Radiotherapy","volume":"13","author":"Shuai","year":"2020","journal-title":"Onco. Targets Ther."},{"key":"ref_67","first-page":"6495","article-title":"Upregulation of circRNA_0000285 serves as a prognostic biomarker for nasopharyngeal carcinoma and is involved in radiosensitivity","volume":"16","author":"Shuai","year":"2018","journal-title":"Oncol. Lett."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1080\/21655979.2021.1872191","article-title":"Circular RNA circ_0001287 inhibits the proliferation, metastasis, and radiosensitivity of non-small cell lung cancer cells by sponging microRNA miR-21 and up-regulating phosphatase and tensin homolog expression","volume":"12","author":"Zhang","year":"2021","journal-title":"Bioengineered"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"96","DOI":"10.4149\/neo_2020_200331N333","article-title":"Circ_0086720 knockdown strengthens the radiosensitivity of non-small cell lung cancer via mediating the miR-375\/SPIN1 axis","volume":"68","author":"Jin","year":"2021","journal-title":"Neoplasma"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"263","DOI":"10.3233\/CBM-203252","article-title":"Silencing circPVT1 enhances radiosensitivity in non-small cell lung cancer by sponging microRNA-1208","volume":"31","author":"Huang","year":"2021","journal-title":"Cancer Biomark."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"110012","DOI":"10.1016\/j.cellsig.2021.110012","article-title":"CircZNF208 enhances the sensitivity to X-rays instead of carbon-ions through the miR-7-5p \/SNCA signal axis in non-small-cell lung cancer cells","volume":"84","author":"Liu","year":"2021","journal-title":"Cell Signal."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1186\/s12957-021-02234-1","article-title":"Circ_0055625 knockdown inhibits tumorigenesis and improves radiosensitivity by regulating miR-338-3p\/MSI1 axis in colon cancer","volume":"19","author":"Gao","year":"2021","journal-title":"World J. Surg. Oncol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/j.prp.2018.12.032","article-title":"Inhibition of hsa_circ_0001313 (circCCDC66) induction enhances the radio-sensitivity of colon cancer cells via tumor suppressor miR-338-3p: Effects of cicr_0001313 on colon cancer radio-sensitivity","volume":"215","author":"Wang","year":"2019","journal-title":"Pathol. Res. Pract."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"8465","DOI":"10.2147\/CMAR.S254815","article-title":"Circ_0007031 Serves as a Sponge of miR-760 to Regulate the Growth and Chemoradiotherapy Resistance of Colorectal Cancer via Regulating DCP1A","volume":"12","author":"Wang","year":"2020","journal-title":"Cancer Manag. Res."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"491","DOI":"10.2147\/OTT.S281011","article-title":"Circ_0067835 Knockdown Enhances the Radiosensitivity of Colorectal Cancer by miR-296-5p\/IGF1R Axis","volume":"14","author":"Wang","year":"2021","journal-title":"Onco. Targets Ther."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"671337","DOI":"10.3389\/fgene.2021.671337","article-title":"Circ-MFN2 Positively Regulates the Proliferation, Metastasis, and Radioresistance of Colorectal Cancer by Regulating the miR-574-3p\/IGF1R Signaling Axis","volume":"12","author":"Liu","year":"2021","journal-title":"Front. Genet."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"e13607","DOI":"10.1111\/eci.13607","article-title":"Circ-ACAP2 facilitates the progression of colorectal cancer through mediating miR-143-3p\/FZD4 axis","volume":"51","author":"Zhang","year":"2021","journal-title":"Eur. J. Clin. Investig."},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Li, H., Jin, X., Liu, B., Zhang, P., Chen, W., and Li, Q. (2019). CircRNA CBL.11 suppresses cell proliferation by sponging miR-6778-5p in colorectal cancer. BMC Cancer, 19.","DOI":"10.1186\/s12885-019-6017-2"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.2147\/CMAR.S297123","article-title":"Exosomal circ_IFT80 Enhances Tumorigenesis and Suppresses Radiosensitivity in Colorectal Cancer by Regulating miR-296-5p\/MSI1 Axis","volume":"13","author":"Li","year":"2021","journal-title":"Cancer Manag. Res."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"118168","DOI":"10.1016\/j.lfs.2020.118168","article-title":"Circular RNA PRKCI silencing represses esophageal cancer progression and elevates cell radiosensitivity through regulating the miR-186-5p\/PARP9 axis","volume":"259","author":"Ma","year":"2020","journal-title":"Life Sci."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1097\/CAD.0000000000001007","article-title":"Circular RNA hsa_circ_0000554 promotes progression and elevates radioresistance through the miR-485-5p\/fermitin family members 1 axis in esophageal cancer","volume":"32","author":"Wang","year":"2021","journal-title":"Anticancer Drugs"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.ijbiomac.2018.11.273","article-title":"CircVRK1 regulates tumor progression and radioresistance in esophageal squamous cell carcinoma by regulating miR-624-3p\/PTEN\/PI3K\/AKT signaling pathway","volume":"125","author":"He","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"e349","DOI":"10.1097\/CAD.0000000000001213","article-title":"Hsa_circ_0014879 regulates the radiosensitivity of esophageal squamous cell carcinoma through miR-519-3p\/CDC25A axis","volume":"33","author":"Liu","year":"2022","journal-title":"Anticancer Drugs"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"11701","DOI":"10.2147\/CMAR.S273826","article-title":"Circ_0062020 Knockdown Strengthens the Radiosensitivity of Prostate Cancer Cells","volume":"12","author":"Li","year":"2020","journal-title":"Cancer Manag. Res."},{"key":"ref_85","first-page":"480","article-title":"Knockdown of Circ_CCNB2 Sensitizes Prostate Cancer to Radiation Through Repressing Autophagy by the miR-30b-5p\/KIF18A Axis","volume":"37","author":"Cai","year":"2020","journal-title":"Cancer Biother. Radiopharm."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"7487","DOI":"10.2147\/CMAR.S257441","article-title":"Circ-ZNF609 Accelerates the Radioresistance of Prostate Cancer Cells by Promoting the Glycolytic Metabolism Through miR-501-3p\/HK2 Axis","volume":"12","author":"Du","year":"2020","journal-title":"Cancer Manag. Res."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"e0063120","DOI":"10.1128\/MCB.00631-20","article-title":"Silencing of hsa_circ_0009035 Suppresses Cervical Cancer Progression and Enhances Radiosensitivity through MicroRNA 889-3p-Dependent Regulation of HOXB7","volume":"41","author":"Zhao","year":"2021","journal-title":"Mol. Cell Biol."},{"key":"ref_88","first-page":"477","article-title":"Circle RNA circABCB10 Modulates PFN2 to Promote Breast Cancer Progression, as Well as Aggravate Radioresistance Through Facilitating Glycolytic Metabolism Via miR-223-3p","volume":"36","author":"Zhao","year":"2021","journal-title":"Cancer Biother. Radiopharm."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1007\/s00401-017-1671-4","article-title":"Glioma: Experimental models and reality","volume":"133","author":"Lenting","year":"2017","journal-title":"Acta Neuropathol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/j.ccell.2017.08.017","article-title":"Integrated Molecular Meta-Analysis of 1,000 Pediatric High-Grade and Diffuse Intrinsic Pontine Glioma","volume":"32","author":"Mackay","year":"2017","journal-title":"Cancer Cell"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1007\/s11060-017-2607-5","article-title":"Epidemiology of glioma: Clinical characteristics, symptoms, and predictors of glioma patients grade I-IV in the the Danish Neuro-Oncology Registry","volume":"135","author":"Rasmussen","year":"2017","journal-title":"J. Neurooncol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1093\/neuonc\/nou087","article-title":"The epidemiology of glioma in adults: A \u201cstate of the science\u201d review","volume":"16","author":"Ostrom","year":"2014","journal-title":"Neuro. Oncol."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.clineuro.2018.04.011","article-title":"Comparison of operative outcomes of eloquent glioma resection performed under awake versus general anesthesia: A systematic review and meta-analysis","volume":"169","author":"Lu","year":"2018","journal-title":"Clin. Neurol. Neurosurg."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"78","DOI":"10.21315\/mjms2017.24.2.10","article-title":"Fluorescence-Guided versus Conventional Surgical Resection of High Grade Glioma: A Single-Centre, 7-Year, Comparative Effectiveness Study","volume":"24","author":"Ng","year":"2017","journal-title":"Malays. J. Med. Sci."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1269\/jrr.43.283","article-title":"Radiosensitization by overexpression of the nonphosphorylation form of IkappaB-alpha in human glioma cells","volume":"43","author":"Honda","year":"2002","journal-title":"J. Radiat. Res."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1007\/s00415-017-8695-5","article-title":"Advances in immunotherapeutic research for glioma therapy","volume":"265","author":"Miyauchi","year":"2018","journal-title":"J. Neurol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1186\/1476-4598-12-152","article-title":"Tumor glycolysis as a target for cancer therapy: Progress and prospects","volume":"12","author":"Geschwind","year":"2013","journal-title":"Mol. Cancer"},{"key":"ref_98","doi-asserted-by":"crossref","unstructured":"Epstein, T., Gatenby, R.A., and Brown, J.S. (2017). The Warburg effect as an adaptation of cancer cells to rapid fluctuations in energy demand. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0185085"},{"key":"ref_99","first-page":"8781","article-title":"MiR-128 promotes the apoptosis of glioma cells via binding to NEK2","volume":"22","author":"Ye","year":"2018","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/s12943-019-1121-0","article-title":"Functions and clinical significance of circular RNAs in glioma","volume":"19","author":"Sun","year":"2020","journal-title":"Mol. Cancer"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"63449","DOI":"10.18632\/oncotarget.11523","article-title":"Silencing of cZNF292 circular RNA suppresses human glioma tube formation via the Wnt\/\u03b2-catenin signaling pathway","volume":"7","author":"Yang","year":"2016","journal-title":"Oncotarget"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"4812","DOI":"10.1158\/0008-5472.CAN-18-0532","article-title":"CircNT5E Acts as a Sponge of miR-422a to Promote Glioblastoma Tumorigenesis","volume":"78","author":"Wang","year":"2018","journal-title":"Cancer Res."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/j.bbrc.2019.02.019","article-title":"CircRNA hsa-circ-0014359 promotes glioma progression by regulating miR-153\/PI3K signaling","volume":"510","author":"Shi","year":"2019","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"3346","DOI":"10.1200\/JCO.2015.60.7846","article-title":"Nasopharyngeal Cancer: Molecular Landscape","volume":"33","author":"Bruce","year":"2015","journal-title":"J. Clin. Oncol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"16075","DOI":"10.18632\/oncotarget.14211","article-title":"The role of long non-coding RNAs in nasopharyngeal carcinoma: As systemic review","volume":"8","author":"He","year":"2017","journal-title":"Oncotarget"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1038\/s41571-021-00524-x","article-title":"Nasopharyngeal carcinoma: An evolving paradigm","volume":"18","author":"Wong","year":"2021","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1038\/bjc.2017.357","article-title":"Systemic therapies for recurrent or metastatic nasopharyngeal carcinoma: A systematic review","volume":"117","author":"Prawira","year":"2017","journal-title":"Br. J. Cancer"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"2490","DOI":"10.1158\/1535-7163.MCT-18-0938","article-title":"Retraction: MiR-125b Increases Nasopharyngeal Carcinoma Radioresistance By Targeting A20\/NF-\u03baB Signaling Pathway","volume":"17","author":"Li","year":"2018","journal-title":"Mol. Cancer Ther."},{"key":"ref_109","doi-asserted-by":"crossref","unstructured":"Zhao, M., Wang, Y., Tan, F., Liu, L., Hou, X., Fan, C., Tang, L., Mo, Y., Wang, Y., and Yan, Q. (2022). Circular RNA circCCNB1 inhibits the migration and invasion of nasopharyngeal carcinoma through binding and stabilizing TJP1 mRNA. Sci. China Life Sci.","DOI":"10.1007\/s11427-021-2089-8"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"12540","DOI":"10.1038\/s41598-019-49021-3","article-title":"ADAM15 mediates upregulation of Claudin-1 expression in breast cancer cells","volume":"9","author":"Mattern","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"41748","DOI":"10.18632\/oncotarget.9410","article-title":"GLK\/MAP4K3 overexpression associates with recurrence risk for non-small cell lung cancer","volume":"7","author":"Hsu","year":"2016","journal-title":"Oncotarget"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"36366","DOI":"10.18632\/oncotarget.8917","article-title":"Altered expression pattern of circular RNAs in primary and metastatic sites of epithelial ovarian carcinoma","volume":"7","author":"Ahmed","year":"2016","journal-title":"Oncotarget"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"e278S","DOI":"10.1378\/chest.12-2359","article-title":"Treatment of stage I and II non-small cell lung cancer: Diagnosis and management of lung cancer, 3rd ed: American College of Chest Physicians evidence-based clinical practice guidelines","volume":"143","author":"Howington","year":"2013","journal-title":"Chest"},{"key":"ref_114","first-page":"4248","article-title":"Diminished LINC00173 expression induced miR-182-5p accumulation promotes cell proliferation, migration and apoptosis inhibition via AGER\/NF-\u03baB pathway in non-small-cell lung cancer","volume":"11","author":"Yang","year":"2019","journal-title":"Am. J. Transl. Res."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1097\/PPO.0b013e318292e4e3","article-title":"Basic mechanisms of therapeutic resistance to radiation and chemotherapy in lung cancer","volume":"19","author":"Willers","year":"2013","journal-title":"Cancer J."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1016\/j.mayocp.2019.01.013","article-title":"Non-Small Cell Lung Cancer: Epidemiology, Screening, Diagnosis, and Treatment","volume":"94","author":"Duma","year":"2019","journal-title":"Mayo Clin. Proc."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.ejcsup.2013.07.022","article-title":"Role of adjuvant radiotherapy in completely resected non-small-cell lung cancer","volume":"11","author":"Mercier","year":"2013","journal-title":"EJC Suppl."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"669","DOI":"10.3892\/ol.2016.5462","article-title":"Plasma miR-145, miR-20a, miR-21 and miR-223 as novel biomarkers for screening early-stage non-small cell lung cancer","volume":"13","author":"Zhang","year":"2017","journal-title":"Oncol. Lett."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/s13046-019-1027-0","article-title":"Extracellular vesicles secreted by hypoxia pre-challenged mesenchymal stem cells promote non-small cell lung cancer cell growth and mobility as well as macrophage M2 polarization via miR-21-5p delivery","volume":"38","author":"Ren","year":"2019","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"84508","DOI":"10.18632\/oncotarget.13022","article-title":"MiR-21 and MiR-155 promote non-small cell lung cancer progression by downregulating SOCS1, SOCS6, and PTEN","volume":"7","author":"Xue","year":"2016","journal-title":"Oncotarget"},{"key":"ref_121","doi-asserted-by":"crossref","unstructured":"Xu, L.F., Wu, Z.P., Chen, Y., Zhu, Q.S., Hamidi, S., and Navab, R. (2014). MicroRNA-21 (miR-21) regulates cellular proliferation, invasion, migration, and apoptosis by targeting PTEN, RECK and Bcl-2 in lung squamous carcinoma, Gejiu City, China. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0103698"},{"key":"ref_122","doi-asserted-by":"crossref","unstructured":"Gkountakos, A., Sartori, G., Falcone, I., Piro, G., Ciuffreda, L., Carbone, C., Tortora, G., Scarpa, A., Bria, E., and Milella, M. (2019). PTEN in Lung Cancer: Dealing with the Problem, Building on New Knowledge and Turning the Game Around. Cancers, 11.","DOI":"10.3390\/cancers11081141"},{"key":"ref_123","doi-asserted-by":"crossref","unstructured":"Chang, H., Cai, Z., and Roberts, T.M. (2019). The Mechanisms Underlying PTEN Loss in Human Tumors Suggest Potential Therapeutic Opportunities. Biomolecules, 9.","DOI":"10.3390\/biom9110713"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1084\/jem.20112741","article-title":"Programmed cell death 1 forms negative costimulatory microclusters that directly inhibit T cell receptor signaling by recruiting phosphatase SHP2","volume":"209","author":"Yokosuka","year":"2012","journal-title":"J. Exp. Med."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1186\/s12943-021-01398-4","article-title":"N(6)-methyladenosine-modified circIGF2BP3 inhibits CD8(+) T-cell responses to facilitate tumor immune evasion by promoting the deubiquitination of PD-L1 in non-small cell lung cancer","volume":"20","author":"Liu","year":"2021","journal-title":"Mol. Cancer"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1186\/s12943-021-01448-x","article-title":"Cancer cell-derived exosomal circUSP7 induces CD8(+) T cell dysfunction and anti-PD1 resistance by regulating the miR-934\/SHP2 axis in NSCLC","volume":"20","author":"Chen","year":"2021","journal-title":"Mol. Cancer"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"394","DOI":"10.3322\/caac.21492","article-title":"Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"68","author":"Bray","year":"2018","journal-title":"CA Cancer J. Clin."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"87","DOI":"10.3322\/caac.21262","article-title":"Global cancer statistics, 2012","volume":"65","author":"Torre","year":"2015","journal-title":"CA Cancer J. Clin."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/S1470-2045(15)00120-5","article-title":"High-dose chemoradiotherapy and watchful waiting for distal rectal cancer: A prospective observational study","volume":"16","author":"Appelt","year":"2015","journal-title":"Lancet Oncol."},{"key":"ref_130","first-page":"2171","article-title":"Effect of colorectal resection combined with intraoperative radiofrequency ablation in treating colorectal cancer with liver metastasis and analysis of its prognosis","volume":"25","author":"Fu","year":"2020","journal-title":"J. Buon"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/s41416-018-0201-z","article-title":"Practice-changing radiation therapy trials for the treatment of cancer: Where are we 150 years after the birth of Marie Curie?","volume":"119","author":"Thompson","year":"2018","journal-title":"Br. J. Cancer"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"6975","DOI":"10.1158\/0008-5472.CAN-17-1525","article-title":"SOCS1 Gene Therapy Improves Radiosensitivity and Enhances Irradiation-Induced DNA Damage in Esophageal Squamous Cell Carcinoma","volume":"77","author":"Sugase","year":"2017","journal-title":"Cancer Res."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"2558","DOI":"10.1159\/000491652","article-title":"Identification of Circular RNAs Altered in Mouse Jejuna After Radiation","volume":"47","author":"Lu","year":"2018","journal-title":"Cell Physiol. Biochem."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"2074","DOI":"10.1245\/s10434-011-1567-9","article-title":"Msi-1 is a predictor of survival and a novel therapeutic target in colon cancer","volume":"18","author":"Li","year":"2011","journal-title":"Ann. Surg. Oncol."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1161\/CIRCRESAHA.115.306324","article-title":"Exosomes: Nanosized cellular messages","volume":"116","author":"Tintut","year":"2015","journal-title":"Circ. Res."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1002\/1878-0261.12637","article-title":"Exosome-transmitted circ_MMP2 promotes hepatocellular carcinoma metastasis by upregulating MMP2","volume":"14","author":"Liu","year":"2020","journal-title":"Mol. Oncol."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.canlet.2020.04.013","article-title":"Insulin-like growth factor-1 receptor induces immunosuppression in lung cancer by upregulating B7-H4 expression through the MEK\/ERK signaling pathway","volume":"485","author":"Zhao","year":"2020","journal-title":"Cancer Lett."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"12","DOI":"10.3389\/fendo.2015.00012","article-title":"Insulin\/Insulin-like growth factors in cancer: New roles for the aryl hydrocarbon receptor, tumor resistance mechanisms, and new blocking strategies","volume":"6","author":"Salisbury","year":"2015","journal-title":"Front. Endocrinol."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/s12943-019-1010-6","article-title":"A novel protein encoded by a circular RNA circPPP1R12A promotes tumor pathogenesis and metastasis of colon cancer via Hippo-YAP signaling","volume":"18","author":"Zheng","year":"2019","journal-title":"Mol. Cancer"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"7933","DOI":"10.3748\/wjg.v21.i26.7933","article-title":"Esophageal cancer: Risk factors, screening and endoscopic treatment in Western and Eastern countries","volume":"21","year":"2015","journal-title":"World J. Gastroenterol."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1007\/s11748-013-0246-0","article-title":"Treatments for esophageal cancer: A review","volume":"61","author":"Kato","year":"2013","journal-title":"Gen. Thorac. Cardiovasc. Surg."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1016\/j.dld.2018.08.002","article-title":"Prognostic factors in esophageal cancer treated with curative intent","volume":"50","author":"Vendrely","year":"2018","journal-title":"Dig Liver Dis."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1111\/cas.12252","article-title":"Newly developed strategies for improving sensitivity to radiation by targeting signal pathways in cancer therapy","volume":"104","author":"Ding","year":"2013","journal-title":"Cancer Sci."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1158\/1541-7786.MCR-12-0155-T","article-title":"Expression of Wnt3 activates Wnt\/\u03b2-catenin pathway and promotes EMT-like phenotype in trastuzumab-resistant HER2-overexpressing breast cancer cells","volume":"10","author":"Wu","year":"2012","journal-title":"Mol. Cancer Res."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.stemcr.2017.05.006","article-title":"PTEN Mediates Activation of Core Clock Protein BMAL1 and Accumulation of Epidermal Stem Cells","volume":"9","author":"Zagni","year":"2017","journal-title":"Stem Cell Rep."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/s12943-018-0803-3","article-title":"PTEN\/PTENP1: \u2018Regulating the regulator of RTK-dependent PI3K\/Akt signalling\u2019, new targets for cancer therapy","volume":"17","author":"Haddadi","year":"2018","journal-title":"Mol. Cancer"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.hoc.2019.08.017","article-title":"Radiation Therapy for Prostate Cancer","volume":"34","author":"Kamran","year":"2020","journal-title":"Hematol. Oncol. Clin. N. Am."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1007\/s10555-014-9493-5","article-title":"Emerging roles of radioresistance in prostate cancer metastasis and radiation therapy","volume":"33","author":"Chang","year":"2014","journal-title":"Cancer Metastasis. Rev."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1007\/s11060-017-2460-6","article-title":"Radiotherapy for cranial and brain metastases from prostate cancer: A systematic review","volume":"133","author":"Sita","year":"2017","journal-title":"J. Neurooncol."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"2147","DOI":"10.1007\/s00432-017-2487-2","article-title":"Role of autophagy in regulating the radiosensitivity of tumor cells","volume":"143","author":"Xin","year":"2017","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1111\/1759-7714.13051","article-title":"High kinesin family member 18A expression correlates with poor prognosis in primary lung adenocarcinoma","volume":"10","author":"Li","year":"2019","journal-title":"Thorac. Cancer"},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"6383685","DOI":"10.1155\/2019\/6383685","article-title":"Kinesin Family Member 18A (KIF18A) Contributes to the Proliferation, Migration, and Invasion of Lung Adenocarcinoma Cells In Vitro and In Vivo","volume":"2019","author":"Chen","year":"2019","journal-title":"Dis. Markers"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1002\/1878-0261.12181","article-title":"Inferences of individual drug responses across diverse cancer types using a novel competing endogenous RNA network","volume":"12","author":"Zhang","year":"2018","journal-title":"Mol. Oncol."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"4688","DOI":"10.1002\/jcp.29347","article-title":"Circular RNA circ_0074026 indicates unfavorable prognosis for patients with glioma and facilitates oncogenesis of tumor cells by targeting miR-1304 to modulate ERBB4 expression","volume":"235","author":"Chen","year":"2020","journal-title":"J. Cell Physiol."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"172643","DOI":"10.1016\/j.ejphar.2019.172643","article-title":"Circular RNA circ-PITX1 promotes the progression of glioblastoma by acting as a competing endogenous RNA to regulate miR-379-5p\/MAP3K2 axis","volume":"863","author":"Lv","year":"2019","journal-title":"Eur. J. Pharmacol."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"e5011","DOI":"10.7717\/peerj.5011","article-title":"Comprehensive circular RNA expression profile in radiation-treated HeLa cells and analysis of radioresistance-related circRNAs","volume":"6","author":"Yu","year":"2018","journal-title":"Peer J."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.canlet.2016.12.006","article-title":"Circular RNA profile identifies circPVT1 as a proliferative factor and prognostic marker in gastric cancer","volume":"388","author":"Chen","year":"2017","journal-title":"Cancer Lett."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1016\/j.bbrc.2019.03.121","article-title":"Circular RNA PVT1 promotes metastasis via miR-145 sponging in CRC","volume":"512","author":"Wang","year":"2019","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1186\/s12935-019-0985-9","article-title":"Potential Role of circPVT1 as a proliferative factor and treatment target in esophageal carcinoma","volume":"19","author":"Zhong","year":"2019","journal-title":"Cancer Cell Int."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"BSR20193045","DOI":"10.1042\/BSR20193045","article-title":"Circular RNA circ-PVT1 contributes to paclitaxel resistance of gastric cancer cells through the regulation of ZEB1 expression by sponging miR-124-3p","volume":"39","author":"Liu","year":"2019","journal-title":"Biosci. Rep."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"109828","DOI":"10.1016\/j.biopha.2020.109828","article-title":"CircPVT1 contributes to chemotherapy resistance of lung adenocarcinoma through miR-145-5p\/ABCC1 axis","volume":"124","author":"Zheng","year":"2020","journal-title":"Biomed. Pharm."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.molonc.2012.01.010","article-title":"Cancer biomarkers","volume":"6","author":"Henry","year":"2012","journal-title":"Mol. Oncol."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/978-981-13-1426-1_11","article-title":"Circular RNA in Saliva","volume":"1087","year":"2018","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"2884","DOI":"10.1093\/nar\/gkz034","article-title":"Human Survival Motor Neuron genes generate a vast repertoire of circular RNAs","volume":"47","author":"Ottesen","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1038\/s41573-021-00162-z","article-title":"Antisense technology: An overview and prospectus","volume":"20","author":"Crooke","year":"2021","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1038\/s41392-021-00569-5","article-title":"Targeting circular RNAs as a therapeutic approach: Current strategies and challenges","volume":"6","author":"He","year":"2021","journal-title":"Signal Transduct Target Ther."}],"container-title":["Biomolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2218-273X\/12\/11\/1586\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:05:12Z","timestamp":1760144712000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2218-273X\/12\/11\/1586"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,28]]},"references-count":166,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2022,11]]}},"alternative-id":["biom12111586"],"URL":"https:\/\/doi.org\/10.3390\/biom12111586","relation":{},"ISSN":["2218-273X"],"issn-type":[{"type":"electronic","value":"2218-273X"}],"subject":[],"published":{"date-parts":[[2022,10,28]]}}}