{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T01:03:15Z","timestamp":1792803795365,"version":"4.5.0"},"reference-count":31,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2022,10,30]],"date-time":"2022-10-30T00:00:00Z","timestamp":1667088000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"IB FRC Komi SC UB RAS","award":["122040600022-1"],"award-info":[{"award-number":["122040600022-1"]}]},{"name":"IB FRC Komi SC UB RAS","award":["20-64-47014"],"award-info":[{"award-number":["20-64-47014"]}]},{"name":"IB FRC Komi SC UB RAS","award":["1\/22-4"],"award-info":[{"award-number":["1\/22-4"]}]},{"DOI":"10.13039\/501100006769","name":"Russian Science Foundation","doi-asserted-by":"publisher","award":["122040600022-1"],"award-info":[{"award-number":["122040600022-1"]}],"id":[{"id":"10.13039\/501100006769","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006769","name":"Russian Science Foundation","doi-asserted-by":"publisher","award":["20-64-47014"],"award-info":[{"award-number":["20-64-47014"]}],"id":[{"id":"10.13039\/501100006769","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006769","name":"Russian Science Foundation","doi-asserted-by":"publisher","award":["1\/22-4"],"award-info":[{"award-number":["1\/22-4"]}],"id":[{"id":"10.13039\/501100006769","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Kazan State Medical University","award":["122040600022-1"],"award-info":[{"award-number":["122040600022-1"]}],"id":[{"id":"https:\/\/ror.org\/013pk4y14","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Kazan State Medical University","award":["20-64-47014"],"award-info":[{"award-number":["20-64-47014"]}],"id":[{"id":"https:\/\/ror.org\/013pk4y14","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Kazan State Medical University","award":["1\/22-4"],"award-info":[{"award-number":["1\/22-4"]}],"id":[{"id":"https:\/\/ror.org\/013pk4y14","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>Natural monoterpenes and their derivatives are widely considered as effective ingredients for the design and production of new biologically active compounds with high antioxidant, antimicrobial and anti-protozoa properties. In this study, we synthesized two series of thiotherpenoids \u201csulfide-sulfoxide-sulfone\u201d, with different bicyclic monoterpene skeleton (bornane and pinane) structures. The effect of the obtained compounds on platelet aggregation was investigated by using the molecular docking technique. The obtained data revealed that all the synthesized compounds may act as potential inhibitors of platelet aggregation. Moreover, the studied sulfides have shown high antioxidant activity as revealed by lipid peroxidation (LPO) process inhibition in a non-cellular substrate containing animal lipids. The sulfides were able to inhibit erythrocyte oxidative hemolysis, to reduce the accumulation of secondary LPO products in cells and to prevent the oxidation of native oxyhemoglobin. Additionally, the corresponding sulfones and sulfoxides exhibited insignificant antioxidant activity. However, the sulfides were found to exhibit significant antiaggregant and anticoagulant effects. These findings suggest as well that the sulfides could serve as a leader compound for future research and possible practical applications.<\/jats:p>","DOI":"10.3390\/biom12111599","type":"journal-article","created":{"date-parts":[[2022,10,30]],"date-time":"2022-10-30T07:26:50Z","timestamp":1667114810000},"page":"1599","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Thioterpenoids as Potential Antithrombotic Drugs: Molecular Docking, Antiaggregant, Anticoagulant and Antioxidant Activities"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8681-0335","authenticated-orcid":false,"given":"Alexander A.","family":"Ksenofontov","sequence":"first","affiliation":[{"name":"G.A. Krestov Institute of Solution Chemistry of the Russian Academy of Sciences, 1 Akademicheskaya Street, 153045 Ivanovo, Russia"},{"name":"Biologically Active Terpenoids Laboratory, Institute of Fundamental Medicine and Biology, Kazan Federal University, 18 Kremlevskaya Street, 420008 Kazan, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8833-8089","authenticated-orcid":false,"given":"Pavel S.","family":"Bocharov","sequence":"additional","affiliation":[{"name":"G.A. Krestov Institute of Solution Chemistry of the Russian Academy of Sciences, 1 Akademicheskaya Street, 153045 Ivanovo, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena V.","family":"Antina","sequence":"additional","affiliation":[{"name":"G.A. Krestov Institute of Solution Chemistry of the Russian Academy of Sciences, 1 Akademicheskaya Street, 153045 Ivanovo, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5331-3201","authenticated-orcid":false,"given":"Oksana G.","family":"Shevchenko","sequence":"additional","affiliation":[{"name":"Center of Collective Usage \u00abMolecular Biology\u00bb, Institute of Biology, Komi Science Centre, Ural Branch of Russian Academy of Sciences, 28 Kommunisticheskaya Street, 167982 Syktyvkar, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9302-499X","authenticated-orcid":false,"given":"Aleksandr V.","family":"Samorodov","sequence":"additional","affiliation":[{"name":"Biologically Active Terpenoids Laboratory, Institute of Fundamental Medicine and Biology, Kazan Federal University, 18 Kremlevskaya Street, 420008 Kazan, Russia"},{"name":"Department of Pharmacology, Bashkir State Medical University, 3 Lenina str., 450008 Ufa, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4351-3378","authenticated-orcid":false,"given":"Ilmir R.","family":"Gilfanov","sequence":"additional","affiliation":[{"name":"Biologically Active Terpenoids Laboratory, Institute of Fundamental Medicine and Biology, Kazan Federal University, 18 Kremlevskaya Street, 420008 Kazan, Russia"},{"name":"Varnishes and Paints Department, Kazan National Research Technological University, 68 K. Marksa Street, 420015 Kazan, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3195-1218","authenticated-orcid":false,"given":"Roman S.","family":"Pavelyev","sequence":"additional","affiliation":[{"name":"Biologically Active Terpenoids Laboratory, Institute of Fundamental Medicine and Biology, Kazan Federal University, 18 Kremlevskaya Street, 420008 Kazan, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga V.","family":"Ostolopovskaya","sequence":"additional","affiliation":[{"name":"Biologically Active Terpenoids Laboratory, Institute of Fundamental Medicine and Biology, Kazan Federal University, 18 Kremlevskaya Street, 420008 Kazan, Russia"},{"name":"General and Organic Chemistry Department, Kazan State Medical University, 49 Butlerova Street, 420012 Kazan, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeriya A.","family":"Startseva","sequence":"additional","affiliation":[{"name":"Biologically Active Terpenoids Laboratory, Institute of Fundamental Medicine and Biology, Kazan Federal University, 18 Kremlevskaya Street, 420008 Kazan, Russia"},{"name":"General and Organic Chemistry Department, Kazan State Medical University, 49 Butlerova Street, 420012 Kazan, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6839-8268","authenticated-orcid":false,"given":"Inna V.","family":"Fedyunina","sequence":"additional","affiliation":[{"name":"Biologically Active Terpenoids Laboratory, Institute of Fundamental Medicine and Biology, Kazan Federal University, 18 Kremlevskaya Street, 420008 Kazan, Russia"},{"name":"General and Organic Chemistry Department, Kazan State Medical University, 49 Butlerova Street, 420012 Kazan, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zulfiya R.","family":"Azizova","sequence":"additional","affiliation":[{"name":"Biologically Active Terpenoids Laboratory, Institute of Fundamental Medicine and Biology, Kazan Federal University, 18 Kremlevskaya Street, 420008 Kazan, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salavat I.","family":"Gaysin","sequence":"additional","affiliation":[{"name":"General and Organic Chemistry Department, Kazan State Medical University, 49 Butlerova Street, 420012 Kazan, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8791-5996","authenticated-orcid":false,"given":"Svetlana V.","family":"Pestova","sequence":"additional","affiliation":[{"name":"Medical Chemistry Laboratory, Institute of Chemistry, Komi Scientific Centre, Ural Branch of Russian Academy of Sciences, 48 Pervomaiskaya Street, 167000 Syktyvkar, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5698-6292","authenticated-orcid":false,"given":"Evgeniy S.","family":"Izmest\u2019ev","sequence":"additional","affiliation":[{"name":"Medical Chemistry Laboratory, Institute of Chemistry, Komi Scientific Centre, Ural Branch of Russian Academy of Sciences, 48 Pervomaiskaya Street, 167000 Syktyvkar, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svetlana A.","family":"Rubtsova","sequence":"additional","affiliation":[{"name":"Medical Chemistry Laboratory, Institute of Chemistry, Komi Scientific Centre, Ural Branch of Russian Academy of Sciences, 48 Pervomaiskaya Street, 167000 Syktyvkar, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7922-4004","authenticated-orcid":false,"given":"Mohammed A.","family":"Khelkhal","sequence":"additional","affiliation":[{"name":"Biologically Active Terpenoids Laboratory, Institute of Fundamental Medicine and Biology, Kazan Federal University, 18 Kremlevskaya Street, 420008 Kazan, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2113-5732","authenticated-orcid":false,"given":"Liliya E.","family":"Nikitina","sequence":"additional","affiliation":[{"name":"Biologically Active Terpenoids Laboratory, Institute of Fundamental Medicine and Biology, Kazan Federal University, 18 Kremlevskaya Street, 420008 Kazan, Russia"},{"name":"General and Organic Chemistry Department, Kazan State Medical University, 49 Butlerova Street, 420012 Kazan, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Zieli\u0144ska-B\u0142ajet, M., and Feder-Kubis, J. 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