{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:58:28Z","timestamp":1792789108699,"version":"4.5.0"},"reference-count":123,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2022,11,3]],"date-time":"2022-11-03T00:00:00Z","timestamp":1667433600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81970889"],"award-info":[{"award-number":["81970889"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81420108010"],"award-info":[{"award-number":["81420108010"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22S31903100"],"award-info":[{"award-number":["22S31903100"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Science and Technology Committee of Shanghai","award":["81970889"],"award-info":[{"award-number":["81970889"]}]},{"name":"Science and Technology Committee of Shanghai","award":["81420108010"],"award-info":[{"award-number":["81420108010"]}]},{"name":"Science and Technology Committee of Shanghai","award":["22S31903100"],"award-info":[{"award-number":["22S31903100"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>Ischemia-reperfusion (I\/R) injury, uncommon among patients suffering from myocardial infarction, stroke, or acute kidney injury, can result in cell death and organ dysfunction. Previous studies have shown that different types of cell death, including apoptosis, necrosis, and autophagy, can occur during I\/R injury. Pyroptosis, which is characterized by cell membrane pore formation, pro-inflammatory cytokine release, and cell burst, and which differentiates itself from apoptosis and necroptosis, has been found to be closely related to I\/R injury. Therefore, targeting the signaling pathways and key regulators of pyroptosis may be favorable for the treatment of I\/R injury, which is far from adequate at present. This review summarizes the current status of pyroptosis and its connection to I\/R in different organs, as well as potential treatment strategies targeting it to combat I\/R injury.<\/jats:p>","DOI":"10.3390\/biom12111625","type":"journal-article","created":{"date-parts":[[2022,11,4]],"date-time":"2022-11-04T03:28:10Z","timestamp":1667532490000},"page":"1625","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":68,"title":["Pyroptosis: A Newly Discovered Therapeutic Target for Ischemia-Reperfusion Injury"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9085-6539","authenticated-orcid":false,"given":"Yu","family":"Zheng","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology, Eye Ear Nose and Throat Hospital, Fudan University, Shanghai 200031, China"},{"name":"Shanghai Clinical Medical Center of Hearing Medicine, Shanghai 200031, China"},{"name":"NHC Key Laboratory of Hearing Medicine, Fudan University, Shanghai 200031, China"},{"name":"Research Institute of Otorhinolaryngology, Fudan University, Shanghai 200031, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1157-8660","authenticated-orcid":false,"given":"Xinda","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Eye Ear Nose and Throat Hospital, Fudan University, Shanghai 200031, China"},{"name":"Shanghai Clinical Medical Center of Hearing Medicine, Shanghai 200031, China"},{"name":"NHC Key Laboratory of Hearing Medicine, Fudan University, Shanghai 200031, China"},{"name":"Research Institute of Otorhinolaryngology, Fudan University, Shanghai 200031, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanglu","family":"Chi","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Eye Ear Nose and Throat Hospital, Fudan University, Shanghai 200031, China"},{"name":"Shanghai Clinical Medical Center of Hearing Medicine, Shanghai 200031, China"},{"name":"NHC Key Laboratory of Hearing Medicine, Fudan University, Shanghai 200031, China"},{"name":"Research Institute of Otorhinolaryngology, Fudan University, Shanghai 200031, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7163-3698","authenticated-orcid":false,"given":"Ning","family":"Cong","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Eye Ear Nose and Throat Hospital, Fudan University, Shanghai 200031, China"},{"name":"Shanghai Clinical Medical Center of Hearing Medicine, Shanghai 200031, China"},{"name":"NHC Key Laboratory of Hearing Medicine, Fudan University, Shanghai 200031, China"},{"name":"Research Institute of Otorhinolaryngology, Fudan University, Shanghai 200031, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1038\/nm.2507","article-title":"Ischemia and reperfusion\u2014From mechanism to translation","volume":"17","author":"Eltzschig","year":"2011","journal-title":"Nat. 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