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Project","award":["YKK22222"],"award-info":[{"award-number":["YKK22222"]}]},{"name":"Lianyungang Science and Technology Bureau Project","award":["JNYYZXKY202201"],"award-info":[{"award-number":["JNYYZXKY202201"]}]},{"name":"Lianyungang Science and Technology Bureau Project","award":["SF2118"],"award-info":[{"award-number":["SF2118"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>Periprosthetic osteolysis (PPO) along with aseptic loosening (AL) caused by wear particles after artificial joint replacement is the key factor in surgical failure and subsequent revision surgery, however, the precise molecular mechanism underlying PPO remains unclear. Aseptic inflammation triggered by metal particles, resulting in the imbalance between bone formation by osteoblasts and bone resorption by osteoclasts may be the decisive factor. Pyroptosis is a new pro-inflammatory pattern of regulated cell death (RCD), mainly mediated by gasdermins (GSDMs) family, among which GSDMD is the best characterized. Recent evidence indicates that activation of NLRP3 inflammasomes and pyroptosis play a pivotal role in the pathological process of PPO. Here, we review the pathological process of PPO, the molecular mechanism of pyroptosis and the interventions to inhibit the inflammation and pyroptosis of different cells during the PPO. Conclusively, this review provides theoretical support for the search for new strategies and new targets for the treatment of PPO by inhibiting pyroptosis and inflammation.<\/jats:p>","DOI":"10.3390\/biom12121733","type":"journal-article","created":{"date-parts":[[2022,11,23]],"date-time":"2022-11-23T02:10:54Z","timestamp":1669169454000},"page":"1733","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Pyroptosis in Periprosthetic Osteolysis"],"prefix":"10.3390","volume":"12","author":[{"given":"Jian","family":"Yin","sequence":"first","affiliation":[{"name":"Department of Orthopedics, Shanghai General Hospital of Nanjing Medical University, Shanghai 201600, China"},{"name":"Department of Orthopedics, The Affiliated Jiangning Hospital with Nanjing Medical University, Nanjing 211100, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhaoyang","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, The Affiliated Lianyungang Hospital of Xuzhou Medical University (The First People\u2019s Hospital of Lianyungang), Lianyungang 222000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201600, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinhui","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, The Affiliated Jiangning Hospital with Nanjing Medical University, Nanjing 211100, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinzhong","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Shanghai General Hospital of Nanjing Medical University, Shanghai 201600, China"},{"name":"Department of Orthopedics, The Affiliated Jiangning Hospital with Nanjing Medical University, Nanjing 211100, China"},{"name":"Department of Orthopedics, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201600, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"8046","DOI":"10.1016\/j.actbio.2013.05.005","article-title":"Osteolysis around total knee arthroplasty: A review of pathogenetic mechanisms","volume":"9","author":"Gallo","year":"2013","journal-title":"Acta Biomater."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1016\/j.arth.2013.07.024","article-title":"Why are total knee arthroplasties failing today--has anything changed after 10 years?","volume":"29","author":"Sharkey","year":"2014","journal-title":"J. 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