{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T00:11:41Z","timestamp":1793059901792,"version":"4.5.0"},"reference-count":296,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2022,11,24]],"date-time":"2022-11-24T00:00:00Z","timestamp":1669248000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>During the last few decades, the micronutrient zinc has proven to be an important metal ion for a well-functioning immune system, and thus also for a suitable immune defense. Nowadays, it is known that the main cause of zinc deficiency is malnutrition. In particular, vulnerable populations, such as the elderly in Western countries and children in developing countries, are often affected. However, sufficient zinc intake and homeostasis is essential for a healthy life, as it is known that zinc deficiency is associated with a multitude of immune disorders such as metabolic and chronic diseases, as well as infectious diseases such as respiratory infections, malaria, HIV, or tuberculosis. Moreover, the modulation of the proinflammatory immune response and oxidative stress is well described. The anti-inflammatory and antioxidant properties of zinc have been known for a long time, but are not comprehensively researched and understood yet. Therefore, this review highlights the current molecular mechanisms underlying the development of a pro-\/ and anti-inflammatory immune response as a result of zinc deficiency and zinc supplementation. Additionally, we emphasize the potential of zinc as a preventive and therapeutic agent, alone or in combination with other strategies, that could ameliorate infectious diseases.<\/jats:p>","DOI":"10.3390\/biom12121748","type":"journal-article","created":{"date-parts":[[2022,11,25]],"date-time":"2022-11-25T02:29:23Z","timestamp":1669343363000},"page":"1748","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":152,"title":["Zinc in Human Health and Infectious Diseases"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7143-6691","authenticated-orcid":false,"given":"Martina","family":"Maywald","sequence":"first","affiliation":[{"name":"Institute of Immunology, Faculty of Medicine, RWTH Aachen University Hospital, 52074 Aachen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5658-2893","authenticated-orcid":false,"given":"Lothar","family":"Rink","sequence":"additional","affiliation":[{"name":"Institute of Immunology, Faculty of Medicine, RWTH Aachen University Hospital, 52074 Aachen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Maret, W. (2017). Zinc in Cellular Regulation: The Nature and Significance of \u201cZinc Signals\u201d. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18112285"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1021\/pr050361j","article-title":"Counting the zinc-proteins encoded in the human genome","volume":"5","author":"Andreini","year":"2006","journal-title":"J. Proteome Res."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"679S","DOI":"10.3945\/ajcn.110.005744","article-title":"Zinc: An essential but elusive nutrient","volume":"94","author":"King","year":"2011","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Maret, W. (2016). The metals in the biological periodic system of the elements: Concepts and conjectures. Int. J. Mol. Sci., 17.","DOI":"10.3390\/ijms17010066"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"3184","DOI":"10.3390\/nu5083184","article-title":"Iron and zinc nutrition in the economically-developed world: A review","volume":"5","author":"Lim","year":"2013","journal-title":"Nutrients"},{"key":"ref_6","first-page":"537","article-title":"Zinc metabolism in patients with the syndrome of iron deficiency anemia, hepatosplenomegaly, dwarfism, and hypogonadism","volume":"61","author":"Prasad","year":"1963","journal-title":"J. Lab. Clin. Med."},{"key":"ref_7","first-page":"224","article-title":"The importance of targeting signalling mechanisms of the SLC39A family of zinc transporters to inhibit endocrine resistant breast cancer","volume":"3","author":"Jones","year":"2022","journal-title":"Explor. Target. Anti-Tumor Ther."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Wan, Y., and Zhang, B. (2022). The Impact of Zinc and Zinc Homeostasis on the Intestinal Mucosal Barrier and Intestinal Diseases. Biomolecules, 12.","DOI":"10.3390\/biom12070900"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"e12314","DOI":"10.7717\/peerj.12314","article-title":"The role of zinc transporter proteins as predictive and prognostic biomarkers of hepatocellular cancer","volume":"9","author":"Bitirim","year":"2021","journal-title":"PeerJ"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.18632\/aging.100978","article-title":"Zinc intake, microRNA dysregulation, and esophageal cancer","volume":"8","author":"Fong","year":"2016","journal-title":"Aging"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"MacKenzie, S., and Bergdahl, A. (2022). Zinc Homeostasis in Diabetes Mellitus and Vascular Complications. Biomedicines, 10.","DOI":"10.3390\/biomedicines10010139"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3746\/pnf.2017.22.1.1","article-title":"Zinc in pancreatic islet biology, insulin sensitivity, and diabetes","volume":"22","author":"Maret","year":"2017","journal-title":"Prev. Nutr. Food Sci."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Wessels, I., Maywald, M., and Rink, L. (2017). Zinc as a gatekeeper of immune function. Nutrients, 9.","DOI":"10.3390\/nu9121286"},{"key":"ref_14","first-page":"389","article-title":"Zinc and human disease","volume":"13","author":"Maret","year":"2013","journal-title":"Met. Ions Life Sci."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1017\/S0007114521000738","article-title":"Zinc deficiency as a possible risk factor for increased susceptibility and severe progression of Corona Virus Disease 19","volume":"127","author":"Wessels","year":"2022","journal-title":"Br. J. Nutr."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.3390\/ijerph7041342","article-title":"The essential toxin: Impact of zinc on human health","volume":"7","author":"Plum","year":"2010","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"ref_17","unstructured":"Ross, A.C., Caballero, B.H., Cousins, R.J., Tucker, K.L., and Ziegler, T.R. (2012). Modern Nutrition in Health and Disease, Wolters Kluwer Health Adis (ESP). [11th ed.]."},{"key":"ref_18","unstructured":"National Institutes of Health (2022, October 06). Zinc, Fact Sheet for Health Professionals, Available online: https:\/\/ods.od.nih.gov\/factsheets\/Zinc-HealthProfessional\/."},{"key":"ref_19","unstructured":"Institute of Medicine (US) Panel on Micronutrients (2001). Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc, National Academies Press (US)."},{"key":"ref_20","unstructured":"Nordberg, G.F., Fowler, B.A., Nordberg, M., and Friberg, L.T. (2007). Handbook on the Toxicology of Metals, Elsevier Inc."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"2606","DOI":"10.1007\/s12011-021-02883-z","article-title":"Comparison of Serum, Plasma, and Liver Zinc Measurements by AAS, ICP-OES, and ICP-MS in Diverse Laboratory Settings","volume":"200","author":"Hall","year":"2022","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/S0076-6879(02)48641-7","article-title":"Optical methods for measuring zinc binding and release, zinc coordination environments in zinc finger proteins, and redox sensitivity and activity of zinc-bound thiols","volume":"Volume 348","author":"Sies","year":"2002","journal-title":"Methods in Enzymology"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.abb.2016.08.018","article-title":"Techniques for measuring cellular zinc","volume":"611","author":"Carpenter","year":"2016","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_24","unstructured":"Rink, L. (2011). Zinc in Human Health, Ios Press."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Jackson, M. (1989). Physiology of zinc: General aspects. Zinc in Human Biology, Springer.","DOI":"10.1007\/978-1-4471-3879-2_1"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Maares, M., and Haase, H. (2020). A guide to human zinc absorption: General overview and recent advances of in vitro intestinal models. Nutrients, 12.","DOI":"10.3390\/nu12030762"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1177\/0884533615570376","article-title":"Zinc: Physiology, deficiency, and parenteral nutrition","volume":"30","author":"Livingstone","year":"2015","journal-title":"Nutr. Clin. Pract."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1152\/physrev.1993.73.1.79","article-title":"The biochemical basis of zinc physiology","volume":"73","author":"Vallee","year":"1993","journal-title":"Physiol. Rev."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1023\/A:1012905406548","article-title":"Functions of zinc in signaling, proliferation and differentiation of mammalian cells","volume":"14","author":"Beyersmann","year":"2001","journal-title":"Biometals"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/978-3-0348-6493-0_1","article-title":"Metallothionein: Historical review and perspectives","volume":"34","author":"Vallee","year":"1979","journal-title":"Experientia Suppl."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1039\/b926662c","article-title":"Cytosolic zinc buffering and muffling: Their role in intracellularzinc homeostasis","volume":"2","author":"Colvin","year":"2010","journal-title":"Metallomics"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1023\/A:1009232311677","article-title":"Uptake and intracellular distribution of labile and total Zn(II) in C6 rat glioma cells investigated with fluorescent probes and atomic absorption","volume":"12","author":"Haase","year":"1999","journal-title":"Biometals"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"28129","DOI":"10.1074\/jbc.R114.592618","article-title":"Lysosome-related organelles as mediators of metal homeostasis","volume":"289","author":"Merchant","year":"2014","journal-title":"J. Biol. Chem."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.abb.2016.04.010","article-title":"The biological inorganic chemistry of zinc ions","volume":"611","author":"Maret","year":"2016","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1038\/350564b0","article-title":"Homeostatic muffling","volume":"350","author":"Thomas","year":"1991","journal-title":"Nature"},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Haase, H., and Maret, W. (2010). The regulatory and signaling functions of zinc ions in human cellular physiology. Cellular and Molecular Biology of Metals, CRC Press.","DOI":"10.1201\/9781420059984-c8"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1017\/S0029665100000781","article-title":"Zinc and the immune system","volume":"59","author":"Rink","year":"2000","journal-title":"Proc. Nutr. Soc."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1177\/0379572116652252","article-title":"A review of dietary zinc recommendations","volume":"37","author":"Gibson","year":"2016","journal-title":"Food Nutr. Bull."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1374S","DOI":"10.1093\/jn\/130.5.1374S","article-title":"Overview of zinc absorption and excretion in the human gastrointestinal tract","volume":"130","author":"Krebs","year":"2000","journal-title":"J. Nutr."},{"key":"ref_40","first-page":"G176","article-title":"Interaction between transport of zinc and other solutes in human intestine","volume":"247","author":"Steinhardt","year":"1984","journal-title":"Am. J. Physiol."},{"key":"ref_41","first-page":"G87","article-title":"Zinc absorption in human small intestine","volume":"256","author":"Lee","year":"1989","journal-title":"Am. J. Physiol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1079\/PNS2003320","article-title":"Intestinal and placental zinc transport pathways","volume":"63","author":"Ford","year":"2004","journal-title":"Proc. Nutr. Soc."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.jtemb.2018.02.020","article-title":"A short 18 items food frequency questionnaire biochemically validated to estimate zinc status in humans","volume":"49","author":"Trame","year":"2018","journal-title":"J. Trace Elem. Med. Biol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1093\/ajcn\/87.5.1336","article-title":"Adaptation in human zinc absorption as influenced by dietary zinc and bioavailability","volume":"87","author":"Hunt","year":"2008","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1378s","DOI":"10.1093\/jn\/130.5.1378S","article-title":"Dietary factors influencing zinc absorption","volume":"130","year":"2000","journal-title":"J. Nutr."},{"key":"ref_46","unstructured":"Medicine, I.o. (2006). Dietary Reference Intakes: The Essential Guide to Nutrient Requirements, The National Academies Press."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1186\/1475-2891-12-116","article-title":"Major food sources of calories, added sugars, and saturated fat and their contribution to essential nutrient intakes in the U.S. diet: Data from the National Health and Nutrition Examination Survey (2003\u20132006)","volume":"12","author":"Huth","year":"2013","journal-title":"Nutr. J."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"858s","DOI":"10.3945\/jn.115.220079","article-title":"Biomarkers of Nutrition for Development (BOND)-Zinc Review","volume":"146","author":"King","year":"2015","journal-title":"J. Nutr."},{"key":"ref_49","unstructured":"Deutsche Gesellschaft f\u00fcr Ern\u00e4hrunf e. V. (2022, October 06). Referenzwerte f\u00fcr die N\u00e4hrstoffzufuhr. Available online: https:\/\/www.dge.de\/wissenschaft\/referenzwerte\/?L=0."},{"key":"ref_50","unstructured":"World Health Organization (1996). Trace Elements in Human Nutrition and Health, World Health Organization."},{"key":"ref_51","first-page":"3893","article-title":"EFSA Panel on Dietetic Products, Nutrition and Allergies","volume":"12","author":"Agostoni","year":"2014","journal-title":"Sci. Opin. Diet. Ref. Values Folate. EFSA J."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1055\/s-0030-1255322","article-title":"Zink und Immunfunktionen","volume":"25","author":"Brieger","year":"2010","journal-title":"Ern\u00e4hrung Med."},{"key":"ref_53","unstructured":"Ezzati, M., Lopez, A.D., Rodgers, A.A., and Murray, C.J.L. (2004). Comparative Quantification of Health Risks: Global and Regional Burden of Disease Attributable to Selected Major Risk Factors, World Health Organization."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1001\/archpedi.1991.02160080029016","article-title":"Zinc deficiency. A public health problem?","volume":"145","author":"Sandstead","year":"1991","journal-title":"Am. J. Dis. Child."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1039\/c3mt00353a","article-title":"Multiple impacts of zinc on immune function","volume":"6","author":"Haase","year":"2014","journal-title":"Metallomics"},{"key":"ref_56","unstructured":"World Health Organization (2005). Vitamin and Mineral Requirements in Human Nutrition, World Health Organization."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"101541","DOI":"10.1016\/j.arr.2021.101541","article-title":"Rebalancing the unbalanced aged immune system-a special focus on zinc","volume":"74","author":"Baarz","year":"2021","journal-title":"Ageing Res. Rev."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.foodchem.2004.03.040","article-title":"Effects of soaking whole cereal and legume seeds on iron, zinc and phytate contents","volume":"89","author":"Lestienne","year":"2005","journal-title":"Food Chem."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/bs.afnr.2014.11.003","article-title":"Vegetarian diets across the lifecycle: Impact on zinc intake and status","volume":"74","author":"Foster","year":"2015","journal-title":"Adv. Food Nutr. Res."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.bbrc.2009.01.074","article-title":"The ligand environment of zinc stored in vesicles","volume":"380","author":"Wellenreuther","year":"2009","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"3281","DOI":"10.1007\/s00018-014-1617-0","article-title":"Current understanding of ZIP and ZnT zinc transporters in human health and diseases","volume":"71","author":"Kambe","year":"2014","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1039\/c1mt00011j","article-title":"Molecular and genetic features of zinc transporters in physiology and pathogenesis","volume":"3","author":"Fukada","year":"2011","journal-title":"Metallomics"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"176","DOI":"10.3945\/an.112.003210","article-title":"Discovery of human zinc deficiency: Its impact on human health and disease","volume":"4","author":"Prasad","year":"2013","journal-title":"Adv. Nutr."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/j.mam.2012.05.011","article-title":"The SLC39 family of zinc transporters","volume":"34","author":"Jeong","year":"2013","journal-title":"Mol. Asp. Med."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/ncomms11601","article-title":"Mutations in SLC39A14 disrupt manganese homeostasis and cause childhood-onset parkinsonism\u2013dystonia","volume":"7","author":"Tuschl","year":"2016","journal-title":"Nat. Commun."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.jphs.2021.11.007","article-title":"Zinc transporters as potential therapeutic targets: An updated review","volume":"148","author":"Hara","year":"2022","journal-title":"J. Pharmacol. Sci."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/j.mam.2012.05.008","article-title":"The SLC30 family of zinc transporters\u2014A review of current understanding of their biological and pathophysiological roles","volume":"34","author":"Huang","year":"2013","journal-title":"Mol. Asp. Med."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1007\/s00775-011-0800-0","article-title":"Redox biochemistry of mammalian metallothioneins","volume":"16","author":"Maret","year":"2011","journal-title":"J. Biol. Inorg. Chem."},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Kimura, T., and Kambe, T. (2016). The Functions of Metallothionein and ZIP and ZnT Transporters: An Overview and Perspective. Int. J. Mol. Sci., 17.","DOI":"10.3390\/ijms17030336"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1039\/c0mt00102c","article-title":"The \u201cmagic numbers\u201d of metallothionein","volume":"3","author":"Sutherland","year":"2011","journal-title":"Metallomics"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/1477-7819-9-54","article-title":"A review of metallothionein isoforms and their role in pathophysiology","volume":"9","author":"Thirumoorthy","year":"2011","journal-title":"World J. Surg. Oncol."},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Va\u0161\u00e1k, M., and Meloni, G. (2017). Mammalian Metallothionein-3: New Functional and Structural Insights. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18061117"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"739918","DOI":"10.3389\/fimmu.2021.739918","article-title":"Metallothionein 1: A New Spotlight on Inflammatory Diseases","volume":"12","author":"Dai","year":"2021","journal-title":"Front. Immunol."},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Yin, X., Knecht, D.A., and Lynes, M.A. (2005). Metallothionein mediates leukocyte chemotaxis. BMC Immunol., 6.","DOI":"10.1186\/1471-2172-6-21"},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Ling, X.B., Wei, H.W., Wang, J., Kong, Y.Q., Wu, Y.Y., Guo, J.L., Li, T.F., and Li, J.K. (2016). Mammalian Metallothionein-2A and Oxidative Stress. Int. J. Mol. Sci., 17.","DOI":"10.3390\/ijms17091483"},{"key":"ref_76","unstructured":"Klaasen, C. (2012). Metallothionein iv, Birkh\u00e4user."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/taap.2001.9323","article-title":"Glucocorticoids suppress the inflammation-mediated tolerance to acute toxicity of cadmium in mice","volume":"178","author":"Min","year":"2002","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_78","first-page":"E399","article-title":"Involvement of hepatic metallothioneins in hypozincemia associated with bacterial infection","volume":"234","author":"Sobocinski","year":"1978","journal-title":"Am. J. Physiol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1007\/s12192-015-0630-z","article-title":"Metallothionein differentially affects the host response to Listeria infection both with and without an additional stress from cold-restraint","volume":"20","author":"Emeny","year":"2015","journal-title":"Cell Stress Chaperones"},{"key":"ref_80","first-page":"1232","article-title":"The importance of Ca2+\/Zn2+ signaling S100 proteins and RAGE in translational medicine","volume":"3","author":"Leclerc","year":"2011","journal-title":"Front. Biosci. (School Ed.)"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1007\/s11427-016-5088-4","article-title":"Binding of transition metals to S100 proteins","volume":"59","author":"Gilston","year":"2016","journal-title":"Sci. China Life Sci."},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Singh, P., and Ali, S.A. (2022). Multifunctional Role of S100 Protein Family in the Immune System: An Update. Cells, 11.","DOI":"10.3390\/cells11152274"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1023\/A:1009212521172","article-title":"New perspectives on S100 proteins: A multi-functional Ca(2+)-, Zn(2+)- and Cu(2+)-binding protein family","volume":"11","author":"Heizmann","year":"1998","journal-title":"Biometals"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"101","DOI":"10.3233\/JAD-2007-12110","article-title":"Zinc dyshomeostasis, ageing and neurodegeneration: Implications of A2M and inflammatory gene polymorphisms","volume":"12","author":"Mocchegiani","year":"2007","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"Guryanova, S.V., and Ovchinnikova, T.V. (2022). Immunomodulatory and Allergenic Properties of Antimicrobial Peptides. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23052499"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1146\/annurev-biochem-062917-012312","article-title":"Transition Metal Sequestration by the Host-Defense Protein Calprotectin","volume":"87","author":"Zygiel","year":"2018","journal-title":"Annu. Rev. Biochem."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1021\/acs.biochem.9b01012","article-title":"Avian MRP126 Restricts Microbial Growth through Ca(II)-Dependent Zn(II) Sequestration","volume":"59","author":"Bozzi","year":"2020","journal-title":"Biochemistry"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1126\/science.1152449","article-title":"Metal chelation and inhibition of bacterial growth in tissue abscesses","volume":"319","author":"Corbin","year":"2008","journal-title":"Science"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1126\/science.1092385","article-title":"Neutrophil extracellular traps kill bacteria","volume":"303","author":"Brinkmann","year":"2004","journal-title":"Science"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"19630","DOI":"10.1038\/s41598-020-76781-0","article-title":"The emerging role of neutrophil extracellular traps in severe acute respiratory syndrome coronavirus 2 (COVID-19)","volume":"10","author":"Arcanjo","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"900895","DOI":"10.3389\/fcimb.2022.900895","article-title":"The emerging role of neutrophil extracellular traps in fungal infection","volume":"12","author":"Liang","year":"2022","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"18026","DOI":"10.1038\/nrdp.2018.26","article-title":"Invasive candidiasis","volume":"4","author":"Pappas","year":"2018","journal-title":"Nat. Rev. Dis. Prim."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/j.immuni.2013.09.006","article-title":"Granulocyte macrophage-colony stimulating factor induced Zn sequestration enhances macrophage superoxide and limits intracellular pathogen survival","volume":"39","author":"Porollo","year":"2013","journal-title":"Immunity"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.cbpa.2009.11.008","article-title":"Nutritional immunity beyond iron: A role for manganese and zinc","volume":"14","author":"Skaar","year":"2010","journal-title":"Curr. Opin. Chem. Biol."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.tim.2012.01.005","article-title":"Metallobiology of host-pathogen interactions: An intoxicating new insight","volume":"20","author":"Botella","year":"2012","journal-title":"Trends Microbiol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"909888","DOI":"10.3389\/fcimb.2022.909888","article-title":"Acclimation to Nutritional Immunity and Metal Intoxication Requires Zinc, Manganese, and Copper Homeostasis in the Pathogenic Neisseriae","volume":"12","author":"Branch","year":"2022","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"28","DOI":"10.34297\/AJBSR.2019.02.000566","article-title":"Review on the role of Zn2+ ions in viral pathogenesis and the effect of Zn2+ ions for host cell-virus growth inhibition","volume":"2","author":"Ishida","year":"2019","journal-title":"Am. J. Biomed. Sci. Res."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"e07805","DOI":"10.1016\/j.heliyon.2021.e07805","article-title":"Nutritional immunity: Targeting fungal zinc homeostasis","volume":"7","author":"Alamir","year":"2021","journal-title":"Heliyon"},{"key":"ref_99","doi-asserted-by":"crossref","unstructured":"Aydemir, T.B., Chang, S.M., Guthrie, G.J., Maki, A.B., Ryu, M.S., Karabiyik, A., and Cousins, R.J. (2012). Zinc transporter ZIP14 functions in hepatic zinc, iron and glucose homeostasis during the innate immune response (endotoxemia). PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0048679"},{"key":"ref_100","first-page":"E952","article-title":"Effects of endotoxin on zinc metabolism in human volunteers","volume":"272","author":"Gaetke","year":"1997","journal-title":"Am. J. Physiol."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1016\/j.tibs.2019.06.010","article-title":"Nutrient Zinc at the Host-Pathogen Interface","volume":"44","author":"Lonergan","year":"2019","journal-title":"Trends Biochem. Sci."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1111\/mmi.12288","article-title":"In vitro resistance mechanisms of Neisseria meningitidis against neutrophil extracellular traps","volume":"89","author":"Lappann","year":"2013","journal-title":"Mol. Microbiol."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1042\/BST20170228","article-title":"Bacterial zinc uptake regulator proteins and their regulons","volume":"46","author":"Mikhaylina","year":"2018","journal-title":"Biochem. Soc. Trans."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"e0177321","DOI":"10.1128\/spectrum.01773-21","article-title":"The Role of ZntA in Klebsiella pneumoniae Zinc Homeostasis","volume":"10","author":"Maunders","year":"2022","journal-title":"Microbiol. Spectr."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"e2104073118","DOI":"10.1073\/pnas.2104073118","article-title":"Yersiniabactin contributes to overcoming zinc restriction during Yersinia pestis infection of mammalian and insect hosts","volume":"118","author":"Price","year":"2021","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"2656","DOI":"10.3389\/fmicb.2017.02656","article-title":"Investigation of the Role of Genes Encoding Zinc Exporters zntA, zitB, and fieF during Salmonella Typhimurium Infection","volume":"8","author":"Huang","year":"2017","journal-title":"Front. Microbiol."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s00005-008-0003-8","article-title":"Modulating the immune response by oral zinc supplementation: A single approach for multiple diseases","volume":"56","author":"Overbeck","year":"2008","journal-title":"Arch. Immunol. Et Ther. Exp."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1128\/AAC.25.1.20","article-title":"Reduction in duration of common colds by zinc gluconate lozenges in a double-blind study","volume":"25","author":"Eby","year":"1984","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1177\/030006059202000305","article-title":"Zinc gluconate and the common cold: A controlled clinical study","volume":"20","author":"Godfrey","year":"1992","journal-title":"J. Int. Med. Res."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/S0011-393X(98)85058-3","article-title":"Randomized, double-masked, placebo-controlled clinical study of the effectiveness of zinc acetate lozenges on common cold symptoms in allergy-tested subjects","volume":"59","author":"Petrus","year":"1998","journal-title":"Curr. Ther. Res. Clin. Exp."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"245","DOI":"10.7326\/0003-4819-133-4-200008150-00006","article-title":"Duration of symptoms and plasma cytokine levels in patients with the common cold treated with zinc acetate. A randomized, double-blind, placebo-controlled trial","volume":"133","author":"Prasad","year":"2000","journal-title":"Ann. Intern. Med."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1086\/317437","article-title":"Effect of treatment with zinc gluconate or zinc acetate on experimental and natural colds","volume":"31","author":"Turner","year":"2000","journal-title":"Clin. Infect. Dis."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.ctcp.2009.02.006","article-title":"Use of zinc supplements to reduce upper respiratory infections in United States Air Force Academy cadets","volume":"15","author":"Veverka","year":"2009","journal-title":"Complement. Ther. Clin. Pract."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1093\/jac\/20.6.893","article-title":"Prophylaxis and treatment of rhinovirus colds with zinc gluconate lozenges","volume":"20","author":"Higgins","year":"1987","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1016\/S0140-6736(04)16252-1","article-title":"Zinc for severe pneumonia in very young children: Double-blind placebo-controlled trial","volume":"363","author":"Brooks","year":"2004","journal-title":"Lancet"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1056\/NEJMoa1915905","article-title":"Lower-Dose Zinc for Childhood Diarrhea\u2014A Randomized, Multicenter Trial","volume":"383","author":"Dhingra","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"ref_117","unstructured":"World Health Organization (2022, October 06). Diarrhoeal Disease. Available online: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/diarrhoeal-disease."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"e323","DOI":"10.1097\/PCC.0b013e31824fbd90","article-title":"Prophylactic zinc supplementation reduces bacterial load and improves survival in a murine model of sepsis","volume":"13","author":"Nowak","year":"2012","journal-title":"Pediatr. Crit. Care Med."},{"key":"ref_119","first-page":"279","article-title":"Zinc gluconate lozenges for common cold. A double-blind clinical trial","volume":"37","author":"Weismann","year":"1990","journal-title":"Dan. Med. Bull."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1128\/AAC.31.8.1263","article-title":"Failure of effervescent zinc acetate lozenges to alter the course of upper respiratory tract infections in Australian adults","volume":"31","author":"Douglas","year":"1987","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1093\/ajcn\/85.3.887","article-title":"Zinc during and in convalescence from diarrhea has no demonstrable effect on subsequent morbidity and anthropometric status among infants <6 mo of age","volume":"85","author":"Walker","year":"2007","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_122","first-page":"HC16","article-title":"Effect of zinc supplementation on viral response in patients with chronic hepatitis C and Beta thalassemia major, a pilot study","volume":"8","author":"Abbasinazari","year":"2014","journal-title":"J. Clin. Diagn. Res. JCDR"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1186\/s13063-021-05583-0","article-title":"Kabasura Kudineer (KSK), a poly-herbal Siddha medicine, reduced SARS-CoV-2 viral load in asymptomatic COVID-19 individuals as compared to vitamin C and zinc supplementation: Findings from a prospective, exploratory, open-labeled, comparative, randomized controlled trial, Tamil Nadu, India","volume":"22","author":"Natarajan","year":"2021","journal-title":"Trials"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"119","DOI":"10.3389\/fnut.2019.00119","article-title":"The Newly Developed Elderly Nutrient-Rich Food Score Is a Useful Tool to Assess Nutrient Density in European Older Adults","volume":"6","author":"Berendsen","year":"2019","journal-title":"Front. Nutr."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/S0891-5849(98)00109-9","article-title":"Copper\/zinc ratio and systemic oxidant load: Effect of aging and aging-related degenerative diseases","volume":"25","author":"Mezzetti","year":"1998","journal-title":"Free. Radic. Biol. Med."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3164\/jcbn.22-40","article-title":"Crosstalk of copper and zinc in the pathogenesis of vascular dementia","volume":"71","author":"Kawahara","year":"2022","journal-title":"J. Clin. Biochem. Nutr."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1093\/cdn\/nzaa061_025","article-title":"Serum Copper and Zinc Levels and Risk of Hepatocellular Carcinoma: A 1: 1 Matched Case-Control Study","volume":"4","author":"Fang","year":"2020","journal-title":"Curr. Dev. Nutr."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"4441","DOI":"10.2147\/CMAR.S250592","article-title":"Five serum trace elements associated with risk of cardia and noncardia gastric cancer in a matched case\u2013control study","volume":"12","author":"Lin","year":"2020","journal-title":"Cancer Manag. Res."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"2798","DOI":"10.4314\/ahs.v19i3.56","article-title":"Serum levels of copper, zinc and disease severity scores in sickle cell disease patients in Benin City, Nigeria","volume":"19","author":"Emokpae","year":"2019","journal-title":"Afr. Health Sci."},{"key":"ref_130","first-page":"7","article-title":"Evaluation of serum levels of zinc, copper, iron, and zinc\/copper ratio in cutaneous leishmaniasis","volume":"3","author":"Pourfallah","year":"2009","journal-title":"Iran. J. Arthropod-Borne Dis."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1093\/labmed\/lmac017","article-title":"Modified Proline Metabolism and Prolidase Enzyme in COVID-19","volume":"53","author":"Tuncay","year":"2022","journal-title":"Lab. Med."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1128\/AAC.31.8.1183","article-title":"Two randomized controlled trials of zinc gluconate lozenge therapy of experimentally induced rhinovirus colds","volume":"31","author":"Farr","year":"1987","journal-title":"Antimicrob Agents Chemother"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"81","DOI":"10.7326\/0003-4819-125-2-199607150-00001","article-title":"Zinc gluconate lozenges for treating the common cold. A randomized, double-blind, placebo-controlled study","volume":"125","author":"Mossad","year":"1996","journal-title":"Ann. Intern. Med."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1080\/08035250600603024","article-title":"The prophylactic and therapeutic effectiveness of zinc sulphate on common cold in children","volume":"95","author":"Akilli","year":"2006","journal-title":"Acta Paediatr."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1089\/rej.2007.0613","article-title":"Zinc supplementation in the elderly reduces spontaneous inflammatory cytokine release and restores T cell functions","volume":"11","author":"Kahmann","year":"2008","journal-title":"Rejuvenation Res."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/0261-5614(89)90036-8","article-title":"Effect of zinc on the immune status of zinc-depleted AIDS related complex patients","volume":"8","author":"Zazzo","year":"1989","journal-title":"Clin. Nutr."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"1862","DOI":"10.1016\/S0140-6736(05)67756-2","article-title":"Safety and efficacy of zinc supplementation for children with HIV-1 infection in South Africa: A randomised double-blind placebo-controlled trial","volume":"366","author":"Bobat","year":"2005","journal-title":"Lancet"},{"key":"ref_138","first-page":"1378","article-title":"A randomised controlled trial of oral zinc on the immune response to tuberculosis in HIV-infected patients","volume":"9","author":"Green","year":"2005","journal-title":"Int. J. Tuberc. Lung Dis."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1093\/ajcn\/81.1.161","article-title":"Trial of zinc supplements in relation to pregnancy outcomes, hematologic indicators, and T cell counts among HIV-1-infected women in Tanzania","volume":"81","author":"Fawzi","year":"2005","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1038\/sj.ejcn.1602391","article-title":"Zinc supplementation to HIV-1-infected pregnant women: Effects on maternal anthropometry, viral load, and early mother-to-child transmission","volume":"60","author":"Villamor","year":"2006","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1016\/j.vaccine.2005.09.047","article-title":"Effect of zinc and vitamin A supplementation on antibody responses to a pneumococcal conjugate vaccine in HIV-positive injection drug users: A randomized trial","volume":"24","author":"Steinhoff","year":"2006","journal-title":"Vaccine"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1086\/652864","article-title":"Randomized, controlled clinical trial of zinc supplementation to prevent immunological failure in HIV-infected adults","volume":"50","author":"Baum","year":"2010","journal-title":"Clin. Infect. Dis."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"469","DOI":"10.7883\/yoken.66.469","article-title":"Low plasma zinc levels and immunological responses to zinc supplementation in HIV-infected patients with immunological discordance after antiretroviral therapy","volume":"66","author":"Asdamongkol","year":"2013","journal-title":"Jpn. J. Infect. Dis."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1186\/s13063-021-05178-9","article-title":"Per-protocol analysis of the ZINC trial for HIV disease among alcohol users","volume":"22","author":"Lodi","year":"2021","journal-title":"Trials"},{"key":"ref_145","doi-asserted-by":"crossref","unstructured":"Silva, M., Montes, C.G., Canals, A., Mackenna, M.J., and Wolff, M. (2021). Role and effects of zinc supplementation in HIV-infected patients with immunovirological discordance: A randomized, double blind, case control study. PLoS ONE, 16.","DOI":"10.1371\/journal.pone.0244823"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"e204330","DOI":"10.1001\/jamanetworkopen.2020.4330","article-title":"Effect of Zinc Supplementation vs Placebo on Mortality Risk and HIV Disease Progression Among HIV-Positive Adults with Heavy Alcohol Use: A Randomized Clinical Trial","volume":"3","author":"Freiberg","year":"2020","journal-title":"JAMA Netw. Open"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1097\/QAI.0000000000002129","article-title":"Brief Report: Zinc Supplementation and Inflammation in Treated HIV","volume":"82","author":"Yu","year":"2019","journal-title":"J. Acquir. Immune. Defic. Syndr."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1097\/QAI.0000000000000191","article-title":"Immunologic effect of zinc supplementation in HIV-infected children receiving highly active antiretroviral therapy: A randomized, double-blind, placebo-controlled trial","volume":"66","author":"Lodha","year":"2014","journal-title":"J. Acquir. Immune. Defic. Syndr."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1046\/j.1365-2893.2001.00311.x","article-title":"Zinc supplementation enhances the response to interferon therapy in patients with chronic hepatitis C","volume":"8","author":"Takagi","year":"2001","journal-title":"J. Viral Hepat."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1385\/BTER:75:1-3:53","article-title":"Preliminary study of combination therapy with interferon-alpha and zinc in chronic hepatitis C patients with genotype 1b","volume":"75","author":"Nagamine","year":"2000","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/j.clinbiochem.2005.04.003","article-title":"The effect of zinc supplementation on the treatment of chronic hepatitis C patients with interferon and ribavirin","volume":"38","author":"Ko","year":"2005","journal-title":"Clin. Biochem."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/s12072-007-9029-y","article-title":"Blood cell, liver function, and response changes by PEG-interferon-alpha2b plus ribavirin with polaprezinc therapy in patients with chronic hepatitis C","volume":"2","author":"Kim","year":"2008","journal-title":"Hepatol. Int."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.3748\/wjg.v12.i8.1265","article-title":"Triple therapy of interferon and ribavirin with zinc supplementation for patients with chronic hepatitis C: A randomized controlled clinical trial","volume":"12","author":"Suzuki","year":"2006","journal-title":"World J. Gastroenterol. WJG"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1080\/00365520701272409","article-title":"Efficacy of zinc administration in patients with hepatitis C virus-related chronic liver disease","volume":"42","author":"Himoto","year":"2007","journal-title":"Scand. J. Gastroenterol."},{"key":"ref_155","first-page":"178","article-title":"Zinc supplementation therapy improves the outcome of patients with chronic hepatitis C","volume":"51","author":"Matsumura","year":"2012","journal-title":"J. Clin. Biochem. Nutr."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"213","DOI":"10.3177\/jnsv.53.213","article-title":"Zinc supplementation prevents the increase of transaminase in chronic hepatitis C patients during combination therapy with pegylated interferon \u03b1-2b and ribavirin","volume":"53","author":"Murakami","year":"2007","journal-title":"J. Nutr. Sci. Vitaminol."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"88","DOI":"10.4103\/ijpvm.IJPVM_367_17","article-title":"A randomized controlled trial of zinc supplementation as adjuvant therapy for dengue viral infection in Thai children","volume":"9","author":"Rerksuppaphol","year":"2018","journal-title":"Int. J. Prev. Med."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1099\/jmm.0.001250","article-title":"Zinc sulfate in combination with a zinc ionophore may improve outcomes in hospitalized COVID-19 patients","volume":"69","author":"Carlucci","year":"2020","journal-title":"J. Med. Microbiol."},{"key":"ref_159","doi-asserted-by":"crossref","unstructured":"Frontera, J.A., Rahimian, J.O., Yaghi, S., Liu, M., Lewis, A., Mainali, S., Huang, J., Scher, E., Wisniewski, T., and Troxel, A.B. (2020). Treatment with Zinc is Associated with Reduced In-Hospital Mortality among COVID-19 Patients: A Multi-Center Cohort Study. Res. Sq., rs-3\u2013rs-94509.","DOI":"10.21203\/rs.3.rs-94509\/v1"},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"106214","DOI":"10.1016\/j.ijantimicag.2020.106214","article-title":"COVID-19 outpatients: Early risk-stratified treatment with zinc plus low-dose hydroxychloroquine and azithromycin: A retrospective case series study","volume":"56","author":"Derwand","year":"2020","journal-title":"Int. J. Antimicrob. Agents"},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.ijid.2020.06.006","article-title":"Treatment of SARS-CoV-2 with high dose oral zinc salts: A report on four patients","volume":"99","author":"Finzi","year":"2020","journal-title":"Int. J. Infect. Dis."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"3261","DOI":"10.1002\/jmv.26895","article-title":"A pilot double-blind safety and feasibility randomized controlled trial of high-dose intravenous zinc in hospitalized COVID-19 patients","volume":"93","author":"Patel","year":"2021","journal-title":"J. Med. Virol."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"3642","DOI":"10.1007\/s12011-020-02512-1","article-title":"Do zinc supplements enhance the clinical efficacy of hydroxychloroquine?: A randomized, multicenter trial","volume":"199","author":"Soliman","year":"2021","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/j.ijid.2022.06.016","article-title":"COVID-19 prophylaxis with doxycycline and zinc in health care workers: A prospective, randomized, double-blind clinical trial","volume":"122","author":"Stambouli","year":"2022","journal-title":"Int. J. Infect. Dis."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1007\/s13312-014-0503-z","article-title":"Zinc supplementation for prevention of acute respiratory infections in infants: A randomized controlled trial","volume":"51","author":"Malik","year":"2014","journal-title":"Indian Pediatr."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.clnu.2012.08.018","article-title":"The efficacy of zinc supplementation in young children with acute lower respiratory infections: A randomized double-blind controlled trial","volume":"32","author":"Shah","year":"2013","journal-title":"Clin. Nutr."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.aller.2015.12.006","article-title":"Effects of zinc supplementation in the prevention of respiratory tract infections and diarrheal disease in Colombian children: A 12-month randomised controlled trial","volume":"44","year":"2016","journal-title":"Allergol. Et Immunopathol."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1542\/peds.102.1.1","article-title":"Zinc supplementation reduces the incidence of acute lower respiratory infections in infants and preschool children: A double-blind, controlled trial","volume":"102","author":"Sazawal","year":"1998","journal-title":"Pediatrics"},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1093\/ajcn\/79.3.430","article-title":"Randomized, double-blind, placebo-controlled clinical trial of the efficacy of treatment with zinc or vitamin A in infants and young children with severe acute lower respiratory infection","volume":"79","author":"Mahalanabis","year":"2004","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1093\/ajcn\/75.4.720","article-title":"A double-blind, placebo-controlled study of vitamin A and zinc supplementation in persons with tuberculosis in Indonesia: Effects on clinical response and nutritional status","volume":"75","author":"Karyadi","year":"2002","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_171","first-page":"8","article-title":"Effect of Zinc Supplementation in Children with Severe Pneumonia: A Randomised Controlled Study","volume":"12","author":"Baruah","year":"2018","journal-title":"J. Clin. Diagn. Res."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1542\/peds.2010-3091","article-title":"A randomized controlled trial of zinc as adjuvant therapy for severe pneumonia in young children","volume":"129","author":"Basnet","year":"2012","journal-title":"Pediatrics"},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1093\/ajcn\/83.5.1089","article-title":"Efficacy of zinc in the treatment of severe pneumonia in hospitalized children <2 y old","volume":"83","author":"Bose","year":"2006","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1093\/tropej\/fmt089","article-title":"Effect of zinc supplementation on duration of hospitalization in Tanzanian children presenting with acute pneumonia","volume":"60","author":"Fataki","year":"2014","journal-title":"J. Trop. Pediatr."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"010418","DOI":"10.7189\/jogh.08.010418","article-title":"Zinc as an adjunct therapy in the management of severe pneumonia among Gambian children: Randomized controlled trial","volume":"8","author":"Howie","year":"2018","journal-title":"J. Glob. Health"},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"497","DOI":"10.3945\/ajcn.113.067892","article-title":"Zinc as an adjunct to the treatment of severe pneumonia in Ecuadorian children: A randomized controlled trial","volume":"99","author":"Estrella","year":"2014","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1824-7288-38-36","article-title":"Role of zinc in severe pneumonia: A randomized double bind placebo controlled study","volume":"38","author":"Shah","year":"2012","journal-title":"Ital. J. Pediatr."},{"key":"ref_178","doi-asserted-by":"crossref","unstructured":"Srinivasan, M.G., Ndeezi, G., Mboijana, C.K., Kiguli, S., Bimenya, G.S., Nankabirwa, V., and Tumwine, J.K. (2012). Zinc adjunct therapy reduces case fatality in severe childhood pneumonia: A randomized double blind placebo-controlled trial. BMC Med., 10.","DOI":"10.1186\/1741-7015-10-14"},{"key":"ref_179","first-page":"37","article-title":"Zinc supplementation for the treatment of severe pneumonia in hospitalized children: A randomized controlled trial","volume":"15","author":"Shehzad","year":"2015","journal-title":"Sudan. J. Paediatr."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"694193","DOI":"10.1155\/2014\/694193","article-title":"The effect of adjuvant zinc therapy on recovery from pneumonia in hospitalized children: A double-blind randomized controlled trial","volume":"2014","author":"Qasemzadeh","year":"2014","journal-title":"Scientifica"},{"key":"ref_181","first-page":"547","article-title":"Oral zinc in recurrent Erythema Nodosum Leprosum reaction","volume":"55","author":"Mathur","year":"1983","journal-title":"Lepr. India"},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/1475-2891-9-41","article-title":"Zinc and vitamin A supplementation fails to reduce sputum conversion time in severely malnourished pulmonary tuberculosis patients in Indonesia","volume":"9","author":"Pakasi","year":"2010","journal-title":"Nutr. J."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"173","DOI":"10.52547\/rbmb.10.2.173","article-title":"Investigation of Zinc Supplement Impact on the Serum Biochemical Parameters in Pulmonary Tuberculosis: A Double Blinded Placebo Control Trial","volume":"10","author":"Zolfaghari","year":"2021","journal-title":"Rep. Biochem. Mol. Biol."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1136\/gut.35.12.1707","article-title":"Enteric protein loss and intestinal permeability changes in children during acute shigellosis and after recovery: Effect of zinc supplementation","volume":"35","author":"Alam","year":"1994","journal-title":"Gut"},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1093\/ajcn\/79.3.444","article-title":"Effect of zinc supplementation on immune and inflammatory responses in pediatric patients with shigellosis","volume":"79","author":"Raqib","year":"2004","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1093\/ajcn.81.2.495","article-title":"Effects of zinc supplementation as adjunct therapy on the systemic immune responses in shigellosis","volume":"81","author":"Rahman","year":"2005","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1038\/sj.ejcn.1602795","article-title":"Zinc supplementation in the management of shigellosis in malnourished children in Bangladesh","volume":"62","author":"Roy","year":"2008","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1046\/j.1365-2036.1999.00510.x","article-title":"Polaprezinc, a mucosal protective agent, in combination with lansoprazole, amoxycillin and clarithromycin increases the cure rate of Helicobacter pylori infection","volume":"13","author":"Kashimura","year":"1999","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"2333794X221099266","DOI":"10.1177\/2333794X221099266","article-title":"Effect of Zinc Supplementation in Children Less than 5 Years on Diarrhea Attacks: A Randomized Controlled Trial","volume":"9","author":"Shouman","year":"2022","journal-title":"Glob. Pediatr. Health"},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"2201","DOI":"10.1053\/j.gastro.2006.02.062","article-title":"Zinc in the treatment of acute diarrhea: Current status and assessment","volume":"130","author":"Hoque","year":"2006","journal-title":"Gastroenterology"},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"4715","DOI":"10.3390\/nu5114715","article-title":"Oral zinc supplementation for the treatment of acute diarrhea in children: A systematic review and meta-analysis","volume":"5","author":"Lamberti","year":"2013","journal-title":"Nutrients"},{"key":"ref_192","first-page":"e4217","article-title":"Effect of zinc supplementation on the frequency and consistency of stool in children with acute diarrhea","volume":"11","author":"Laghari","year":"2019","journal-title":"Cureus"},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"162","DOI":"10.5223\/pghn.2019.22.2.162","article-title":"Treating viral diarrhea in children by probiotic and zinc supplements","volume":"22","author":"Ahmadipour","year":"2019","journal-title":"Pediatr. Gastroenterol. Hepatol. Nutr."},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"010424","DOI":"10.7189\/jogh.10.010424","article-title":"Effects of therapeutic zinc supplementation for diarrhea and two preventive zinc supplementation regimens on the incidence and duration of diarrhea and acute respiratory tract infections in rural Laotian children: A randomized controlled trial","volume":"10","author":"Barffour","year":"2020","journal-title":"J. Glob. Health"},{"key":"ref_195","doi-asserted-by":"crossref","unstructured":"Negru\u021b, N. (2014). Zinc therapy for acute diarrhea in children under three years of age. BMC Infect. Dis., 14.","DOI":"10.1186\/1471-2334-14-S7-P80"},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1475-2891-7-7","article-title":"Major reduction of malaria morbidity with combined vitamin A and zinc supplementation in young children in Burkina Faso: A randomized double blind trial","volume":"7","author":"Zeba","year":"2008","journal-title":"Nutr. J."},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"663","DOI":"10.4269\/ajtmh.2000.62.663","article-title":"The influence of zinc supplementation on morbidity due to Plasmodium falciparum: A randomized trial in preschool children in Papua New Guinea","volume":"62","author":"Shankar","year":"2000","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1079\/BJN19930026","article-title":"A trial of zinc supplementation in young rural Gambian children","volume":"69","author":"Bates","year":"1993","journal-title":"Br. J. Nutr."},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1136\/bmj.322.7302.1567","article-title":"Effect of zinc supplementation on malaria and other causes of morbidity in west African children: Randomised double blind placebo controlled trial","volume":"322","author":"Becher","year":"2001","journal-title":"BMJ"},{"key":"ref_200","doi-asserted-by":"crossref","unstructured":"Zinc Against Plasmodium Study Group (2002). Effect of zinc on the treatment of Plasmodium falciparum malaria in children: A randomized controlled trial. Am. J. Clin. Nutr., 76, 805\u2013812.","DOI":"10.1093\/ajcn\/76.4.805"},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"126","DOI":"10.4269\/ajtmh.2006.75.1.0750126","article-title":"Zinc and iron supplementation and malaria, diarrhea, and respiratory infections in children in the Peruvian Amazon","volume":"75","author":"Richard","year":"2006","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"826","DOI":"10.4269\/ajtmh.16-0599","article-title":"Vitamin A and Zinc Supplementation among Pregnant Women to Prevent Placental Malaria: A Randomized, Double-Blind, Placebo-Controlled Trial in Tanzania","volume":"96","author":"Darling","year":"2017","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"e007828","DOI":"10.1136\/bmjopen-2015-007828","article-title":"Effect of zinc added to a daily small-quantity lipid-based nutrient supplement on diarrhoea, malaria, fever and respiratory infections in young children in rural Burkina Faso: A cluster-randomised trial","volume":"5","author":"Abbeddou","year":"2015","journal-title":"BMJ Open"},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1186\/1475-2891-12-131","article-title":"Impact of vitamin A with zinc supplementation on malaria morbidity in Ghana","volume":"12","author":"Newton","year":"2013","journal-title":"Nutr. J."},{"key":"ref_205","doi-asserted-by":"crossref","unstructured":"Veenemans, J., Milligan, P., Prentice, A.M., Schouten, L.R., Inja, N., van der Heijden, A.C., de Boer, L.C., Jansen, E.J., Koopmans, A.E., and Enthoven, W.T. (2011). Effect of supplementation with zinc and other micronutrients on malaria in Tanzanian children: A randomised trial. PLoS Med., 8.","DOI":"10.1371\/journal.pmed.1001125"},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1046\/j.1365-2230.2001.00752.x","article-title":"Oral zinc sulphate in the treatment of acute cutaneous leishmaniasis","volume":"26","author":"Sharquie","year":"2001","journal-title":"Clin. Exp. Dermatol."},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"23353","DOI":"10.3402\/fnr.v58.23353","article-title":"Nutritional status in patients with cutaneous leishmaniasis and a study of the effects of zinc supplementation together with antimony treatment","volume":"58","author":"Rojas","year":"2014","journal-title":"Food Nutr. Res."},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1007\/s12639-018-1044-5","article-title":"Evaluation of the efficacy of intralesional Glucantime plus niosomal zinc sulphate in comparison with intralesional Glucantime plus cryotherapy in the treatment of acute cutaneous leishmaniasis, a randomized clinical trial","volume":"42","author":"Farajzadeh","year":"2018","journal-title":"J. Parasit. Dis."},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"e50","DOI":"10.1590\/s1678-9946201860050","article-title":"Potential role of zinc in the visceromegaly regression and recovery of hematological parameters during treatment of visceral leishmaniasis in children from an endemic area","volume":"60","author":"Carbone","year":"2018","journal-title":"Rev. Inst. Med. Trop. Sao Paulo"},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"118","DOI":"10.4103\/0019-5154.94279","article-title":"Comparison of intralesional two percent zinc sulfate and glucantime injection in treatment of acute cutaneous leishmaniasis","volume":"57","author":"Maleki","year":"2012","journal-title":"Indian J. Dermatol."},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1159\/000078586","article-title":"Comparison of intralesionally injected zinc sulfate with meglumine antimoniate in the treatment of acute cutaneous leishmaniasis","volume":"209","author":"Iraji","year":"2004","journal-title":"Dermatology"},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"170","DOI":"10.3164\/jcbn.18-74","article-title":"Zinc supplementation reduces Candida infections in pediatric intensive care unit: A randomized placebo-controlled clinical trial","volume":"64","author":"Xie","year":"2019","journal-title":"J. Clin. Biochem. Nutr."},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1016\/j.immuni.2022.03.016","article-title":"Nonresolving inflammation redux","volume":"55","author":"Nathan","year":"2022","journal-title":"Immunity"},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"31","DOI":"10.2147\/ITT.S243238","article-title":"Novel Resolution Mediators of Severe Systemic Inflammation","volume":"9","author":"Gudernatsch","year":"2020","journal-title":"ImmunoTargets Ther."},{"key":"ref_215","doi-asserted-by":"crossref","unstructured":"Gammoh, N.Z., and Rink, L. (2017). Zinc in Infection and Inflammation. Nutrients, 9.","DOI":"10.20944\/preprints201705.0176.v1"},{"key":"ref_216","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1038\/nri.2016.49","article-title":"Neutrophil migration in infection and wound repair: Going forward in reverse","volume":"16","author":"Rosowski","year":"2016","journal-title":"Nat. Rev. Immunol."},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.cell.2010.01.022","article-title":"Pattern recognition receptors and inflammation","volume":"140","author":"Takeuchi","year":"2010","journal-title":"Cell"},{"key":"ref_218","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1177\/1753425912458815","article-title":"Zinc signals in neutrophil granulocytes are required for the formation of neutrophil extracellular traps","volume":"19","author":"Hasan","year":"2013","journal-title":"Innate Immun."},{"key":"ref_219","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/s12011-015-0515-0","article-title":"Chelation of Free Zn2+ Impairs Chemotaxis, Phagocytosis, Oxidative Burst, Degranulation, and Cytokine Production by Neutrophil Granulocytes","volume":"171","author":"Hasan","year":"2016","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1136\/adc.55.12.966","article-title":"Zinc-dependent chemotactic defect in an infant with acrodermatitis","volume":"55","author":"Businco","year":"1980","journal-title":"Arch. Dis. Child."},{"key":"ref_221","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.ccr.2016.07.002","article-title":"The metal face of protein tyrosine phosphatase 1B","volume":"327\u2013328","author":"Bellomo","year":"2016","journal-title":"Coord. Chem. Rev."},{"key":"ref_222","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1038\/nri1530","article-title":"Protein tyrosine phosphatases and the immune response","volume":"5","author":"Mustelin","year":"2005","journal-title":"Nat. Rev. Immunol."},{"key":"ref_223","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1002\/1522-7243(200009\/10)15:5<321::AID-BIO605>3.0.CO;2-O","article-title":"Effects of zinc on the reactive oxygen species generating capacity of human neutrophils and on the serum opsonic activity in vitro","volume":"15","author":"Hasegawa","year":"2000","journal-title":"Luminescence"},{"key":"ref_224","doi-asserted-by":"crossref","first-page":"3139","DOI":"10.1523\/JNEUROSCI.20-09-03139.2000","article-title":"Zinc-induced cortical neuronal death: Contribution of energy failure attributable to loss of NAD(+) and inhibition of glycolysis","volume":"20","author":"Sheline","year":"2000","journal-title":"J. Neurosci."},{"key":"ref_225","doi-asserted-by":"crossref","first-page":"e162","DOI":"10.1002\/mco2.162","article-title":"Molecular mechanisms and therapeutic target of NETosis in diseases","volume":"3","author":"Huang","year":"2022","journal-title":"MedComm"},{"key":"ref_226","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1100\/tsw.2010.14","article-title":"Immunosenescence of polymorphonuclear neutrophils","volume":"10","author":"Wessels","year":"2010","journal-title":"ScientificWorldJournal"},{"key":"ref_227","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.jnutbio.2012.06.007","article-title":"Zinc deficiency induces production of the proinflammatory cytokines IL-1\u03b2 and TNF\u03b1 in promyeloid cells via epigenetic and redox-dependent mechanisms","volume":"24","author":"Wessels","year":"2013","journal-title":"J. Nutr. Biochem."},{"key":"ref_228","doi-asserted-by":"crossref","first-page":"G768","DOI":"10.1152\/ajpgi.00179.2015","article-title":"Zinc dyshomeostasis during polymicrobial sepsis in mice involves zinc transporter Zip14 and can be overcome by zinc supplementation","volume":"309","author":"Wessels","year":"2015","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"ref_229","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.3945\/ajcn.110.008417","article-title":"A comparison of zinc metabolism, inflammation, and disease severity in critically ill infected and noninfected adults early after intensive care unit admission","volume":"93","author":"Besecker","year":"2011","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_230","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s10787-017-0309-4","article-title":"Antioxidant and anti-inflammatory effects of zinc. Zinc-dependent NF-\u03baB signaling","volume":"25","author":"Jarosz","year":"2017","journal-title":"Inflammopharmacology"},{"key":"ref_231","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/nrm2083","article-title":"Integrating cell-signalling pathways with NF-kappaB and IKK function","volume":"8","author":"Perkins","year":"2007","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_232","doi-asserted-by":"crossref","first-page":"676","DOI":"10.3390\/nu4070676","article-title":"Zinc and regulation of inflammatory cytokines: Implications for cardiometabolic disease","volume":"4","author":"Foster","year":"2012","journal-title":"Nutrients"},{"key":"ref_233","doi-asserted-by":"crossref","first-page":"6491","DOI":"10.4049\/jimmunol.181.9.6491","article-title":"Zinc signals are essential for lipopolysaccharide-induced signal transduction in monocytes","volume":"181","author":"Haase","year":"2008","journal-title":"J. Immunol."},{"key":"ref_234","doi-asserted-by":"crossref","first-page":"2350","DOI":"10.1073\/pnas.0409856102","article-title":"Phosphorylation at Thr-290 regulates Tpl2 binding to NF-kappaB1\/p105 and Tpl2 activation and degradation by lipopolysaccharide","volume":"102","author":"Cho","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_235","doi-asserted-by":"crossref","first-page":"2928","DOI":"10.1016\/j.febslet.2014.05.043","article-title":"Separation of zinc-dependent and zinc-independent events during early LPS-stimulated TLR4 signaling in macrophage cells","volume":"588","author":"Wan","year":"2014","journal-title":"FEBS Lett."},{"key":"ref_236","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1016\/j.nut.2010.08.010","article-title":"Zinc-suppressed inflammatory cytokines by induction of A20-mediated inhibition of nuclear factor-\u03baB","volume":"27","author":"Prasad","year":"2011","journal-title":"Nutrition"},{"key":"ref_237","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1016\/j.freeradbiomed.2004.07.007","article-title":"Antioxidant effect of zinc in humans","volume":"37","author":"Prasad","year":"2004","journal-title":"Free. Radic. Biol. Med."},{"key":"ref_238","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1038\/ni1110","article-title":"The ubiquitin-modifying enzyme A20 is required for termination of Toll-like receptor responses","volume":"5","author":"Boone","year":"2004","journal-title":"Nat. Immunol."},{"key":"ref_239","doi-asserted-by":"crossref","first-page":"4180","DOI":"10.4049\/jimmunol.179.6.4180","article-title":"Zinc-dependent suppression of TNF-alpha production is mediated by protein kinase A-induced inhibition of Raf-1, I kappa B kinase beta, and NF-kappa B","volume":"179","author":"Dubben","year":"2007","journal-title":"J. Immunol."},{"key":"ref_240","doi-asserted-by":"crossref","first-page":"1808","DOI":"10.4049\/jimmunol.1301261","article-title":"Differential regulation of TLR-dependent MyD88 and TRIF signaling pathways by free zinc ions","volume":"191","author":"Brieger","year":"2013","journal-title":"J. Immunol."},{"key":"ref_241","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1002\/mnfr.201400761","article-title":"Zinc deficiency enhanced inflammatory response by increasing immune cell activation and inducing IL6 promoter demethylation","volume":"59","author":"Wong","year":"2015","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_242","doi-asserted-by":"crossref","unstructured":"Hu, J., Yang, Z., Wang, J., Yu, J., Guo, J., Liu, S., Qian, C., Song, L., Wu, Y., and Cheng, J. (2016). Zinc Chloride Transiently Maintains Mouse Embryonic Stem Cell Pluripotency by Activating Stat3 Signaling. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0148994"},{"key":"ref_243","doi-asserted-by":"crossref","first-page":"S65","DOI":"10.1111\/j.1753-4887.1998.tb01647.x","article-title":"Changes in regulation of lymphopoiesis and myelopoiesis in the zinc-deficient mouse","volume":"56","author":"Fraker","year":"1998","journal-title":"Nutr. Rev."},{"key":"ref_244","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.redox.2016.12.027","article-title":"Zinc deficiency affects the STAT1\/3 signaling pathways in part through redox-mediated mechanisms","volume":"11","author":"Supasai","year":"2017","journal-title":"Redox Biol."},{"key":"ref_245","first-page":"661","article-title":"Zinc deficiency adversely influences interleukin-4 and interleukin-6 signaling","volume":"27","author":"Gruber","year":"2013","journal-title":"J. Biol. Regul. Homeost. Agents"},{"key":"ref_246","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/0008-8749(91)90039-E","article-title":"Recombinant human interleukin 6 (rhIL-6) promotes the terminal differentiation of in vivo-activated human B cells into antibody-secreting cells","volume":"132","author":"Lue","year":"1991","journal-title":"Cell. Immunol."},{"key":"ref_247","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1093\/intimm\/dxq017","article-title":"Zinc suppresses Th17 development via inhibition of STAT3 activation","volume":"22","author":"Kitabayashi","year":"2010","journal-title":"Int. Immunol."},{"key":"ref_248","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1016\/j.jaci.2020.03.017","article-title":"Influence of immune aging on vaccine responses","volume":"145","author":"Gustafson","year":"2020","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_249","first-page":"E1002","article-title":"Changes in cytokine production and T cell subpopulations in experimentally induced zinc-deficient humans","volume":"272","author":"Beck","year":"1997","journal-title":"Am. J. Physiol."},{"key":"ref_250","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1111\/imm.12536","article-title":"Inhibition of interleukin-1\u03b2-mediated interleukin-1 receptor-associated kinase 4 phosphorylation by zinc leads to repression of memory T helper type 17 response in humans","volume":"146","author":"Lee","year":"2015","journal-title":"Immunology"},{"key":"ref_251","doi-asserted-by":"crossref","first-page":"1864","DOI":"10.4049\/jimmunol.1600410","article-title":"Zinc Induces Dendritic Cell Tolerogenic Phenotype and Skews Regulatory T Cell-Th17 Balance","volume":"197","author":"George","year":"2016","journal-title":"J. Immunol."},{"key":"ref_252","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1038\/sj.bmt.1704509","article-title":"Zinc in pharmacological doses suppresses allogeneic reaction without affecting the antigenic response","volume":"33","author":"Faber","year":"2004","journal-title":"Bone Marrow Transpl."},{"key":"ref_253","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1007\/s10534-014-9786-8","article-title":"Oral zinc aspartate treats experimental autoimmune encephalomyelitis","volume":"27","author":"Schubert","year":"2014","journal-title":"Biometals"},{"key":"ref_254","doi-asserted-by":"crossref","first-page":"201600493","DOI":"10.1002\/mnfr.201600493","article-title":"Zinc supplementation augments TGF-\u03b21-dependent regulatory T cell induction","volume":"61","author":"Maywald","year":"2017","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_255","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1002\/mnfr.201500524","article-title":"Zinc supplementation induces regulatory T cells by inhibition of Sirt-1 deacetylase in mixed lymphocyte cultures","volume":"60","author":"Rosenkranz","year":"2016","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_256","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1007\/s00394-016-1228-7","article-title":"Zinc supplementation induces CD4(+)CD25(+)Foxp3(+) antigen-specific regulatory T cells and suppresses IFN-\u03b3 production by upregulation of Foxp3 and KLF-10 and downregulation of IRF-1","volume":"56","author":"Maywald","year":"2017","journal-title":"Eur. J. Nutr."},{"key":"ref_257","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.4049\/jimmunol.181.3.1673","article-title":"IFN regulatory factor-1 negatively regulates CD4+ CD25+ regulatory T cell differentiation by repressing Foxp3 expression","volume":"181","author":"Fragale","year":"2008","journal-title":"J. Immunol."},{"key":"ref_258","doi-asserted-by":"crossref","first-page":"24914","DOI":"10.1074\/jbc.M109.000059","article-title":"Kruppel-like factor KLF10 targets transforming growth factor-beta1 to regulate CD4(+)CD25(-) T cells and T regulatory cells","volume":"284","author":"Cao","year":"2009","journal-title":"J. Biol. Chem."},{"key":"ref_259","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/0047-6374(96)01708-3","article-title":"Dysregulation between TH1 and TH2 T cell subpopulations in the elderly","volume":"87","author":"Cakman","year":"1996","journal-title":"Mech. Ageing Dev."},{"key":"ref_260","doi-asserted-by":"crossref","first-page":"S62","DOI":"10.1086\/315916","article-title":"Effects of zinc deficiency on Th1 and Th2 cytokine shifts","volume":"182","author":"Prasad","year":"2000","journal-title":"J. Infect. Dis."},{"key":"ref_261","doi-asserted-by":"crossref","first-page":"E1095","DOI":"10.1152\/ajpendo.00545.2002","article-title":"Zinc modulates mRNA levels of cytokines","volume":"285","author":"Bao","year":"2003","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"ref_262","doi-asserted-by":"crossref","first-page":"2401","DOI":"10.1002\/eji.201646440","article-title":"T-cell development is regulated by the coordinated function of proximal and distal Lck promoters active at different developmental stages","volume":"46","author":"Chiang","year":"2016","journal-title":"Eur. J. Immunol."},{"key":"ref_263","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1002\/eji.200939574","article-title":"Zinc signals promote IL-2-dependent proliferation of T cells","volume":"40","author":"Kaltenberg","year":"2010","journal-title":"Eur. J. Immunol."},{"key":"ref_264","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1039\/c3mt00197k","article-title":"PTEN-inhibition by zinc ions augments interleukin-2-mediated Akt phosphorylation","volume":"6","author":"Plum","year":"2014","journal-title":"Metallomics"},{"key":"ref_265","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1093\/jn\/132.7.2033","article-title":"Immune functions are maintained in healthy men with low zinc intake","volume":"132","author":"Pinna","year":"2002","journal-title":"J. Nutr."},{"key":"ref_266","doi-asserted-by":"crossref","first-page":"3263","DOI":"10.1016\/j.clnu.2020.10.052","article-title":"Zinc deficiency leads to reduced interleukin-2 production by active gene silencing due to enhanced CREM\u03b1 expression in T cells","volume":"40","author":"Kloubert","year":"2021","journal-title":"Clin. Nutr."},{"key":"ref_267","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/s12979-022-00295-8","article-title":"Short-term zinc supplementation of zinc-deficient seniors counteracts CREM\u03b1\u2014Mediated IL-2 suppression","volume":"19","author":"Baarz","year":"2022","journal-title":"Immun. Ageing"},{"key":"ref_268","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1079\/BJN19840103","article-title":"Hexose transport and mucosal morphology in the small intestine of the zinc-deficient rat","volume":"52","author":"Southon","year":"1984","journal-title":"Br. J. Nutr."},{"key":"ref_269","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1079\/BJN19860065","article-title":"Intestinal microflora, morphology and enzyme activity in zinc-deficient and Zn-supplemented rats","volume":"55","author":"Southon","year":"1986","journal-title":"Br. J. Nutr."},{"key":"ref_270","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1002\/path.1711300106","article-title":"Ultrastructural changes in the small intestine of zinc deficient rats","volume":"130","author":"Elmes","year":"1980","journal-title":"J. Pathol."},{"key":"ref_271","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1079\/BJN19850013","article-title":"Intestinal cellular proliferation and protein synthesis in zinc-deficient rats","volume":"53","author":"Southon","year":"1985","journal-title":"Br. J. Nutr."},{"key":"ref_272","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1093\/jn\/138.9.1664","article-title":"Zinc deficiency induces membrane barrier damage and increases neutrophil transmigration in Caco-2 cells","volume":"138","author":"Finamore","year":"2008","journal-title":"J. Nutr."},{"key":"ref_273","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1203\/00006450-198512000-00026","article-title":"Effects of short-term isolated zinc deficiency on intestinal growth and activities of several brush border enzymes in weaning rats","volume":"19","author":"Park","year":"1985","journal-title":"Pediatr. Res."},{"key":"ref_274","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.ijpharm.2017.09.018","article-title":"Physicochemical properties of mucus and their impact on transmucosal drug delivery","volume":"532","author":"Leal","year":"2017","journal-title":"Int. J. Pharm."},{"key":"ref_275","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1038\/nri.2016.88","article-title":"Immunological aspects of intestinal mucus and mucins","volume":"16","author":"Johansson","year":"2016","journal-title":"Nat. Rev. Immunol."},{"key":"ref_276","doi-asserted-by":"crossref","unstructured":"Maares, M., Keil, C., Koza, J., Straubing, S., Schwerdtle, T., and Haase, H. (2018). In Vitro Studies on Zinc Binding and Buffering by Intestinal Mucins. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19092662"},{"key":"ref_277","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1038\/nrmicro2538","article-title":"Mucin dynamics and enteric pathogens","volume":"9","author":"McGuckin","year":"2011","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_278","doi-asserted-by":"crossref","first-page":"447s","DOI":"10.1093\/ajcn\/68.2.447S","article-title":"Zinc and immune function: The biological basis of altered resistance to infection","volume":"68","author":"Shankar","year":"1998","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_279","first-page":"e8197","article-title":"Role of Zinc in Mucosal Health and Disease: A Review of Physiological, Biochemical, and Molecular Processes","volume":"12","author":"Hassan","year":"2020","journal-title":"Cureus"},{"key":"ref_280","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1086\/428504","article-title":"Zinc inhibits cholera toxin-induced, but not Escherichia coli heat-stable enterotoxin-induced, ion secretion in human enterocytes","volume":"191","author":"Canani","year":"2005","journal-title":"J. Infect. Dis."},{"key":"ref_281","doi-asserted-by":"crossref","first-page":"L1132","DOI":"10.1152\/ajplung.00207.2006","article-title":"Zinc modulates cytokine-induced lung epithelial cell barrier permeability","volume":"291","author":"Bao","year":"2006","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"ref_282","doi-asserted-by":"crossref","first-page":"3503","DOI":"10.2147\/COPD.S149589","article-title":"Zinc deficiency as a codeterminant for airway epithelial barrier dysfunction in an ex vivo model of COPD","volume":"12","author":"Roscioli","year":"2017","journal-title":"Int. J. Chron. Obstruct. Pulmon. Dis."},{"key":"ref_283","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/j.1524-475X.2006.00179.x","article-title":"Zinc in wound healing: Theoretical, experimental, and clinical aspects","volume":"15","author":"Lansdown","year":"2007","journal-title":"Wound Repair Regen."},{"key":"ref_284","doi-asserted-by":"crossref","first-page":"2249","DOI":"10.1084\/jem.178.6.2249","article-title":"An essential role for interferon gamma in resistance to Mycobacterium tuberculosis infection","volume":"178","author":"Flynn","year":"1993","journal-title":"J. Exp. Med."},{"key":"ref_285","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1093\/ajcn\/86.4.1167","article-title":"Serum zinc and pneumonia in nursing home elderly","volume":"86","author":"Meydani","year":"2007","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_286","first-page":"Cd010205","article-title":"Zinc supplementation for the promotion of growth and prevention of infections in infants less than six months of age","volume":"4","author":"Lassi","year":"2020","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_287","doi-asserted-by":"crossref","first-page":"102433","DOI":"10.1016\/j.jaut.2020.102433","article-title":"The epidemiology and pathogenesis of coronavirus disease (COVID-19) outbreak","volume":"109","author":"Rothan","year":"2020","journal-title":"J. Autoimmun."},{"key":"ref_288","doi-asserted-by":"crossref","first-page":"e18","DOI":"10.1016\/S2213-2600(20)30110-7","article-title":"Respiratory support for patients with COVID-19 infection","volume":"8","year":"2020","journal-title":"Lancet Respir. Med."},{"key":"ref_289","first-page":"1891","article-title":"Long Covid: Where we stand and challenges ahead","volume":"29","author":"Mantovani","year":"2022","journal-title":"Cell Death Differ."},{"key":"ref_290","doi-asserted-by":"crossref","unstructured":"Te Velthuis, A.J., van den Worm, S.H., Sims, A.C., Baric, R.S., Snijder, E.J., and van Hemert, M.J. (2010). Zn2+ inhibits coronavirus and arterivirus RNA polymerase activity in vitro and zinc ionophores block the replication of these viruses in cell culture. PLoS Pathog., 6.","DOI":"10.1371\/journal.ppat.1001176"},{"key":"ref_291","doi-asserted-by":"crossref","first-page":"6","DOI":"10.2500\/ajra.2010.24.3379","article-title":"Zinc increases ciliary beat frequency in a calcium-dependent manner","volume":"24","author":"Woodworth","year":"2010","journal-title":"Am. J. Rhinol. Allergy"},{"key":"ref_292","doi-asserted-by":"crossref","first-page":"78","DOI":"10.18585\/inabj.v12i1.998","article-title":"Zinc supplementation effect on the bronchial cilia length, the number of cilia, and the number of intact bronchial cell in zinc deficiency rats","volume":"12","author":"Darma","year":"2020","journal-title":"Indones. Biomed. J."},{"key":"ref_293","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.cytogfr.2014.07.015","article-title":"Interferons: Success in anti-viral immunotherapy","volume":"25","author":"Lin","year":"2014","journal-title":"Cytokine Growth Factor Rev."},{"key":"ref_294","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1093\/advances\/nmz013","article-title":"The Role of Zinc in Antiviral Immunity","volume":"10","author":"Read","year":"2019","journal-title":"Adv. Nutr."},{"key":"ref_295","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1128\/AAC.48.3.783-790.2004","article-title":"Effect of zinc salts on respiratory syncytial virus replication","volume":"48","author":"Suara","year":"2004","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_296","first-page":"2405","article-title":"Investigation on relationship between whole blood zinc and Fe elements with children pneumonia caused by respiratory syncytial virus","volume":"2401\u20132402","author":"Che","year":"2016","journal-title":"Int. J. Lab. 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