{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T00:17:31Z","timestamp":1793146651820,"version":"4.5.0"},"reference-count":166,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2022,11,25]],"date-time":"2022-11-25T00:00:00Z","timestamp":1669334400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>Trigeminal nerve injury is one of the causes of chronic orofacial pain. Patients suffering from this condition have a significantly reduced quality of life. The currently available management modalities are associated with limited success. This article reviews some of the common causes and clinical features associated with post-traumatic trigeminal neuropathic pain (PTNP). A cascade of events in the peripheral and central nervous system function is involved in the pathophysiology of pain following nerve injuries. Central and peripheral processes occur in tandem and may often be co-dependent. Due to the complexity of central mechanisms, only peripheral events contributing to the pathophysiology have been reviewed in this article. Future investigations will hopefully help gain insight into trigeminal-specific events in the pathophysiology of the development and maintenance of neuropathic pain secondary to nerve injury and enable the development of new therapeutic modalities.<\/jats:p>","DOI":"10.3390\/biom12121753","type":"journal-article","created":{"date-parts":[[2022,11,28]],"date-time":"2022-11-28T03:28:49Z","timestamp":1669606129000},"page":"1753","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Pathophysiology of Post-Traumatic Trigeminal Neuropathic Pain"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8399-794X","authenticated-orcid":false,"given":"Olga A.","family":"Korczeniewska","sequence":"first","affiliation":[{"name":"Center for Orofacial Pain and Temporomandibular Disorders, Department of Diagnostic Sciences, Rutgers School of Dental Medicine, Rutgers, The State University of New Jersey, Room D-837, 110 Bergen Street, Newark, NJ 07101, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7122-2776","authenticated-orcid":false,"given":"Divya","family":"Kohli","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Nova College of Dental Medicine, Nova Southeastern University, Davie, FL 33328, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Benoliel","sequence":"additional","affiliation":[{"name":"Unit for Oral Medicine, Department of Oral and Maxillofacial Surgery, Division of ENT, Head and Neck and Oral and Maxillofacial Surgery, Sourasky Medical Center, Ichilov, Tel Aviv 64239, Israel"},{"name":"Rutgers School of Dental Medicine, Rutgers, The State University of New Jersey, Newark, NJ 07101, USA"},{"name":"Eastman Institute of Oral Health, University of Rochester Medical Center, Rochester, NY 14620, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7196-1456","authenticated-orcid":false,"given":"Sita Mahalakshmi","family":"Baddireddy","sequence":"additional","affiliation":[{"name":"Qassim Dental Hospital, Unaizah 56461, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eli","family":"Eliav","sequence":"additional","affiliation":[{"name":"Eastman Institute of Oral Health, University of Rochester Medical Center, Rochester, NY 14620, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.pain.2010.07.031","article-title":"NeuPSIG guidelines on neuropathic pain assessment","volume":"152","author":"Attal","year":"2011","journal-title":"Pain"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"(2020). 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