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Medicine","award":["CI2021A01601"],"award-info":[{"award-number":["CI2021A01601"]}]},{"name":"Open Project of National Facility for Translational Medicine","award":["ZYYCXTD-D-202001"],"award-info":[{"award-number":["ZYYCXTD-D-202001"]}]},{"name":"Open Project of National Facility for Translational Medicine","award":["TMSK-2021-407"],"award-info":[{"award-number":["TMSK-2021-407"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>The pancreatic duodenum homeobox-1 (PDX-1) is a transcription factor encoded by a Hox-like homeodomain gene that plays a crucial role in pancreatic development, \u03b2-cell differentiation, and the maintenance of mature \u03b2-cell functions. Research on the relationship between PDX-1 and diabetes has gained much attention because of the increasing prevalence of diabetes melitus (DM). Recent studies have shown that the overexpression of PDX-1 regulates pancreatic development and promotes \u03b2-cell differentiation and insulin secretion. It also plays a vital role in cell remodeling, gene editing, and drug development. Conversely, the absence of PDX-1 increases susceptibility to DM. Therefore, in this review, we summarized the role of PDX-1 in pancreatic development and the pathogenesis of DM. A better understanding of PDX-1 will deepen our knowledge of the pathophysiology of DM and provide a scientific basis for exploring PDX-1 as a potential target for treating diabetes.<\/jats:p>","DOI":"10.3390\/biom12121785","type":"journal-article","created":{"date-parts":[[2022,11,30]],"date-time":"2022-11-30T02:21:57Z","timestamp":1669774917000},"page":"1785","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":61,"title":["PDX-1: A Promising Therapeutic Target to Reverse Diabetes"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6453-8948","authenticated-orcid":false,"given":"Yanjiao","family":"Zhang","sequence":"first","affiliation":[{"name":"Institute of Metabolic Diseases, Guang\u2019anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyi","family":"Fang","sequence":"additional","affiliation":[{"name":"Institute of Metabolic Diseases, Guang\u2019anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China"},{"name":"Graduate College, Beijing University of Chinese Medicine, Beijing 100029, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahua","family":"Wei","sequence":"additional","affiliation":[{"name":"Graduate College, Changchun University of Chinese Medicine, Changchun 130117, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Runyu","family":"Miao","sequence":"additional","affiliation":[{"name":"Institute of Metabolic Diseases, Guang\u2019anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China"},{"name":"Graduate College, Beijing University of Chinese Medicine, Beijing 100029, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoran","family":"Wu","sequence":"additional","affiliation":[{"name":"Graduate College, Beijing University of Chinese Medicine, Beijing 100029, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaile","family":"Ma","sequence":"additional","affiliation":[{"name":"Institute of Metabolic Diseases, Guang\u2019anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxing","family":"Tian","sequence":"additional","affiliation":[{"name":"Institute of Metabolic Diseases, Guang\u2019anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Vieira, R., Souto, S.B., S\u00e1nchez-L\u00f3pez, E., Machado, A.L., Severino, P., Jose, S., Santini, A., Fortuna, A., Garc\u00eda, M.L., and Silva, A.M. 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