{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T15:34:19Z","timestamp":1790609659456,"version":"4.1.0"},"reference-count":23,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2022,12,14]],"date-time":"2022-12-14T00:00:00Z","timestamp":1670976000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"French National Institute for Health and Medical Research","award":["ANR-18-CE14-0023"],"award-info":[{"award-number":["ANR-18-CE14-0023"]}]},{"name":"French National Institute for Health and Medical Research","award":["ED569"],"award-info":[{"award-number":["ED569"]}]},{"name":"Universit\u00e9 Paris-Saclay","award":["ANR-18-CE14-0023"],"award-info":[{"award-number":["ANR-18-CE14-0023"]}]},{"name":"Universit\u00e9 Paris-Saclay","award":["ED569"],"award-info":[{"award-number":["ED569"]}]},{"name":"Marie Lannelongue Hospital","award":["ANR-18-CE14-0023"],"award-info":[{"award-number":["ANR-18-CE14-0023"]}]},{"name":"Marie Lannelongue Hospital","award":["ED569"],"award-info":[{"award-number":["ED569"]}]},{"name":"French National Agency for Research","award":["ANR-18-CE14-0023"],"award-info":[{"award-number":["ANR-18-CE14-0023"]}]},{"name":"French National Agency for Research","award":["ED569"],"award-info":[{"award-number":["ED569"]}]},{"name":"French Fondation du Souffle","award":["ANR-18-CE14-0023"],"award-info":[{"award-number":["ANR-18-CE14-0023"]}]},{"name":"French Fondation du Souffle","award":["ED569"],"award-info":[{"award-number":["ED569"]}]},{"name":"Therapeutic Innovation Doctoral School","award":["ANR-18-CE14-0023"],"award-info":[{"award-number":["ANR-18-CE14-0023"]}]},{"name":"Therapeutic Innovation Doctoral School","award":["ED569"],"award-info":[{"award-number":["ED569"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>Pulmonary veno-occlusive disease (PVOD) is a rare form of pulmonary arterial hypertension (PAH) occurring in a heritable form (hPVOD) due to biallelic inactivating mutations of EIF2AK4 (encoding GCN2, general control nonderepressible 2) or in a sporadic form in older age (sPVOD), following exposure to chemotherapy or organic solvents. In contrast to PAH, PVOD is characterized by a particular remodeling of the pulmonary venous system and the obliteration of small pulmonary veins by fibrous intimal thickening and patchy capillary proliferation. The pathobiological knowledge of PVOD is poor, explaining the absence of medical therapy for PVOD. Lung transplantation remains the only therapy for eligible PVOD patients. As we recently demonstrated, respiratory diseases, chronic obstructive pulmonary disease, or cystic fibrosis exhibit lipointoxication signatures characterized by excessive levels of saturated phospholipids contributing to the pathological features of these diseases, including endoplasmic reticulum stress, pro-inflammatory cytokines production, and bronchoconstriction. In this study, we investigated and compared the clinical data and lung lipid signature of control (10 patients), idiopathic PAH (7 patients), heritable PAH (9 BMPR2 mutations carriers), hPVOD (10 EIF2AK4 mutation carriers), and sPVOD (6 non-carriers) subjects. Mass spectrometry analyses demonstrated lung lipointoxication only in hPVOD patients, characterized by an increased abundance of saturated phosphatidylcholine (PC) at the expense of the polyunsaturated species in the lungs of hPVOD patients. The present data suggest that lipointoxication could be a potential player in the etiology of PVOD.<\/jats:p>","DOI":"10.3390\/biom12121878","type":"journal-article","created":{"date-parts":[[2022,12,15]],"date-time":"2022-12-15T01:52:30Z","timestamp":1671069150000},"page":"1878","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Lipidomic Profile Analysis of Lung Tissues Revealed Lipointoxication in Pulmonary Veno-Occlusive Disease"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0365-7406","authenticated-orcid":false,"given":"Spiro","family":"Khoury","sequence":"first","affiliation":[{"name":"Laboratoire Cooperatif \u201cLipotoxicity and Channelopathies-ConicMeds\u201d, Universite de Poitiers, Rue Georges Bonnet, 86073 Poitiers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Beauvais","sequence":"additional","affiliation":[{"name":"Facultede Medecine, Universite Paris-Saclay, 94270 Le Kremlin-Bic\u00eatre, France"},{"name":"INSERM, UMR-S 999, H\u00f4pital Marie Lannelongue, 92350 Le Plessis-Robinson, France"},{"name":"Assistance Publique-H\u00f4pitaux de Paris (AP-HP), Service de Pneumologie et Soins Intensifs Respiratoires, Centre de R\u00e9f\u00e9rence de l\u2019Hypertension Pulmonaire, H\u00f4pital Bic\u00eatre, 94270 Le Kremlin-Bic\u00eatre, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenny","family":"Colas","sequence":"additional","affiliation":[{"name":"Laboratoire Cooperatif \u201cLipotoxicity and Channelopathies-ConicMeds\u201d, Universite de Poitiers, Rue Georges Bonnet, 86073 Poitiers, France"},{"name":"PReTI Laboratory, University of Poitiers, 86073 Poitiers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana\u00efs","family":"Saint-Martin Willer","sequence":"additional","affiliation":[{"name":"Facultede Medecine, Universite Paris-Saclay, 94270 Le Kremlin-Bic\u00eatre, France"},{"name":"INSERM, UMR-S 999, H\u00f4pital Marie Lannelongue, 92350 Le Plessis-Robinson, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7730-2427","authenticated-orcid":false,"given":"Fr\u00e9d\u00e9ric","family":"Perros","sequence":"additional","affiliation":[{"name":"Facultede Medecine, Universite Paris-Saclay, 94270 Le Kremlin-Bic\u00eatre, France"},{"name":"INSERM, UMR-S 999, H\u00f4pital Marie Lannelongue, 92350 Le Plessis-Robinson, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0703-2892","authenticated-orcid":false,"given":"Marc","family":"Humbert","sequence":"additional","affiliation":[{"name":"Facultede Medecine, Universite Paris-Saclay, 94270 Le Kremlin-Bic\u00eatre, France"},{"name":"INSERM, UMR-S 999, H\u00f4pital Marie Lannelongue, 92350 Le Plessis-Robinson, France"},{"name":"Assistance Publique-H\u00f4pitaux de Paris (AP-HP), Service de Pneumologie et Soins Intensifs Respiratoires, Centre de R\u00e9f\u00e9rence de l\u2019Hypertension Pulmonaire, H\u00f4pital Bic\u00eatre, 94270 Le Kremlin-Bic\u00eatre, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9401-0546","authenticated-orcid":false,"given":"Clarisse","family":"Vandebrouck","sequence":"additional","affiliation":[{"name":"Laboratoire Cooperatif \u201cLipotoxicity and Channelopathies-ConicMeds\u201d, Universite de Poitiers, Rue Georges Bonnet, 86073 Poitiers, France"},{"name":"PReTI Laboratory, University of Poitiers, 86073 Poitiers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9358-6922","authenticated-orcid":false,"given":"David","family":"Montani","sequence":"additional","affiliation":[{"name":"Facultede Medecine, Universite Paris-Saclay, 94270 Le Kremlin-Bic\u00eatre, France"},{"name":"INSERM, UMR-S 999, H\u00f4pital Marie Lannelongue, 92350 Le Plessis-Robinson, France"},{"name":"Assistance Publique-H\u00f4pitaux de Paris (AP-HP), Service de Pneumologie et Soins Intensifs Respiratoires, Centre de R\u00e9f\u00e9rence de l\u2019Hypertension Pulmonaire, H\u00f4pital Bic\u00eatre, 94270 Le Kremlin-Bic\u00eatre, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Laboratoire Cooperatif \u201cLipotoxicity and Channelopathies-ConicMeds\u201d, Universite de Poitiers, Rue Georges Bonnet, 86073 Poitiers, France"},{"name":"PReTI Laboratory, University of Poitiers, 86073 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