{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:51:35Z","timestamp":1787165495569,"version":"build-2736575974"},"reference-count":139,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2022,12,22]],"date-time":"2022-12-22T00:00:00Z","timestamp":1671667200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"JSPS KAKENHI Grant, Grant-in-Aid for Scientific Research (C)","award":["22K08404"],"award-info":[{"award-number":["22K08404"]}]},{"name":"Lydia O\u2019Leary Memorial Pias Dermatological Foundation","award":["22K08404"],"award-info":[{"award-number":["22K08404"]}]},{"name":"Shiseido basic medical research grant","award":["22K08404"],"award-info":[{"award-number":["22K08404"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>Melanogenesis is a major part of the environmental responses and tissue development of the integumentary system. The balance between reduction and oxidation (redox) governs pigmentary responses, for which coordination among epidermal resident cells is indispensable. Here, we review the current understanding of melanocyte biology with a particular focus on the \u201cmaster regulator\u201d of oxidative stress responses (i.e., the Kelch-like erythroid cell-derived protein with cap\u2018n\u2019collar homology-associated protein 1-nuclear factor erythroid-2-related factor 2 system) and the autoimmune pigment disorder vitiligo. Our investigation revealed that the former is essential in pigmentogenesis, whereas the latter results from unbalanced redox homeostasis and\/or defective intercellular communication in the interfollicular epidermis (IFE). Finally, we propose a model in which keratinocytes provide a \u201cniche\u201d for differentiated melanocytes and may \u201cimprint\u201d IFE pigmentation.<\/jats:p>","DOI":"10.3390\/biom13010020","type":"journal-article","created":{"date-parts":[[2022,12,23]],"date-time":"2022-12-23T02:09:03Z","timestamp":1671761343000},"page":"20","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["NRF2 in the Epidermal Pigmentary System"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1124-4572","authenticated-orcid":false,"given":"Tatsuya","family":"Ogawa","sequence":"first","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba 305-8575, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1733-5427","authenticated-orcid":false,"given":"Yosuke","family":"Ishitsuka","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita 565-0871, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/S1369-5274(99)80033-2","article-title":"Oxidative stress","volume":"2","author":"Storz","year":"1999","journal-title":"Curr. 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