{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T18:52:30Z","timestamp":1775674350871,"version":"3.50.1"},"reference-count":58,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2022,12,29]],"date-time":"2022-12-29T00:00:00Z","timestamp":1672272000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002347","name":"German Federal Ministries of Education and Research (BMBF)","doi-asserted-by":"publisher","award":["IP7\/01KI1725D"],"award-info":[{"award-number":["IP7\/01KI1725D"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"German Federal Ministries of Education and Research (BMBF)","doi-asserted-by":"publisher","award":["01KI2007D"],"award-info":[{"award-number":["01KI2007D"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"German Federal Ministries of Education and Research (BMBF)","doi-asserted-by":"publisher","award":["ZIM, ZF4117908 AJ8"],"award-info":[{"award-number":["ZIM, ZF4117908 AJ8"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006360","name":"Federal Ministry for Economic Affairs and Energy","doi-asserted-by":"publisher","award":["IP7\/01KI1725D"],"award-info":[{"award-number":["IP7\/01KI1725D"]}],"id":[{"id":"10.13039\/501100006360","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006360","name":"Federal Ministry for Economic Affairs and Energy","doi-asserted-by":"publisher","award":["01KI2007D"],"award-info":[{"award-number":["01KI2007D"]}],"id":[{"id":"10.13039\/501100006360","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006360","name":"Federal Ministry for Economic Affairs and Energy","doi-asserted-by":"publisher","award":["ZIM, ZF4117908 AJ8"],"award-info":[{"award-number":["ZIM, ZF4117908 AJ8"]}],"id":[{"id":"10.13039\/501100006360","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>The progressively rising food-borne Campylobacter jejuni infections pose serious health problems and socioeconomic burdens. Given that antibiotic therapy is not recommended for most campylobacteriosis patients, novel treatment options include strategies targeting iron homeostasis that impacts both C. jejuni virulence and inflammatory cell damage caused by toxic oxygen species. In our preclinical intervention study, we tested potential disease-alleviating effects upon prophylactic oral application of the iron-chelating compound desferoxamine (DESF) in acute murine campylobacteriosis. Therefore, microbiota-depleted IL-10\u2212\/\u2212 mice received synthetic DESF via the drinking water starting seven days before oral infection with C. jejuni strain 81-176. Results revealed that the DESF application did not reduce gastrointestinal pathogen loads but significantly improved the clinical outcome of infected mice at day 6 post-infection. This was accompanied by less pronounced colonic epithelial cell apoptosis, attenuated accumulation of neutrophils in the infected large intestines and abolished intestinal IFN-\u03b3 and even systemic MCP-1 secretion. In conclusion, our study highlights the applied murine campylobacteriosis model as suitable for investigating the role of iron in C. jejuni infection in vivo as demonstrated by the disease-alleviating effects of specific iron binding by oral DESF application in acute C. jejuni induced enterocolitis.<\/jats:p>","DOI":"10.3390\/biom13010071","type":"journal-article","created":{"date-parts":[[2022,12,30]],"date-time":"2022-12-30T03:31:17Z","timestamp":1672371077000},"page":"71","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Iron Deprivation by Oral Deferoxamine Application Alleviates Acute Campylobacteriosis in a Clinical Murine Campylobacter jejuni Infection Model"],"prefix":"10.3390","volume":"13","author":[{"given":"Stefan","family":"Bereswill","sequence":"first","affiliation":[{"name":"Gastrointestinal Microbiology Research Group, Institute of Microbiology, Infectious Diseases and Immunology, Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin, Humboldt-Universit\u00e4t zu Berlin, and Berlin Institute of Health, 12203 Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soraya","family":"Mousavi","sequence":"additional","affiliation":[{"name":"Gastrointestinal Microbiology Research Group, Institute of Microbiology, Infectious Diseases and Immunology, Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin, Humboldt-Universit\u00e4t zu Berlin, and Berlin Institute of Health, 12203 Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dennis","family":"Weschka","sequence":"additional","affiliation":[{"name":"Gastrointestinal Microbiology Research Group, Institute of Microbiology, Infectious Diseases and Immunology, Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin, Humboldt-Universit\u00e4t zu Berlin, and Berlin Institute of Health, 12203 Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9360-4118","authenticated-orcid":false,"given":"Agnes","family":"Buczkowski","sequence":"additional","affiliation":[{"name":"Gastrointestinal Microbiology Research Group, Institute of Microbiology, Infectious Diseases and Immunology, Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin, Humboldt-Universit\u00e4t zu Berlin, and Berlin Institute of Health, 12203 Berlin, Germany"},{"name":"Hofmann & Sommer GmbH und Co. KG, B\u00fcro Berlin, 12489 Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastian","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Gastrointestinal Microbiology Research Group, Institute of Microbiology, Infectious Diseases and Immunology, Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin, Humboldt-Universit\u00e4t zu Berlin, and Berlin Institute of Health, 12203 Berlin, Germany"},{"name":"Hofmann & Sommer GmbH und Co. KG, B\u00fcro Berlin, 12489 Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6399-651X","authenticated-orcid":false,"given":"Markus M.","family":"Heimesaat","sequence":"additional","affiliation":[{"name":"Gastrointestinal Microbiology Research Group, Institute of Microbiology, Infectious Diseases and Immunology, Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin, Humboldt-Universit\u00e4t zu Berlin, and Berlin Institute of Health, 12203 Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Klein, G. (2017). Human campylobacteriosis. Campylobacter, Academic Press. 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