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This implies that metastatic activity has advanced to the peritoneal cavity. It is associated with both genetic and phenotypic heterogeneity, which considerably increase the risks of relapse and reduce the survival rate. To understand ovarian cancer pathophysiology and strengthen the ability for drug screening, further development of relevant in vitro models that recapitulate the complexity of OC microenvironment and dynamics of OC cell population is required. In this line, the recent advances of tridimensional (3D) cell culture and microfluidics have allowed the development of highly innovative models that could bridge the gap between pathophysiology and mechanistic models for clinical research. This review first describes the pathophysiology of OC before detailing the engineering strategies developed to recapitulate those main biological features.<\/jats:p>","DOI":"10.3390\/biom13010103","type":"journal-article","created":{"date-parts":[[2023,1,5]],"date-time":"2023-01-05T01:33:30Z","timestamp":1672882410000},"page":"103","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["In Vitro Models of Ovarian Cancer: Bridging the Gap between Pathophysiology and Mechanistic Models"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3926-1964","authenticated-orcid":false,"given":"Elliot","family":"Lopez","sequence":"first","affiliation":[{"name":"PASTEUR, D\u00e9partement de Chimie, \u00c9cole Normale Sup\u00e9rieure, PSL University, Sorbonne Universit\u00e9, CNRS, 75005 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sahil","family":"Kamboj","sequence":"additional","affiliation":[{"name":"Equipe de Recherche sur les Relations Matrice Extracellulaire-Cellules, ERRMECe, EA1391, Groupe Matrice Extracellulaire et Physiopathologie (MECuP), Institut des Mat\u00e9riaux, I-MAT (FD4122), CY Cergy Paris Universit\u00e9, CEDEX, 95031 Neuville sur Oise, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changchong","family":"Chen","sequence":"additional","affiliation":[{"name":"PASTEUR, D\u00e9partement de Chimie, \u00c9cole Normale Sup\u00e9rieure, PSL University, Sorbonne Universit\u00e9, CNRS, 75005 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1835-9794","authenticated-orcid":false,"given":"Zixu","family":"Wang","sequence":"additional","affiliation":[{"name":"PASTEUR, D\u00e9partement de Chimie, \u00c9cole Normale Sup\u00e9rieure, PSL University, Sorbonne Universit\u00e9, CNRS, 75005 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina","family":"Kellouche","sequence":"additional","affiliation":[{"name":"Equipe de Recherche sur les Relations Matrice Extracellulaire-Cellules, ERRMECe, EA1391, Groupe Matrice Extracellulaire et Physiopathologie (MECuP), Institut des Mat\u00e9riaux, I-MAT (FD4122), CY Cergy Paris Universit\u00e9, CEDEX, 95031 Neuville sur Oise, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanne","family":"Leroy-Dudal","sequence":"additional","affiliation":[{"name":"Equipe de Recherche sur les Relations Matrice Extracellulaire-Cellules, ERRMECe, EA1391, Groupe Matrice Extracellulaire et Physiopathologie (MECuP), Institut des Mat\u00e9riaux, I-MAT (FD4122), CY Cergy Paris Universit\u00e9, CEDEX, 95031 Neuville sur Oise, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franck","family":"Carreiras","sequence":"additional","affiliation":[{"name":"Equipe de Recherche sur les Relations Matrice Extracellulaire-Cellules, ERRMECe, EA1391, Groupe Matrice Extracellulaire et Physiopathologie (MECuP), Institut des Mat\u00e9riaux, I-MAT (FD4122), CY Cergy Paris Universit\u00e9, CEDEX, 95031 Neuville sur Oise, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ambroise","family":"Lambert","sequence":"additional","affiliation":[{"name":"Equipe de Recherche sur les Relations Matrice Extracellulaire-Cellules, ERRMECe, EA1391, Groupe Matrice Extracellulaire et Physiopathologie (MECuP), Institut des Mat\u00e9riaux, I-MAT (FD4122), CY Cergy Paris Universit\u00e9, CEDEX, 95031 Neuville sur Oise, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7013-2231","authenticated-orcid":false,"given":"Carole","family":"Aim\u00e9","sequence":"additional","affiliation":[{"name":"PASTEUR, D\u00e9partement de Chimie, \u00c9cole Normale Sup\u00e9rieure, PSL University, Sorbonne Universit\u00e9, CNRS, 75005 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"284","DOI":"10.3322\/caac.21456","article-title":"Ovarian Cancer Statistics, 2018","volume":"68","author":"Torre","year":"2018","journal-title":"CA Cancer J. 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