{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:10:35Z","timestamp":1787069435614,"version":"build-2736575974"},"reference-count":30,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2023,1,23]],"date-time":"2023-01-23T00:00:00Z","timestamp":1674432000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Key Research and Development Program of China","award":["2020YFC2006404"],"award-info":[{"award-number":["2020YFC2006404"]}]},{"name":"National Key Research and Development Program of China","award":["2020YFC2006402"],"award-info":[{"award-number":["2020YFC2006402"]}]},{"name":"National Key Research and Development Program of China","award":["2020YFC2006400"],"award-info":[{"award-number":["2020YFC2006400"]}]},{"name":"National Key Research and Development Program of China","award":["3332021078"],"award-info":[{"award-number":["3332021078"]}]},{"name":"National Key Research and Development Program of China","award":["PKU2017ZC001-4"],"award-info":[{"award-number":["PKU2017ZC001-4"]}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["2020YFC2006404"],"award-info":[{"award-number":["2020YFC2006404"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["2020YFC2006402"],"award-info":[{"award-number":["2020YFC2006402"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["2020YFC2006400"],"award-info":[{"award-number":["2020YFC2006400"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["3332021078"],"award-info":[{"award-number":["3332021078"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["PKU2017ZC001-4"],"award-info":[{"award-number":["PKU2017ZC001-4"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Peking University Medical Science Center-Ulm University Joint Research Center for Neuroscience Funding Project","award":["2020YFC2006404"],"award-info":[{"award-number":["2020YFC2006404"]}]},{"name":"Peking University Medical Science Center-Ulm University Joint Research Center for Neuroscience Funding Project","award":["2020YFC2006402"],"award-info":[{"award-number":["2020YFC2006402"]}]},{"name":"Peking University Medical Science Center-Ulm University Joint Research Center for Neuroscience Funding Project","award":["2020YFC2006400"],"award-info":[{"award-number":["2020YFC2006400"]}]},{"name":"Peking University Medical Science Center-Ulm University Joint Research Center for Neuroscience Funding Project","award":["3332021078"],"award-info":[{"award-number":["3332021078"]}]},{"name":"Peking University Medical Science Center-Ulm University Joint Research Center for Neuroscience Funding Project","award":["PKU2017ZC001-4"],"award-info":[{"award-number":["PKU2017ZC001-4"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>We investigated retinal structure changes in patients with Parkinson\u2019s disease (PD), multiple system atrophy (MSA), progressive supranuclear palsy (PSP), and controls, and explored the value of this method in differential diagnosis. Spectral domain optical coherence tomography (SD-OCT) was used to measure peripapillary retinal nerve fiber layer (pRNFL) thickness, and macular thickness and volume. PSP patients showed higher temporal pRNFL thickness than PD and MSA patients. Peripapillary RNFL thickness could be used for discriminating PSP from MSA and PD. PD and MSA patients showed retinal thinning in the foveal center circle and nasal inner sectors compared to controls. Macular thickness and volume could be used for discriminating MSA from PD. There were negative correlations between disease duration and OCT parameters in PD, MSA, and PSP, independent of age, sex ratio, and the side of the eye. PD and atypical parkinsonism correlate with specific patterns of retina alterations. OCT could be a biomarker for differential diagnosis and progression evaluation of parkinsonian syndrome.<\/jats:p>","DOI":"10.3390\/biom13020218","type":"journal-article","created":{"date-parts":[[2023,1,23]],"date-time":"2023-01-23T02:27:45Z","timestamp":1674440865000},"page":"218","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Retinal Structure Abnormalities in Parkinson\u2019s Disease and Atypical Parkinsonism"],"prefix":"10.3390","volume":"13","author":[{"given":"Xinxin","family":"Ma","sequence":"first","affiliation":[{"name":"Department of Neurology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing 100730, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuhua","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing 100730, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bodi","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing 100730, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing 100730, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huijing","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing 100730, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing 100730, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoxia","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Peking University First Hospital, Beijing 100034, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haibo","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing 100730, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Neurology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing 100730, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,23]]},"reference":[{"key":"ref_1","first-page":"1117","article-title":"Diagnostic Approach to Atypical Parkinsonian Syndromes","volume":"22","author":"McFarland","year":"2016","journal-title":"Continuum"},{"key":"ref_2","first-page":"61","article-title":"The Differential Diagnosis and Treatment of Atypical Parkinsonism","volume":"113","author":"Levin","year":"2016","journal-title":"Dtsch. 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