{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T04:12:45Z","timestamp":1780632765866,"version":"3.54.1"},"reference-count":170,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2023,1,24]],"date-time":"2023-01-24T00:00:00Z","timestamp":1674518400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["19AIREA34470007"],"award-info":[{"award-number":["19AIREA34470007"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>Acid-sensing ion channels (ASICs) are proton-gated, voltage-independent sodium channels widely expressed throughout the central and peripheral nervous systems. They are involved in synaptic plasticity, learning\/memory, fear conditioning and pain. Zinc, an important trace metal in the body, contributes to numerous physiological functions, with neurotransmission being of note. Zinc has been implicated in the modulation of ASICs by binding to specific sites on these channels and exerting either stimulatory or inhibitory effects depending on the ASIC subtype. ASICs have been linked to several neurological and psychological disorders, such as Alzheimer\u2019s disease, Parkinson\u2019s disease, ischemic stroke, epilepsy and cocaine addiction. Different ASIC isoforms contribute to the persistence of each of these neurological and psychological disorders. It is critical to understand how various zinc concentrations can modulate specific ASIC subtypes and how zinc regulation of ASICs can contribute to neurological and psychological diseases. This review elucidates zinc\u2019s structural interactions with ASICs and discusses the potential therapeutic implications zinc may have on neurological and psychological diseases through targeting ASICs.<\/jats:p>","DOI":"10.3390\/biom13020229","type":"journal-article","created":{"date-parts":[[2023,1,25]],"date-time":"2023-01-25T03:53:18Z","timestamp":1674618798000},"page":"229","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["The Role of Zinc in Modulating Acid-Sensing Ion Channel Function"],"prefix":"10.3390","volume":"13","author":[{"given":"Amber W.","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences, School of Medicine, University of Missouri-Kansas City, Kansas City, MO 64108, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5144-5817","authenticated-orcid":false,"given":"Michelle H.","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, School of Medicine, University of Missouri-Kansas City, Kansas City, MO 64108, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3624-7382","authenticated-orcid":false,"given":"Madhumathi","family":"Vijayalingam","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, School of Medicine, University of Missouri-Kansas City, Kansas City, MO 64108, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1768-562X","authenticated-orcid":false,"given":"Michael J.","family":"Wacker","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, School of Medicine, University of Missouri-Kansas City, Kansas City, MO 64108, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6781-0468","authenticated-orcid":false,"given":"Xiang-Ping","family":"Chu","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, School of Medicine, University of Missouri-Kansas City, Kansas City, MO 64108, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1038\/386173a0","article-title":"A proton-gated cation channel involved in acid-sensing","volume":"386","author":"Waldmann","year":"1997","journal-title":"Nature"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Ruan, N., Tribble, J., Peterson, A.M., Jiang, Q., Wang, J.Q., and Chu, X.P. (2021). Acid-Sensing Ion Channels and Mechanosensation. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22094810"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.2174\/1570159X19666210125151824","article-title":"Acid-Sensing Ion Channels: Focus on Physiological and Some Pathological Roles in the Brain","volume":"19","author":"Storozhuk","year":"2021","journal-title":"Curr. Neuropharmacol."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Jiang, Q., Peterson, A.M., Chu, Y., Yao, X., Zha, X.M., and Chu, X.P. (2020). Histidine Residues Are Responsible for Bidirectional Effects of Zinc on Acid-Sensing Ion Channel 1a\/3 Heteromeric Channels. Biomolecules, 10.","DOI":"10.3390\/biom10091264"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"e2109040118","DOI":"10.1073\/pnas.2109040118","article-title":"Follistatin mediates learning and synaptic plasticity via regulation of Asic4 expression in the hippocampus","volume":"118","author":"Chen","year":"2021","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"18242","DOI":"10.1038\/srep18242","article-title":"Acid-sensing ion channel (ASIC) 4 predominantly localizes to an early endosome-related organelle upon heterologous expression","volume":"5","author":"Schwartz","year":"2015","journal-title":"Sci. Rep."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.neulet.2017.03.054","article-title":"Distribution of ASIC4 transcripts in the adult wild-type mouse brain","volume":"651","author":"Hoshikawa","year":"2017","journal-title":"Neurosci. Lett."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"2902","DOI":"10.1161\/STROKEAHA.119.025940","article-title":"\u03b2-Estradiol protects against acidosis-mediated and ischemic neuronal injury by promoting ASIC1a (acid-sensing ion channel 1a) protein degradation","volume":"50","author":"Zhou","year":"2019","journal-title":"Stroke"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.nbd.2008.05.008","article-title":"Amiloride is neuroprotective in an MPTP model of Parkinson\u2019s disease","volume":"31","author":"Arias","year":"2008","journal-title":"Neurobiol. Dis."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"295","DOI":"10.5483\/BMBRep.2013.46.6.121","article-title":"Acid-sensing ion channels (ASICs): Therapeutic targets for neurological diseases and their regulation","volume":"46","author":"Kweon","year":"2013","journal-title":"BMB Rep."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1038\/nn.3750","article-title":"Acid-sensing ion channels contribute to synaptic transmission and inhibit cocaine-evoked plasticity","volume":"17","author":"Kreple","year":"2014","journal-title":"Nat. Neurosci."},{"key":"ref_12","first-page":"84","article-title":"Inhibition of human acid-sensing ion channel 1b by zinc","volume":"4","author":"Jiang","year":"2012","journal-title":"Int. J. Physiol. Pathophysiol. Pharmacol."},{"key":"ref_13","first-page":"288","article-title":"Modulation of acid-sensing ion channels: Molecular mechanisms and therapeutic potential","volume":"3","author":"Chu","year":"2011","journal-title":"Int. J. Physiol. Pathophysiol. Pharmacol."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Sivils, A., Yang, F., Wang, J.Q., and Chu, X.P. (2022). Acid-Sensing Ion Channel 2: Function and Modulation. Membranes, 12.","DOI":"10.3390\/membranes12020113"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1038\/nature08218","article-title":"Pore architecture and ion sites in acid-sensing ion channels and P2X receptors","volume":"460","author":"Gonzales","year":"2009","journal-title":"Nature"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.neuropharm.2017.04.042","article-title":"Acid-sensing ion channel (ASIC) structure and function: Insights from spider, snake and sea anemone venoms","volume":"127","author":"Rash","year":"2017","journal-title":"Neuropharmacology"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1038\/nature06163","article-title":"Structure of acid-sensing ion channel 1 at 1.9 A resolution and low pH","volume":"449","author":"Jasti","year":"2007","journal-title":"Nature"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"35361","DOI":"10.1074\/jbc.M105208200","article-title":"Zn2+ and H+ are coactivators of acid-sensing ion channels","volume":"276","author":"Baron","year":"2001","journal-title":"J. Biol. Chem."},{"key":"ref_19","first-page":"8197","article-title":"Role of Zinc in Mucosal Health and Disease: A Review of Physiological, Biochemical, and Molecular Processes","volume":"12","author":"Hassan","year":"2020","journal-title":"Cureus"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.pharmthera.2018.08.013","article-title":"Zinc signaling and epilepsy","volume":"193","author":"Doboszewska","year":"2019","journal-title":"Pharmacol. Ther."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.neuro.2019.07.007","article-title":"The role of zinc, copper, manganese and iron in neurodegenerative diseases","volume":"74","author":"Mezzaroba","year":"2019","journal-title":"Neurotoxicology"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/s00394-020-02454-3","article-title":"Neurobiology of zinc and its role in neurogenesis","volume":"60","author":"Kumar","year":"2021","journal-title":"Eur. J. Nutr."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.3389\/fonc.2020.01293","article-title":"Zinc Deficiency in Men Over 50 and Its Implications in Prostate Disorders","volume":"10","author":"Sauer","year":"2020","journal-title":"Front. Oncol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"14","DOI":"10.4103\/0970-1591.78405","article-title":"Zinc status of patients with benign prostatic hyperplasia and prostate carcinoma","volume":"27","author":"Christudoss","year":"2011","journal-title":"Ind. J. Urol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.abb.2016.04.014","article-title":"A comprehensive review of the role of zinc in normal prostate function and metabolism; and its implications in prostate cancer","volume":"611","author":"Costello","year":"2016","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Portbury, S.D., and Adlard, P.A. (2017). Zinc Signal in Brain Diseases. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18122506"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"760567","DOI":"10.3389\/fnins.2021.760567","article-title":"Zinc Finger Proteins in Neuro-Related Diseases Progression","volume":"15","author":"Bu","year":"2021","journal-title":"Front. Neurosci."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Mammadova-Bach, E., and Braun, A. (2019). Zinc Homeostasis in Platelet-Related Diseases. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20215258"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1038\/s41586-020-2933-1","article-title":"Discoveries in structure and physiology of mechanically activated ion channels","volume":"587","author":"Kefauver","year":"2020","journal-title":"Nature"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"079","DOI":"10.1152\/physrev.00052.2017","article-title":"The Role of Voltage-Gated Sodium Channels in Pain Signaling","volume":"99","author":"Bennett","year":"2019","journal-title":"Physiol. Rev."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Peralta, F.A., and Huidobro-Toro, J.P. (2016). Zinc as Allosteric Ion Channel Modulator: Ionotropic Receptors as Metalloproteins. Int. J. Mol. Sci., 17.","DOI":"10.3390\/ijms17071059"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.imr.2015.07.004","article-title":"The direct modulatory activity of zinc toward ion channels","volume":"4","author":"Noh","year":"2015","journal-title":"Integr. Med. Res."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"3677","DOI":"10.1007\/s00018-015-1948-5","article-title":"Structure of potassium channels","volume":"72","author":"Kuang","year":"2015","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1177\/1073858418763752","article-title":"Potassium Channel Gain of Function in Epilepsy: An Unresolved Paradox","volume":"24","author":"Niday","year":"2018","journal-title":"Neuroscientist"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1111\/cns.12804","article-title":"Potassium channel dysfunction in neurons and astrocytes in Huntington\u2019s disease","volume":"24","author":"Zhang","year":"2018","journal-title":"CNS Neurosci. Ther."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1038\/s41586-021-03185-z","article-title":"A growth-factor-activated lysosomal K+ channel regulates Parkinson\u2019s pathology","volume":"591","author":"Wie","year":"2021","journal-title":"Nature"},{"key":"ref_37","first-page":"4195","article-title":"Kv1.3 modulates neuroinflammation and neurodegeneration in Parkinson\u2019s disease","volume":"130","author":"Sarkar","year":"2020","journal-title":"J. Clin. Investig."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1007\/s00424-018-2163-7","article-title":"Calcium channel gating","volume":"470","author":"Hering","year":"2018","journal-title":"Pflug. Arch."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/j.neuron.2018.03.017","article-title":"Calcium Channels, Synaptic Plasticity, and Neuropsychiatric Disease","volume":"98","author":"Nanou","year":"2018","journal-title":"Neuron"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1007S","DOI":"10.1093\/jn\/130.4.1007S","article-title":"Glutamate as a neurotransmitter in the brain: Review of physiology and pathology","volume":"130","author":"Meldrum","year":"2000","journal-title":"J. Nutr."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1515\/revneuro-2019-0058","article-title":"Synaptic plasticity in Alzheimer\u2019s disease and healthy aging","volume":"31","author":"Cardenas","year":"2020","journal-title":"Rev. Neurosci."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"107426","DOI":"10.1016\/j.pharmthera.2019.107426","article-title":"The origin of NMDA receptor hypofunction in schizophrenia","volume":"205","author":"Nakazawa","year":"2020","journal-title":"Pharmacol. Ther."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"174310","DOI":"10.1016\/j.ejphar.2021.174310","article-title":"NMDA and AMPA receptors dysregulation in Alzheimer\u2019s disease","volume":"908","author":"Babaei","year":"2021","journal-title":"Eur. J. Pharmacol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/978-981-10-7757-9_6","article-title":"Transient Receptor Potential (TRP) Channels","volume":"87","author":"Samanta","year":"2018","journal-title":"Subcell Biochem."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1038\/s41586-018-0255-3","article-title":"Structure of a human synaptic GABAA receptor","volume":"559","author":"Zhu","year":"2018","journal-title":"Nature"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"8678","DOI":"10.1523\/JNEUROSCI.2844-04.2004","article-title":"Subunit-Dependent High-Affinity Zinc Inhibition of Acid-Sensing Ion Channels","volume":"24","author":"Chu","year":"2004","journal-title":"J. Neurosci."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1111\/ejn.12905","article-title":"Genetic mapping of ASIC4 and contrasting phenotype to ASIC1a in modulating innate fear and anxiety","volume":"41","author":"Lin","year":"2015","journal-title":"Eur. J. Neurosci."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/s11010-017-3212-9","article-title":"Acid-sensing ion channel 1a mediates acid-induced inhibition of matrix metabolism of rat articular chondrocytes via the MAPK signaling pathway","volume":"443","author":"Sun","year":"2018","journal-title":"Mol. Cell. Biochem."},{"key":"ref_49","first-page":"151158","article-title":"Prolonged activation of ASIC1a and the time window for neuroprotection in cerebral ischaemia","volume":"130","author":"Pignataro","year":"2007","journal-title":"Brain A J. Neurol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"9723","DOI":"10.1523\/JNEUROSCI.1665-11.2011","article-title":"Heteromeric acid-sensing ion channels (ASICs) composed of ASIC2b and ASIC1a display novel channel properties and contribute to acidosis-induced neuronal death","volume":"31","author":"Sherwood","year":"2011","journal-title":"J. Neurosci."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.neuroscience.2011.07.021","article-title":"Cysteine 149 in the extracellular finger domain of acid-sensing ion channel 1b subunit is critical for zinc-mediated inhibition","volume":"193","author":"Jiang","year":"2011","journal-title":"Neuroscience"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1016\/j.neuroscience.2010.05.043","article-title":"Inhibitory regulation of acid-sensing ion channel 3 by zinc","volume":"169","author":"Jiang","year":"2010","journal-title":"Neuroscience"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1124\/mol.118.114918","article-title":"Opioid-mediated modulation of acid-sensing ion channel currents in adult rat sensory neurons","volume":"95","author":"Zaremba","year":"2019","journal-title":"Mol. Pharmacol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/978-981-13-1756-9_4","article-title":"Roles of ASICs in nociception and proprioception","volume":"1099","author":"Lee","year":"2018","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1085\/jgp.200509303","article-title":"The tarantula toxin psalmotoxin 1 inhibits acid-sensing ion channel (ASIC) 1a by increasing its apparent H+ affinity","volume":"126","author":"Chen","year":"2005","journal-title":"J. Gen. Physiol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"28519","DOI":"10.1074\/jbc.M004114200","article-title":"Mammalian ASIC2a and ASIC3 subunits co-assemble into heteromeric proton-gated channels sensitive to Gd3+","volume":"275","author":"Babinski","year":"2000","journal-title":"J. Biol. Chem."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"542","DOI":"10.5483\/BMBRep.2016.49.10.057","article-title":"ASIC2a-dependent increase of ASIC3 surface expression enhances the sustained component of the currents","volume":"49","author":"Kweon","year":"2016","journal-title":"BMB Rep."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1016\/j.tips.2021.09.008","article-title":"Acid-sensing ion channels as potential therapeutic targets","volume":"42","author":"Heusser","year":"2021","journal-title":"Trends Pharmacol. Sci."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"5870","DOI":"10.1038\/s41598-017-05038-0","article-title":"Glucose Deficiency Elevates Acid-Sensing Ion Channel 2a Expression and Increases Seizure Susceptibility in Temporal Lobe Epilepsy","volume":"7","author":"Zhang","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1161\/01.RES.0000238388.79295.4c","article-title":"Sustained currents through ASIC3 ion channels at the modest pH changes that occur during myocardial ischemia","volume":"99","author":"Yagi","year":"2006","journal-title":"Circ. Res."},{"key":"ref_61","first-page":"483","article-title":"Acid-Sensing Ion Channels Expression, Identity and Role in the Excitability of the Cochlear Afferent Neurons","volume":"9","author":"Vega","year":"2015","journal-title":"Front. Cell. Neurosci."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"634","DOI":"10.3109\/17453676908989529","article-title":"Synovial pH in rheumatoid knee-joints I. The effect of synovectomy","volume":"40","author":"Goldie","year":"1969","journal-title":"Acta Orthop."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.neurobiolaging.2020.12.007","article-title":"Decreased pH in the aging brain and Alzheimer\u2019s disease","volume":"101","author":"Decker","year":"2021","journal-title":"Neurobiol. Aging"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1080\/19336950.2020.1852831","article-title":"Acid-sensing ion channel 3: An analgesic target","volume":"15","author":"Dulai","year":"2021","journal-title":"Channels"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1111\/epi.12550","article-title":"ILAE official report: A practical clinical definition of epilepsy","volume":"55","author":"Fisher","year":"2014","journal-title":"Epilepsia"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0006-3495(01)75684-6","article-title":"High-affinity Zn block in recombinant N-methyl-D-aspartate receptors with cysteine substitutions at the Q\/R\/N site","volume":"81","author":"Amar","year":"2001","journal-title":"Biophys. J."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1161\/01.STR.0000251443.68897.99","article-title":"Extracellular zinc protects against acidosis-induced injury of cells expressing Ca2+-permeable acid-sensing ion channels","volume":"38","author":"Hey","year":"2007","journal-title":"Stroke"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1016\/0306-4522(94)90282-8","article-title":"Zinc toxicity on cultured cortical neurons: Involvement of N-methyl-d-aspartate receptors","volume":"60","author":"Koh","year":"1994","journal-title":"Neuroscience"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1152\/physrev.00034.2015","article-title":"Pathophysiology of Migraine: A Disorder of Sensory Processing","volume":"97","author":"Goadsby","year":"2017","journal-title":"Physiol. Rev."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"102253","DOI":"10.1016\/j.redox.2022.102253","article-title":"ASIC1a senses lactate uptake to regulate metabolism in neurons","volume":"51","author":"Azoulay","year":"2022","journal-title":"Redox Biol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"4154","DOI":"10.1111\/bph.14462","article-title":"Effects of systemic inhibitors of acid-sensing ion channels 1 (ASIC1) against acute and chronic mechanical allodynia in a rodent model of migraine","volume":"175","author":"Verkest","year":"2018","journal-title":"Br. J. Pharmacol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1186\/s12937-020-00618-9","article-title":"Zinc supplementation affects favorably the frequency of migraine attacks: A double-blind randomized placebo-controlled clinical trial","volume":"19","author":"Ahmadi","year":"2020","journal-title":"Nutr. J."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"127","DOI":"10.7762\/cnr.2021.10.2.127","article-title":"Assessing the Effect of Zinc Supplementation on the Frequency of Migraine Attack, Duration, Severity, Lipid Profile and hs-CRP in Adult Women","volume":"10","author":"Mazaheri","year":"2021","journal-title":"Clin. Nutr. Res."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.pneurobio.2015.12.005","article-title":"Ashina, M. Challenges in developing drugs for primary headaches","volume":"152","author":"Schytz","year":"2017","journal-title":"Prog. Neurobiol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1111\/head.13115","article-title":"Allodynia Is Associated With Initial and Sustained Response to Acute Migraine Treatment: Results from the American Migraine Prevalence and Prevention Study","volume":"57","author":"Lipton","year":"2017","journal-title":"Headache"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/6374","article-title":"Impaired synaptic plasticity and learning in aged amyloid precursor protein transgenic mice","volume":"2","author":"Chapman","year":"1999","journal-title":"Nat. Neurosci."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"555","DOI":"10.3389\/fphar.2019.00555","article-title":"Acid-Sensing ion channel 1a is involved in N-Methyl D-aspartate receptor-dependent long-term depression in the hippocampus","volume":"10","author":"Mango","year":"2019","journal-title":"Front. Pharmacol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1126\/science.8073293","article-title":"Rapid induction of Alzheimer A beta amyloid formation by zinc","volume":"265","author":"Bush","year":"1994","journal-title":"Science"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"dmm031781","DOI":"10.1242\/dmm.031781","article-title":"Molecular biomarkers of Alzheimer\u2019s disease: Progress and prospects","volume":"11","author":"Lashley","year":"2018","journal-title":"Dis. Model. Mech."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"4772","DOI":"10.1038\/s41598-018-23122-x","article-title":"Zinc ion rapidly induces toxic, off-pathway amyloid-beta oligomers distinct from amyloid-beta derived diffusible ligands in Alzheimer\u2019s disease","volume":"8","author":"Lee","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1021\/acschemneuro.6b00362","article-title":"Iron, copper, and zinc concentration in abeta plaques in the APP\/PS1 mouse model of Alzheimer\u2019s disease correlates with metal levels in the surrounding neuropil","volume":"8","author":"James","year":"2017","journal-title":"ACS Chem. Neurosci."},{"key":"ref_82","first-page":"358","article-title":"Brain iron is associated with accelerated cognitive decline in people with Alzheimer pathology","volume":"45","author":"Ayton","year":"2019","journal-title":"Mol. Psychiatry"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"2728","DOI":"10.1038\/s41380-020-0800-y","article-title":"Alzheimer risk factors age and female sex induce cortical A\u03b2 aggregation by raising extracellular zinc","volume":"25","author":"Datki","year":"2020","journal-title":"Mol. Psychiatry"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.ccr.2017.05.007","article-title":"Alzheimer\u2019s disease: How metal ions define \u03b2-amyloid function","volume":"351","author":"Kepp","year":"2017","journal-title":"Coord. Chem. Rev."},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"Zhang, H.L., Wang, X.C., and Liu, R. (2022). Zinc in Regulating Protein Kinases and Phosphatases in Neurodegenerative Diseases. Biomolecules, 12.","DOI":"10.3390\/biom12060785"},{"key":"ref_86","doi-asserted-by":"crossref","unstructured":"Squitti, R., Pal, A., Picozza, M., Avan, A., Ventriglia, M., Rongioletti, M.C., and Hoogenraad, T. (2020). Zinc Therapy in Early Alzheimer\u2019s Disease: Safety and Potential Therapeutic Efficacy. Biomolecules, 10.","DOI":"10.3390\/biom10081164"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"4784268","DOI":"10.1155\/2018\/4784268","article-title":"Linking Neuroinflammation and Neurodegeneration in Parkinson\u2019s Disease","volume":"2018","author":"Gelders","year":"2018","journal-title":"J. Immunol. Res."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.nbd.2015.04.010","article-title":"Intracellular zinc is a critical intermediate in the excitotoxic cascade","volume":"81","author":"Granzotto","year":"2015","journal-title":"Neurobiol. Dis."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1002\/mds.25096","article-title":"New synaptic and molecular targets for neuroprotection in Parkinson\u2019s disease","volume":"28","author":"Calabresi","year":"2013","journal-title":"Mov. Disord."},{"key":"ref_90","doi-asserted-by":"crossref","unstructured":"Ahmed, S.S., and Santosh, W. (2010). Metallomic profiling and linkage map analysis of early Parkinson\u2019s disease: A new insight to aluminum marker for the possible diagnosis. PLoS ONE, 5.","DOI":"10.1371\/journal.pone.0011252"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.jtemb.2004.09.003","article-title":"Serum trace element levels and the complexity of inter-element relations in patients with Parkinson\u2019s disease","volume":"18","author":"Hegde","year":"2004","journal-title":"J. Trace Elem. Med. Biol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.neulet.2007.03.073","article-title":"Zinc protects SK-N-SH cells from methamphetamine-induced alpha-synuclein expression","volume":"419","author":"Ajjimaporn","year":"2007","journal-title":"Neurosci. Lett."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.brainresbull.2008.09.006","article-title":"Zinc rescues dopaminergic SK-N-SH cell lines from methamphetamine-induced toxicity","volume":"77","author":"Ajjimaporn","year":"2008","journal-title":"Brain Res. Bull."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0304-3940(02)01158-8","article-title":"Zinc potentiates 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine induced dopamine depletion in caudate nucleus of mice brain","volume":"335","author":"Hussain","year":"2002","journal-title":"Neurosci. Lett."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"135383","DOI":"10.1016\/j.neulet.2021.135873","article-title":"Metals associated neurodegeneration in Parkinson\u2019s disease: Insight to physiological, pathological mechanisms and management","volume":"753","author":"Raj","year":"2021","journal-title":"Neurosci. Lett."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1038\/33416","article-title":"Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism","volume":"392","author":"Kitada","year":"1998","journal-title":"Nature"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"3105","DOI":"10.1091\/mbc.e05-11-1027","article-title":"Parkin-mediated monoubiquitination of the PDZ protein PICK1 regulates the activity of acid-sensing ion channels","volume":"18","author":"Joch","year":"2007","journal-title":"Mol. Biol. Cell"},{"key":"ref_98","unstructured":"GBD 2017 Disease and Injury Incidence and Prevalence Collaborators (2018). Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990\u20132017: A systematic analysis for the Global Burden of Disease Study 2017. Lancet, 392, 1789\u20131858."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.brainresbull.2021.02.003","article-title":"Interaction between zinc, the GPR39 zinc receptor and the serotonergic system in depression","volume":"170","author":"Nowak","year":"2021","journal-title":"Brain Res. Bull."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1038\/328640a0","article-title":"Micromolar concentrations of Zn2+ antagonize NMDA and GABA responses of hippocampal neurons","volume":"328","author":"Westbrook","year":"1987","journal-title":"Nature"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1038\/308734a0","article-title":"Release of endogenous Zn2+ from brain tissue during activity","volume":"308","author":"Assaf","year":"1984","journal-title":"Nature"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1136\/bmj.326.7386.409","article-title":"Zinc deficiency","volume":"326","author":"Prasad","year":"2003","journal-title":"Bmj"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.jad.2008.10.015","article-title":"HPA axis hyperactivity and attempted suicide in young adult mood disorder inpatients","volume":"116","author":"Jokinen","year":"2009","journal-title":"J. Affect. Disord."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.brainresbull.2015.04.005","article-title":"Investigation of the GPR39 zinc receptor following inhibition of monoaminergic neurotransmission and potentialization of glutamatergic neurotransmission","volume":"115","author":"Librowski","year":"2015","journal-title":"Brain Res. Bull."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"2897","DOI":"10.1007\/s12035-017-0536-0","article-title":"Allosteric Inhibition of Serotonin 5-HT7 Receptors by Zinc Ions","volume":"55","author":"Lenda","year":"2018","journal-title":"Mol. Neurobiol."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.jad.2020.03.137","article-title":"GPR39 protects against corticosterone-induced neuronal injury in hippocampal cells through the CREB-BDNF signaling pathway","volume":"272","author":"Mo","year":"2020","journal-title":"J. Affect. Disord."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1038\/jcbfm.2009.80","article-title":"Decreased brain zinc availability reduces hippocampal neurogenesis in mice and rats","volume":"29","author":"Suh","year":"2009","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"ref_108","doi-asserted-by":"crossref","unstructured":"Wang, J., Um, P., Dickerman, B.A., and Liu, J. (2018). Zinc, Magnesium, Selenium and Depression: A Review of the Evidence, Potential Mechanisms and Implications. Nutrients, 10.","DOI":"10.3390\/nu10050584"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.neuroscience.2015.04.047","article-title":"Hippocampal neuroplasticity in major depressive disorder","volume":"309","author":"Malykhin","year":"2015","journal-title":"Neuroscience"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1111\/gbb.12398","article-title":"ASIC1A in neurons is critical for fear-related behaviors","volume":"16","author":"Taugher","year":"2017","journal-title":"Genes Brain Behav."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"5381","DOI":"10.1523\/JNEUROSCI.0360-09.2009","article-title":"Acid-sensing ion channel-1a in the amygdala, a novel therapeutic target in depression-related behavior","volume":"29","author":"Coryell","year":"2009","journal-title":"J. Neurosci."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"5496","DOI":"10.1523\/JNEUROSCI.23-13-05496.2003","article-title":"Acid-sensing ion channel 1 is localized in brain regions with high synaptic density and contributes to fear conditioning","volume":"23","author":"Wemmie","year":"2003","journal-title":"J. Neurosci."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"828447","DOI":"10.3389\/fimmu.2022.828447","article-title":"Interleukins and Ischemic Stroke","volume":"13","author":"Zhu","year":"2022","journal-title":"Front. Immunol."},{"key":"ref_114","doi-asserted-by":"crossref","unstructured":"Maida, C.D., Norrito, R.L., Daidone, M., Tuttolomondo, A., and Pinto, A. (2020). Neuroinflammatory Mechanisms in Ischemic Stroke: Focus on Cardioembolic Stroke, Background, and Therapeutic Approaches. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21186454"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.ceca.2018.11.005","article-title":"Store-operated calcium entry in thrombosis and thrombo-inflammation","volume":"77","author":"Nagy","year":"2019","journal-title":"Cell Calcium"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/S0306-4522(02)00513-4","article-title":"Zinc translocation accelerates infarction after mild transient focal ischemia","volume":"115","author":"Lee","year":"2002","journal-title":"Neuroscience"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1111\/j.1440-1681.2007.04858.x","article-title":"Systemic administration of Zn2+ during the reperfusion phase of transient cerebral ischaemia protects rat hippocampus against iron-catalysed postischaemic injury","volume":"35","author":"Helal","year":"2008","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1179\/147683009X423445","article-title":"Normalization of zinc intake enhances neurological retrieval of patients suffering from ischemic strokes","volume":"12","author":"Aquilani","year":"2009","journal-title":"Nutr. Neurosci."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.cell.2004.08.026","article-title":"Neuroprotection in ischemia: Blocking calcium-permeable acid-sensing ion channels","volume":"118","author":"Xiong","year":"2004","journal-title":"Cell"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/s12975-013-0319-5","article-title":"Translational strategies for neuroprotection in ischemic stroke--focusing on acid-sensing ion channel 1a","volume":"5","author":"Vann","year":"2014","journal-title":"Transl. Stroke Res."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.neuron.2005.10.011","article-title":"Coupling between NMDA receptor and acid-sensing ion channel contributes to ischemic neuronal death","volume":"48","author":"Gao","year":"2005","journal-title":"Neuron"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"e12690","DOI":"10.1111\/adb.12690","article-title":"Overexpression of ASIC1A in the nucleus accumbens of rats potentiates cocaine-seeking behavior","volume":"25","author":"Gutman","year":"2020","journal-title":"Addict. Biol."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1038\/s41398-021-01693-0","article-title":"Synaptic Zn2+ potentiates the effects of cocaine on striatal dopamine neurotransmission and behavior","volume":"11","author":"Gomez","year":"2021","journal-title":"Transl. Psychiatry"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.neuroscience.2009.04.029","article-title":"Characterization of acid-sensing ion channels in medium spiny neurons of mouse striatum","volume":"162","author":"Jiang","year":"2009","journal-title":"Neuroscience"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1021\/cn500154w","article-title":"Drug abuse and the simplest neurotransmitter","volume":"5","author":"Kreple","year":"2014","journal-title":"ACS Chem. Neurosci."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1017\/S0007114520002810","article-title":"Sensitivity and reliability of zinc transporter and metallothionein gene expression in peripheral blood mononuclear cells as indicators of zinc status: Responses to ex vivo zinc exposure and habitual zinc intake in humans","volume":"125","author":"Hennigar","year":"2021","journal-title":"Br. J. Nutr."},{"key":"ref_127","first-page":"47","article-title":"The effect of zinc deficiency on morphine antinociception","volume":"16","author":"Dursun","year":"1995","journal-title":"Res. Commun. Alcohol. Subst. Abus."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1515\/sjpain-2019-0138","article-title":"Role of the immune system in neuropathic pain","volume":"20","author":"Malcangio","year":"2019","journal-title":"Scand. J. Pain"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"2034","DOI":"10.7150\/ijbs.59918","article-title":"The Impact of TRPV1 on Cancer Pathogenesis and Therapy: A Systematic Review","volume":"17","author":"Li","year":"2021","journal-title":"Int. J. Biol. Sci."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/0028-3908(96)84630-2","article-title":"Zinc reduces the hyperalgesia and upregulation of NGF and IL-1 beta produced by peripheral inflammation in the rat","volume":"35","author":"Poole","year":"1996","journal-title":"Neuropharmacology"},{"key":"ref_131","first-page":"1319","article-title":"Manipulations of zinc in the spinal cord, by intrathecal injection of zinc chloride, disodium-calcium-EDTA, or dipicolinic acid, alter nociceptive activity in mice","volume":"282","author":"Larson","year":"1997","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.3389\/fnins.2019.01247","article-title":"Involvement of Acid-Sensing Ion Channel 1b in the Development of Acid-Induced Chronic Muscle Pain","volume":"13","author":"Chang","year":"2019","journal-title":"Front. Neurosci."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1523\/JNEUROSCI.1816-17.2017","article-title":"Zinc Inhibits TRPV1 to Alleviate Chemotherapy-Induced Neuropathic Pain","volume":"38","author":"Luo","year":"2018","journal-title":"J. Neurosci."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s10534-007-9103-x","article-title":"Depletion of vesicular zinc in dorsal horn of spinal cord causes increased neuropathic pain in mice","volume":"21","author":"Jo","year":"2008","journal-title":"Biometals"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"41852","DOI":"10.1074\/jbc.M110.171330","article-title":"Identification of a calcium permeable human acid-sensing ion channel 1 transcript variant","volume":"285","author":"Hoagland","year":"2010","journal-title":"J. Biol. Chem."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.pain.2005.05.021","article-title":"Electrophysiological and in vivo characterization of A-317567, a novel blocker of acid sensing ion channels","volume":"117","author":"Lehto","year":"2005","journal-title":"Pain"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1096\/fj.12-220400","article-title":"Acid-sensing ion channels (ASICs) in mouse skeletal muscle afferents are heteromers composed of ASIC1a, ASIC2, and ASIC3 subunits","volume":"27","author":"Gautam","year":"2013","journal-title":"FASEB J."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.neuroscience.2018.06.033","article-title":"Acid Sensing Ion Channel 1a (ASIC1a) Mediates Activity-induced Pain by Modulation of Heteromeric ASIC Channel Kinetics","volume":"386","author":"Gregory","year":"2018","journal-title":"Neuroscience"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.survophthal.2012.12.002","article-title":"Iron, zinc, and copper in retinal physiology and disease","volume":"58","author":"Ugarte","year":"2013","journal-title":"Surv. Ophthalmol."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1002\/mnfr.201801049","article-title":"Zinc Nutrition and Inflammation in the Aging Retina","volume":"63","author":"Gilbert","year":"2019","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_141","doi-asserted-by":"crossref","unstructured":"Blasiak, J., Pawlowska, E., Chojnacki, J., Szczepanska, J., Chojnacki, C., and Kaarniranta, K. (2020). Zinc and Autophagy in Age-Related Macular Degeneration. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21144994"},{"key":"ref_142","first-page":"CD000254","article-title":"Antioxidant vitamin and mineral supplements for slowing the progression of age-related macular degeneration","volume":"7","author":"Evans","year":"2017","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"3382","DOI":"10.1002\/jemt.24193","article-title":"Consequences of zinc deficiency on zinc localization, taurine transport, and zinc transporters in rat retina","volume":"85","author":"Salazar","year":"2022","journal-title":"Microsc. Res. Tech."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"43716","DOI":"10.1074\/jbc.M403557200","article-title":"Characterization of acid-sensing ion channels in dorsal horn neurons of rat spinal cord","volume":"279","author":"Wu","year":"2004","journal-title":"J. Biol. Chem."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"103","DOI":"10.3389\/fncel.2020.00103","article-title":"Differential Expression of Acid\u2014Sensing Ion Channels in Mouse Primary Afferents in Na\u00efve and Injured Conditions","volume":"14","author":"Labrecque","year":"2020","journal-title":"Front. Cell. Neurosci."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"8438","DOI":"10.1523\/JNEUROSCI.1284-09.2009","article-title":"ASIC2 Subunits target acid-sensing ion channels to the synapse via an association with PSD-95","volume":"29","author":"Zha","year":"2009","journal-title":"J. Neurosci."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1177\/0271678X16630558","article-title":"Region specific contribution of ASIC2 to acidosis-and ischemia-induced neuronal injury","volume":"37","author":"Jiang","year":"2017","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.neuropharm.2014.12.010","article-title":"Two aspects of ASIC function: Synaptic plasticity and neuronal injury","volume":"94","author":"Huang","year":"2015","journal-title":"Neuropharmacology."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"8281","DOI":"10.1073\/pnas.1324060111","article-title":"Acid-sensing ion channel (ASIC) 1a\/2a heteromers have a flexible 2:1\/1:2 stoichiometry","volume":"111","author":"Bartoi","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1085\/jgp.201310990","article-title":"Acid-sensing ion channels in mouse olfactory bulb M\/T neurons","volume":"143","author":"Li","year":"2014","journal-title":"J. Gen. Physiol."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1515\/bc.2010.052","article-title":"Zinc supplement greatly improves the condition of parkin mutant Drosophila","volume":"391","author":"Saini","year":"2010","journal-title":"Biol. Chem."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"18296","DOI":"10.1074\/jbc.M312145200","article-title":"Acid-sensing ion channel 2 (ASIC2) modulates ASIC1 H+-activated currents in hippocampal neurons","volume":"279","author":"Askwith","year":"2004","journal-title":"J. Biol. Chem."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1523\/JNEUROSCI.4698-03.2004","article-title":"Acid-sensing ion channel 2 is important for retinal function and protects against light-induced retinal degeneration","volume":"24","author":"Ettaiche","year":"2004","journal-title":"J. Neurosci."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"720288","DOI":"10.3389\/fcell.2021.720288","article-title":"Effects of Iron and Zinc on Mitochondria: Potential Mechanisms of Glaucomatous Injury","volume":"9","author":"Tang","year":"2021","journal-title":"Front. Cell. Dev. Biol."},{"key":"ref_155","first-page":"E209","article-title":"Mobile zinc increases rapidly in the retina after optic nerve injury and regulates ganglion cell survival and optic nerve regeneration","volume":"114","author":"Li","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1161\/CIRCRESAHA.109.202036","article-title":"ASIC2a and ASIC3 heteromultimerize to form pH-sensitive channels in mouse cardiac dorsal root ganglia neurons","volume":"105","author":"Hattori","year":"2009","journal-title":"Circ. Res."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1038\/aps.2018.25","article-title":"Zinc deficiency and cellular oxidative stress: Prognostic implications in cardiovascular diseases","volume":"39","author":"Choi","year":"2018","journal-title":"Acta Pharmacol. Sin."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"646533","DOI":"10.3389\/fbioe.2021.646533","article-title":"Short-Term Inhalation of Ultrafine Zinc Particles Could Alleviate Cardiac Dysfunctions in Rats of Myocardial Infarction","volume":"9","author":"Li","year":"2021","journal-title":"Front. Bioeng. Biotechnol."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1159\/000494011","article-title":"Zinc Supplementation Attenuates Cardiac Remodeling After Experimental Myocardial Infarction","volume":"50","author":"Polegato","year":"2018","journal-title":"Cell. Physiol. Biochem."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"582223","DOI":"10.3389\/fphys.2021.582223","article-title":"Supplementation of Lipoic Acid, Zinc and Clopidogrel Reduces Mortality Rate and Incidence of Ventricular Arrhythmia in Experimental Myocardial Infarction","volume":"12","author":"Mohamed","year":"2021","journal-title":"Front Physiol."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.pharmthera.2011.12.009","article-title":"Targeting ASIC3 for pain, anxiety, and insulin resistance","volume":"134","author":"Wu","year":"2012","journal-title":"Pharmacol. Ther."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1111\/j.1476-5381.2010.00918.x","article-title":"Reversal of acid-induced and inflammatory pain by the selective ASIC3 inhibitor, APETx2","volume":"161","author":"Karczewski","year":"2010","journal-title":"Br. J. Pharmacol."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"F870","DOI":"10.1152\/ajprenal.00630.2017","article-title":"ASIC3 fine-tunes bladder sensory signaling","volume":"315","author":"Montalbetti","year":"2018","journal-title":"Am. J. Physiol. Renal. Physiol."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/s12929-018-0448-y","article-title":"Acid-sensing ion channels: Dual function proteins for chemo-sensing and mechano-sensing","volume":"25","author":"Cheng","year":"2018","journal-title":"J. Biomed Sci."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12011-019-01892-3","article-title":"Role of Zinc Supplementation on Ischemia\/Reperfusion Injury in Various Organs","volume":"196","author":"Akbari","year":"2020","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"30406","DOI":"10.1074\/jbc.M702229200","article-title":"Zebrafish acid-sensing ion channel (ASIC) 4, characterization of homo- and heteromeric channels, and identification of regions important for activation by H+","volume":"282","author":"Chen","year":"2007","journal-title":"J. Biol. Chem."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"18783","DOI":"10.1074\/jbc.M401477200","article-title":"A family of acid-sensing ion channels from the zebrafish: Widespread expression in the central nervous system suggests a conserved role in neuronal communication","volume":"279","author":"Paukert","year":"2004","journal-title":"J. Biol. Chem."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1007\/s00424-013-1310-4","article-title":"Pharmacological and electrophysiological characterization of the human bile acid-sensitive ion channel (hBASIC)","volume":"466","author":"Diakov","year":"2014","journal-title":"Pflug. Arch.\u2013Eur. J. Physiol."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"29","DOI":"10.4161\/chan.27493","article-title":"The bile acid-sensitive ion channel (BASIC), the ignored cousin of ASICs and ENaC","volume":"8","author":"Wiemuth","year":"2014","journal-title":"Channels"},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"2168","DOI":"10.1038\/s41598-020-58901-y","article-title":"Cerebellar Ataxia Caused by Type II Unipolar Brush Cell Dysfunction in the Asic5 Knockout Mouse","volume":"10","author":"Boiko","year":"2020","journal-title":"Sci. Rep."}],"container-title":["Biomolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2218-273X\/13\/2\/229\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:14:54Z","timestamp":1760120094000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2218-273X\/13\/2\/229"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,24]]},"references-count":170,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2023,2]]}},"alternative-id":["biom13020229"],"URL":"https:\/\/doi.org\/10.3390\/biom13020229","relation":{},"ISSN":["2218-273X"],"issn-type":[{"value":"2218-273X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,24]]}}}