{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T21:34:10Z","timestamp":1787261650034,"version":"build-2736575974"},"reference-count":59,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Department of Excellence Initiative of the Italian Ministry of Research, the French Agence Nationale de la Recherche (ANR)","award":["ANR-22-CE16-0002"],"award-info":[{"award-number":["ANR-22-CE16-0002"]}]},{"name":"Department of Excellence Initiative of the Italian Ministry of Research, the French Agence Nationale de la Recherche (ANR)","award":["CHUBX 2022\/07"],"award-info":[{"award-number":["CHUBX 2022\/07"]}]},{"name":"the Center of Excellence in Neurodegeneration (CoEN) Bordeaux Initiative for Neurodegenerative Disorders (BIND)","award":["ANR-22-CE16-0002"],"award-info":[{"award-number":["ANR-22-CE16-0002"]}]},{"name":"the Center of Excellence in Neurodegeneration (CoEN) Bordeaux Initiative for Neurodegenerative Disorders (BIND)","award":["CHUBX 2022\/07"],"award-info":[{"award-number":["CHUBX 2022\/07"]}]},{"name":"the MSA Coalition Global Seed Grant (project FibrilloScreen)","award":["ANR-22-CE16-0002"],"award-info":[{"award-number":["ANR-22-CE16-0002"]}]},{"name":"the MSA Coalition Global Seed Grant (project FibrilloScreen)","award":["CHUBX 2022\/07"],"award-info":[{"award-number":["CHUBX 2022\/07"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>\u03b1-Synucleinopathies are spreading neurodegenerative disorders characterized by the intracellular accumulation of insoluble aggregates populated by \u03b1-Synuclein (\u03b1-Syn) fibrils. In Parkinson\u2019s disease (PD) and dementia with Lewy bodies, intraneuronal \u03b1-Syn aggregates are referred to as Lewy bodies in the somata and as Lewy neurites in the neuronal processes. In multiple system atrophy (MSA) \u03b1-Syn aggregates are also found within mature oligodendrocytes (OLs) where they form Glial Cytoplasmic Inclusions (GCIs). However, the origin of GCIs remains enigmatic: (i) mature OLs do not express \u03b1-Syn, precluding the seeding and the buildup of inclusions and (ii) the artificial overexpression of \u03b1-Syn in OLs of transgenic mice results in a burden of soluble phosphorylated \u03b1-Syn but fails to form \u03b1-Syn fibrils. In contrast, mass spectrometry of \u03b1-Syn fibrillar aggregates from MSA patients points to the neuronal origin of the proteins intimately associated with the fibrils within the GCIs. This suggests that GCIs are preassembled in neurons and only secondarily incorporated into OLs. Interestingly, we recently isolated a synthetic human \u03b1-Syn fibril strain (1B fibrils) capable of seeding a type of neuronal inclusion observed early and specifically during MSA. Our goal was thus to investigate whether the neuronal \u03b1-Syn pathology seeded by 1B fibrils could eventually be transmitted to OLs to form GCIs in vivo. After confirming that mature OLs did not express \u03b1-Syn to detectable levels in the adult mouse brain, a series of mice received unilateral intra-striatal injections of 1B fibrils. The resulting \u03b1-Syn pathology was visualized using phospho-S129 \u03b1-Syn immunoreactivity (pSyn). We found that even though 1B fibrils were injected unilaterally, many pSyn-positive neuronal somas were present in layer V of the contralateral perirhinal cortex after 6 weeks. This suggested a fast retrograde spread of the pathology along the axons of crossing cortico-striatal neurons. We thus scrutinized the posterior limb of the anterior commissure, i.e., the myelinated interhemispheric tract containing the axons of these neurons: we indeed observed numerous pSyn-positive linear Lewy Neurites oriented parallel to the commissural axis, corresponding to axonal segments filled with aggregated \u03b1-Syn, with no obvious signs of OL \u03b1-Syn pathology at this stage. After 6 months however, the commissural Lewy neurites were no longer parallel but fragmented, curled up, sometimes squeezed in-between two consecutive OLs in interfascicular strands, or even engulfed inside OL perikarya, thus forming GCIs. We conclude that the 1B fibril strain can rapidly induce an \u03b1-Syn pathology typical of MSA in mice, in which the appearance of GCIs results from the pruning of diseased axonal segments containing aggregated \u03b1-Syn.<\/jats:p>","DOI":"10.3390\/biom13020269","type":"journal-article","created":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T02:29:03Z","timestamp":1675218543000},"page":"269","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Oligodendrocytes Prune Axons Containing \u03b1-Synuclein Aggregates In Vivo: Lewy Neurites as Precursors of Glial Cytoplasmic Inclusions in Multiple System Atrophy?"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2041-0149","authenticated-orcid":false,"given":"Francesco","family":"De Nuccio","sequence":"first","affiliation":[{"name":"Department of Biological and Environmental Sciences and Technologies, Section of Human Anatomy, University of Salento, I-73100 Lecce, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianna","family":"Kashyrina","sequence":"additional","affiliation":[{"name":"Department of Biological and Environmental Sciences and Technologies, Section of Human Anatomy, University of Salento, I-73100 Lecce, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Serinelli","sequence":"additional","affiliation":[{"name":"Department of Biological and Environmental Sciences and Technologies, Section of Human Anatomy, University of Salento, I-73100 Lecce, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0753-5505","authenticated-orcid":false,"given":"Florent","family":"Laferri\u00e8re","sequence":"additional","affiliation":[{"name":"Institut des Maladies Neurod\u00e9g\u00e9n\u00e9ratives, CNRS, Universit\u00e9 de Bordeaux, UMR 5293, 33076 Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0106-3615","authenticated-orcid":false,"given":"Dario Domenico","family":"Lofrumento","sequence":"additional","affiliation":[{"name":"Department of Biological and Environmental Sciences and Technologies, Section of Human Anatomy, University of Salento, I-73100 Lecce, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4850-3582","authenticated-orcid":false,"given":"Francesca","family":"De Giorgi","sequence":"additional","affiliation":[{"name":"Institut des Maladies Neurod\u00e9g\u00e9n\u00e9ratives, CNRS, Universit\u00e9 de Bordeaux, UMR 5293, 33076 Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8184-5248","authenticated-orcid":false,"given":"Fran\u00e7ois","family":"Ichas","sequence":"additional","affiliation":[{"name":"Institut des Maladies Neurod\u00e9g\u00e9n\u00e9ratives, CNRS, Universit\u00e9 de Bordeaux, UMR 5293, 33076 Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"de Giorgi, F., Uversky, V.N., and Ichas, F. (2022). \u03b1-Synuclein Fibrils as Penrose Machines: A Chameleon in the Gear. Biomolecules, 12.","DOI":"10.3390\/biom12040494"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1002\/ana.410440324","article-title":"Glial Cytoplasmic Inclusions in White Matter Oligodendrocytes of Multiple System Atrophy Brains Contain Insoluble \u03b1-Synuclein","volume":"44","author":"Tu","year":"1998","journal-title":"Ann. Neurol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1212\/01.wnl.0000256715.13907.d3","article-title":"DLB and PDD Boundary Issues: Diagnosis, Treatment, Molecular Pathology, and Biomarkers","volume":"68","author":"Lippa","year":"2007","journal-title":"Neurology"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1111\/j.1749-6632.2000.tb06900.x","article-title":"The \u03b1-Synucleinopathies: Parkinson\u2019s Disease, Dementia with Lewy Bodies, and Multiple System Atrophy","volume":"920","author":"Spillantini","year":"2006","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1212\/01.wnl.0000187889.17253.b1","article-title":"Diagnosis and Management of Dementia with Lewy Bodies: Third Report of the DLB Consortium","volume":"65","author":"McKeith","year":"2005","journal-title":"Neurology"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1038\/nrneurol.2017.26","article-title":"Multiple System Atrophy: Insights into a Rare and Debilitating Movement Disorder","volume":"13","author":"Krismer","year":"2017","journal-title":"Nat. Rev. Neurol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.neulet.2003.09.075","article-title":"\u03b1-Synuclein Immunoreactivity in Neuronal Nuclear Inclusions and Neurites in Multiple System Atrophy","volume":"354","author":"Lin","year":"2004","journal-title":"Neurosci. Lett."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1111\/j.1365-2990.2004.00564.x","article-title":"A Quantitative Investigation of Neuronal Cytoplasmic and Intranuclear Inclusions in the Pontine and Inferior Olivary Nuclei in Multiple System Atrophy","volume":"30","author":"Nishie","year":"2004","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1111\/j.1440-1789.2006.00713.x","article-title":"Cellular pathology in multiple system atrophy","volume":"26","author":"Wakabayashi","year":"2006","journal-title":"Neuropathology"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/s00401-012-1004-6","article-title":"Protein Degradation Pathways in Parkinson\u2019s Disease: Curse or Blessing","volume":"124","author":"Wahlster","year":"2012","journal-title":"Acta Neuropathol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.neuron.2006.09.026","article-title":"Mechanisms of Parkinson\u2019s Disease Linked to Pathological \u03b1-Synuclein: New Targets for Drug Discovery","volume":"52","author":"Lee","year":"2006","journal-title":"Neuron"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1093\/embo-reports\/kvf109","article-title":"Hyperphosphorylation and Insolubility of \u03b1-Synuclein in Transgenic Mouse Oligodendrocytes","volume":"3","author":"Kahle","year":"2002","journal-title":"EMBO Rep."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"10689","DOI":"10.1523\/JNEUROSCI.3527-05.2005","article-title":"Neurological and Neurodegenerative Alterations in a Transgenic Mouse Model Expressing Human \u03b1-Synuclein under Oligodendrocyte Promoter: Implications for Multiple System Atrophy","volume":"25","author":"Shults","year":"2005","journal-title":"J. Neurosci."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/j.neuron.2005.01.032","article-title":"Mouse Model of Multiple System Atrophy \u03b1-Synuclein Expression in Oligodendrocytes Causes Glial and Neuronal Degeneration","volume":"45","author":"Yazawa","year":"2005","journal-title":"Neuron"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s40478-016-0279-6","article-title":"Animal Modeling an Oligodendrogliopathy\u2013Multiple System Atrophy","volume":"4","author":"Bleasel","year":"2016","journal-title":"Acta Neuropathol. Commun."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Laferri\u00e8re, F., He, X., Zinghirino, F., Doudnikoff, E., Faggiani, E., Meissner, W.G., Bezard, E., de Giorgi, F., and Ichas, F. (2020). Overexpression of \u03b1-Synuclein by Oligodendrocytes in Transgenic Mice Does Not Recapitulate the Fibrillar Aggregation Seen in Multiple System Atrophy. Cells, 9.","DOI":"10.3390\/cells9112371"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1002\/glia.22653","article-title":"Alpha-Synuclein MRNA Expression in Oligodendrocytes in MSA","volume":"62","author":"Asi","year":"2014","journal-title":"Glia"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1007\/s00702-005-0378-1","article-title":"Absence of \u03b1-Synuclein mRNA Expression in Normal and Multiple System Atrophy Oligodendroglia","volume":"112","author":"Miller","year":"2005","journal-title":"J. Neural Transm."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1002\/mds.21259","article-title":"Gene Expression Changes in Postmortem Tissue from the Rostral Pons of Multiple System Atrophy Patients","volume":"22","author":"Langerveld","year":"2007","journal-title":"Mov. Disord."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"eabc4364","DOI":"10.1126\/sciadv.abc4364","article-title":"Novel Self-Replicating \u03b1-Synuclein Polymorphs That Escape ThT Monitoring Can Spontaneously Emerge and Acutely Spread in Neurons","volume":"6","author":"Zinghirino","year":"2020","journal-title":"Sci. Adv."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1523\/JNEUROSCI.06-03-00650.1986","article-title":"Expression of Neurofilament Subunits in Neurons of the Central and Peripheral Nervous System: An Immunohistochemical Study with Monoclonal Antibodies","volume":"6","author":"Trojanowski","year":"1986","journal-title":"J. Neurosci."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1111\/jnc.13745","article-title":"The Oligodendrocyte-Specific Antibody \u201cCC1\u201d Binds Quaking 7","volume":"139","author":"Bin","year":"2016","journal-title":"J. Neurochem."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"607303","DOI":"10.3389\/fnmol.2021.607303","article-title":"Neuronal and Glial Distribution of Tau Protein in the Adult Rat and Monkey","volume":"14","author":"Kanaan","year":"2021","journal-title":"Front. Mol. Neurosci."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1002\/cne.24577","article-title":"Distribution of Endogenous Normal Tau in the Mouse Brain","volume":"527","author":"Kubo","year":"2019","journal-title":"J. Comp. Neurol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1038\/nmeth.2075","article-title":"Icy: An Open Bioimage Informatics Platform for Extended Reproducible Research","volume":"9","author":"Dallongeville","year":"2012","journal-title":"Nat. Methods"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1038\/nature14547","article-title":"\u03b1-Synuclein Strains Cause Distinct Synucleinopathies after Local and Systemic Administration","volume":"522","author":"Peelaerts","year":"2015","journal-title":"Nature"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1186\/s13024-022-00579-z","article-title":"Multiple System Atrophy: \u03b1-Synuclein Strains at the Neuron-Oligodendrocyte Crossroad","volume":"17","author":"Reddy","year":"2022","journal-title":"Mol. Neurodegener."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.stemcr.2015.07.002","article-title":"Alpha-Synuclein Expression in the Oligodendrocyte Lineage: An in Vitro and in Vivo Study Using Rodent and Human Models","volume":"5","author":"Djelloul","year":"2015","journal-title":"Stem Cell Rep."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1038\/s41531-021-00264-w","article-title":"Similar Neuronal Imprint and No Cross-Seeded Fibrils in \u03b1-Synuclein Aggregates from MSA and Parkinson\u2019s Disease","volume":"8","author":"Claverol","year":"2022","journal-title":"NPJ Park. Dis."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1093\/jnen\/nlz070","article-title":"Slow Progressive Accumulation of Oligodendroglial Alpha-Synuclein (a-Syn) Pathology in Synthetic a-Syn Fibril-Induced Mouse Models of Synucleinopathy","volume":"78","author":"Uemura","year":"2019","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"3373","DOI":"10.1016\/j.celrep.2016.08.053","article-title":"Molecular and Biological Compatibility with Host Alpha-Synuclein Influences Fibril Pathogenicity","volume":"16","author":"Luk","year":"2016","journal-title":"Cell Rep."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"2575","DOI":"10.1038\/ncomms3575","article-title":"Structural and Functional Characterization of Two Alpha-Synuclein Strains","volume":"4","author":"Bousset","year":"2013","journal-title":"Nat. Commun."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1038\/s41586-020-1984-7","article-title":"Discriminating \u03b1-Synuclein Strains in Parkinson\u2019s Disease and Multiple System Atrophy","volume":"578","author":"Shahnawaz","year":"2020","journal-title":"Nature"},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"de Giorgi, F., Abdul-Shukkoor, M.B., Kashyrina, M., Largitte, L.A., de Nuccio, F., Kauffmann, B., Lends, A., Laferri\u00e8re, F., Bonhommeau, S., and Lofrumento, D.D. (2022). Neurons with Cat\u2019s Eyes: A Synthetic Strain of \u03b1-Synuclein Fibrils Seeding Neuronal Intranuclear Inclusions. Biomolecules, 12.","DOI":"10.3390\/biom12030436"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/j.1365-2990.2006.00819.x","article-title":"Abnormalities of the Nucleus and Nuclear Inclusions in Neurodegenerative Disease: A Work in Progress","volume":"33","author":"Woulfe","year":"2007","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1111\/nan.12402","article-title":"Novel Conformation-Selective Alpha-Synuclein Antibodies Raised against Different in Vitro Fibril Forms Show Distinct Patterns of Lewy Pathology in Parkinson\u2019s Disease","volume":"43","author":"Covell","year":"2017","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1126\/science.1227157","article-title":"Pathological \u03b1-Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice","volume":"338","author":"Luk","year":"2012","journal-title":"Science"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1093\/brain\/awt037","article-title":"Prion-like Spreading of Pathological \u03b1-Synuclein in Brain","volume":"136","author":"Nonaka","year":"2013","journal-title":"Brain"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/0306-4522(89)90128-0","article-title":"The Organization of the Projection from the Cerebral Cortex to the Striatum in the Rat","volume":"29","author":"McGeorge","year":"1989","journal-title":"Neuroscience"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"64","DOI":"10.3389\/fnsys.2011.00064","article-title":"The Corticostriatal and Corticosubthalamic Pathways: Two Entries, One Target. So What?","volume":"5","author":"Mathai","year":"2011","journal-title":"Front. Syst. Neurosci."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"9622","DOI":"10.1073\/pnas.1808262115","article-title":"A Pan-Mammalian Map of Interhemispheric Brain Connections Predates the Evolution of the Corpus Callosum","volume":"115","author":"Paolino","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1038\/nn.4332","article-title":"The Mouse Cortico-Striatal Projectome","volume":"19","author":"Hintiryan","year":"2016","journal-title":"Nat. Neurosci."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1002\/cne.903380209","article-title":"The Patterns of Afferent Innervation of the Core and Shell in the \u201cAccumbens\u201d Part of the Rat Ventral Striatum: Immunohistochemical Detection of Retrogradely Transported Fluoro-gold","volume":"338","author":"Brog","year":"1993","journal-title":"J. Comp. Neurol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1038\/s41598-022-04780-4","article-title":"Phosphorylation of Endogenous \u03b1-Synuclein Induced by Extracellular Seeds Initiates at the Pre-Synaptic Region and Spreads to the Cell Body","volume":"12","author":"Awa","year":"2022","journal-title":"Sci. Rep."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1093\/brain\/awab440","article-title":"Differentially Targeted Seeding Reveals Unique Pathological Alpha-Synuclein Propagation Patterns","volume":"145","author":"Rahayel","year":"2022","journal-title":"Brain"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s13024-020-00368-6","article-title":"Initiation and Propagation of \u03b1-Synuclein Aggregation in the Nervous System","volume":"15","author":"Hijaz","year":"2020","journal-title":"Mol. Neurodegener."},{"key":"ref_47","first-page":"111","article-title":"Age-Related Changes in the Number of Myelinated Axons and Glial Cells in the Anterior and Posterior Limbs of the Mouse Anterior Commissure","volume":"150","author":"Sturrock","year":"1987","journal-title":"J. Anat."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"eaba6905","DOI":"10.1126\/science.aba6905","article-title":"Myelin: A Gatekeeper of Activity-Dependent Circuit Plasticity?","volume":"374","author":"Bonetto","year":"2021","journal-title":"Science"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"10369","DOI":"10.1073\/pnas.92.22.10369","article-title":"Functional Implications for the Microtubule-Associated Protein Tau: Localization in Oligodendrocytes","volume":"92","author":"Lopresti","year":"1995","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1038\/s41593-019-0491-3","article-title":"Single-Cell Transcriptomic Profiling of the Aging Mouse Brain","volume":"22","author":"Ximerakis","year":"2019","journal-title":"Nat. Neurosci."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/0022-510X(92)90286-T","article-title":"Accumulation of Tubular Structures in Oligodendroglial and Neuronal Cells as the Basic Alteration in Multiple System Atrophy","volume":"107","author":"Papp","year":"1992","journal-title":"J. Neurol. Sci."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1038\/cr.2013.62","article-title":"Developmental Pruning of Early-Stage Myelin Segments during CNS Myelination in Vivo","volume":"23","author":"Liu","year":"2013","journal-title":"Cell Res."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1038\/s41593-022-01023-7","article-title":"Oligodendrocyte Precursor Cells Sculpt the Visual System by Regulating Axonal Remodeling","volume":"25","author":"Xiao","year":"2022","journal-title":"Nat. Neurosci."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"e2202580119","DOI":"10.1073\/pnas.2202580119","article-title":"Oligodendrocyte Precursor Cells Ingest Axons in the Mouse Neocortex","volume":"119","author":"Buchanan","year":"2022","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1186\/s40478-021-01173-y","article-title":"Robust \u03b1-Synuclein Pathology in Select Brainstem Neuronal Populations Is a Potential Instigator of Multiple System Atrophy","volume":"9","author":"Hass","year":"2021","journal-title":"Acta Neuropathol. Commun."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.nbd.2014.11.008","article-title":"Changes in Total Cell Numbers of the Basal Ganglia in Patients with Multiple System Atrophy\u2014A Stereological Study","volume":"74","author":"Salvesen","year":"2015","journal-title":"Neurobiol. Dis."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/0022-510X(89)90219-0","article-title":"Glial Cytoplasmic Inclusions in the CNS of Patients with Multiple System Atrophy (Striatonigral Degeneration, Olivopontocerebellar Atrophy and Shy-Drager Syndrome)","volume":"94","author":"Papp","year":"1989","journal-title":"J. Neurol. Sci."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1816","DOI":"10.1002\/mds.25491","article-title":"Diffusion Tensor Imaging of Parkinson\u2019s Disease, Atypical Parkinsonism, and Essential Tremor","volume":"28","author":"Prodoehl","year":"2013","journal-title":"Mov. Disord."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1002\/mds.22413","article-title":"Proposed Neuroimaging Criteria for the Diagnosis of Multiple System Atrophy","volume":"24","author":"Brooks","year":"2009","journal-title":"Mov. 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