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The stomach is involved in the emetic reflex but no study investigated the effects of oxaliplatin treatment on the stomach. In this study, the in vivo effects of oxaliplatin treatment on eating behaviour, stomach content, intrinsic gastric neuronal population, extrinsic innervation to the stomach, levels of mucosal serotonin (5-hydroxytryptamine, 5-HT), and parasympathetic vagal efferent nerve activity were analysed. Chronic systemic oxaliplatin treatment in mice resulted in pica, indicated by increased kaolin consumption and a reduction in body weight. Oxaliplatin treatment significantly increased the stomach weight and content. The total number of myenteric and nitric oxide synthase-immunoreactive neurons as well as the density of sympathetic, parasympathetic, and sensory fibres in the stomach were decreased significantly with oxaliplatin treatment. Oxaliplatin treatment significantly increased the levels in mucosal 5-HT and the number of enterochromaffin-like cells. Chronic oxaliplatin treatment also caused a significant increase in the vagal efferent nerve activity. The findings of this study indicate that oxaliplatin exposure has adverse effects on multiple components of gastric innervation, which could be responsible for pica and gastric dysmotility.<\/jats:p>","DOI":"10.3390\/biom13020276","type":"journal-article","created":{"date-parts":[[2023,2,2]],"date-time":"2023-02-02T02:21:12Z","timestamp":1675304472000},"page":"276","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Oxaliplatin-Induced Damage to the Gastric Innervation: Role in Nausea and Vomiting"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4394-0118","authenticated-orcid":false,"given":"Ahmed A.","family":"Rahman","sequence":"first","affiliation":[{"name":"Institute for Health & Sport, Victoria University, Melbourne, VIC 3021, Australia"},{"name":"Department of Pediatric Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philenkosini","family":"Masango","sequence":"additional","affiliation":[{"name":"Institute for Health & Sport, Victoria University, Melbourne, VIC 3021, Australia"},{"name":"College of Health & Biomedicine, Victoria University, Melbourne, VIC 3011, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rhian","family":"Stavely","sequence":"additional","affiliation":[{"name":"Institute for Health & Sport, Victoria University, Melbourne, VIC 3021, Australia"},{"name":"Department of Pediatric Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1122-2306","authenticated-orcid":false,"given":"Paul","family":"Bertrand","sequence":"additional","affiliation":[{"name":"School of Health and Biomedical Sciences, Royal Melbourne Institute of Technology University, Melbourne, VIC 3083, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7086-5865","authenticated-orcid":false,"given":"Amanda","family":"Page","sequence":"additional","affiliation":[{"name":"Vagal Afferent Research Group, Centre for Nutrition and Gastrointestinal Disease, Adelaide Medical School, University of Adelaide, Adelaide, SA 5005, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2597-6929","authenticated-orcid":false,"given":"Kulmira","family":"Nurgali","sequence":"additional","affiliation":[{"name":"Institute for Health & Sport, Victoria University, Melbourne, VIC 3021, Australia"},{"name":"Department of Medicine Western Health, The University of Melbourne, Melbourne, VIC 3010, Australia"},{"name":"Regenerative Medicine and Stem Cells Program, Australian Institute for Musculoskeletal Science (AIMSS), Melbourne, VIC 3021, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.critrevonc.2010.01.010","article-title":"Colon cancer","volume":"74","author":"Labianca","year":"2010","journal-title":"Crit. 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