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The aim of the present study was to investigate the lipid contents of the synovial fluids from controls and patients suffering from chronic joint pain in order to identify characteristic lipid signatures associated with specific joint diseases. For this purpose, lipids were extracted from the synovial fluids and analyzed by mass spectrometry. Lipidomic analyses identified certain choline-containing lipid classes and molecular species as biomarkers of chronic joint pain, regardless of the pathology, with significantly higher levels detected in the patient samples. Moreover, correlations were observed between certain lipid levels and the type of joint pathologies. Interestingly, LPC16:0 levels appeared to correlate with the metabolic status of patients while other choline-containing lipids were more specifically associated with the inflammatory state. Overall, these data point at selective lipid species in synovial fluid as being strong predictors of specific joint pathologies which could help in the selection of the most adapted treatment.<\/jats:p>","DOI":"10.3390\/biom13020342","type":"journal-article","created":{"date-parts":[[2023,2,10]],"date-time":"2023-02-10T02:33:27Z","timestamp":1675996407000},"page":"342","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Identification of Lipid Biomarkers for Chronic Joint Pain Associated with Different Joint Diseases"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0365-7406","authenticated-orcid":false,"given":"Spiro","family":"Khoury","sequence":"first","affiliation":[{"name":"Universit\u00e9 de Poitiers, Laboratoire Lipotoxicity and Channelopathies (LiTch)\u2014ConicMeds, 86073 Poitiers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenny","family":"Colas","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Poitiers, Laboratoire Lipotoxicity and Channelopathies (LiTch)\u2014ConicMeds, 86073 Poitiers, France"},{"name":"Universit\u00e9 de Poitiers, Laboratoire PR\u00e9TI, 86073 Poitiers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3027-2739","authenticated-orcid":false,"given":"V\u00e9ronique","family":"Breuil","sequence":"additional","affiliation":[{"name":"Universit\u00e9 C\u00f4te d\u2019Azur (UCA), UMR E-4320 MATOs CEA\/iBEB\/SBTN, Facult\u00e9 de M\u00e9decine, CEDEX 2, 06107 Nice, France"},{"name":"Service de Rhumatologie, H\u00f4pital Pasteur, CHU de Nice, 06000 Nice, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Kosek","sequence":"additional","affiliation":[{"name":"Department of Clinical Neuroscience, Karolinska Institutet, 17165 Solna, Sweden"},{"name":"Department of Surgical Sciences, Uppsala University, 75185 Uppsala, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aisha S.","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine and Surgery, Karolinska Institutet, 17176 Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camilla I.","family":"Svensson","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, Center for Molecular Medicine, Karolinska Institutet, 17165 Solna, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabien","family":"Marchand","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Clermont Auvergne, Inserm U1107 Neuro-Dol, Pharmacologie Fondamentale et Clinique de la Douleur, 63001 Clermont-Ferrand, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Deval","sequence":"additional","affiliation":[{"name":"Universit\u00e9 C\u00f4te d\u2019Azur, CNRS, IPMC, LabEx ICST, FHU InovPain, 06560 Valbonne, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Poitiers, Laboratoire Lipotoxicity and Channelopathies (LiTch)\u2014ConicMeds, 86073 Poitiers, France"},{"name":"Universit\u00e9 de Poitiers, Laboratoire PR\u00e9TI, 86073 Poitiers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,9]]},"reference":[{"key":"ref_1","first-page":"78314428","article-title":"Background Paper 6.12 Osteoarthritis","volume":"31","author":"Wittenauer","year":"2004","journal-title":"Backgr. 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