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Unfortunately, treatment options for many autoimmune skin diseases are limited. Local and systemic corticosteroids remain the current standard-of-care but are associated with significant adverse effects. Hence, there is an unmet need for novel therapies that block molecular drivers of disease in a local and\/or targeted manner. Granzyme B (GzmB) is a serine protease with known cytotoxic activity and emerging extracellular functions, including the cleavage of cell\u2013cell junctions, basement membranes, cell receptors, and other structural proteins. While minimal to absent in healthy skin, GzmB is markedly elevated in alopecia areata, interface dermatitis, pemphigoid disease, psoriasis, systemic sclerosis, and vitiligo. This review will discuss the role of GzmB in immunity, blistering, apoptosis, and barrier dysfunction in the context of autoimmune skin disease. GzmB plays a causal role in the development of pemphigoid disease and carries diagnostic and prognostic significance in cutaneous lupus erythematosus, vitiligo, and alopecia areata. Taken together, these data support GzmB as a promising therapeutic target for autoimmune skin diseases impacted by impaired barrier function, inflammation, and\/or blistering.<\/jats:p>","DOI":"10.3390\/biom13020388","type":"journal-article","created":{"date-parts":[[2023,2,20]],"date-time":"2023-02-20T03:56:07Z","timestamp":1676865367000},"page":"388","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Granzyme B in Autoimmune Skin Disease"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6020-9349","authenticated-orcid":false,"given":"Anna","family":"Gleave","sequence":"first","affiliation":[{"name":"British Columbia Professional Firefighters\u2019 Burn and Wound Healing Laboratory, International Collaboration On Repair Discoveries (ICORD) Centre, Vancouver Coastal Health Research Institute, University of British Columbia, Vancouver, BC V5Z 1M9, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6985-2816","authenticated-orcid":false,"given":"David J.","family":"Granville","sequence":"additional","affiliation":[{"name":"British Columbia Professional Firefighters\u2019 Burn and Wound Healing Laboratory, International Collaboration On Repair Discoveries (ICORD) Centre, Vancouver Coastal Health Research Institute, University of British Columbia, Vancouver, BC V5Z 1M9, Canada"},{"name":"Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC V6T 1Z7, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1093\/rheumatology\/keaa537","article-title":"Systemic autoimmune disease as a cause of death: Mortality burden and comorbidities","volume":"60","author":"Mitratza","year":"2020","journal-title":"Rheumatology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.jaut.2009.09.008","article-title":"Recent insights in the epidemiology of autoimmune diseases: Improved prevalence estimates and understanding of clustering of diseases","volume":"33","author":"Cooper","year":"2009","journal-title":"J. Autoimmun."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"151","DOI":"10.12691\/ijcd-3-4-8","article-title":"The World Incidence and Prevalence of Autoimmune Diseases is Increasing","volume":"3","author":"Lerner","year":"2015","journal-title":"Int. J. Celiac Dis."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2032","DOI":"10.1002\/art.42330","article-title":"Increasing Prevalence of Antinuclear Antibodies in the United States","volume":"74","author":"Dinse","year":"2022","journal-title":"Arthritis Rheumatol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"2228","DOI":"10.1172\/JCI78088","article-title":"Mechanisms of human autoimmunity","volume":"125","author":"Rosenblum","year":"2015","journal-title":"J. Clin. Investig."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1097\/01.NUMA.0000455740.32485.9c","article-title":"Autoimmune disease","volume":"45","author":"Julian","year":"2014","journal-title":"Nurs. Manag."},{"key":"ref_7","first-page":"1","article-title":"Inflammatory cytokines and change of Th1\/Th2 balance as prognostic indicators for hepatocellular carcinoma in patients treated with transarterial chemoembolization","volume":"9","author":"Lee","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-1-4615-0171-8_1","article-title":"Cytokines and Chemokines in Autoimmune Disease: An Overview","volume":"520","author":"Santamaria","year":"2003","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1159\/000131754","article-title":"Skin Involvement in Systemic Autoimmune Diseases","volume":"10","author":"Rashtak","year":"2008","journal-title":"Dermatol. Immun."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"7","DOI":"10.4103\/2229-5178.126020","article-title":"Cutaneous lupus erythematosus: An update","volume":"5","author":"Nyberg","year":"2014","journal-title":"Indian Dermatol. Online J."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1093\/rheumatology\/kew047","article-title":"Digital Ulcers in Systemic Sclerosis","volume":"56","author":"Hughes","year":"2017","journal-title":"Rheumatology"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1007\/s40257-020-00584-2","article-title":"Dermatitis Herpetiformis: An Update on Diagnosis and Management","volume":"22","author":"Reunala","year":"2021","journal-title":"Am. J. Clin. Dermatol."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Whitton, M.E., Pinart, M., Batchelor, J., Leonardi-Bee, J., Gonz\u00e1lez, U., Jiyad, Z., Eleftheriadou, V., and Ezzedine, K. (2015). Interventions for Vitiligo. Cochrane Database Syst. Rev.","DOI":"10.1002\/14651858.CD003263.pub5"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Hannon, C.W., McCourt, C., Lima, H.C., Chen, S., and Bennett, C. (2021). Interventions for Cutaneous Disease in Systemic Lupus Ery-thematosus. Cochrane Database Syst. Rev.","DOI":"10.1002\/14651858.CD007478.pub2"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"371","DOI":"10.4103\/0378-6323.178903","article-title":"Topical corticosteroids in dermatology","volume":"82","author":"Mehta","year":"2016","journal-title":"Indian J. Dermatol. Venereol. Leprol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"C170","DOI":"10.1152\/ajpcell.00052.2022","article-title":"Granzyme B in epithelial barrier dysfunction and related skin diseases","volume":"323","author":"Jung","year":"2022","journal-title":"Am. J. Physiol. Physiol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.jdermsci.2021.10.006","article-title":"Pathological functions of granzyme B in inflammatory skin diseases","volume":"104","author":"Hiroyasu","year":"2021","journal-title":"J. Dermatol. Sci."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.matbio.2017.12.005","article-title":"Granzyme B in skin inflammation and disease","volume":"75\u201376","author":"Turner","year":"2019","journal-title":"Matrix Biol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1034\/j.1600-065X.2003.00044.x","article-title":"Granzyme B: A natural born killer","volume":"193","author":"Lord","year":"2003","journal-title":"Immunol. Rev."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1038\/nri3839","article-title":"Perforin and granzymes: Function, dysfunction and human pathology","volume":"15","author":"Voskoboinik","year":"2015","journal-title":"Nat. Rev. Immunol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1002\/eji.1830250432","article-title":"Serial killing by cytotoxic T lymphocytes: T cell receptor triggers degranulation, re-filling of the lytic granules and secretion of lytic proteins via a non-granule pathway","volume":"25","author":"Isaaz","year":"1995","journal-title":"Eur. J. Immunol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"e13086","DOI":"10.1111\/sji.13086","article-title":"Dual roles of granzyme B","volume":"94","author":"Wang","year":"2021","journal-title":"Scand. J. Immunol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1038\/labinvest.2009.91","article-title":"Intracellular versus extracellular granzyme B in immunity and disease: Challenging the dogma","volume":"89","author":"Boivin","year":"2009","journal-title":"Lab. Investig."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1111\/acel.12298","article-title":"Granzyme B mediates both direct and indirect cleavage of extracellular matrix in skin after chronic low-dose ultraviolet light irradiation","volume":"14","author":"Parkinson","year":"2014","journal-title":"Aging Cell"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"ltab008","DOI":"10.1093\/immadv\/ltab008","article-title":"Behind the scenes with basophils: An emerging therapeutic target","volume":"1","author":"Shah","year":"2021","journal-title":"Immunother. Adv."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"28364","DOI":"10.18632\/oncotarget.25342","article-title":"Tumor-derived granzyme B-expressing neutrophils acquire antitumor potential after lipid A treatment","volume":"9","author":"Martin","year":"2018","journal-title":"Oncotarget"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"75","DOI":"10.2147\/JIR.S286426","article-title":"The Role of Regulatory B Cells in Health and Diseases: A Systemic Review","volume":"14","author":"Abebe","year":"2021","journal-title":"J. Inflamm. Res."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"3103","DOI":"10.1182\/blood-2012-08-452995","article-title":"IL-21\u2013stimulated human plasmacytoid dendritic cells secrete granzyme B, which impairs their capacity to induce T-cell proliferation","volume":"121","author":"Karrich","year":"2013","journal-title":"Blood"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1097\/01.MP.0000067424.12280.BC","article-title":"Granzyme B in Atherosclerosis and Transplant Vascular Disease: Association with Cell Death and Atherosclerotic Disease Severity","volume":"16","author":"Choy","year":"2003","journal-title":"Mod. Pathol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"909","DOI":"10.4049\/immunohorizons.2100017","article-title":"Granzyme-Producing CD4 T Cells in Cancer and Autoimmune Disease","volume":"5","author":"Park","year":"2021","journal-title":"Immunohorizons"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"750542","DOI":"10.3389\/fimmu.2021.750542","article-title":"Regulatory T Cells: Regulation of Identity and Function","volume":"12","author":"Grover","year":"2021","journal-title":"Front. Immunol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"13525","DOI":"10.1074\/jbc.M512694200","article-title":"Human Keratinocytes Acquire Cellular Cytotoxicity under UV-B Irradiation: Implication of Granzyme B and Perforin","volume":"281","author":"Jean","year":"2006","journal-title":"J. Biol. Chem."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1038\/cdd.2009.169","article-title":"Control of granzymes by serpins","volume":"17","author":"Kaiserman","year":"2009","journal-title":"Cell Death Differ."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1038\/s41467-020-20604-3","article-title":"Granzyme B inhibition reduces disease severity in autoimmune blistering diseases","volume":"12","author":"Hiroyasu","year":"2021","journal-title":"Nat. Commun."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/0888-7543(89)90093-1","article-title":"Genomic organization and chromosomal assignment for a serine protease gene (CSPB) expressed by human cytotoxic lymphocytes","volume":"5","author":"Klein","year":"1989","journal-title":"Genomics"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1146\/annurev.immunol.26.021607.090404","article-title":"Death by a Thousand Cuts: Granzyme Pathways of Programmed Cell Death","volume":"26","author":"Chowdhury","year":"2008","journal-title":"Annu. Rev. Immunol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1038\/78992","article-title":"The structure of the pro-apoptotic protease granzyme B reveals the molecular determinants of its specificity","volume":"7","author":"Waugh","year":"2000","journal-title":"Nat. Struct. Biol."},{"key":"ref_38","first-page":"1203","article-title":"Crystal Structure of the Caspase Activator Human Granzyme B, a Proteinase Highly Specific for an Asp-P1 Residue","volume":"381","author":"Belorgey","year":"2000","journal-title":"Biol. Chem."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"27802","DOI":"10.1074\/jbc.271.44.27802","article-title":"A Cytosolic Granzyme B Inhibitor Related to the Viral Apoptotic Regulator Cytokine Response Modifier A Is Present in Cytotoxic Lymphocytes","volume":"271","author":"Sun","year":"1996","journal-title":"J. Biol. Chem."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-018-28070-0","article-title":"Granzyme B is elevated in autoimmune blistering diseases and cleaves key anchoring proteins of the dermal-epidermal junction","volume":"8","author":"Russo","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.1016\/S0960-894X(02)00363-3","article-title":"Discovery of potent, selective human granzyme B inhibitors that inhibit CTL mediated apoptosis","volume":"12","author":"Willoughby","year":"2002","journal-title":"Bioorganic Med. Chem. Lett."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"17907","DOI":"10.1074\/jbc.272.29.17907","article-title":"A Combinatorial Approach Defines Specificities of Members of the Caspase Family and Granzyme B","volume":"272","author":"Thornberry","year":"1997","journal-title":"J. Biol. Chem."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"27364","DOI":"10.1074\/jbc.273.42.27364","article-title":"Definition and Redesign of the Extended Substrate Specificity of Granzyme B","volume":"273","author":"Harris","year":"1998","journal-title":"J. Biol. Chem."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s12276-018-0095-0","article-title":"Topical small molecule granzyme B inhibitor improves remodeling in a murine model of impaired burn wound healing","volume":"50","author":"Shen","year":"2018","journal-title":"Exp. Mol. Med."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.jid.2020.05.095","article-title":"Granzyme B Contributes to Barrier Dysfunction in Oxazolone-Induced Skin Inflammation through E-Cadherin and FLG Cleavage","volume":"141","author":"Turner","year":"2020","journal-title":"J. Investig. Dermatol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1038\/labinvest.3780138","article-title":"Local Immune Response in Skin of Generalized Vitiligo Patients","volume":"80","author":"Wijngaard","year":"2000","journal-title":"Lab. Investig."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1111\/j.1600-0625.2007.00543.x","article-title":"Detection of perforin and granzyme B mRNA expressing cells in lichen sclerosus","volume":"16","author":"Hunger","year":"2007","journal-title":"Exp. Dermatol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1111\/j.1600-0560.2011.01781.x","article-title":"Perforin and granzyme B expression in oral and cutaneous lichen planus\u2014A comparative study","volume":"38","author":"Lage","year":"2011","journal-title":"J. Cutan. Pathol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1136\/jcp.2006.037010","article-title":"Immunohistological analysis of immune cells in blistering skin lesions","volume":"60","author":"Hussein","year":"2007","journal-title":"J. Clin. Pathol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1002\/art.20745","article-title":"Increase in activated CD8+ T lymphocytes expressing perforin and granzyme B correlates with disease activity in patients with systemic lupus erythematosus","volume":"52","author":"Blanco","year":"2005","journal-title":"Arthritis Rheum."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1093\/rheumatology\/kex332","article-title":"Systemic and local granzyme B levels are associated with disease activity, kidney damage and interferon signature in systemic lupus erythematosus","volume":"56","author":"Kok","year":"2017","journal-title":"Rheumatology"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.cellimm.2011.03.004","article-title":"Soluble granzyme B and cytotoxic T lymphocyte activity in the pathogenesis of systemic lupus erythematosus","volume":"269","author":"Shah","year":"2011","journal-title":"Cell. Immunol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1111\/pcmr.12219","article-title":"Type I interferon signature in the initiation of the immune response in vitiligo","volume":"27","author":"Bertolotti","year":"2014","journal-title":"Pigment. Cell Melanoma Res."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"872458","DOI":"10.3389\/fimmu.2022.872458","article-title":"Skin Interstitial Fluid and Plasma Multiplex Cytokine Analysis Reveals IFN-\u03b3 Signatures and Granzyme B as Useful Biomarker for Activity, Severity and Prognosis Assessment in Vitiligo","volume":"13","author":"Ng","year":"2022","journal-title":"Front. Immunol."},{"key":"ref_55","first-page":"427","article-title":"The Possible Linkage of Granzyme B-Producing Skin T Cells with the Disease Prognosis of Alopecia Areata","volume":"141","author":"Watanabe","year":"2020","journal-title":"J. Investig. Dermatol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1111\/j.1365-2133.2010.09775.x","article-title":"Type 1 interferon signature in the scalp lesions of alopecia areata","volume":"163","author":"Ghoreishi","year":"2010","journal-title":"Br. J. Dermatol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1111\/bjd.19040","article-title":"Frontal fibrosing alopecia shows robust T helper 1 and Janus kinase 3 skewing","volume":"183","author":"Ruiz","year":"2020","journal-title":"Br. J. Dermatol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"17011","DOI":"10.1038\/nrdp.2017.11","article-title":"Alopecia Areata","volume":"3","author":"Pratt","year":"2017","journal-title":"Nat. Rev. Dis. Primers"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1038\/nm.3645","article-title":"Alopecia areata is driven by cytotoxic T lymphocytes and is reversed by JAK inhibition","volume":"20","author":"Xing","year":"2014","journal-title":"Nat. Med."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1111\/jdv.15489","article-title":"JAK inhibitors for alopecia areata: A systematic review and meta-analysis","volume":"33","author":"Phan","year":"2019","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1007\/s40265-017-0701-9","article-title":"JAK\u2013STAT Signaling as a Target for Inflammatory and Auto-immune Diseases: Current and Future Prospects","volume":"77","author":"Banerjee","year":"2017","journal-title":"Drugs"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.crimmu.2021.02.001","article-title":"Immunopathogenesis of alopecia areata","volume":"2","author":"Olayinka","year":"2021","journal-title":"Curr. Res. Immunol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1038\/jid.2012.344","article-title":"Endogenous Retinoids in the Pathogenesis of Alopecia Areata","volume":"133","author":"Duncan","year":"2013","journal-title":"J. Investig. Dermatol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.3945\/jn.110.124461","article-title":"Vitamin A as a Regulator of Antigen Presenting Cells","volume":"140","author":"Duriancik","year":"2010","journal-title":"J. Nutr."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1038\/sj.jid.5700704","article-title":"Substance P as an Immunomodulatory Neuropeptide in a Mouse Model for Autoimmune Hair Loss (Alopecia Areata)","volume":"127","author":"Siebenhaar","year":"2007","journal-title":"J. Investig. Dermatol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1002\/jcp.20061","article-title":"The role of substance P in inflammatory disease","volume":"201","author":"Goode","year":"2004","journal-title":"J. Cell. Physiol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1586\/1744666X.2015.1085306","article-title":"The role of lymphocytes in the development and treatment of alopecia areata","volume":"11","author":"Guo","year":"2015","journal-title":"Expert Rev. Clin. Immunol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1038\/jid.2012.17","article-title":"Increased Expression of Cxcr3 and Its Ligands, Cxcl9 and Cxcl10, during the Development of Alopecia Areata in the Mouse","volume":"132","author":"McPhee","year":"2012","journal-title":"J. Investig. Dermatol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.jdermsci.2021.04.009","article-title":"Induction of alopecia areata in C3H\/HeJ mice using cryopreserved lymphocytes","volume":"102","author":"Hashimoto","year":"2021","journal-title":"J. Dermatol. Sci."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"397","DOI":"10.2147\/CCID.S53985","article-title":"Epidemiology and Burden of Alopecia Areata: A Systematic Review","volume":"8","author":"Miteva","year":"2015","journal-title":"Clin. Cosmet. Investig. Dermatol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"e14916","DOI":"10.1111\/dth.14916","article-title":"Treatments for alopecia areata: A systematic review and network meta-analysis","volume":"34","author":"Fukumoto","year":"2021","journal-title":"Dermatol. Ther."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1111\/ajd.12913","article-title":"Systemic treatments for alopecia areata: A systematic review","volume":"60","author":"Lai","year":"2018","journal-title":"Australas. J. Dermatol."},{"key":"ref_73","first-page":"435","article-title":"Cicatricial alopecia","volume":"16","author":"Kanti","year":"2018","journal-title":"JDDG J. Dtsch. Dermatol. Ges."},{"key":"ref_74","first-page":"137","article-title":"Quality of life and psychosocial impact of scarring and non-scarring alopecia in women","volume":"13","author":"Katoulis","year":"2015","journal-title":"JDDG J. Dtsch. Dermatol. Ges."},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Boivin, W.A., Shackleford, M., Hoek, A.V., Zhao, H., Hackett, T.L., Knight, D.A., and Granville, D.J. (2012). Granzyme B Cleaves Decorin, Biglycan and Soluble Betaglycan, Releasing Active Transforming Growth Factor-\u03b21. PLoS ONE, 7.","DOI":"10.1371\/annotation\/b1e4ff60-ba18-4f92-b856-0f2dd27e9a65"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1111\/j.1524-475X.2011.00677.x","article-title":"Small leucine-rich proteoglycans, decorin and fibromodulin, are reduced in postburn hypertrophic scar","volume":"19","author":"Honardoust","year":"2011","journal-title":"Wound Repair Regen."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.burns.2008.07.012","article-title":"Low decorin expression along with inherent activation of ERK1,2 in ear lobe keloids","volume":"35","author":"Meenakshi","year":"2009","journal-title":"Burns"},{"key":"ref_78","first-page":"999","article-title":"Syndecan-2 and Decorin: Proteoglycans with a Difference\u2014Implications in Keloid Pathogenesis","volume":"68","author":"Mukhopadhyay","year":"2010","journal-title":"J. Trauma: Inj. Infect. Crit. Care"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"e209","DOI":"10.1038\/cddis.2011.88","article-title":"Serpina3n attenuates granzyme B-mediated decorin cleavage and rupture in a murine model of aortic aneurysm","volume":"2","author":"Ang","year":"2011","journal-title":"Cell Death Dis."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1111\/j.1365-2133.2004.05976.x","article-title":"Evaluation of inflammatory infiltrate and fibrogenic cytokines in pseudopelade of Brocq suggests the involvement of T-helper 2 and 3 cytokines","volume":"151","author":"Moretti","year":"2004","journal-title":"Br. J. Dermatol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1016\/j.jaad.2018.05.1257","article-title":"Fibroproliferative genes are preferentially expressed in central centrifugal cicatricial alopecia","volume":"79","author":"Aguh","year":"2018","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"2152","DOI":"10.2353\/ajpath.2010.100454","article-title":"The Pathogenesis of Primary Cicatricial Alopecias","volume":"177","author":"Harries","year":"2010","journal-title":"Am. J. Pathol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"349","DOI":"10.4103\/0378-6323.110780","article-title":"Interface Dermatitis","volume":"79","author":"Joshi","year":"2013","journal-title":"Indian J. Dermatol. Venereol. Leprol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1111\/j.1365-2230.2009.03297.x","article-title":"Identification of granzyme B-expressing CD-8-positive T cells in lymphocytic inflammatory infiltrate in cutaneous lupus erythematosus and in dermatomyositis","volume":"34","author":"Grassi","year":"2009","journal-title":"Clin. Exp. Dermatol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1038\/jid.2009.42","article-title":"Lichenoid Tissue Reaction\/Interface Dermatitis: Clinical and Histological Perspectives","volume":"129","author":"Sontheimer","year":"2009","journal-title":"J. Investig. Dermatol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.jdermsci.2015.03.001","article-title":"Clinical perspectives and murine models of lichenoid tissue reaction\/interface dermatitis","volume":"78","author":"Okiyama","year":"2015","journal-title":"J. Dermatol. Sci."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"737813","DOI":"10.3389\/fmed.2021.737813","article-title":"Lichen Planus","volume":"8","author":"Boch","year":"2021","journal-title":"Front. Med."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1111\/j.1600-0560.2006.00527.x","article-title":"Type I interferon-associated cytotoxic inflammation in lichen planus","volume":"33","author":"Wenzel","year":"2006","journal-title":"J. Cutan. Pathol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1007\/s004030050234","article-title":"The role of granzyme B-expressing CD8-positive T cells in apoptosis of keratinocytes in lichen planus","volume":"289","author":"Shimizu","year":"1997","journal-title":"Arch. Dermatol. Res."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1111\/j.1600-0560.2007.00892.x","article-title":"Involvement of granzyme B and granulysin in the cytotoxic response in lichen planus","volume":"35","author":"Ammar","year":"2008","journal-title":"J. Cutan. Pathol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1111\/j.1600-0714.2010.00917.x","article-title":"Perforin and granzyme B involvement in oral lesions of lichen planus and chronic GVHD","volume":"39","author":"Pimentel","year":"2010","journal-title":"J. Oral Pathol. Med."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.ijwd.2019.07.004","article-title":"Cutaneous lupus erythematosus: A review of the literature","volume":"5","author":"Blake","year":"2019","journal-title":"Int. J. Women\u2019s Dermatol."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1038\/nrrheum.2016.186","article-title":"New insights into the immunopathogenesis of systemic lupus erythematosus","volume":"12","author":"Tsokos","year":"2016","journal-title":"Nat. Rev. Rheumatol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.3389\/fimmu.2020.01353","article-title":"Current Insights in Cutaneous Lupus Erythematosus Immunopathogenesis","volume":"11","author":"Garelli","year":"2020","journal-title":"Front. Immunol."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1084\/jem.190.6.815","article-title":"Cleavage by Granzyme B Is Strongly Predictive of Autoantigen Status","volume":"190","author":"Andrade","year":"1999","journal-title":"J. Exp. Med."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"408","DOI":"10.3109\/01913123.2013.816400","article-title":"Immunohistochemical Expression of Granzyme B and Perforin in Discoid Lupus Erythematosus","volume":"37","author":"Abdou","year":"2013","journal-title":"Ultrastruct. Pathol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1111\/j.1365-2133.2005.06784.x","article-title":"Scarring skin lesions of discoid lupus erythematosus are characterized by high numbers of skin-homing cytotoxic lymphocytes associated with strong expression of the type I interferon-induced protein MxA","volume":"153","author":"Wenzel","year":"2005","journal-title":"Br. J. Dermatol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.jaad.2019.06.1309","article-title":"Dermatomyositis: Clinical features and pathogenesis","volume":"82","author":"DeWane","year":"2020","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1111\/j.1365-2230.2010.03808.x","article-title":"The Fas\/Fas ligand system, rather than granzyme B, may represent the main mediator of epidermal apoptosis in dermatomyositis","volume":"35","author":"Torchia","year":"2010","journal-title":"Clin. Exp. Dermatol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"2905","DOI":"10.1172\/JCI118749","article-title":"Differential expression of perforin in muscle-infiltrating T cells in polymyositis and dermatomyositis","volume":"97","author":"Goebels","year":"1996","journal-title":"J. Clin. Investig."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1111\/j.1749-6632.2009.05119.x","article-title":"Dermatomyositis and Polymyositis: Clinical Presentation, Autoantibodies, and Pathogenesis","volume":"1184","author":"Mammen","year":"2010","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1111\/jdv.15679","article-title":"Review of Autoimmune Blistering Diseases: The Pemphigoid Diseases","volume":"33","author":"Daniel","year":"2019","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"220","DOI":"10.3389\/fmed.2018.00220","article-title":"The Growing Incidence of Bullous Pemphigoid: Overview and Potential Explanations","volume":"5","author":"Kridin","year":"2018","journal-title":"Front. Med."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1080\/09546634.2020.1782325","article-title":"Emerging treatments for bullous pemphigoid","volume":"33","author":"Garrido","year":"2021","journal-title":"J. Dermatol. Treat."},{"key":"ref_105","doi-asserted-by":"crossref","unstructured":"Kirtschig, G., Middleton, P., Bennett, C., Murrell, D.F., Wojnarowska, F., and Khumalo, N.P. (2010). Interventions for Bullous Pemphigoid. Cochrane Database Syst. Rev.","DOI":"10.1002\/14651858.CD002292.pub3"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.3389\/fimmu.2019.01454","article-title":"Proteases in Pemphigoid Diseases","volume":"10","author":"Hiroyasu","year":"2019","journal-title":"Front. Immunol."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"102","DOI":"10.2340\/00015555-3399","article-title":"Collagen XVII Processing and Blistering Skin Diseases","volume":"100","author":"Nishie","year":"2020","journal-title":"Acta Derm. Venereol."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1001\/jama.2020.4006","article-title":"Pathophysiology, Clinical Presentation, and Treatment of Psoriasis: A Review","volume":"323","author":"Armstrong","year":"2020","journal-title":"JAMA\u2014J. Am. Med. Assoc."},{"key":"ref_109","doi-asserted-by":"crossref","unstructured":"Rendon, A., and Sch\u00e4kel, K. (2019). Psoriasis Pathogenesis and Treatment. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20061475"},{"key":"ref_110","doi-asserted-by":"crossref","unstructured":"R\u00f8nholt, K., and Iversen, L. (2017). Old and New Biological Therapies for Psoriasis. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18112297"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1046\/j.1365-2133.2001.04222.x","article-title":"Perforin and granzyme B may contribute to skin inflammation in atopic dermatitis and psoriasis","volume":"144","author":"Yawalkar","year":"2001","journal-title":"Br. J. Dermatol."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.jdermsci.2016.09.009","article-title":"Relationships among plasma granzyme B level, pruritus and dermatitis in patients with atopic dermatitis","volume":"84","author":"Kamata","year":"2016","journal-title":"J. Dermatol. Sci."},{"key":"ref_113","doi-asserted-by":"crossref","unstructured":"Fenix, K., Wijesundara, D.K., Cowin, A.J., Grubor-Bauk, B., and Kopecki, Z. (2020). Immunological Memory in Imiquimod-Induced Murine Model of Psoriasiform Dermatitis. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21197228"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"e13599","DOI":"10.1111\/dth.13599","article-title":"Tapering and discontinuation of systemic medications in psoriasis patients with low disease activity","volume":"33","author":"Shi","year":"2020","journal-title":"Dermatol. Ther."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"251","DOI":"10.2340\/00015555-2209","article-title":"Down-titration of Adalimumab and Etanercept in Psoriatic Patients: A Multicentre Observational Study","volume":"96","author":"Piaserico","year":"2016","journal-title":"Acta Derm. Venereol."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1016\/S0140-6736(17)30933-9","article-title":"Systemic Sclerosis","volume":"390","author":"Denton","year":"2017","journal-title":"Lancet"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1007\/s00011-016-0982-6","article-title":"Subset-specific alterations in frequencies and functional signatures of \u03b3\u03b4 T cells in systemic sclerosis patients","volume":"65","author":"Henriques","year":"2016","journal-title":"Inflamm. Res."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1002\/art.11485","article-title":"Selective cleavage of nucleolar autoantigen B23 by granzyme B in differentiated vascular smooth muscle cells: Insights into the association of specific autoantibodies with distinct disease phenotypes","volume":"50","author":"Ulanet","year":"2004","journal-title":"Arthritis Rheum."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"e147","DOI":"10.1016\/j.vph.2006.08.384","article-title":"Granzyme B-dependent matrix degradation generates anti-angiostatic activity in scleroderma patients","volume":"45","author":"Drinane","year":"2006","journal-title":"Vasc. Pharmacol."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.1002\/art.10407","article-title":"Recognition of Granzyme B-generated autoantigen fragments in scleroderma patients with ischemic digital loss","volume":"46","author":"Schachna","year":"2002","journal-title":"Arthritis Rheum."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1038\/cdd.2009.197","article-title":"Granzyme B cleavage of autoantigens in autoimmunity","volume":"17","author":"Darrah","year":"2010","journal-title":"Cell Death Differ."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1159\/000506103","article-title":"Vitiligo: A Review","volume":"236","author":"Bergqvist","year":"2020","journal-title":"Dermatology"},{"key":"ref_123","doi-asserted-by":"crossref","unstructured":"Zhang, Y., Cai, Y., Shi, M., Jiang, S., Cui, S., Wu, Y., Gao, X.-H., and Chen, H.-D. (2016). The Prevalence of Vitiligo: A Meta-Analysis. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0163806"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.det.2016.11.014","article-title":"Vitiligo Pathogenesis and Emerging Treatments","volume":"35","author":"Rashighi","year":"2017","journal-title":"Dermatol. Clin."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1111\/j.1365-4632.2011.05377.x","article-title":"A review of the worldwide prevalence of vitiligo in children\/adolescents and adults","volume":"51","author":"Schallreuter","year":"2012","journal-title":"Int. J. Dermatol."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1038\/jid.2013.5","article-title":"Risk of Generalized Vitiligo Is Associated with the Common 55R-94A-247H Variant Haplotype of GZMB (Encoding Granzyme B)","volume":"133","author":"Ferrara","year":"2013","journal-title":"J. Investig. Dermatol."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1038\/s41598-020-79705-0","article-title":"Association of GZMB polymorphisms and susceptibility to non-segmental vitiligo in a Korean population","volume":"11","author":"Jeong","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"13001","DOI":"10.1038\/s41598-018-31233-8","article-title":"Genetic polymorphisms of GZMB and vitiligo: A genetic association study based on Chinese Han population","volume":"8","author":"Xu","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"2178","DOI":"10.1038\/s41467-019-09963-8","article-title":"Innate lymphocyte-induced CXCR3B-mediated melanocyte apoptosis is a potential initiator of T-cell autoreactivity in vitiligo","volume":"10","author":"Tulic","year":"2019","journal-title":"Nat. Commun."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.jid.2017.08.038","article-title":"Vitiligo Skin Is Imprinted with Resident Memory CD8 T Cells Expressing CXCR3","volume":"138","author":"Boniface","year":"2017","journal-title":"J. Investig. Dermatol."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"664","DOI":"10.2340\/00015555-2080","article-title":"Interferon-gamma Inhibits Melanogenesis and Induces Apoptosis in Melanocytes: A Pivotal Role of CD8+ Cytotoxic T Lymphocytes in Vitiligo","volume":"95","author":"Yang","year":"2015","journal-title":"Acta Dermato-Venereologica"}],"container-title":["Biomolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2218-273X\/13\/2\/388\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:35:59Z","timestamp":1760121359000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2218-273X\/13\/2\/388"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,18]]},"references-count":131,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2023,2]]}},"alternative-id":["biom13020388"],"URL":"https:\/\/doi.org\/10.3390\/biom13020388","relation":{},"ISSN":["2218-273X"],"issn-type":[{"value":"2218-273X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,18]]}}}