{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T14:57:01Z","timestamp":1792421821895,"version":"4.5.0"},"reference-count":96,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2023,3,2]],"date-time":"2023-03-02T00:00:00Z","timestamp":1677715200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>Polymers, in general, and Poly (Ether-Ether-Ketone) (PEEK) have emerged as potential alternatives to conventional osseous implant biomaterials. Due to its distinct advantages over metallic implants, PEEK has been gaining increasing attention as a prime candidate for orthopaedic and dental implants. However, PEEK has a highly hydrophobic and bioinert surface that attenuates the differentiation and proliferation of osteoblasts and leads to implant failure. Several improvements have been made to the osseointegration potential of PEEK, which can be classified into three main categories: (1) surface functionalization with bioactive agents by physical or chemical means; (2) incorporation of bioactive materials either as surface coatings or as composites; and (3) construction of three-dimensionally porous structures on its surfaces. The physical treatments, such as plasma treatments of various elements, accelerated neutron beams, or conventional techniques like sandblasting and laser or ultraviolet radiation, change the micro-geometry of the implant surface. The chemical treatments change the surface composition of PEEK and should be titrated at the time of exposure. The implant surface can be incorporated with a bioactive material that should be selected following the desired use, loading condition, and antimicrobial load around the implant. For optimal results, a combination of the methods above is utilized to compensate for the limitations of individual methods. This review summarizes these methods and their combinations for optimizing the surface of PEEK for utilization as an implanted biomaterial.<\/jats:p>","DOI":"10.3390\/biom13030464","type":"journal-article","created":{"date-parts":[[2023,3,3]],"date-time":"2023-03-03T02:27:25Z","timestamp":1677810445000},"page":"464","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":84,"title":["Surface Treatments of PEEK for Osseointegration to Bone"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5730-3940","authenticated-orcid":false,"given":"Jay R.","family":"Dondani","sequence":"first","affiliation":[{"name":"McGill Craniofacial Tissue Engineering and Stem Cells Laboratory, Faculty of Dental Medicine and Oral Health Sciences, McGill University, 3640 University Street, Montreal, QC H3A 0C7, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2033-7391","authenticated-orcid":false,"given":"Janaki","family":"Iyer","sequence":"additional","affiliation":[{"name":"McGill Craniofacial Tissue Engineering and Stem Cells Laboratory, Faculty of Dental Medicine and Oral Health Sciences, McGill University, 3640 University Street, Montreal, QC H3A 0C7, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5594-359X","authenticated-orcid":false,"given":"Simon D.","family":"Tran","sequence":"additional","affiliation":[{"name":"McGill Craniofacial Tissue Engineering and Stem Cells Laboratory, Faculty of Dental Medicine and Oral Health Sciences, McGill University, 3640 University Street, Montreal, QC H3A 0C7, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"100402","DOI":"10.1016\/j.mtbio.2022.100402","article-title":"Strategies to improve bioactive and antibacterial properties of polyetheretherketone (PEEK) for use as orthopedic implants","volume":"16","author":"Zheng","year":"2022","journal-title":"Mater. Today Bio"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"5426","DOI":"10.3390\/ijms15045426","article-title":"Current Strategies to Improve the Bioactivity of PEEK","volume":"15","author":"Ma","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"4845","DOI":"10.1016\/j.biomaterials.2007.07.013","article-title":"PEEK biomaterials in trauma, orthopedic, and spinal implants","volume":"28","author":"Kurtz","year":"2007","journal-title":"Biomaterials"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1900271","DOI":"10.1002\/mabi.201900271","article-title":"Surface Modification Strategies to Improve the Osseointegration of Poly(etheretherketone) and Its Composites","volume":"20","author":"Buck","year":"2020","journal-title":"Macromol. Biosci."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1016\/j.biomaterials.2007.12.001","article-title":"The in vitro response of human osteoblasts to polyetheretherketone (PEEK) substrates compared to commercially pure titanium","volume":"29","author":"Sagomonyants","year":"2008","journal-title":"Biomaterials"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1097\/BRS.0000000000000778","article-title":"Implant Materials Generate Different Peri-implant Inflammatory Factors: Poly-ether-ether-ketone Promotes Fibrosis and Microtextured Titanium Promotes Osteogenic Factors","volume":"40","author":"Hyzy","year":"2015","journal-title":"Spine"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1590\/S1678-77572012000500015","article-title":"Micro-leakage at the implant-abutment interface with different tightening torques in vitro","volume":"20","author":"Prudente","year":"2012","journal-title":"J. Appl. Oral Sci."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1111\/j.1600-0501.2006.01353.x","article-title":"Effect of material characteristics and\/or surface topography on biofilm development","volume":"17","author":"Teughels","year":"2006","journal-title":"Clin. Oral Implant. Res."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1034\/j.1600-051X.2002.290511.x","article-title":"Soft tissue reactions to plaque formation at implant abutments with different surface topography: An experimental study in dogs","volume":"29","author":"Zitzmann","year":"2002","journal-title":"J. Clin. Periodontol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1111\/j.1600-051X.2008.01275.x","article-title":"Peri-implant diseases: Diagnosis and risk indicators","volume":"35","year":"2008","journal-title":"J. Clin. Periodontol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1111\/j.1600-051X.2008.01274.x","article-title":"Definition and prevalence of peri-implant diseases","volume":"35","author":"Zitzmann","year":"2008","journal-title":"J. Clin. Periodontol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.colsurfb.2014.02.019","article-title":"Enhanced osteoblast responses to poly ether ether ketone surface modified by water plasma immersion ion implantation","volume":"117","author":"Wang","year":"2014","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.biomaterials.2019.05.014","article-title":"Triple-functional polyetheretherketone surface with enhanced bacteriostasis and anti-inflammatory and osseointegrative properties for implant application","volume":"212","author":"Xu","year":"2019","journal-title":"Biomaterials"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.actbio.2019.01.016","article-title":"Multifunctional sulfonated polyetheretherketone coating with beta-defensin-14 for yielding durable and broad-spectrum antibacterial activity and osseointegration","volume":"86","author":"Yuan","year":"2019","journal-title":"Acta Biomater."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"381759","DOI":"10.1155\/2015\/381759","article-title":"Nanomodified Peek Dental Implants: Bioactive Composites and Surface Modification\u2014A Review","volume":"2015","author":"Najeeb","year":"2015","journal-title":"Int. J. Dent."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"412","DOI":"10.4103\/jips.jips_199_21","article-title":"Assessment of different surface treatments and shear bond characteristics of poly-ether-ether-ketone: An in vitro SEM analysis","volume":"21","author":"Parkar","year":"2021","journal-title":"J. Indian Prosthodont. Soc."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"9761","DOI":"10.1021\/acs.langmuir.9b00641","article-title":"Surface Modification of Poly(ether ether ketone) through Friedel\u2013Crafts Reaction for High Adhesion Strength","volume":"35","author":"Miyagaki","year":"2019","journal-title":"Langmuir"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"9561","DOI":"10.1021\/acs.macromol.7b02203","article-title":"Exchange Reactions of Poly(arylene ether ketone) Dithioketals with Aliphatic Diols: Formation and Deprotection of Poly(arylene ether ketal)s","volume":"50","author":"Manolakis","year":"2017","journal-title":"Macromolecules"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"7226","DOI":"10.1021\/acs.macromol.1c00647","article-title":"Analyses of the Adhesion Interphase of Isotactic Polypropylene Using Hot-Melt Polyolefin Adhesives","volume":"54","author":"Matsumoto","year":"2021","journal-title":"Macromolecules"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Lu, C., Qiu, S., Lu, X., Wang, J., Xiao, L., Zheng, T., Wang, X., and Zhang, D. (2019). Enhancing the Interfacial Strength of Carbon Fiber\/Poly(ether ether ketone) Hybrid Composites by Plasma Treatments. Polymers, 11.","DOI":"10.3390\/polym11050753"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"e15","DOI":"10.1016\/j.dental.2020.09.020","article-title":"The impact of different low-pressure plasma types on the physical, chemical and biological surface properties of PEEK","volume":"37","author":"Fu","year":"2021","journal-title":"Dent. Mater."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1007\/s10856-013-5072-5","article-title":"Differentiation of human mesenchymal stem cells on plasma-treated polyetheretherketone","volume":"25","author":"Salamon","year":"2014","journal-title":"J. Mater. Sci. Mater. Med."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"e263","DOI":"10.1016\/j.dental.2016.08.215","article-title":"Bioactivity and antibacterial effect of nitrogen plasma immersion ion implantation on polyetheretherketone","volume":"32","author":"Gan","year":"2016","journal-title":"Dent. Mater."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1016\/j.dental.2022.04.026","article-title":"Tailoring the biologic responses of 3D printed PEEK medical implants by plasma functionalization","volume":"38","author":"Han","year":"2022","journal-title":"Dent. Mater."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1023\/A:1018535923173","article-title":"Surface activation of polyetheretherketone (PEEK) and formation of calcium phosphate coatings by precipitation","volume":"8","author":"Ha","year":"1997","journal-title":"J. Mater. Sci. Mater. Med."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.dental.2020.10.007","article-title":"The effects of three cold plasma treatments on the osteogenic activity and antibacterial property of PEEK","volume":"37","author":"Liu","year":"2021","journal-title":"Dent. Mater."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"11748","DOI":"10.1021\/la901072z","article-title":"Mechanisms of Oxygen Plasma Nanotexturing of Organic Polymer Surfaces: From Stable Super Hydrophilic to Super Hydrophobic Surfaces","volume":"25","author":"Tsougeni","year":"2009","journal-title":"Langmuir"},{"key":"ref_28","first-page":"4427","article-title":"An in vitro investigation of bacteria-osteoblast competition on oxygen plasma-modified PEEK: An in vitro investigation of bacteria-osteoblast competition","volume":"102","author":"Rochford","year":"2014","journal-title":"J. Biomed. Mater. Res. A"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Czwartos, J., Budner, B., Bartnik, A., Wachulak, P., Butruk-Raszeja, B.A., Lech, A., Ciach, T., and Fiedorowicz, H. (2021). Effect of Extreme Ultraviolet (EUV) Radiation and EUV Induced, N2 and O2 Based Plasmas on a PEEK Surface\u2019s Physico-Chemical Properties and MG63 Cell Adhesion. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22168455"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/s10856-014-5359-1","article-title":"Apatite-forming PEEK with TiO2 surface layer coating","volume":"26","author":"Kizuki","year":"2015","journal-title":"J. Mater. Sci. Mater. Med."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"16824","DOI":"10.1021\/acsami.7b02521","article-title":"Enhanced Bioactivity and Bacteriostasis of Surface Fluorinated Polyetheretherketone","volume":"9","author":"Chen","year":"2017","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1021\/acsbiomaterials.8b01425","article-title":"Nano Textured PEEK Surface for Enhanced Osseointegration","volume":"5","author":"Ouyang","year":"2019","journal-title":"ACS Biomater. Sci. Eng."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1007\/s10103-014-1567-7","article-title":"Surface topography and wetting modifications of PEEK for implant applications","volume":"29","author":"Akkan","year":"2014","journal-title":"Lasers Med. Sci."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"112109","DOI":"10.1016\/j.msec.2021.112109","article-title":"Construction and performance evaluation of a sustained release implant material polyetheretherketone with antibacterial properties","volume":"126","author":"Chen","year":"2021","journal-title":"Mater. Sci. Eng. C"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"026109","DOI":"10.1063\/1.5010346","article-title":"Plasma ion implantation enabled bio-functionalization of PEEK improves osteoblastic activity","volume":"2","author":"Wakelin","year":"2018","journal-title":"APL Bioeng."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.1002\/jbm.b.35062","article-title":"Construction of a BMP -2 gene delivery system for polyetheretherketone bone implant material and its effect on bone formation in vitro","volume":"110","author":"Qin","year":"2022","journal-title":"J. Biomed. Mater. Res. B Appl. Biomater."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1016\/j.nano.2017.01.011","article-title":"Layer-by-layer self-assembled multilayers on PEEK implants improve osseointegration in an osteoporosis rabbit model","volume":"13","author":"Liu","year":"2017","journal-title":"Nanomed. Nanotechnol. Biol. Med."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"791725","DOI":"10.1155\/2015\/791725","article-title":"Surface Modifications and Their Effects on Titanium Dental Implants","volume":"2015","author":"Jemat","year":"2015","journal-title":"BioMed Res. Int."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1111\/cid.12793","article-title":"Bone loss around oral and orthopedic implants: An immunologically based condition","volume":"21","author":"Albrektsson","year":"2019","journal-title":"Clin. Implant. Dent. Relat. Res."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.biomaterials.2015.02.018","article-title":"Enhanced osteointegration on tantalum-implanted polyetheretherketone surface with bone-like elastic modulus","volume":"51","author":"Lu","year":"2015","journal-title":"Biomaterials"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.bioactmat.2019.02.001","article-title":"Surface bioactivation of PEEK by neutral atom beam technology","volume":"4","author":"Khoury","year":"2019","journal-title":"Bioact. Mater."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1002\/jbm.b.33570","article-title":"Enhanced bioactivity and osseointegration of PEEK with accelerated neutral atom beam technology: Enhanced Bioactivity and Osseointegration of Peek","volume":"105","author":"Khoury","year":"2017","journal-title":"J. Biomed. Mater. Res. B Appl. Biomater."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1166\/jbn.2022.3247","article-title":"Accelerated Neutral Atom Beam (ANAB) Modified Poly-Ether-Ether-Ketone for Increasing In Vitro Bone Cell Functions and Reducing Bacteria Colonization without Drugs or Antibiotics","volume":"18","author":"Webster","year":"2022","journal-title":"J. Biomed. Nanotechnol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1002\/jbm.b.33681","article-title":"Augmenting the bioactivity of polyetheretherketone using a novel accelerated neutral atom beam technique: Bioactivity of polyetheretherketone","volume":"105","author":"Ajami","year":"2017","journal-title":"J. Biomed. Mater. Res. B Appl. Biomater."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"102765","DOI":"10.1016\/j.pdpdt.2022.102765","article-title":"Shear bond characteristics and surface roughness of poly-ether-ether-ketone treated with contemporary surface treatment regimes bonded to composite resin","volume":"38","author":"Binhasan","year":"2022","journal-title":"Photodiagnosis Photodyn. Ther."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Peng, T.-Y., Lin, D.-J., Mine, Y., Tasi, C.-Y., Li, P.-J., Shih, Y.-H., Chiu, K.-C., Wang, T.-H., Hsia, S.-M., and Shieh, T.-M. (2021). Biofilm Formation on the Surface of (Poly)Ether-Ether-Ketone and In Vitro Antimicrobial Efficacy of Photodynamic Therapy on Peri-Implant Mucositis. Polymers, 13.","DOI":"10.3390\/polym13060940"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1080\/09205063.2018.1461448","article-title":"Effect of micro-roughening of poly(ether ether ketone) on bone marrow derived stem cell and macrophage responses, and osseointegration","volume":"29","author":"Sunarso","year":"2018","journal-title":"J. Biomater. Sci. Polym. Ed."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"112021","DOI":"10.1016\/j.colsurfb.2021.112021","article-title":"Femtosecond laser-induced periodic grooves and nanopore clusters make a synergistic effect on osteogenic differentiation","volume":"208","author":"Xie","year":"2021","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1177\/0885328220935008","article-title":"Effects of different sulfonation times and post-treatment methods on the characterization and cytocompatibility of sulfonated PEEK","volume":"35","author":"Ma","year":"2020","journal-title":"J. Biomater. Appl."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"20180955","DOI":"10.1098\/rsif.2018.0955","article-title":"PEEK surface modification by fast ambient-temperature sulfonation for bone implant applications","volume":"16","author":"Wang","year":"2019","journal-title":"J. R. Soc. Interface"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"5713","DOI":"10.1039\/C9TB00943D","article-title":"Regulation of surface micro\/nano structure and composition of polyetheretherketone and their influence on the behavior of MC3T3-E1 pre-osteoblasts","volume":"7","author":"Cheng","year":"2019","journal-title":"J. Mater. Chem. B"},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Dos Santos, F.S.F., Vieira, M., da Silva, H.N., Tom\u00e1s, H., and Fook, M.V.L. (2021). Surface Bioactivation of Polyether Ether Ketone (PEEK) by Sulfuric Acid and Piranha Solution: Influence of the Modification Route in Capacity for Inducing Cell Growth. Biomolecules, 11.","DOI":"10.3390\/biom11091260"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s10856-019-6349-0","article-title":"Surface sulfonation and nitrification enhance the biological activity and osteogenesis of polyetheretherketone by forming an irregular nano-porous monolayer","volume":"31","author":"Li","year":"2020","journal-title":"J. Mater. Sci. Mater. Med."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1002\/jbm.a.37079","article-title":"Hydrofluoric acid and nitric acid cotreatment for biofunctionalization of polyetheretherketone in M2 macrophage polarization and osteogenesis","volume":"109","author":"Huo","year":"2021","journal-title":"J. Biomed. Mater. Res. A"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"3015","DOI":"10.1002\/jbm.a.35842","article-title":"Chemical, microscopic, and microbiological analysis of a functionalized poly-ether-ether-ketone-embedding antibiofilm compounds: SPEEK Containing Antibiofilm Compound","volume":"104","author":"Montero","year":"2016","journal-title":"J. Biomed. Mater. Res. A"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"111920","DOI":"10.1016\/j.colsurfb.2021.111920","article-title":"In situ preparation of porous metal-organic frameworks ZIF-8@Ag on poly-ether-ether-ketone with synergistic antibacterial activity","volume":"205","author":"Yang","year":"2021","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/s10856-021-06614-7","article-title":"Antibacterial activity, bio-compatibility and osteogenic differentiation of graphene oxide coating on 3D-network poly-ether-ether-ketone for orthopaedic implants","volume":"32","author":"Guo","year":"2021","journal-title":"J. Mater. Sci. Mater. Med."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"2237","DOI":"10.1080\/09205063.2018.1534668","article-title":"Simvastatin delivery on PEEK for bioactivity and osteogenesis enhancements","volume":"29","author":"Deng","year":"2018","journal-title":"J. Biomater. Sci. Polym. Ed."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"14971","DOI":"10.1021\/acsami.0c02304","article-title":"Multifunctional Surface with Enhanced Angiogenesis for Improving Long-Term Osteogenic Fixation of Poly(ether ether ketone) Implants","volume":"12","author":"Dong","year":"2020","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"59731","DOI":"10.1021\/acsami.1c19834","article-title":"Facile and Versatile Surface Functional Polyetheretherketone with Enhanced Bacteriostasis and Osseointegrative Capability for Implant Application","volume":"13","author":"Li","year":"2021","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.actbio.2019.04.041","article-title":"In vivo and in vitro bioactivity of a \u201cprecursor of apatite\u201d treatment on polyetheretherketone","volume":"91","author":"Masamoto","year":"2019","journal-title":"Acta Biomater."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"27503","DOI":"10.1021\/acsami.9b03030","article-title":"Facile Surface Modification Method for Synergistically Enhancing the Biocompatibility and Bioactivity of Poly(ether ether ketone) That Induced Osteodifferentiation","volume":"11","author":"Zhu","year":"2019","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1080\/09205063.2018.1425181","article-title":"Enhanced antibacterial property and osteo-differentiation activity on plasma treated porous polyetheretherketone with hierarchical micro\/nano-topography","volume":"29","author":"Wang","year":"2018","journal-title":"J. Biomater. Sci. Polym. Ed."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.colsurfb.2018.05.027","article-title":"Micro-porous polyetheretherketone implants decorated with BMP-2 via phosphorylated gelatin coating for enhancing cell adhesion and osteogenic differentiation","volume":"169","author":"Wu","year":"2018","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Kim, H., Lee, Y.H., Kim, N.K., and Kang, I.K. (2022). Immobilization of Collagen on the Surface of a PEEK Implant with Monolayer Nanopores. Polymers, 14.","DOI":"10.3390\/polym14091633"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"30076","DOI":"10.1039\/C9RA05229A","article-title":"Surface phosphonation treatment shows dose-dependent enhancement of the bioactivity of polyetheretherketone","volume":"9","author":"Liu","year":"2019","journal-title":"RSC Adv."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.colsurfb.2018.10.031","article-title":"Enhanced osteogenic activity of phosphorylated polyetheretherketone via surface-initiated grafting polymerization of vinylphosphonic acid","volume":"173","author":"Zheng","year":"2019","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.actbio.2016.10.004","article-title":"Surface phosphonation enhances hydroxyapatite coating adhesion on polyetheretherketone and its osseointegration potential","volume":"47","author":"Mahjoubi","year":"2017","journal-title":"Acta Biomater."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/j.msec.2015.05.070","article-title":"Bone-like apatite coating on functionalized poly(etheretherketone) surface via tailored silanization layers technique","volume":"55","author":"Zheng","year":"2015","journal-title":"Mater. Sci. Eng. C"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1002\/jbm.b.33578","article-title":"Preparation, characterization and in vitro response of bioactive coatings on polyether ether ketone: Response Of Bioactive Coatings on Polyether Ether Ketone","volume":"105","author":"Durham","year":"2017","journal-title":"J. Biomed. Mater. Res. B Appl. Biomater."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"2621","DOI":"10.1002\/jbm.a.34557","article-title":"Processing and evaluation of bioactive coatings on polymeric implants: Processing and Evaluation of Bioactive HA Coatings on PEEK","volume":"101A","author":"Rabiei","year":"2013","journal-title":"J. Biomed. Mater. Res. A"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.msec.2016.11.111","article-title":"Fabrication of hydroxyapatite thin films on polyetheretherketone substrates using a sputtering technique","volume":"72","author":"Ozeki","year":"2017","journal-title":"Mater. Sci. Eng. C"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"3903","DOI":"10.2147\/IJN.S60387","article-title":"Biomechanical evaluation and surface characterization of a nano-modified surface on PEEK implants: A study in the rabbit tibia","volume":"9","author":"Johansson","year":"2014","journal-title":"Int. J. Nanomed."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"228","DOI":"10.4103\/0975-7406.155917","article-title":"Osseointegration","volume":"7","author":"Dhinakarsamy","year":"2015","journal-title":"J. Pharm. Bioallied Sci."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"117","DOI":"10.4103\/0975-7406.113310","article-title":"Evaluation of implant success: A review of past and present concepts","volume":"5","author":"Karthik","year":"2013","journal-title":"J. Pharm. Bioallied Sci."},{"key":"ref_76","first-page":"523","article-title":"Nonalloyed titanium as a bioinert metal\u2014A review","volume":"36","author":"Tschernitschek","year":"2005","journal-title":"Quintessence Int. Berl. Ger."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"S1345","DOI":"10.4103\/jpbs.jpbs_159_21","article-title":"Prevalence of Titanium Hypersensitivity in Patients with Titanium Implants: A Systematic Review and Meta-analysis","volume":"13","author":"Singh","year":"2021","journal-title":"J. Pharm. Bioallied Sci."},{"key":"ref_78","first-page":"1850401","article-title":"Biomechanical Consequences of the Elastic Properties of Dental Implant Alloys on the Supporting Bone: Finite Element Analysis","volume":"2016","author":"Monticelli","year":"2016","journal-title":"BioMed Res. Int."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s10544-021-00559-y","article-title":"Vacuum plasma sprayed porous titanium coating on polyetheretherketone for ACDF improves the osteogenic ability: An in vitro and in vivo study","volume":"23","author":"Liu","year":"2021","journal-title":"Biomed. Microdevices"},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Yang, Y., Zhang, H., Komasa, S., Kusumoto, T., Kuwamoto, S., Okunishi, T., Kobayashi, Y., Hashimoto, Y., Sekino, T., and Okazaki, J. (2022). Immunomodulatory Properties and Osteogenic Activity of Polyetheretherketone Coated with Titanate Nanonetwork Structures. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23020612"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.actbio.2016.02.007","article-title":"Bioactivity of sol\u2013gel-derived TiO2 coating on polyetheretherketone: In vitro and in vivo studies","volume":"35","author":"Shimizu","year":"2016","journal-title":"Acta Biomater."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"328943","DOI":"10.1155\/2015\/328943","article-title":"In Vivo Osseointegration Performance of Titanium Dioxide Coating Modified Polyetheretherketone Using Arc Ion Plating for Spinal Implant Application","volume":"2015","author":"Tsou","year":"2015","journal-title":"BioMed Res. Int."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"110782","DOI":"10.1016\/j.msec.2020.110782","article-title":"Rapid construction of polyetheretherketone (PEEK) biological implants incorporated with brushite (CaHPO4\u00b72H2O) and antibiotics for anti-infection and enhanced osseointegration","volume":"111","author":"Xue","year":"2020","journal-title":"Mater. Sci. Eng. C"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1002\/jbm.b.33479","article-title":"Red selenium nanoparticles and gray selenium nanorods as antibacterial coatings for PEEK medical devices: Antibacterial Coatings for Peek Medical Devices","volume":"104","author":"Wang","year":"2016","journal-title":"J. Biomed. Mater. Res. B Appl. Biomater."},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"Hu, C.-C., Kumar, S.R., Vi, T.T.T., Huang, Y.-T., Chen, D.W., and Lue, S.J. (2021). Facilitating GL13K Peptide Grafting on Polyetheretherketone via 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide: Surface Properties and Antibacterial Activity. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23010359"},{"key":"ref_86","first-page":"100148","article-title":"Programmed surface on poly(aryl-ether-ether-ketone) initiating immune mediation and fulfilling bone regeneration sequentially","volume":"2","author":"Xie","year":"2021","journal-title":"Innovation"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"50836","DOI":"10.1021\/acsami.1c18088","article-title":"Fabrication of Dexamethasone-Loaded Dual-Metal\u2013Organic Frameworks on Polyetheretherketone Implants with Bacteriostasis and Angiogenesis Properties for Promoting Bone Regeneration","volume":"13","author":"Xiao","year":"2021","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1016\/j.biomaterials.2009.10.055","article-title":"Self-initiated surface grafting with poly(2-methacryloyloxyethyl phosphorylcholine) on poly(ether-ether-ketone)","volume":"31","author":"Kyomoto","year":"2010","journal-title":"Biomaterials"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"5561","DOI":"10.1021\/acsami.5b00210","article-title":"Nano-TiO2 Reinforced PEEK\/PEI Blends as Biomaterials for Load-Bearing Implant Applications","volume":"7","year":"2015","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.ijbiomac.2020.09.175","article-title":"Lattice design and 3D-printing of PEEK with Ca10(OH)(PO4)3 and in-vitro bio-composite for bone implant","volume":"165","author":"Oladapo","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1039\/C5TB01784J","article-title":"rBMSC and bacterial responses to isoelastic carbon fiber-reinforced poly(ether-ether-ketone) modified by zirconium implantation","volume":"4","author":"Li","year":"2016","journal-title":"J. Mater. Chem. B"},{"key":"ref_92","doi-asserted-by":"crossref","unstructured":"Yamane, Y., Yabutsuka, T., Takaoka, Y., Ishizaki, C., Takai, S., and Fujibayashi, S. (2021). Surface Modification of Carbon Fiber-Polyetheretherketone Composite to Impart Bioactivity by Using Apatite Nuclei. Materials, 14.","DOI":"10.3390\/ma14216691"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"2375","DOI":"10.1021\/acsbiomaterials.2c00095","article-title":"Surface Modification of Carbon Fiber-Reinforced Polyetheretherketone with MXene Nanosheets for Enhanced Photothermal Antibacterial Activity and Osteogenicity","volume":"8","author":"Du","year":"2022","journal-title":"ACS Biomater. Sci. Eng."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.msec.2016.08.058","article-title":"Bioactive carbon\u2013PEEK composites prepared by chemical surface treatment","volume":"70","author":"Miyazaki","year":"2017","journal-title":"Mater. Sci. Eng. C"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"2254","DOI":"10.1002\/jbm.b.34025","article-title":"Fabrication of Bioactive Fiber-reinforced PEEK and MXD6 by Incorporation of Precursor of Apatite: Fabrication of bioactive fiber-reinforced peek and mxd6","volume":"106","author":"Yabutsuka","year":"2018","journal-title":"J. Biomed. Mater. Res. B Appl. Biomater."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"2174","DOI":"10.1002\/jbm.b.34865","article-title":"Ambient temperature sulfonated carbon fiber reinforced PEEK with hydroxyapatite and reduced graphene oxide hydroxyapatite composite coating","volume":"109","author":"Wang","year":"2021","journal-title":"J. Biomed. Mater. Res. B Appl. Biomater."}],"container-title":["Biomolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2218-273X\/13\/3\/464\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:46:15Z","timestamp":1760121975000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2218-273X\/13\/3\/464"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,2]]},"references-count":96,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2023,3]]}},"alternative-id":["biom13030464"],"URL":"https:\/\/doi.org\/10.3390\/biom13030464","relation":{},"ISSN":["2218-273X"],"issn-type":[{"value":"2218-273X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,2]]}}}