{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T15:09:26Z","timestamp":1789571366032,"version":"build-2803163510"},"reference-count":100,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2023,3,7]],"date-time":"2023-03-07T00:00:00Z","timestamp":1678147200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"ASTaR\/ Johnson &amp;Johnson Vision Care","award":["IAF-ICP 1700052"],"award-info":[{"award-number":["IAF-ICP 1700052"]}]},{"DOI":"10.13039\/501100001468","name":"Singapore Eye Research Institute","doi-asserted-by":"publisher","award":["SNEC\/HREF\/2018\/0618-8"],"award-info":[{"award-number":["SNEC\/HREF\/2018\/0618-8"]}],"id":[{"id":"10.13039\/501100001468","id-type":"DOI","asserted-by":"publisher"}]},{"name":"SingHealth Duke-NUS Academic Medicine Research Grant","award":["AM-SU048-2020"],"award-info":[{"award-number":["AM-SU048-2020"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>Myopia is a globally emerging concern accompanied by multiple medical and socio-economic burdens with no well-established causal treatment to control thus far. The study of the genomics and transcriptomics of myopia treatment is crucial to delineate disease pathways and provide valuable insights for the design of precise and effective therapeutics. A strong understanding of altered biochemical pathways and underlying pathogenesis leading to myopia may facilitate early diagnosis and treatment of myopia, ultimately leading to the development of more effective preventive and therapeutic measures. In this review, we summarize current data about the genomics and transcriptomics of myopia in human and animal models. We also discuss the potential applicability of these findings to precision medicine for myopia treatment.<\/jats:p>","DOI":"10.3390\/biom13030494","type":"journal-article","created":{"date-parts":[[2023,3,8]],"date-time":"2023-03-08T05:01:12Z","timestamp":1678251672000},"page":"494","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Applications of Genomics and Transcriptomics in Precision Medicine for Myopia Control or Prevention"],"prefix":"10.3390","volume":"13","author":[{"given":"Liqin","family":"Jiang","sequence":"first","affiliation":[{"name":"Singapore Eye Research Institute, Singapore National Eye Centre, Eye ACP Duke-NUS Medical School, Singapore 169856, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong Xuan","family":"Goh","sequence":"additional","affiliation":[{"name":"Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore 636921, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James Hao Zhong","family":"Koh","sequence":"additional","affiliation":[{"name":"Singapore Eye Research Institute, Singapore National Eye Centre, Eye ACP Duke-NUS Medical School, Singapore 169856, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5946-0322","authenticated-orcid":false,"given":"Xavier","family":"Chan","sequence":"additional","affiliation":[{"name":"Singapore Eye Research Institute, Singapore National Eye Centre, Eye ACP Duke-NUS Medical School, Singapore 169856, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noel A.","family":"Brennan","sequence":"additional","affiliation":[{"name":"Johnson & Johnson Vision, Jacksonville, FL 32256, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6477-9784","authenticated-orcid":false,"given":"Veluchamy Amutha","family":"Barathi","sequence":"additional","affiliation":[{"name":"Singapore Eye Research Institute, Singapore National Eye Centre, Eye ACP Duke-NUS Medical School, Singapore 169856, Singapore"},{"name":"Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5486-9292","authenticated-orcid":false,"given":"Quan V.","family":"Hoang","sequence":"additional","affiliation":[{"name":"Singapore Eye Research Institute, Singapore National Eye Centre, Eye ACP Duke-NUS Medical School, Singapore 169856, Singapore"},{"name":"Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore"},{"name":"Department of Ophthalmology, Columbia University, New York, NY 10032, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,7]]},"reference":[{"key":"ref_1","first-page":"35","article-title":"Myopia: A growing global problem with sight-threatening complications","volume":"28","author":"Holden","year":"2015","journal-title":"Community Eye Health"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"27","DOI":"10.47102\/https:\/\/doi.org\/10.47102\/annals-acadmedsg.V33N1p27","article-title":"Prevalence of myopia in Taiwanese schoolchildren: 1983 to 2000","volume":"33","author":"Lin","year":"2004","journal-title":"Ann. 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