{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T10:23:23Z","timestamp":1792664603894,"version":"4.5.0"},"reference-count":202,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2023,3,9]],"date-time":"2023-03-09T00:00:00Z","timestamp":1678320000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>Osteopontin (OPN) is a bone-derived phosphoglycoprotein related to physiological and pathological mechanisms that nowadays has gained relevance due to its role in the immune system response to chronic degenerative diseases, including rheumatoid arthritis (RA) and osteoarthritis (OA). OPN is an extracellular matrix (ECM) glycoprotein that plays a critical role in bone remodeling. Therefore, it is an effector molecule that promotes joint and cartilage destruction observed in clinical studies, in vitro assays, and animal models of RA and OA. Since OPN undergoes multiple modifications, including posttranslational changes, proteolytic cleavage, and binding to a wide range of receptors, the mechanisms by which it produces its effects, in some cases, remain unclear. Although there is strong evidence that OPN contributes significantly to the immunopathology of RA and OA when considering it as a common denominator molecule, some experimental trial results argue for its protective role in rheumatic diseases. Elucidating in detail OPN involvement in bone and cartilage degeneration is of interest to the field of rheumatology. This review aims to provide evidence of the OPN\u2019s multifaceted role in promoting joint and cartilage destruction and propose it as a common denominator of AR and OA immunopathology.<\/jats:p>","DOI":"10.3390\/biom13030502","type":"journal-article","created":{"date-parts":[[2023,3,9]],"date-time":"2023-03-09T03:46:40Z","timestamp":1678333600000},"page":"502","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":59,"title":["Osteopontin: A Bone-Derived Protein Involved in Rheumatoid Arthritis and Osteoarthritis Immunopathology"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6756-4316","authenticated-orcid":false,"given":"Beatriz Teresita","family":"Mart\u00edn-M\u00e1rquez","sequence":"first","affiliation":[{"name":"Departamento de Biolog\u00eda Molecular y Gen\u00f3mica, Instituto de Investigaci\u00f3n en Reumatolog\u00eda y del Sistema M\u00fasculo Esquel\u00e9tico (IIRSME), Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, JAL, Mexico"},{"name":"Cuerpo Acad\u00e9mico UDG-CA-703 \u201cInmunolog\u00eda y Reumatolog\u00eda\u201d, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, JAL, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavio","family":"Sandoval-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Departamento de Biolog\u00eda Molecular y Gen\u00f3mica, Instituto de Investigaci\u00f3n en Reumatolog\u00eda y del Sistema M\u00fasculo Esquel\u00e9tico (IIRSME), Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, JAL, Mexico"},{"name":"Cuerpo Acad\u00e9mico UDG-CA-703 \u201cInmunolog\u00eda y Reumatolog\u00eda\u201d, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, JAL, Mexico"},{"name":"Departamento de Neurociencias, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, JAL, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7267-1482","authenticated-orcid":false,"given":"Fernanda Isadora","family":"Corona-Meraz","sequence":"additional","affiliation":[{"name":"Departamento de Ciencias Biom\u00e9dicas, Divisi\u00f3n de Ciencias de la Salud, Centro Universitario de Tonal\u00e1, Tonal\u00e1 45425, JAL, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6486-1086","authenticated-orcid":false,"given":"Erika Aurora","family":"Mart\u00ednez-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Departamento de Biolog\u00eda Molecular y Gen\u00f3mica, Instituto de Investigaci\u00f3n en Reumatolog\u00eda y del Sistema M\u00fasculo Esquel\u00e9tico (IIRSME), Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, JAL, Mexico"},{"name":"Cuerpo Acad\u00e9mico UDG-CA-703 \u201cInmunolog\u00eda y Reumatolog\u00eda\u201d, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, JAL, Mexico"},{"name":"Departamento de Fisiolog\u00eda, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, JAL, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5047-8115","authenticated-orcid":false,"given":"Pedro Ernesto","family":"S\u00e1nchez-Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Departamento de Fisiolog\u00eda, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, JAL, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Salazar-P\u00e1ramo","sequence":"additional","affiliation":[{"name":"Cuerpo Acad\u00e9mico UDG-CA-703 \u201cInmunolog\u00eda y Reumatolog\u00eda\u201d, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, JAL, Mexico"},{"name":"Departamento de Fisiolog\u00eda, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, JAL, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3420-8574","authenticated-orcid":false,"given":"Ana Lilia","family":"Fletes-Rayas","sequence":"additional","affiliation":[{"name":"Departamento de Enfermer\u00eda Cl\u00ednica Aplicada, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, JAL, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Gonz\u00e1lez-Inostroz","sequence":"additional","affiliation":[{"name":"Departamento de Biolog\u00eda Molecular y Gen\u00f3mica, Instituto de Investigaci\u00f3n en Reumatolog\u00eda y del Sistema M\u00fasculo Esquel\u00e9tico (IIRSME), Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, JAL, Mexico"},{"name":"Departamento de Biolog\u00eda Molecular y Gen\u00f3mica, Doctorado en Biolog\u00eda Molecular en Medicina, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, JAL, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3823-4676","authenticated-orcid":false,"given":"Monica","family":"Vazquez-Del Mercado","sequence":"additional","affiliation":[{"name":"Departamento de Biolog\u00eda Molecular y Gen\u00f3mica, Instituto de Investigaci\u00f3n en Reumatolog\u00eda y del Sistema M\u00fasculo Esquel\u00e9tico (IIRSME), Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, JAL, Mexico"},{"name":"Cuerpo Acad\u00e9mico UDG-CA-703 \u201cInmunolog\u00eda y Reumatolog\u00eda\u201d, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, JAL, Mexico"},{"name":"Hospital Civil de Guadalajara \u201cDr. Juan I. Menchaca\u201d, Especialidad de Reumatolog\u00eda, Padr\u00f3n Nacional de Posgrados de Calidad (PNPC) Consejo Nacional de Ciencia y Tecnolog\u00eda (CONACyT), Guadalajara 44340, JAL, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1517\/14728222.2014.925447","article-title":"Osteopontin as a therapeutic target for cancer","volume":"18","author":"Bandopadhyay","year":"2014","journal-title":"Expert Opin. Ther. Targets"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.molmet.2014.03.004","article-title":"Osteopontin: A novel regulator at the cross roads of inflammation, obesity and diabetes","volume":"3","author":"Kahles","year":"2014","journal-title":"Mol. 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