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Dorsal root ganglion (DRG) neurons regulate the expression of different molecules, such as neurotrophins and their receptors, to promote axon regeneration after injury. However, the molecular players driving axonal regrowth need to be better defined. The membrane glycoprotein GPM6a has been described to contribute to neuronal development and structural plasticity in central-nervous-system neurons. Recent evidence indicates that GPM6a interacts with molecules from the PNS, although its role in DRG neurons remains unknown. Here, we characterized the expression of GPM6a in embryonic and adult DRGs by combining analysis of public RNA-seq datasets with immunochemical approaches utilizing cultures of rat DRG explants and dissociated neuronal cells. M6a was detected on the cell surfaces of DRG neurons throughout development. Moreover, GPM6a was required for DRG neurite elongation in vitro. In summary, we provide evidence on GPM6a being present in DRG neurons for the first time. Data from our functional experiments support the idea that GPM6a could contribute to axon regeneration in the PNS.<\/jats:p>","DOI":"10.3390\/biom13040594","type":"journal-article","created":{"date-parts":[[2023,3,27]],"date-time":"2023-03-27T03:31:48Z","timestamp":1679887908000},"page":"594","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Endogenous Glycoprotein GPM6a Is Involved in Neurite Outgrowth in Rat Dorsal Root Ganglion Neurons"],"prefix":"10.3390","volume":"13","author":[{"given":"Gabriela I.","family":"Aparicio","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, College of Medicine, University of Kentucky, Lexington, KY 40536-0298, USA"},{"name":"Brain Restoration Center, College of Medicine, University of Kentucky, Lexington, KY 40536-0298, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonella","family":"Le\u00f3n","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones Biotecnol\u00f3gicas, Universidad Nacional de San Mart\u00edn (UNSAM), Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET), San Mart\u00edn, Buenos Aires 1650, Argentina"},{"name":"Escuela de Bio y Nanotecnolog\u00edas (EByN), Universidad Nacional de San Mart\u00edn, San Mart\u00edn, Buenos Aires 1650, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roc\u00edo","family":"Guti\u00e9rrez Fuster","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones Biotecnol\u00f3gicas, Universidad Nacional de San Mart\u00edn (UNSAM), Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET), San Mart\u00edn, Buenos Aires 1650, Argentina"},{"name":"Escuela de Bio y Nanotecnolog\u00edas (EByN), Universidad Nacional de San Mart\u00edn, San Mart\u00edn, Buenos Aires 1650, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baylen","family":"Ravenscraft","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, Stark Neuroscience Research Institute, Indiana University School of Medicine, Indianapolis, IN 46202, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula V.","family":"Monje","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, College of Medicine, University of Kentucky, Lexington, KY 40536-0298, USA"},{"name":"Brain Restoration Center, College of Medicine, University of Kentucky, Lexington, KY 40536-0298, USA"},{"name":"Department of Neurological Surgery, Stark Neuroscience Research Institute, Indiana University School of Medicine, Indianapolis, IN 46202, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2163-948X","authenticated-orcid":false,"given":"Camila","family":"Scorticati","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones Biotecnol\u00f3gicas, Universidad Nacional de San Mart\u00edn (UNSAM), Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET), San Mart\u00edn, Buenos Aires 1650, Argentina"},{"name":"Escuela de Bio y Nanotecnolog\u00edas (EByN), Universidad Nacional de San Mart\u00edn, San Mart\u00edn, Buenos Aires 1650, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1038\/s41583-018-0001-8","article-title":"Intrinsic mechanisms of neuronal axon regeneration","volume":"19","author":"Mahar","year":"2018","journal-title":"Nat. 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