{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T11:43:04Z","timestamp":1791546184521,"version":"4.3.4"},"reference-count":238,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2023,3,26]],"date-time":"2023-03-26T00:00:00Z","timestamp":1679788800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the Direcci\u00f3n de Investigaci\u00f3n, Pontificia Universidad Cat\u00f3lica de Valpara\u00edso, Chile","award":["039.334\/2022"],"award-info":[{"award-number":["039.334\/2022"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>Trypanosomiases are a group of tropical diseases that have devastating health and socio-economic effects worldwide. In humans, these diseases are caused by the pathogenic kinetoplastids Trypanosoma brucei, causing African trypanosomiasis or sleeping sickness, and Trypanosoma cruzi, causing American trypanosomiasis or Chagas disease. Currently, these diseases lack effective treatment. This is attributed to the high toxicity and limited trypanocidal activity of registered drugs, as well as resistance development and difficulties in their administration. All this has prompted the search for new compounds that can serve as the basis for the development of treatment of these diseases. Antimicrobial peptides (AMPs) are small peptides synthesized by both prokaryotes and (unicellular and multicellular) eukaryotes, where they fulfill functions related to competition strategy with other organisms and immune defense. These AMPs can bind and induce perturbation in cell membranes, leading to permeation of molecules, alteration of morphology, disruption of cellular homeostasis, and activation of cell death. These peptides have activity against various pathogenic microorganisms, including parasitic protists. Therefore, they are being considered for new therapeutic strategies to treat some parasitic diseases. In this review, we analyze AMPs as therapeutic alternatives for the treatment of trypanosomiases, emphasizing their possible application as possible candidates for the development of future natural anti-trypanosome drugs.<\/jats:p>","DOI":"10.3390\/biom13040599","type":"journal-article","created":{"date-parts":[[2023,3,27]],"date-time":"2023-03-27T03:31:48Z","timestamp":1679887908000},"page":"599","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Antimicrobial Peptides (AMPs): Potential Therapeutic Strategy against Trypanosomiases?"],"prefix":"10.3390","volume":"13","author":[{"given":"Maura","family":"Rojas-Pirela","sequence":"first","affiliation":[{"name":"Instituto de Biolog\u00eda, Facultad de Ciencias, Pontificia Universidad Cat\u00f3lica de Valpara\u00edso, Valpara\u00edso 2373223, Chile"},{"name":"Instituto de Ciencias Biom\u00e9dicas, Facultad de Medicina, Universidad de Chile, Santiago de Chile 8380453, Chile"},{"name":"Laboratorio de Enzimolog\u00eda de Par\u00e1sitos, Departamento de Biolog\u00eda, Facultad de Ciencias, Universidad de Los Andes, M\u00e9rida 5101, Venezuela"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0201-1665","authenticated-orcid":false,"given":"Ulrike","family":"Kemmerling","sequence":"additional","affiliation":[{"name":"Instituto de Ciencias Biom\u00e9dicas, Facultad de Medicina, Universidad de Chile, Santiago de Chile 8380453, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilfredo","family":"Qui\u00f1ones","sequence":"additional","affiliation":[{"name":"Laboratorio de Enzimolog\u00eda de Par\u00e1sitos, Departamento de Biolog\u00eda, Facultad de Ciencias, Universidad de Los Andes, M\u00e9rida 5101, Venezuela"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3726-6104","authenticated-orcid":false,"given":"Paul A. M.","family":"Michels","sequence":"additional","affiliation":[{"name":"School of Biological Sciences, The University of Edinburgh, The King\u2019s Buildings, Edinburgh EH9 3FL, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ver\u00f3nica","family":"Rojas","sequence":"additional","affiliation":[{"name":"Instituto de Biolog\u00eda, Facultad de Ciencias, Pontificia Universidad Cat\u00f3lica de Valpara\u00edso, Valpara\u00edso 2373223, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1590\/0074-02760150253","article-title":"Exploring the Environmental Diversity of Kinetoplastid Flagellates in the High-Throughput DNA Sequencing Era","volume":"110","author":"Boucinha","year":"2015","journal-title":"Mem\u00f3rias Inst. 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