{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:35:14Z","timestamp":1787027714005,"version":"build-2736575974"},"reference-count":369,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2023,3,28]],"date-time":"2023-03-28T00:00:00Z","timestamp":1679961600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the National Science Centre, Poland","award":["Opus Project No. 2018\/31\/B\/ST8\/03277"],"award-info":[{"award-number":["Opus Project No. 2018\/31\/B\/ST8\/03277"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>Growth factors are a class of proteins that play a role in the proliferation (the increase in the number of cells resulting from cell division) and differentiation (when a cell undergoes changes in gene expression becoming a more specific type of cell) of cells. They can have both positive (accelerating the normal healing process) and negative effects (causing cancer) on disease progression and have potential applications in gene therapy and wound healing. However, their short half-life, low stability, and susceptibility to degradation by enzymes at body temperature make them easily degradable in vivo. To improve their effectiveness and stability, growth factors require carriers for delivery that protect them from heat, pH changes, and proteolysis. These carriers should also be able to deliver the growth factors to their intended destination. This review focuses on the current scientific literature concerning the physicochemical properties (such as biocompatibility, high affinity for binding growth factors, improved bioactivity and stability of the growth factors, protection from heat, pH changes or appropriate electric charge for growth factor attachment via electrostatic interactions) of macroions, growth factors, and macroion-growth factor assemblies, as well as their potential uses in medicine (e.g., diabetic wound healing, tissue regeneration, and cancer therapy). Specific attention is given to three types of growth factors: vascular endothelial growth factors, human fibroblast growth factors, and neurotrophins, as well as selected biocompatible synthetic macroions (obtained through standard polymerization techniques) and polysaccharides (natural macroions composed of repeating monomeric units of monosaccharides). Understanding the mechanisms by which growth factors bind to potential carriers could lead to more effective delivery methods for these proteins, which are of significant interest in the diagnosis and treatment of neurodegenerative and civilization diseases, as well as in the healing of chronic wounds.<\/jats:p>","DOI":"10.3390\/biom13040609","type":"journal-article","created":{"date-parts":[[2023,3,29]],"date-time":"2023-03-29T02:03:53Z","timestamp":1680055433000},"page":"609","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Biocompatible Macroion\/Growth Factor Assemblies for Medical Applications"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7141-3262","authenticated-orcid":false,"given":"Aneta","family":"Michna","sequence":"first","affiliation":[{"name":"Jerzy Haber Institute of Catalysis and Surface Chemistry, Polish Academy of Sciences, Niezapominajek 8, PL-30239 Krakow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0029-4013","authenticated-orcid":false,"given":"Agata","family":"Pomorska","sequence":"additional","affiliation":[{"name":"Jerzy Haber Institute of Catalysis and Surface Chemistry, Polish Academy of Sciences, Niezapominajek 8, PL-30239 Krakow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ozlem","family":"Ozcan","sequence":"additional","affiliation":[{"name":"Bundesanstalt f\u00fcr Materialforschung und-pr\u00fcfung (BAM), Unter den Eichen 87, DE-12205 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.cis.2017.09.004","article-title":"Macroion Adsorption\u2014Electrokinetic and Optical Methods","volume":"250","author":"Michna","year":"2017","journal-title":"Adv. Colloid Interface Sci."},{"key":"ref_2","unstructured":"Lyklema, J. (2005). Fundamentals of Interface and Colloid Science, Academic Press. [1st ed.]."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1002\/adma.201001215","article-title":"Antifouling Coatings: Recent Developments in the Design of Surfaces That Prevent Fouling by Proteins, Bacteria, and Marine Organisms","volume":"23","author":"Banerjee","year":"2011","journal-title":"Adv. Mater."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.cocis.2010.05.007","article-title":"Polysaccharide-Based Polyelectrolyte Multilayers","volume":"15","author":"Crouzier","year":"2010","journal-title":"Curr. Opin. Colloid Interface Sci."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1126\/science.277.5330.1232","article-title":"Fuzzy Nanoassemblies: Toward Layered Polymeric Multicomposites","volume":"277","author":"Decher","year":"1997","journal-title":"Science"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/j.jcis.2018.07.006","article-title":"Colloidal Characteristics and Functionality of Rationally Designed Esculin-Loaded Hydrogel Microcapsules","volume":"530","author":"Michna","year":"2018","journal-title":"J. Colloid Interface Sci."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1021\/acs.biomac.0c01520","article-title":"Efficient Synthesis of Folate-Conjugated Hollow Polymeric Capsules for Accurate Drug Delivery to Cancer Cells","volume":"22","author":"Song","year":"2021","journal-title":"Biomacromolecules"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1073\/pnas.012581399","article-title":"Biosensors from Conjugated Polyelectrolyte Complexes","volume":"99","author":"Wang","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"8301","DOI":"10.1039\/C5CS00092K","article-title":"Carbohydrate Nanocarriers in Biomedical Applications: Functionalization and Construction","volume":"44","author":"Kang","year":"2015","journal-title":"Chem. Soc. Rev."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"8864","DOI":"10.1016\/j.actbio.2013.06.012","article-title":"Polyelectrolyte\/Silver Nanocomposite Multilayer Films as Multifunctional Thin Film Platforms for Remote Activated Protein and Drug Delivery","volume":"9","author":"Anandhakumar","year":"2013","journal-title":"Acta Biomater."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.jiec.2015.10.009","article-title":"Nanoporous Multilayer Films for Controlled Antigen Protein Release","volume":"33","author":"Yang","year":"2016","journal-title":"J. Ind. Eng. Chem."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1002\/jbm.b.30794","article-title":"Incorporation of Basic Fibroblast Growth Factor by a Layer-by-Layer Assembly Technique to Produce Bioactive Substrates","volume":"83","author":"Ma","year":"2007","journal-title":"J. Biomed. Mater. Res. Part B Appl. Biomater."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"2053","DOI":"10.1021\/bm100413w","article-title":"Characterization of Tunable FGF-2 Releasing Polyelectrolyte Multilayers","volume":"11","author":"MacDonald","year":"2010","journal-title":"Biomacromolecules"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.colsurfb.2011.06.023","article-title":"Bacterial-Growth Inhibiting Properties of Multilayers Formed with Modified Polyvinylamine","volume":"88","author":"Ek","year":"2011","journal-title":"Colloids Surfaces B Biointerfaces"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"218142","DOI":"10.4061\/2010\/218142","article-title":"Fibroblast Growth Factors: Biology, Function, and Application for Tissue Regeneration","volume":"2010","author":"Yun","year":"2010","journal-title":"J. Tissue Eng."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1038\/s41467-017-01249-1","article-title":"Sequence and Entropy-Based Control of Complex Coacervates","volume":"8","author":"Chang","year":"2017","journal-title":"Nat. Commun."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1016\/j.ijbiomac.2018.10.144","article-title":"Complex Coacervation: Principles, Mechanisms and Applications in Microencapsulation","volume":"121","author":"Timilsena","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.colsurfb.2007.03.004","article-title":"Fabrication of Ultrathin Polyelectrolyte Fibers and Their Controlled Release Properties","volume":"58","author":"Chunder","year":"2007","journal-title":"Colloids Surfaces B Biointerfaces"},{"key":"ref_19","unstructured":"K\u00f6se, M.D., Bayraktar, O., and Heinz, \u00d6.K. (2018). Design and Development of New Nanocarriers, William Andrew Publishing."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1021\/bm101465y","article-title":"Protein Purification by Polyelectrolyte Coacervation: Influence of Protein Charge Anisotropy on Selectivity","volume":"12","author":"Xu","year":"2011","journal-title":"Biomacromolecules"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.actbio.2019.03.052","article-title":"Coacervate-Mediated Exogenous Growth Factor Delivery for Scarless Skin Regeneration","volume":"90","author":"Park","year":"2019","journal-title":"Acta Biomater."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Jeong, S., Kim, B., Lau, H.C., and Kim, A. (2019). Gelatin-Alginate Complexes for EGF Encapsulation: Effects of H-Bonding and Electrostatic Interactions. Pharmaceutics, 11.","DOI":"10.3390\/pharmaceutics11100530"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"e13196","DOI":"10.1111\/jfpe.13196","article-title":"Comparison of Rheological Properties of Different Protein\/Gum Arabic Complex Coacervates","volume":"42","author":"Dong","year":"2019","journal-title":"J. Food Process Eng."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1159\/000490139","article-title":"Dual Delivery of BFGF- and NGF-Binding Coacervate Confers Neuroprotection by Promoting Neuronal Proliferation","volume":"47","author":"Wu","year":"2018","journal-title":"Cell. Physiol. Biochem."},{"key":"ref_25","first-page":"175","article-title":"7-Chitosan-Based Scaffolds for Growth Factor Delivery","volume":"Volume 2","author":"Jennings","year":"2017","journal-title":"Chitosan Based Biomaterials"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1530\/JOE-10-0377","article-title":"Extracellular Matrix and Cell Signalling: The Dynamic Cooperation of Integrin, Proteoglycan and Growth Factor Receptor","volume":"209","author":"Kim","year":"2011","journal-title":"J. Endocrinol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1093\/glycob\/cwy003","article-title":"Keratan Sulfate, a Complex Glycosaminoglycan with Unique Functional Capability","volume":"28","author":"Caterson","year":"2018","journal-title":"Glycobiology"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"3791","DOI":"10.1002\/1873-3468.13026","article-title":"Proteoglycans in Brain Development and Pathogenesis","volume":"592","author":"Schwartz","year":"2018","journal-title":"FEBS Lett."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1111\/j.1524-475X.2009.00466.x","article-title":"Interactions between Extracellular Matrix and Growth Factors in Wound Healing","volume":"17","author":"Schultz","year":"2009","journal-title":"Wound Repair Regen."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1098\/rsif.2010.0223","article-title":"Growth Factor Delivery-Based Tissue Engineering: General Approaches and a Review of Recent Developments","volume":"8","author":"Lee","year":"2011","journal-title":"J. R. Soc. Interface"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.devcel.2004.08.004","article-title":"Spatial Regulation of Wingless Morphogen Distribution and Signaling by Dally-like Protein","volume":"7","author":"Kirkpatrick","year":"2004","journal-title":"Dev. Cell"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.devcel.2004.08.005","article-title":"Opposing Activities of Dally-like Glypican at High and Low Levels of Wingless Morphogen Activity","volume":"7","author":"Kreuger","year":"2004","journal-title":"Dev. Cell"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"4177","DOI":"10.1242\/dev.011171","article-title":"Heparanase Cleavage of Perlecan Heparan Sulfate Modulates FGF10 Activity during Ex Vivo Submandibular Gland Branching Morphogenesis","volume":"134","author":"Patel","year":"2007","journal-title":"Development"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"e435","DOI":"10.1038\/am.2017.171","article-title":"Novel Biomaterial Strategies for Controlled Growth Factor Delivery for Biomedical Applications","volume":"9","author":"Wang","year":"2017","journal-title":"NPG Asia Mater."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.matbio.2018.02.019","article-title":"A Role for Proteoglycans in Vascular Disease","volume":"71\u201372","author":"Wight","year":"2018","journal-title":"Matrix Biol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.semcancer.2019.07.007","article-title":"Revisiting the Hallmarks of Cancer: The Role of Hyaluronan","volume":"62","author":"Caon","year":"2020","journal-title":"Semin. Cancer Biol."},{"key":"ref_37","unstructured":"Balaji, A.B., Pakalapati, H., Khalid, M., Walvekar, R., and Siddiqui, H. (2017). Biodegradable and Biocompatible Polymer Composites: Processing, Properties and Applications, Elsevier Ltd."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"2004","DOI":"10.1002\/1521-3773(20010601)40:11<2004::AID-ANIE2004>3.0.CO;2-5","article-title":"Click Chemistry: Diverse Chemical Function from a Few Good Reactions","volume":"40","author":"Kolb","year":"2001","journal-title":"Angew. Chemie-Int. Ed."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1039\/C1PY00002K","article-title":"Stimuli-Responsive Star Polymers through Thiol-Yne Core Functionalization\/Crosslinking of Block Copolymer Micelles","volume":"2","author":"Schlaad","year":"2011","journal-title":"Polym. Chem."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/j.polymer.2007.12.029","article-title":"PH-Responsive Biodegradable Amphiphilic Networks","volume":"49","author":"Zednik","year":"2008","journal-title":"Polymer"},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Peppas, N.A., and Langer, R.S. (1995). Biopolymers II. Advances in Polymer Science, Springer.","DOI":"10.1007\/3-540-58788-8"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.ijbiomac.2016.11.095","article-title":"A Review on Synthesis, Properties and Applications of Natural Polymer Based Carrageenan Blends and Composites","volume":"96","author":"Zia","year":"2017","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1002\/anie.199001381","article-title":"Starburst Dendrimers: Molecular-Level Control of Size, Shape, Surface Chemistry, Topology, and Flexibility from Atoms to Macroscopic Matter","volume":"29","author":"Tomalia","year":"1990","journal-title":"Angew. Chem. Int. Ed. Engl."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"4755","DOI":"10.1039\/c2cs35146c","article-title":"Branched and Linear Poly(Ethylene Imine)-Based Conjugates: Synthetic Modification, Characterization, and Application","volume":"41","author":"Schubert","year":"2012","journal-title":"Chem. Soc. Rev."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Bhatia, S. (2016). Natural Polymer Drug Delivery Systems: Nanoparticles, Plants, and Algae, Springer International Publishing.","DOI":"10.1007\/978-3-319-41129-3"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/3-540-70733-6_3","article-title":"Diallyldimethylammonium Chloride and Its Polymers","volume":"145","author":"Wandrey","year":"1999","journal-title":"Radic. Polym. Polyelectrolytes"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"9568","DOI":"10.1021\/ma9003874","article-title":"Hydrophobic Polyelectrolytes in Better Polar Solvent. Structure and Chain Conformation as Seen by SAXS and SANS","volume":"42","author":"Essafi","year":"2009","journal-title":"Macromolecules"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.jcis.2014.04.013","article-title":"Formation of PDADMAC Monolayers Evaluated in Situ by QCM and Streaming Potential Measurements","volume":"428","author":"Michna","year":"2014","journal-title":"J. Colloid Interface Sci."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.colsurfa.2017.05.033","article-title":"Formation and Stability of Polyelectrolyte\/Polypeptide Monolayers Determined by Electrokinetic Measurements","volume":"529","author":"Morga","year":"2017","journal-title":"Colloids Surfaces A Physicochem. Eng. Asp."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.jcis.2016.09.007","article-title":"Monolayers of Poly(Amido Amine) Dendrimers on Mica\u2013In Situ Streaming Potential Measurements","volume":"485","author":"Michna","year":"2017","journal-title":"J. Colloid Interface Sci."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.carbpol.2019.05.067","article-title":"Review of Polysaccharide Particle-Based Functional Drug Delivery","volume":"221","author":"Barclay","year":"2019","journal-title":"Carbohydr. Polym."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.1002\/marc.201400406","article-title":"Recent Strategies to Develop Polysaccharide-Based Nanomaterials for Biomedical Applications","volume":"35","author":"Wen","year":"2014","journal-title":"Macromol. Rapid Commun."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.1021\/bm8002573","article-title":"Polyelectrolyte Multilayer Assembly as a Function of PH and Ionic Strength Using the Polysaccharides Chitosan and Heparin","volume":"9","author":"Boddohi","year":"2008","journal-title":"Biomacromolecules"},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Isbell, H.S. (1973). Carbohydrates in Solution, ACS Publications.","DOI":"10.1021\/ba-1971-0117"},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Zhang, Y., Song, W., Lu, Y., Xu, Y., Wang, C., Yu, D.G., and Kim, I. (2022). Recent Advances in Poly(\u03b1-L-Glutamic Acid)-Based Nanomaterials for Drug Delivery. Biomolecules, 12.","DOI":"10.3390\/biom12050636"},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Fraser-Reid, B.O., Tatsuta, K., and Thiem, J. (2008). Glycoscience. Chemistry and Chemical Biology, Springer. [2nd ed.].","DOI":"10.1007\/978-3-540-30429-6"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"147","DOI":"10.2147\/IJN.S8692","article-title":"Preparation and Characterization of Low-Molecular-Weight Heparin \/ Protamine Nanoparticles (LMW-H\/P NPs ) as FGF-2 Carrier","volume":"5","author":"Mori","year":"2010","journal-title":"Int. J. Nanomed."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1016\/j.chembiol.2007.07.007","article-title":"Potentiation of Fibroblast Growth Factor Activity by Synthetic Heparin Oligosaccharide Glycodendrimers","volume":"14","author":"Noti","year":"2007","journal-title":"Chem. Biol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1002\/2211-5463.12696","article-title":"Sulfated Polysaccharides Interact with Fibroblast Growth Factors and Protect from Denaturation","volume":"9","author":"Sun","year":"2019","journal-title":"FEBS Open Bio"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1021\/bc9900439","article-title":"Synthesis of Polyallylamine Derivatives and Their Use as Gene Transfer Vectors in Vitro","volume":"10","author":"Boussif","year":"1999","journal-title":"Bioconjug. Chem."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"10761","DOI":"10.1021\/ja0015388","article-title":"Degradable Poly (\u03b2-Amino Esters ): Synthesis, Characterization, and Self-Assembly with Plasmid DNA","volume":"122","author":"Lynn","year":"2000","journal-title":"J. Am. Chem. Soc."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1140\/epje\/e2004-00039-x","article-title":"Attraction of Like-Charged Macroions in the Strong-Coupling Limit","volume":"13","author":"Naji","year":"2004","journal-title":"Eur. Phys. J. E"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"9971","DOI":"10.1021\/acs.jpcb.9b06545","article-title":"Attraction between Like-Charged Macroions Mediated by Specific Counterion Configurations","volume":"123","author":"Stelmakh","year":"2019","journal-title":"J. Phys. Chem. B"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"4412","DOI":"10.1021\/acs.biomac.2c00933","article-title":"Biomolecular Complexation on the \u201cWrong Side\u201d: A Case Study of the Influence of Salts and Sugars on the Interactions between Bovine Serum Albumin and Sodium Polystyrene Sulfonate","volume":"23","author":"Hritz","year":"2022","journal-title":"Biomacromolecules"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1039\/C0NJ00371A","article-title":"Correlation between Gel-Forming Ability, Supramolecular Aggregates and Main-Chain Conformation of Dendronized Polymer Gelators","volume":"35","author":"Zhang","year":"2011","journal-title":"N. J. Chem."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"11389","DOI":"10.1021\/ie3008538","article-title":"Cellulase Adsorption and Reactivity on a Cellulose Surface from Flow Ellipsometry","volume":"51","author":"Maurer","year":"2012","journal-title":"Ind. Eng. Chem. Res."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1920","DOI":"10.1039\/C2SM26884A","article-title":"Study of the Multilayer Assembly and Complex Formation of Poly(Diallyldimethylammonium Chloride) (PDADMAC) and Poly(Acrylic Acid) (PAA) as a Function of PH","volume":"9","author":"Alonso","year":"2013","journal-title":"Soft Matter"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.jpowsour.2013.03.162","article-title":"Cross-Linked Poly(Vinyl Alcohol)\/Poly (Diallyldimethylammonium Chloride) as Anion-Exchange Membrane for Fuel Cell Applications","volume":"240","author":"Zhang","year":"2013","journal-title":"J. Power Sources"},{"key":"ref_69","first-page":"e3962","article-title":"Production of Medical Grade Silicone for Facial Prosthesis with Bactericidal Properties from the Inclusion of Poly (Diallyldimethylammonium Chloride): An in Vitro Study","volume":"19","author":"Gamarra","year":"2019","journal-title":"Pesqui. Bras. Odontopediatria Clin. Integr."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.jcis.2014.07.037","article-title":"Influence of Ionic Strength on Poly(Diallyldimethylammonium Chloride) Macromolecule Conformations in Electrolyte Solutions","volume":"435","author":"Adamczyk","year":"2014","journal-title":"J. Colloid Interface Sci."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1016\/j.polymer.2003.06.002","article-title":"Conformational Properties of Poly(Diallyldimethyl Ammonium Chloride) (PDDA) Determined by Combination of Molecular Dynamics, Rotational Isomeric States and Monte Carlo Procedures","volume":"45","author":"Marcelo","year":"2004","journal-title":"Polymer"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0144-8617(01)00231-4","article-title":"Comparative Studies on Molecular Chain Parameters of Chitosans and Poly(Diallyldimethylammonium Chloride): The Stiffness B-Parameter and the Temperature Coefficient of Intrinsic Viscosity","volume":"48","author":"Staszewska","year":"2002","journal-title":"Carbohydr. Polym."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"4864","DOI":"10.1021\/la9007608","article-title":"Structure of an Adsorbed Polyelectrolyte Monolayer on Oppositely Charged Colloidal Particles","volume":"25","author":"Vaccaro","year":"2009","journal-title":"Langmuir"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"12421","DOI":"10.1021\/la4020702","article-title":"Polyelectrolyte Adsorption on Solid Surfaces: Theoretical Predictions and Experimental Measurements","volume":"29","author":"Xie","year":"2013","journal-title":"Langmuir"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"10517","DOI":"10.1021\/la040064d","article-title":"Characterization of Polyelectrolyte Multilayers by the Streaming Potential Method","volume":"20","author":"Adamczyk","year":"2004","journal-title":"Langmuir"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"2975","DOI":"10.1016\/j.biomaterials.2004.08.013","article-title":"Modulation of Protein Adsorption and Cell Adhesion by Poly(Allylamine Hydrochloride) Heparin Films","volume":"26","author":"Kreke","year":"2005","journal-title":"Biomaterials"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"17506","DOI":"10.1021\/la303937g","article-title":"Response of Adsorbed Polyelectrolyte Monolayers to Changes in Solution Composition","volume":"28","author":"Porus","year":"2012","journal-title":"Langmuir"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"3090","DOI":"10.1021\/la703307f","article-title":"Stability of Self-Assembled Polymer Films Investigated by Optical Laser Reflectometry","volume":"24","author":"Dejeu","year":"2008","journal-title":"Langmuir"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.jcis.2013.05.069","article-title":"Monolayers of Cationic Polyelectrolytes on Mica-Electrokinetic Studies","volume":"407","author":"Morga","year":"2013","journal-title":"J. Colloid Interface Sci."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"5102","DOI":"10.1039\/c2nr31290e","article-title":"Surface Engineering of Gold Nanoparticles for in Vitro SiRNA Delivery","volume":"4","author":"Zhao","year":"2012","journal-title":"Nanoscale"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"6331465","DOI":"10.1155\/2022\/6331465","article-title":"Layer-by-Layer Fabrication of PAH\/PAMAM\/Nano-CaCO3 Composite Films and Characterization for Enhanced Biocompatibility","volume":"2022","author":"Shifeta","year":"2022","journal-title":"Int. J. Biomater."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1021\/bm050174e","article-title":"Controlled Drug Release from Porous Polyelectrolyte Multilayers","volume":"7","author":"Berg","year":"2006","journal-title":"Biomacromolecules"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/j.ijpharm.2014.11.053","article-title":"Gene Delivery Efficiency and Intracellular Trafficking of Novel Poly(Allylamine) Derivatives","volume":"478","author":"Wytrwal","year":"2015","journal-title":"Int. J. Pharm."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1007\/s00396-015-3561-4","article-title":"Synthesis, Characterisation and in Vitro Evaluation of Novel Thiolated Derivatives of Polyallylamine and Quaternised Polyallylamine","volume":"293","author":"Ibie","year":"2015","journal-title":"Colloid Polym. Sci."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1021\/bc970190b","article-title":"Micropatterned Immobilization of Epidermal Growth Factor To Regulate Cell Function","volume":"9","author":"Ito","year":"1998","journal-title":"Bioconjug. Chem."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"1801359","DOI":"10.1002\/adhm.201801359","article-title":"Poly(\u03b2-Amino Esters): Synthesis, Formulations, and Their Biomedical Applications","volume":"8","author":"Liu","year":"2019","journal-title":"Adv. Healthc. Mater."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"5793","DOI":"10.1021\/acsami.6b15005","article-title":"Thermo- and PH-Responsive, Coacervate-Forming Hyperbranched Poly(\u03b2-Amino Ester)s for Selective Cell Binding","volume":"9","author":"Zhou","year":"2017","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1002\/mabi.201200122","article-title":"Tunable PH-Sensitive Poly(\u03b2-Amino Ester)s Synthesized from Primary Amines and Diacrylates for Intracellular Drug Delivery","volume":"12","author":"Song","year":"2012","journal-title":"Macromol. Biosci."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1021\/bm2016338","article-title":"Characterization of Degradable Polyelectrolyte Multilayers Fabricated Using DNA and a Fluorescently-Labeled Poly(\u03b2-Amino Ester): Shedding Light on the Role of the Cationic Polymer in Promoting Surface-Mediated Gene Delivery","volume":"13","author":"Bechler","year":"2012","journal-title":"Biomacromolecules"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"7418","DOI":"10.1021\/acsabm.0c00561","article-title":"Development of a Gene Delivery System Composed of a Cell-Penetrating Peptide and a Nontoxic Polymer","volume":"3","author":"Shrestha","year":"2020","journal-title":"ACS Appl. Bio Mater."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"3411","DOI":"10.1021\/acsbiomaterials.0c00271","article-title":"Efficiency of Cytosolic Delivery with Poly(\u03b2-Amino Ester) Nanoparticles Is Dependent on the Effective PKa of the Polymer","volume":"6","author":"Routkevitch","year":"2020","journal-title":"ACS Biomater. Sci. Eng."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"9056","DOI":"10.3390\/molecules17089056","article-title":"Da Synthesis and Characterization of Cationic Glycidyl-Based Poly(Aminoester)-Folic Acid Targeting Conjugates and Study on Gene Delivery","volume":"17","author":"Tsai","year":"2012","journal-title":"Molecules"},{"key":"ref_93","doi-asserted-by":"crossref","unstructured":"Liu, Q., Su, R.C., Yi, W.J., and Zhao, Z.G. (2017). Biodegradable Poly(Amino Ester) with Aromatic Backbone as Efficient Nonviral Gene Delivery Vectors. Molecules, 22.","DOI":"10.3390\/molecules22040566"},{"key":"ref_94","doi-asserted-by":"crossref","unstructured":"Li, Y., He, Z., Lyu, J., Wang, X., Qiu, B., Lara-s, I., Zhang, J., Zeng, M., Xu, Q., and Sigen, A. (2022). Hyperbranched Poly (\u03b2-Amino Ester)s (HPAEs ) Structure Optimisation for Enhanced Gene Delivery: Non-Ideal Termination Elimination. Nanomaterials, 12.","DOI":"10.3390\/nano12213892"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"3640","DOI":"10.1021\/acs.biomac.6b01120","article-title":"Highly Branched Poly(\u03b2-Amino Esters) for Non-Viral Gene Delivery: High Transfection Efficiency and Low Toxicity Achieved by Increasing Molecular Weight","volume":"17","author":"Gao","year":"2016","journal-title":"Biomacromolecules"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"2609","DOI":"10.1021\/acs.biomac.5b00966","article-title":"Highly Branched Poly(\u03b2-Amino Esters): Synthesis and Application in Gene Delivery","volume":"16","author":"Cutlar","year":"2015","journal-title":"Biomacromolecules"},{"key":"ref_97","first-page":"23","article-title":"Cytotoxic Impacts of Linear and Branched Polyethylenimine Nanostructures in A431 Cells","volume":"1","author":"Kafil","year":"2011","journal-title":"BioImpacts"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"2500","DOI":"10.1021\/ma020819s","article-title":"Synthesis and Protonation Behavior of Comblike Poly(Ethyleneimine)","volume":"36","author":"Koper","year":"2003","journal-title":"Macromolecules"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1021\/je060388z","article-title":"Thermodynamic Study for the Protonation of Branched Poly(Ethylenimine) in NaCl(Aq) and Its Dependence on Ionic Strength","volume":"52","author":"Crea","year":"2007","journal-title":"J. Chem. Eng. Data"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"3539","DOI":"10.1021\/ma0478409","article-title":"Charge on Poly(Ethylene Imine): Comparing Electrophoretic NMR Measurements and PH Titrations","volume":"38","author":"Griffiths","year":"2005","journal-title":"Macromolecules"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"3219","DOI":"10.1021\/la9808925","article-title":"Detection of a Single Molecule Adsorption Structure of Poly (Ethylenimine) Macromolecules by AFM","volume":"15","author":"Pfau","year":"1999","journal-title":"Langmuir"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.apsusc.2012.12.042","article-title":"Investigation of Thin Polymer Layers for Biosensor Applications","volume":"281","author":"Saftics","year":"2013","journal-title":"Appl. Surf. Sci."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1002\/1097-4636(20000905)51:3<321::AID-JBM5>3.0.CO;2-R","article-title":"Poly (Ethylenimine) -Mediated Transfection: A New Paradigm for Gene Delivery","volume":"51","author":"Godbey","year":"1999","journal-title":"Inc. J. Biomed. Mater. Res."},{"key":"ref_104","unstructured":"Narain, R. (2016). Polymers and Nanomaterials for Gene Therapy, Woodhead Publishing."},{"key":"ref_105","doi-asserted-by":"crossref","unstructured":"de la Hoz, R., Diban, N., Berciano, M.T., San Emeterio, C., Urtiaga, A., Lafarga, M., Rodr\u00edguez-Rey, J.C., and Tapia, O. (2022). Coaxial Synthesis of PEI-Based Nanocarriers of Encapsulated RNA-Therapeutics to Specifically Target Muscle Cells. Biomolecules, 12.","DOI":"10.3390\/biom12081012"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1186\/1556-276X-9-247","article-title":"Dendrimers: Synthesis, Applications, and Properties","volume":"9","author":"Abbasi","year":"2014","journal-title":"Nanoscale Res. Lett."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.addr.2012.09.030","article-title":"Dendrimers in Biomedical Applications-Reflections on the Field","volume":"64","author":"Svenson","year":"2012","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"139","DOI":"10.4103\/0975-7406.130965","article-title":"Dendrimers in Drug Delivery and Targeting: Drug-Dendrimer Interactions and Toxicity Issues","volume":"6","author":"Madaan","year":"2014","journal-title":"J. Pharm. Bioallied Sci."},{"key":"ref_109","doi-asserted-by":"crossref","unstructured":"Vu, M.T., Bach, L.G., Nguyen, D.C., Ho, M.N., Nguyen, N.H., Tran, N.Q., Nguyen, D.H., Nguyen, C.K., and Thi, T.T.H. (2019). Modified Carboxyl-Terminated PAMAM Dendrimers as Great Cytocompatible Nano-Based Drug Delivery System. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20082016"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"1808","DOI":"10.1021\/mp4006358","article-title":"Poly(Amidoamine) Dendrimer Nanocarriers and Their Aerosol Formulations for SiRNA Delivery to the Lung Epithelium","volume":"11","author":"Conti","year":"2014","journal-title":"Mol. Pharm."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"4201","DOI":"10.1021\/ma0300241","article-title":"Microscopic Protonation Equilibria of Poly(Amidoamine) Dendrimers from Macroscopic Titrations","volume":"36","author":"Cakara","year":"2003","journal-title":"Macromolecules"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"5274","DOI":"10.1021\/cr500542t","article-title":"Surface-Engineered Dendrimers in Gene Delivery","volume":"115","author":"Yang","year":"2015","journal-title":"Chem. Rev."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"4172","DOI":"10.1021\/ma991474p","article-title":"Size Invariance of Polyelectrolyte Dendrimers","volume":"33","author":"Nisato","year":"2000","journal-title":"Macromolecules"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"14772","DOI":"10.1021\/jp805297a","article-title":"Structural Investigation of PAMAM Dendrimers in Aqueous Solutions Using Small-Angle Neutron Scattering: Effect of Generation","volume":"112","author":"Porcar","year":"2008","journal-title":"J. Phys. Chem. B"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1139\/cjc-2017-0244","article-title":"PAMAM Dendrimer: A PH Controlled Nanosponge","volume":"95","author":"Maiti","year":"2017","journal-title":"Can. J. Chem."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"5892","DOI":"10.1021\/ma980198w","article-title":"Tuning the Density Profile of Dendritic Polyelectrolytes","volume":"31","author":"Welch","year":"1998","journal-title":"Macromolecules"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"4510","DOI":"10.1021\/ma010354q","article-title":"Structural Molecular Dynamics Studies on Polyamidoamine Dendrimers for a Therapeutic Application: Effects of PH and Generation","volume":"35","author":"Lee","year":"2002","journal-title":"Macromolecules"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"19678","DOI":"10.1021\/acs.jpcc.6b05020","article-title":"Combining Surface Plasmon Resonance and Quartz Crystal Microbalance to Determine Hydration of Dendrimer Monolayers","volume":"120","author":"Jachimska","year":"2016","journal-title":"J. Phys. Chem. C"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.jcis.2017.05.002","article-title":"Quantitative Interpretation of PAMAM Dendrimers Adsorption on Silica Surface","volume":"503","author":"Tokarczyk","year":"2017","journal-title":"J. Colloid Interface Sci."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"5069","DOI":"10.1021\/ma201103n","article-title":"Conformational Changes of Polyamidoamine (PAMAM) Dendrimers Adsorbed on Silica Substrates","volume":"44","author":"Maroni","year":"2011","journal-title":"Macromolecules"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"3919","DOI":"10.1021\/ma3004295","article-title":"Ion-Specific Responsiveness of Polyamidoamine (PAMAM) Dendrimers Adsorbed on Silica Substrates","volume":"45","author":"Porus","year":"2012","journal-title":"Macromolecules"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"22603","DOI":"10.1021\/acs.jpcc.9b05752","article-title":"Conformational Properties of PAMAM Dendrimers Adsorbed on the Gold Surface Studied by Molecular Dynamics Simulation","volume":"123","author":"Wolski","year":"2019","journal-title":"J. Phys. Chem. C"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"8663","DOI":"10.1021\/jp0471958","article-title":"Dynamics and Thermodynamics of Water in PAMAM Dendrimers at Subnanosecond Time Scales","volume":"109","author":"Lin","year":"2005","journal-title":"J. Phys. Chem. B"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1021\/bc00023a012","article-title":"Polyamidoamine Cascade Polymers Mediate Efficient Transfection of Cells in Culture","volume":"4","author":"Haensler","year":"1993","journal-title":"Bioconjug. Chem."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.jconrel.2008.11.007","article-title":"Osteogenic Differentiation of Mesenchymal Stem Cells Using PAMAM Dendrimers as Gene Delivery Vectors","volume":"134","author":"Santos","year":"2009","journal-title":"J. Control. Release"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1016\/j.bmcl.2009.11.065","article-title":"Dendrimer-Based Tumor Cell Targeting of Fibroblast Growth Factor-1","volume":"20","author":"Thomas","year":"2010","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.ijpharm.2018.04.032","article-title":"PAMAM Dendrimers as a Carbamazepine Delivery System for Neurodegenerative Diseases: A Biophysical and Nanotoxicological Characterization","volume":"544","author":"Martinez","year":"2018","journal-title":"Int. J. Pharm."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1002\/jgm.2618","article-title":"Effective Healing of Diabetic Skin Wounds by Using Nonviral Gene Therapy Based on Minicircle Vascular Endothelial Growth Factor DNA and a Cationic Dendrimer","volume":"14","author":"Kwon","year":"2012","journal-title":"J. Gene Med."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1021\/mp200027z","article-title":"Injectable PAMAM Dendrimer-PEG Hydrogels for the Treatment of Genital Infections: Formulation and in Vitro and in Vivo Evaluation","volume":"8","author":"Navath","year":"2011","journal-title":"Mol. Pharm."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1021\/mp3005325","article-title":"Dendrimer Nanoscaffolds for Potential Theranostics of Prostate Cancer with a Focus on Radiochemistry","volume":"10","author":"Lo","year":"2013","journal-title":"Mol. Pharm."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1021\/mp200463e","article-title":"Nanoparticle Size and Surface Charge Determine Effects of PAMAM Dendrimers on Human Platelets in Vitro","volume":"9","author":"Dobrovolskaia","year":"2012","journal-title":"Mol. Pharm."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0168-3659(99)00246-1","article-title":"Dendrimers: Relationship between Structure and Biocompatibility in Vitro, and Preliminary Studies on the Biodistribution of 125I-Labelled Polyamidoamine Dendrimers in Vivo","volume":"65","author":"Malik","year":"2000","journal-title":"J. Control. Release"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"351","DOI":"10.2131\/jts.41.351","article-title":"Effects of PAMAM Dendrimers with Various Surface Functional Groups and Multiple Generations on Cytotoxicity and Neuronal Differentiation Using Human Neural Progenitor Cells","volume":"41","author":"Zeng","year":"2016","journal-title":"J. Toxicol. Sci."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.apmt.2018.05.002","article-title":"PAMAM Dendrimers as Efficient Drug and Gene Delivery Nanosystems for Cancer Therapy","volume":"12","author":"Dehghan","year":"2018","journal-title":"Appl. Mater. Today"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"2371","DOI":"10.1021\/acs.biomac.7b00567","article-title":"A Combination of Guanidyl and Phenyl Groups on a Dendrimer Enables Efficient SiRNA and DNA Delivery","volume":"18","author":"Chang","year":"2017","journal-title":"Biomacromolecules"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.ijpharm.2010.05.030","article-title":"Inhibition of Bacterial Growth and Intramniotic Infection in a Guinea Pig Model of Chorioamnionitis Using PAMAM Dendrimers","volume":"395","author":"Wang","year":"2010","journal-title":"Int. J. Pharm."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1080\/10837450.2016.1219372","article-title":"The Effect of PAMAM Dendrimer Concentration, Generation Size and Surface Functional Group on the Aqueous Solubility of Candesartan Cilexetil","volume":"22","year":"2017","journal-title":"Pharm. Dev. Technol."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"6229","DOI":"10.1103\/PhysRevE.58.6229","article-title":"Structural Properties of Methanol-Polyamidoamine Dendrimer Solutions","volume":"58","author":"Micali","year":"1998","journal-title":"Phys. Rev. E"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"3271","DOI":"10.1021\/la804234p","article-title":"Liquid-like Ordering of Negatively Charged Poly (Amidoamine) (PAMAM) Dendrimers in Solution","volume":"25","author":"Lombardo","year":"2009","journal-title":"Langmuir"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"2171","DOI":"10.1021\/la960603h","article-title":"Self-Assembled Multilayer Films from Dendrimers","volume":"13","author":"Tsukruk","year":"1997","journal-title":"Langmuir"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"5670","DOI":"10.1021\/la063717u","article-title":"Carboxyl-Terminated Dendrimer-Coated Bioactive Interface for Protein Microarray: High-Sensitivity Detection of Antigen in Complex Biological Samples","volume":"23","author":"Ajikumar","year":"2007","journal-title":"Langmuir"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.jcis.2011.09.029","article-title":"Surface-Immobilized PAMAM-Dendrimers Modified with Cationic or Anionic Terminal Functions: Physicochemical Surface Properties and Conformational Changes after Application of Liquid Interface Stress","volume":"366","author":"Katzur","year":"2012","journal-title":"J. Colloid Interface Sci."},{"key":"ref_143","first-page":"4121","article-title":"Selective Cytotoxicity of PAMAM G5 Core\u2013PAMAM G2.5 Shell Tecto-Dendrimers on Melanoma Cells","volume":"7","author":"Schilrreff","year":"2012","journal-title":"Int. J. Nanomed."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1006\/jcis.1999.6469","article-title":"Binding and Ion-Exchange Analysis in the Process of Adsorption of Anionic Polyelectrolytes on Barium Sulfate","volume":"219","author":"Balastre","year":"1999","journal-title":"J. Colloid Interface Sci."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"22426","DOI":"10.1021\/jp063981w","article-title":"Structure of Poly(Acrylic Acid) in Electrolyte Solutions Determined from Simulations and Viscosity Measurements","volume":"110","author":"Adamczyk","year":"2006","journal-title":"J. Phys. Chem. B"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"24583","DOI":"10.1039\/C7CP02547E","article-title":"Ability of the Poisson-Boltzmann Equation to Capture Molecular Dynamics Predicted Ion Distribution around Polyelectrolytes","volume":"19","author":"Batys","year":"2017","journal-title":"Phys. Chem. Chem. Phys."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.colsurfa.2009.01.037","article-title":"Colloid Particle Deposition on Heterogeneous Surfaces Produced by Polyelectrolyte Adsorption","volume":"343","author":"Adamczyk","year":"2009","journal-title":"Colloids Surfaces A Physicochem. Eng. Asp."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.1002\/mabi.201500153","article-title":"Cellular Response to Linear and Branched Poly(Acrylic Acid)","volume":"15","author":"Whitty","year":"2015","journal-title":"Macromol. Biosci."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"5137","DOI":"10.1021\/la0529613","article-title":"Water Distribution in Multilayers of Weak Polyelectrolytes","volume":"22","author":"Tanchak","year":"2006","journal-title":"Langmuir"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.jcis.2004.08.075","article-title":"Adsorption of Poly(Acrylic Acid) onto the Surface of Titanium Dioxide and the Colloidal Stability of Aqueous Suspension","volume":"281","author":"Liufu","year":"2005","journal-title":"J. Colloid Interface Sci."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0021-9797(03)00698-2","article-title":"Application of the SAXS Method and Viscometry for Determination of the Thickness of Adsorbed Polymer Layers at the ZrO2-Polymer Solution Interface","volume":"267","author":"Chibowski","year":"2003","journal-title":"J. Colloid Interface Sci."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"9351","DOI":"10.1039\/c2jm30834g","article-title":"Charged Drug Delivery by Ultrafast Exponentially Grown Weak Polyelectrolyte Multilayers: Amphoteric Properties, Ultrahigh Loading Capacity and PH-Responsiveness","volume":"22","author":"Yuan","year":"2012","journal-title":"J. Mater. Chem."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"3530","DOI":"10.1021\/acs.biomac.5b00967","article-title":"Growth Factor-Bearing Polymer Brushes-Versatile Bioactive Substrates Influencing Cell Response","volume":"16","author":"Psarra","year":"2015","journal-title":"Biomacromolecules"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"7016","DOI":"10.1021\/la200093e","article-title":"Cellular Responses to Patterned Poly(Acrylic Acid) Brushes","volume":"27","author":"Chiang","year":"2011","journal-title":"Langmuir"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"6526","DOI":"10.1016\/j.actbio.2013.01.041","article-title":"Dual PH- and Temperature-Responsive Microparticles for Protein Delivery to Ischemic Tissues","volume":"9","author":"Joshi","year":"2013","journal-title":"Acta Biomater."},{"key":"ref_156","unstructured":"Tekade, R.K. (2019). Basic Fundamentals of Drug Delivery, Academic Press."},{"key":"ref_157","unstructured":"Maiti, S., and Jana, S. (2019). Polysaccharide Carriers for Drug Delivery, Woodhead Publishing Limited. [1st ed.]."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.antiviral.2014.05.018","article-title":"In Vitro and in Vivo Evaluation of Two Carrageenan-Based Formulations to Prevent HPV Acquisition","volume":"108","author":"Kleinbeck","year":"2014","journal-title":"Antivir. Res."},{"key":"ref_159","doi-asserted-by":"crossref","unstructured":"Harding, S.E., Tombs, M.P., Adams, G.G., Paulsen, B.S., Inngjerdingen, K.T., and Barsett, H. (2017). An Introduction to Polysaccharide Biotechnology, Taylor & Francis Group.","DOI":"10.1201\/9781315372730"},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"7533","DOI":"10.1039\/C7RA13510F","article-title":"A Functional Chitosan-Based Hydrogel as a Wound Dressing and Drug Delivery System in the Treatment of Wound Healing","volume":"8","author":"Liu","year":"2018","journal-title":"RSC Adv."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"3196","DOI":"10.1021\/bm100736w","article-title":"Conformational Flexibility of Chitosan: A Molecular Modeling Study","volume":"11","author":"Skovstrup","year":"2010","journal-title":"Biomacromolecules"},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/S0142-9612(00)00183-6","article-title":"Influence of the Degree of Acetylation on Some Biological Properties of Chitosan Films","volume":"22","author":"Chatelet","year":"2001","journal-title":"Biomaterials"},{"key":"ref_163","first-page":"411","article-title":"Chitin and Chitosan: Production and Application of Versatile Biomedical Nanomaterials","volume":"4","author":"Hamblin","year":"2016","journal-title":"Int. J. Adv. Res."},{"key":"ref_164","doi-asserted-by":"crossref","unstructured":"Tsereteli, L., and Grafm\u00fcller, A. (2017). An Accurate Coarse-Grained Model for Chitosan Polysaccharides in Aqueous Solution. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0180938"},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1021\/bm010151+","article-title":"Viscosity of Semiflexible Chitosan Solutions: Influence of Concentration, Temperature, and Role of Intermolecular Interactions","volume":"3","author":"Desbrieres","year":"2002","journal-title":"Biomacromolecules"},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"7029","DOI":"10.1016\/S0032-3861(99)00056-7","article-title":"Influence of Acetic Acid Concentration on the Solubilization of Chitosan","volume":"40","author":"Rinaudo","year":"1999","journal-title":"Polymer"},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1080\/10236669908009742","article-title":"Solubilization of Chitosan in Strong Acid Medium","volume":"5","author":"Rinaudo","year":"1999","journal-title":"Int. J. Polym. Anal. Characr."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/j.carbpol.2008.11.025","article-title":"Macromolecular Conformation of Chitosan in Dilute Solution: A New Global Hydrodynamic Approach","volume":"76","author":"Morris","year":"2009","journal-title":"Carbohydr. Polym."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1021\/la00041a027","article-title":"PH-Dependent Interactions between Adsorbed Chitosan Layers","volume":"8","author":"Claesson","year":"1992","journal-title":"Langmuir"},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"4980","DOI":"10.1021\/la500680g","article-title":"Mechanism of Chitosan Adsorption on Silica from Aqueous Solutions","volume":"30","author":"Tiraferri","year":"2014","journal-title":"Langmuir"},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"6228","DOI":"10.1021\/la050502w","article-title":"Influence of Droplet Characteristics on the Formation of Oil-in-Water Emulsions Stabilized by Surfactant-Chitosan Layers","volume":"21","author":"Mun","year":"2005","journal-title":"Langmuir"},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1080\/10667857.2018.1521063","article-title":"Deposition of Thin Metal Layers on Chitosan Films","volume":"33","year":"2018","journal-title":"Mater. Technol."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"2892","DOI":"10.1002\/jps.21210","article-title":"Wound Healing Dressings and Drug Delivery Systems: A Review","volume":"97","author":"Boateng","year":"2008","journal-title":"J. Pharm. Sci."},{"key":"ref_174","doi-asserted-by":"crossref","unstructured":"de Sousa Victor, R., da Cunha Santos, A., de Sousa, B.V., de Ara\u00fajo Neves, G., de Lima Santana, L.N., and Menezes, R.R. (2020). A Review on Chitosan\u2019s Uses as Biomaterial: Tissue Engineering, Drug Delivery Systems and Cancer Treatment. Materials, 13.","DOI":"10.3390\/ma13214995"},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"5401461","DOI":"10.1155\/2022\/5401461","article-title":"Towards Induction of Angiogenesis in Dental Pulp Stem Cells Using Chitosan-Based Hydrogels Releasing Basic Fibroblast Growth Factor","volume":"2022","author":"Divband","year":"2022","journal-title":"Biomed Res. Int."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1080\/10717544.2022.2058645","article-title":"Gemcitabine Cationic Polymeric Nanoparticles against Ovarian Cancer: Formulation, Characterization, and Targeted Drug Delivery","volume":"29","author":"Bhattacharya","year":"2022","journal-title":"Drug Deliv."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"397","DOI":"10.17221\/1930-VETMED","article-title":"Hyaluronic Acid (Hyaluronan): A Review","volume":"53","author":"Necas","year":"2008","journal-title":"Vet. Med."},{"key":"ref_178","doi-asserted-by":"crossref","unstructured":"Fallacara, A., Baldini, E., Manfredini, S., and Vertuani, S. (2018). Hyaluronic Acid in the Third Millennium. Polymers, 10.","DOI":"10.3390\/polym10070701"},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/j.carres.2005.01.022","article-title":"Experimental Approaches to Hyaluronan Structure","volume":"340","author":"Cowman","year":"2005","journal-title":"Carbohydr. Res."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1529\/biophysj.104.049361","article-title":"Extended, Relaxed, and Condensed Conformations of Hyaluronan Observed by Atomic Force Microscopy","volume":"88","author":"Cowman","year":"2005","journal-title":"Biophys. J."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.jcis.2015.01.060","article-title":"Adsorption of Hyaluronic Acid on Solid Supports: Role of PH and Surface Chemistry in Thin Film Self-Assembly","volume":"448","author":"Choi","year":"2015","journal-title":"J. Colloid Interface Sci."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1007\/s40883-018-0072-0","article-title":"Polymeric Biomaterials for Scaffold-Based Bone Regenerative Engineerings","volume":"5","author":"Ogueri","year":"2019","journal-title":"Regen. Eng. Transl. Med."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"4742","DOI":"10.1021\/acsnano.9b01087","article-title":"Catalase-Integrated Hyaluronic Acid as Nanocarriers for Enhanced Photodynamic Therapy in Solid Tumor","volume":"13","author":"Phua","year":"2019","journal-title":"ACS Nano"},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.jconrel.2015.02.008","article-title":"Hyaluronic Acid Nanogels with Enzyme-Sensitive Cross-Linking Group for Drug Delivery","volume":"205","author":"Yang","year":"2015","journal-title":"J. Control. Release"},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/j.cej.2019.01.028","article-title":"Degradable Conductive Injectable Hydrogels as Novel Antibacterial, Anti-Oxidant Wound Dressings for Wound Healing","volume":"362","author":"Qu","year":"2019","journal-title":"Chem. Eng. J."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1002\/1521-3773(20020201)41:3<390::AID-ANIE390>3.0.CO;2-B","article-title":"Heparin-Protein Interactions","volume":"41","author":"Capila","year":"2002","journal-title":"Angew. Chem. Int. Ed."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.ancr.2014.12.001","article-title":"Quantitative Compositional Analysis of Heparin Using Exhaustive Heparinase Digestion and Strong Anion Exchange Chromatography","volume":"3","author":"Mourier","year":"2015","journal-title":"Anal. Chem. Res."},{"key":"ref_188","doi-asserted-by":"crossref","unstructured":"Banik, N., Yang, S.B., Kang, T.B., Lim, J.H., and Park, J. (2021). Heparin and Its Derivatives: Challenges and Advances in Therapeutic Biomolecules. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms221910524"},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s11095-008-9713-1","article-title":"Intracellular Delivery of Heparin Complexed with Chitosan-g-Poly(Ethylene Glycol) for Inducing Apoptosis","volume":"26","author":"Bae","year":"2009","journal-title":"Pharm. Res."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.jcis.2016.09.046","article-title":"Poly-L-Lysine\/Heparin Multilayer Coatings Prevent Blood Protein Adsorption","volume":"485","author":"Barrantes","year":"2017","journal-title":"J. Colloid Interface Sci."},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"469","DOI":"10.3389\/fbioe.2019.00469","article-title":"Growth Factor Engineering Strategies for Regenerative Medicine Applications","volume":"7","author":"Ren","year":"2020","journal-title":"Front. Bioeng. Biotechnol."},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1007\/s00216-010-4121-x","article-title":"Analysis and Characterization of Heparin Impurities","volume":"399","author":"Beni","year":"2011","journal-title":"Anal. Bioanal. Chem."},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1182\/blood.V79.1.1.1","article-title":"Low Molecular Weight Heparins","volume":"79","author":"Hirsh","year":"1992","journal-title":"Blood"},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"3214","DOI":"10.1248\/cpb.31.3214","article-title":"Effects of Calcium and Magnesium on the Anticoagulant Action of Heparin","volume":"31","author":"Yamane","year":"1983","journal-title":"Chem. Pharm. Bull."},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1007\/s00249-003-0316-9","article-title":"Conformation of Heparin Studied with Macromolecular Hydrodynamic Methods and X-Ray Scattering","volume":"32","author":"Pavlov","year":"2003","journal-title":"Eur. Biophys. J."},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/0168-3659(94)90264-X","article-title":"On the Employment of \u03bb-Carrageenan in a Matrix System. II. \u03bb-Carrageenan and Hydroxypropylmethylcellulose Mixtures","volume":"30","author":"Bonferoni","year":"1994","journal-title":"J. Control. Release"},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1128\/AAC.31.10.1524","article-title":"Purification and Characterization of an Avian Myeloblastosis and Human Immunodeficiency Virus Reverse Transcriptase Inhibitor, Sulfated Polysaccharides Extracted from Sea Algae","volume":"31","author":"Nakashima","year":"1987","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1007\/s10811-020-02143-y","article-title":"The COVID 19 Novel Coronavirus Pandemic 2020: Seaweeds to the Rescue? Why Does Substantial, Supporting Research about the Antiviral Properties of Seaweed Polysaccharides Seem to Go Unrecognized by the Pharmaceutical Community in These Desperate Times?","volume":"32","author":"Pereira","year":"2020","journal-title":"J. Appl. Phycol."},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"233","DOI":"10.4236\/aces.2014.42026","article-title":"Antibacterial Activity of Polyethylenimine\/Carrageenan Multilayer against Pathogenic Bacteria","volume":"4","author":"Briones","year":"2014","journal-title":"Adv. Chem. Eng. Sci."},{"key":"ref_200","doi-asserted-by":"crossref","unstructured":"Phillips, G.O., and Williams, P.A. (2009). Handbook of Hydrocolloids, Woodhead Publishing.","DOI":"10.1533\/9781845695873"},{"key":"ref_201","first-page":"3","article-title":"Effect of Process Conditions on the Gel Viscosity and Gel Strength of Semi-Refined Carrageenan (SRC) Produced from Seaweed (Kappaphycus Alvarezii)","volume":"26","author":"Bono","year":"2014","journal-title":"J. King Saud Univ.-Eng. Sci."},{"key":"ref_202","unstructured":"Reis, R.L., Neves, N., Mano, J.F., Gomes, M.E., Marques, A.P., and Azevedo, H.S. (2008). Natural-Based Polymers for Biomedical Applications, Woodhead Publishing."},{"key":"ref_203","unstructured":"Melton, L., Shahidi, F., and Varelis, P. (2019). Reference Module in Food Science, Academic Press."},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.carbpol.2013.04.027","article-title":"An Analytical Ultracentrifugation Based Study on the Conformation of Lambda Carrageenan in Aqueous Solution","volume":"97","author":"Almutairi","year":"2013","journal-title":"Carbohydr. Polym."},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"3508","DOI":"10.1002\/app.28937","article-title":"Physicochemical Characterization of Carrageenans\u2014A Critical Reinvestigation","volume":"110","author":"Berth","year":"2008","journal-title":"J. Appl. Polym. Sci."},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.phrs.2003.12.002","article-title":"In Vivo Antitumor and Immunomodulation Activities of Different Molecular Weight Lambda-Carrageenans from Chondrus Ocellatus","volume":"50","author":"Zhou","year":"2004","journal-title":"Pharmacol. Res."},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"487","DOI":"10.2109\/jcersj2.118.487","article-title":"Apatite Formation Abilities of Various Carrageenan Gels in Simulated Body Environment","volume":"118","author":"Nakata","year":"2010","journal-title":"J. Ceram. Soc. Jpn."},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1042\/bj2890331","article-title":"Carrageenans Inhibit Growth-Factor Binding","volume":"289","author":"Hoffman","year":"1993","journal-title":"Biochem. J."},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"119045","DOI":"10.1016\/j.carbpol.2021.119045","article-title":"Carrageenans for Tissue Engineering and Regenerative Medicine Applications: A Review","volume":"281","author":"Jafari","year":"2022","journal-title":"Carbohydr. Polym."},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1002\/1521-3935(20020101)203:1<15::AID-MACP15>3.0.CO;2-1","article-title":"Molecular Characteristics and Gelling Properties of the Carrageenan Family, 1: Preparation of Novel Carrageenans and Their Dilute Solution Properties","volume":"203","author":"Yuguchi","year":"2002","journal-title":"Macromol. Chem. Phys."},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/0141-8130(91)90005-F","article-title":"Dynamic Light Scattering by \u03ba- and \u03bb-Carrageenan Solutions","volume":"13","author":"Slootmaekers","year":"1991","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1111\/j.1365-2621.1965.tb00272.x","article-title":"The Effect of Selected Anions of Potassium Salts on the Viscosities of Lambda-Carrageenan Dispersions","volume":"30","author":"Zabik","year":"1965","journal-title":"J. Food Sci."},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1111\/j.1365-2621.1967.tb01966.x","article-title":"The Effect of Cations on the Viscosity of Lambda-Carrageenan","volume":"32","author":"Zabik","year":"1967","journal-title":"J. Food Sci."},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"4406","DOI":"10.1039\/c3tb20624f","article-title":"Nanocoatings Containing Sulfated Polysaccharides Prepared by Layer-by-Layer Assembly as Models to Study Cell-Material Interactions","volume":"1","author":"Oliveira","year":"2013","journal-title":"J. Mater. Chem. B"},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.biomaterials.2015.01.020","article-title":"Layer-by-Layer Assembled Cell Instructive Nanocoatings Containing Platelet Lysate","volume":"48","author":"Oliveira","year":"2015","journal-title":"Biomaterials"},{"key":"ref_216","doi-asserted-by":"crossref","first-page":"2065","DOI":"10.1021\/bm060378a","article-title":"Polyelectrolyte Films Based on Polysaccharides of Different Conformations: Effects on Multilayer Structure and Mechanical Properties","volume":"7","author":"Schoeler","year":"2006","journal-title":"Biomacromolecules"},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.carbpol.2013.02.048","article-title":"Oxygen Barrier of Multilayer Thin Films Comprised of Polysaccharides and Clay","volume":"95","author":"Laufer","year":"2013","journal-title":"Carbohydr. Polym."},{"key":"ref_218","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.jcis.2016.02.052","article-title":"Fabrication of Polyelectrolyte Multilayered Nano-Capsules Using a Continuous Layer-by-Layer Approach","volume":"470","author":"Elizarova","year":"2016","journal-title":"J. Colloid Interface Sci."},{"key":"ref_219","doi-asserted-by":"crossref","first-page":"7797","DOI":"10.1021\/acs.jpcb.1c03550","article-title":"Effect of the Anchoring Layer and Transport Type on the Adsorption Kinetics of Lambda Carrageenan","volume":"125","author":"Michna","year":"2021","journal-title":"J. Phys. Chem. B"},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1002\/jctb.4454","article-title":"Chondroitin Sulfate: Extraction, Purification, Microbial and Chemical Synthesis","volume":"89","author":"Shi","year":"2014","journal-title":"J. Chem. Technol. Biotechnol."},{"key":"ref_221","doi-asserted-by":"crossref","first-page":"119305","DOI":"10.1016\/j.carbpol.2022.119305","article-title":"Chondroitin Sulfate: Emerging Biomaterial for Biopharmaceutical Purpose and Tissue Engineering","volume":"286","author":"Sharma","year":"2022","journal-title":"Carbohydr. Polym."},{"key":"ref_222","doi-asserted-by":"crossref","unstructured":"Vessella, G., V\u00e1zquez, J.A., Valc\u00e1rcel, J., Lagartera, L., Monterrey, D.T., Bastida, A., Garc\u00eda-junceda, E., Bedini, E., Fern\u00e1ndez-mayoralas, A., and Revuelta, J. (2021). Deciphering Structural Determinants in Chondroitin Sulfate Binding to FGF-2: Paving the Way to Enhanced Predictability of Their Biological Functions. Polymers, 13.","DOI":"10.3390\/polym13020313"},{"key":"ref_223","doi-asserted-by":"crossref","first-page":"4277","DOI":"10.3390\/molecules20034277","article-title":"Discrepancies in Composition and Biological Effects of Different Formulations of Chondroitin Sulfate","volume":"20","author":"Farran","year":"2015","journal-title":"Molecules"},{"key":"ref_224","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.surfcoat.2017.02.037","article-title":"Electrophoretic Deposition of Chondroitin Sulfate-Chitosan\/Bioactive Glass Composite Coatings with Multilayer Design","volume":"315","author":"Boccaccini","year":"2017","journal-title":"Surf. Coatings Technol."},{"key":"ref_225","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.matlet.2014.01.099","article-title":"Chitosan\/Chondroitin Sulfate Multilayers as Supports for Calcium Phosphate Biomineralization","volume":"121","author":"Leite","year":"2014","journal-title":"Mater. Lett."},{"key":"ref_226","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1186\/s12951-022-01261-8","article-title":"Chondroitin Sulfate-AuNRs Electroactive Scaffolds for on-Demand Release of Biofactors","volume":"20","author":"Malki","year":"2022","journal-title":"J. Nanobiotechnol."},{"key":"ref_227","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1021\/acs.bioconjchem.5b00266","article-title":"Growth Factor Tethering to Protein Nanoparticles via Coiled-Coil Formation for Targeted Drug Delivery","volume":"26","author":"Assal","year":"2015","journal-title":"Bioconjug. Chem."},{"key":"ref_228","doi-asserted-by":"crossref","first-page":"3939","DOI":"10.1021\/acsbiomaterials.8b01098","article-title":"Protein Nanoparticles: Promising Platforms for Drug Delivery Applications","volume":"4","author":"Jain","year":"2018","journal-title":"ACS Biomater. Sci. Eng."},{"key":"ref_229","doi-asserted-by":"crossref","first-page":"31600","DOI":"10.1021\/acsami.7b10408","article-title":"Targeted Delivery System Based on Gemcitabine-Loaded Silk Fibroin Nanoparticles for Lung Cancer Therapy","volume":"9","author":"Mottaghitalab","year":"2017","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_230","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.ijbiomac.2015.08.006","article-title":"Recent Advancement of Gelatin Nanoparticles in Drug and Vaccine Delivery","volume":"81","author":"Sahoo","year":"2015","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_231","doi-asserted-by":"crossref","unstructured":"Hong, S., Choi, D.W., Kim, H.N., Park, C.G., Lee, W., and Park, H.H. (2020). Protein-Based Nanoparticles as Drug Delivery Systems. Pharmaceutics, 12.","DOI":"10.3390\/pharmaceutics12070604"},{"key":"ref_232","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.jconrel.2012.12.015","article-title":"Combined Delivery of BMP-2 and BFGF from Nanostructured Colloidal Gelatin Gels and Its Effect on Bone Regeneration in Vivo","volume":"166","author":"Wang","year":"2013","journal-title":"J. Control. Release"},{"key":"ref_233","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.ijpharm.2009.12.052","article-title":"Silk Fibroin Nanoparticles for Cellular Uptake and Control Release","volume":"388","author":"Kundu","year":"2010","journal-title":"Int. J. Pharm."},{"key":"ref_234","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1002\/btpr.12","article-title":"Polyethylenimine-Coated Albumin Nanoparticles for BMP-2 Delivery","volume":"24","author":"Zhang","year":"2008","journal-title":"Biotechnol. Prog."},{"key":"ref_235","doi-asserted-by":"crossref","first-page":"2505","DOI":"10.1002\/smll.201200066","article-title":"Epidermal Growth Factor-Ferritin H-Chain Protein Nanoparticles for Tumor Active Targeting","volume":"8","author":"Li","year":"2012","journal-title":"Small"},{"key":"ref_236","doi-asserted-by":"crossref","first-page":"346","DOI":"10.3390\/polym6020346","article-title":"Hyaluronic Acid Bioconjugates for the Delivery of Bioactive Molecules","volume":"6","author":"Mero","year":"2014","journal-title":"Polymers"},{"key":"ref_237","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/0003-9861(88)90153-1","article-title":"Self-Association of Hyaluronate Segments in Aqueous NaCl Solution","volume":"265","author":"Turner","year":"1988","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_238","first-page":"327","article-title":"Hyaluronan: Pharmaceutical Characterization and Drug Delivery","volume":"12","author":"Liao","year":"2005","journal-title":"Drug Deliv. J. Deliv. Target. Ther. Agents"},{"key":"ref_239","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1023\/A:1007502828372","article-title":"Growth Factor Delivery for Tissue Engineering","volume":"17","author":"Babensee","year":"2000","journal-title":"Pharm. Res."},{"key":"ref_240","doi-asserted-by":"crossref","unstructured":"Vishwakarma, A., Sharpe, P., Shi, S., and Ramalingam, M. (2015). Stem Cell Biology and Tissue Engineering in Dental Sciences, Academic Press.","DOI":"10.1016\/B978-0-12-397157-9.00001-1"},{"key":"ref_241","doi-asserted-by":"crossref","unstructured":"Asakura, H., Aoyagi, Y., and Nakazawa, S. (2001). Trends in Gastroenterology and Hepatology, Springer.","DOI":"10.1007\/978-4-431-67895-3"},{"key":"ref_242","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.matbio.2018.03.007","article-title":"Connective Tissue Growth Factor (CTGF) from Basics to Clinics","volume":"68\u201369","author":"Ramazani","year":"2018","journal-title":"Matrix Biol."},{"key":"ref_243","doi-asserted-by":"crossref","unstructured":"Bauersachs, J., Butler, J., and Sandner, P. (2016). Heart Failure. Handbook of Experimental Pharmacology, Springer.","DOI":"10.1007\/978-3-319-59659-4"},{"key":"ref_244","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.cytogfr.2014.07.018","article-title":"The IL-2 Cytokine Family in Cancer Immunotherapy","volume":"25","author":"Sim","year":"2014","journal-title":"Cytokine Growth Factor Rev."},{"key":"ref_245","doi-asserted-by":"crossref","first-page":"5634","DOI":"10.1038\/s41598-021-85149-x","article-title":"Epidermal and Fibroblast Growth Factors Incorporated Polyvinyl Alcohol Electrospun Nanofibers as Biological Dressing Scaffold","volume":"11","author":"Asiri","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_246","doi-asserted-by":"crossref","first-page":"118256","DOI":"10.1016\/j.carbpol.2021.118256","article-title":"Sulfated Carboxymethylcellulose Conjugated Electrospun Fibers as a Growth Factor Presenting System for Tissue Engineering","volume":"268","author":"Bhutada","year":"2021","journal-title":"Carbohydr. Polym."},{"key":"ref_247","doi-asserted-by":"crossref","first-page":"599631","DOI":"10.3389\/fchem.2021.599631","article-title":"Electrically Stimulated Tunable Drug Delivery From Polypyrrole-Coated Polyvinylidene Fluoride","volume":"9","author":"Miar","year":"2021","journal-title":"Front. Chem."},{"key":"ref_248","doi-asserted-by":"crossref","unstructured":"Benbow, N.L., Karpiniec, S., Krasowska, M., and Beattie, D.A. (2020). Incorporation of FGF-2 into Pharmaceutical Grade Fucoidan\/Chitosan Polyelectrolyte Multilayers. Mar. Drugs, 18.","DOI":"10.3390\/md18110531"},{"key":"ref_249","doi-asserted-by":"crossref","first-page":"6183","DOI":"10.1016\/j.biomaterials.2011.04.036","article-title":"Tunable Dual Growth Factor Delivery from Polyelectrolyte Multilayer Films","volume":"32","author":"Shah","year":"2011","journal-title":"Biomaterials"},{"key":"ref_250","doi-asserted-by":"crossref","first-page":"113162","DOI":"10.1016\/j.bbr.2021.113162","article-title":"The Role of Pro- and Mature Neurotrophins in the Depression","volume":"404","author":"Xue","year":"2021","journal-title":"Behav. Brain Res."},{"key":"ref_251","unstructured":"Litwack, G. (2020). Hormonal Signaling in Biology and Medicine, Academic Press."},{"key":"ref_252","doi-asserted-by":"crossref","first-page":"8292","DOI":"10.1167\/iovs.13-12221","article-title":"Long-Term Neuroprotective Effects of NT-4-Engineered Mesenchymal Stem Cells Injected Intravitreally in a Mouse Model of Acute Retinal Injury","volume":"54","author":"Kawa","year":"2013","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_253","doi-asserted-by":"crossref","first-page":"9548","DOI":"10.1021\/acs.langmuir.7b00909","article-title":"Adsorption\/Desorption Transition of Recombinant Human Neurotrophin 4: Physicochemical Characterization","volume":"33","author":"Adamczak","year":"2017","journal-title":"Langmuir"},{"key":"ref_254","first-page":"790","article-title":"Therapeutic Potential of Neurotrophins for Repair after Brain Injury: A Helping Hand from Biomaterials","volume":"13","author":"Houlton","year":"2019","journal-title":"Front. Genet."},{"key":"ref_255","doi-asserted-by":"crossref","first-page":"939","DOI":"10.3389\/fimmu.2018.00939","article-title":"Nerve Growth Factor and Pathogenesis of Leprosy: Review and Update","volume":"9","author":"Quaresma","year":"2018","journal-title":"Front. Immunol."},{"key":"ref_256","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1038\/mp.2010.103","article-title":"The Role of Neurotrophic Factors in Autism","volume":"16","author":"Michel","year":"2011","journal-title":"Mol. Psychiatry"},{"key":"ref_257","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.jmb.2012.08.002","article-title":"The Crystal Structures of TrkA and TrkB Suggest Key Regions for Achieving Selective Inhibition","volume":"423","author":"Bertrand","year":"2012","journal-title":"J. Mol. Biol."},{"key":"ref_258","doi-asserted-by":"crossref","first-page":"10084","DOI":"10.1021\/acs.jmedchem.6b00850","article-title":"The Discovery of a Potent, Selective, and Peripherally Restricted Pan-Trk Inhibitor (PF-06273340) for the Treatment of Pain","volume":"59","author":"Skerratt","year":"2016","journal-title":"J. Med. Chem."},{"key":"ref_259","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/bs.vh.2016.10.007","article-title":"Structural Characterization of the P75 Neurotrophin Receptor: A Stranger in the TNFR Superfamily","volume":"Volume 104","author":"Litwack","year":"2017","journal-title":"Vitamins and Hormones"},{"key":"ref_260","doi-asserted-by":"crossref","unstructured":"Liu, P., Li, S., and Tang, L. (2021). Nerve Growth Factor: A Potential Therapeutic Target for Lung Diseases. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22179112"},{"key":"ref_261","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/s41584-020-00528-4","article-title":"The Evolution of Nerve Growth Factor Inhibition in Clinical Medicine","volume":"17","author":"Wise","year":"2021","journal-title":"Nat. Rev. Rheumatol."},{"key":"ref_262","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/bs.vh.2016.11.002","article-title":"Neurotrophins: Role in Placental Growth and Development","volume":"Volume 104","author":"Litwack","year":"2017","journal-title":"Vitamins and Hormones"},{"key":"ref_263","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1111\/j.1432-1033.1972.tb02004.x","article-title":"The Isolation and Characterization of Nerve-Growth Factor from the Venom of Vipera Russelli","volume":"29","author":"Pearce","year":"1972","journal-title":"Eur. J. Biochem."},{"key":"ref_264","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1002\/j.1460-2075.1982.tb01207.x","article-title":"Purification of a New Neurotrophic Factor from Mammalian Brain","volume":"1","author":"Barde","year":"1982","journal-title":"EMBO J."},{"key":"ref_265","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.5114\/aoms.2015.56342","article-title":"Brain-Derived Neurotrophic Factor and Its Clinical Implications","volume":"11","author":"Bathina","year":"2015","journal-title":"Arch. Med. Sci."},{"key":"ref_266","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1186\/s12951-020-00673-8","article-title":"Novel Design of (PEG-ylated ) PAMAM - Based Nanoparticles for Sustained Delivery of BDNF to Neurotoxin-Injured Differentiated Neuroblastoma Cells","volume":"18","author":"Wasilewska","year":"2020","journal-title":"J. Nanobiotechnol."},{"key":"ref_267","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1039\/C3CP52499J","article-title":"Adsorption of NGF and BDNF Derived Peptides on Gold Surfaces","volume":"16","author":"Forte","year":"2014","journal-title":"Phys. Chem. Chem. Phys."},{"key":"ref_268","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.1126\/science.2321006","article-title":"Neurotrophin-3: A Neurotrophic Factor Related to NGF and BDNF","volume":"247","author":"Maisonpierre","year":"1990","journal-title":"Science"},{"key":"ref_269","doi-asserted-by":"crossref","unstructured":"Matatagui, D., Bastida, \u00c1., and Horrillo, M.C. (2022). Novel SH-SAW Biosensors for Ultra-Fast Recognition of Growth Factors. Biosensors, 12.","DOI":"10.3390\/bios12010017"},{"key":"ref_270","doi-asserted-by":"crossref","first-page":"6117","DOI":"10.2147\/IJN.S210140","article-title":"Electrostatic Complex of Neurotrophin 4 with Dendrimer Nanoparticles: Controlled Release of Protein in Vitro and in Vivo","volume":"14","author":"Adamczak","year":"2019","journal-title":"Int. J. Nanomed."},{"key":"ref_271","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.genhosppsych.2015.03.001","article-title":"Serum Brain-Derived Neurotrophic Factor Differences between the Luteal and Follicular Phases in Premenstrual Dysphoric Disorder","volume":"37","author":"Oral","year":"2015","journal-title":"Gen. Hosp. Psychiatry"},{"key":"ref_272","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.jpsychires.2019.03.024","article-title":"Cerebrospinal Fluid BDNF Pro-Peptide Levels in Major Depressive Disorder and Schizophrenia","volume":"113","author":"Mizui","year":"2019","journal-title":"J. Psychiatr. Res."},{"key":"ref_273","doi-asserted-by":"crossref","first-page":"323","DOI":"10.4252\/wjsc.v12.i5.323","article-title":"Advances in Treatment of Neurodegenerative Diseases: Perspectives for Combination of Stem Cells with Neurotrophic Factors","volume":"12","author":"Wang","year":"2020","journal-title":"World J. Stem Cells"},{"key":"ref_274","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1002\/ana.20794","article-title":"Expectations and Challenges in the Therapeutic Use of Neurotrophic Factors","volume":"59","author":"Kotzbauer","year":"2006","journal-title":"Ann. Neurol."},{"key":"ref_275","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/0169-328X(95)00250-V","article-title":"Permeability at the Blood-Brain and Blood-Nerve Barriers of the Neurotrophic Factors: NGF, CNTF, NT-3, BDNF","volume":"36","author":"Poduslo","year":"1996","journal-title":"Mol. Brain Res."},{"key":"ref_276","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1212\/WNL.60.1.69","article-title":"Randomized, Double-Blind Trial of Glial Cell Line-Derived Neurotrophic Factor (GDNF) in PD","volume":"60","author":"Nutt","year":"2003","journal-title":"Neurology"},{"key":"ref_277","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1080\/08977194.2017.1395420","article-title":"Cardiac Autonomic Denervation and Expression of Neurotrophins (NGF and BDNF) and Their Receptors during Experimental Chagas Disease","volume":"35","author":"Oliveira","year":"2017","journal-title":"Growth Factors"},{"key":"ref_278","first-page":"127","article-title":"Effect of Recombinant Human Nerve Growth Factor Eye Drops in Patients with Dry Eye: A Phase IIa, Open Label, Multiple-Dose Study","volume":"104","author":"Sacchetti","year":"2020","journal-title":"Br. J. Ophthalmol."},{"key":"ref_279","doi-asserted-by":"crossref","first-page":"2165","DOI":"10.1161\/STROKEAHA.106.477331","article-title":"Intravenous Brain-Derived Neurotrophic Factor Enhances Poststroke Sensorimotor Recovery and Stimulates Neurogenesis","volume":"38","author":"Steigleder","year":"2007","journal-title":"Stroke"},{"key":"ref_280","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.expneurol.2010.01.011","article-title":"Transgenic BDNF Induces Nerve Fiber Regrowth into the Auditory Epithelium in Deaf Cochleae","volume":"223","author":"Shibata","year":"2010","journal-title":"Exp. Neurol."},{"key":"ref_281","doi-asserted-by":"crossref","first-page":"846681","DOI":"10.3389\/fnins.2022.846681","article-title":"Neurotrophins as Therapeutic Agents for Parkinson\u2019s Disease; New Chances From Focused Ultrasound?","volume":"16","author":"Stefani","year":"2022","journal-title":"Front. Neurosci."},{"key":"ref_282","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.jconrel.2004.05.003","article-title":"Controlled Release of Neurotrophin-3 from Fibrin Gels for Spinal Cord Injury","volume":"98","author":"Taylor","year":"2004","journal-title":"J. Control. Release"},{"key":"ref_283","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1093\/jb\/mvq121","article-title":"Fibroblast Growth Factors: From Molecular Evolution to Roles in Development, Metabolism and Disease","volume":"149","author":"Itoh","year":"2011","journal-title":"J. Biochem."},{"key":"ref_284","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1002\/wdev.176","article-title":"The Fibroblast Growth Factor Signaling Pathway","volume":"4","author":"Ornitz","year":"2015","journal-title":"Wiley Interdiscip. Rev. Dev. Biol."},{"key":"ref_285","doi-asserted-by":"crossref","first-page":"3627","DOI":"10.1210\/jc.2008-0746","article-title":"Plasma Concentrations of Fibroblast Growth Factors 19 and 21 in Patients with Anorexia Nervosa","volume":"93","year":"2008","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_286","first-page":"797","article-title":"Roles of FGF8 Subfamily in Embryogenesis and Oral-maxillofacial Diseases (Review)","volume":"54","author":"Hao","year":"2019","journal-title":"Int. J. Oncol."},{"key":"ref_287","doi-asserted-by":"crossref","first-page":"500","DOI":"10.3389\/fgene.2018.00500","article-title":"Regulation of FGF10 Signaling in Development and Disease","volume":"9","author":"Watson","year":"2018","journal-title":"Front. Genet."},{"key":"ref_288","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1016\/S0002-9149(00)00787-6","article-title":"Effects of a Single Intracoronary Injection of Basic Fibroblast Growth Factor in Stable Angina Pectoris","volume":"85","author":"Unger","year":"2000","journal-title":"Am. J. Cardiol."},{"key":"ref_289","first-page":"5365","article-title":"Experimental Study of Epidermal Growth Factor and Acidic Fibroblast Growth Factor in the Treatment of Diabetic Foot Wounds","volume":"15","author":"Xu","year":"2018","journal-title":"Exp. Ther. Med."},{"key":"ref_290","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.mce.2015.09.018","article-title":"Fibroblast Growth Factor-21, Energy Balance and Obesity","volume":"418","author":"Giralt","year":"2015","journal-title":"Mol. Cell. Endocrinol."},{"key":"ref_291","first-page":"151","article-title":"Fibroblast Growth Factor 1 Gene-Transfected Adipose-Derived Mesenchymal Stem Cells Modulate Apoptosis and Inflammation in the Chronic Constriction Injury Model of Neuropathic Pain","volume":"19","author":"Forouzanfar","year":"2020","journal-title":"Iran. J. Pharm. Res."},{"key":"ref_292","doi-asserted-by":"crossref","first-page":"211","DOI":"10.2174\/157489006777442478","article-title":"Fibroblast Growth Factors, Fibroblast Growth Factor Receptors, Diseases, and Drugs","volume":"1","author":"Chen","year":"2006","journal-title":"Recent Pat. Cardiovasc. Drug Discov."},{"key":"ref_293","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1007\/PL00001972","article-title":"Induktion Der Myokardialen Neoangiogenese Durch Humane Wachstumsfaktoren (Induction of Myocardial Neoangiogenesis by Human Growth Factors. A New Therapeutic Option in Coronary Heart Disease)","volume":"25","author":"Stegmann","year":"2000","journal-title":"Herz"},{"key":"ref_294","doi-asserted-by":"crossref","unstructured":"Huang, H.W., Yang, C.M., and Yang, C.H. (2021). Fibroblast Growth Factor Type 1 Ameliorates High-glucose-induced Oxidative Stress and Neuroinflammation in Retinal Pigment Epithelial Cells and a Streptozotocin-induced Diabetic Rat Model. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22137233"},{"key":"ref_295","doi-asserted-by":"crossref","first-page":"112187","DOI":"10.1016\/j.msec.2021.112187","article-title":"Polyelectrolyte Multilayer Composite Coating on 316 L Stainless Steel for Controlled Release of Dual Growth Factors Accelerating Restoration of Bone Defects","volume":"126","author":"Liu","year":"2021","journal-title":"Mater. Sci. Eng. C"},{"key":"ref_296","doi-asserted-by":"crossref","first-page":"104933","DOI":"10.1016\/j.reactfunctpolym.2021.104933","article-title":"Effects of Basic Fibroblast Growth Factor Combined with an Injectable in Situ Crosslinked Hyaluronic Acid Hydrogel for a Dermal Filler","volume":"164","author":"Kim","year":"2021","journal-title":"React. Funct. Polym."},{"key":"ref_297","doi-asserted-by":"crossref","unstructured":"Hu, C., Ayan, B., Chiang, G., Chan, A.H.P., Rando, T.A., and Huang, N.F. (2022). Comparative Effects of Basic Fibroblast Growth Factor Delivery or Voluntary Exercise on Muscle Regeneration after Volumetric Muscle Loss. Bioengineering, 9.","DOI":"10.3390\/bioengineering9010037"},{"key":"ref_298","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1159\/000513534","article-title":"FGF3 from the Hypothalamus Regulates the Guidance of Thalamocortical Axons","volume":"42","author":"Liu","year":"2021","journal-title":"Dev. Neurosci."},{"key":"ref_299","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1016\/j.jacc.2007.06.010","article-title":"Effects of Ad5FGF-4 in Patients With Angina","volume":"50","author":"Henry","year":"2007","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_300","doi-asserted-by":"crossref","first-page":"e14530","DOI":"10.1111\/dth.14530","article-title":"Effect of Cysteine-Free Human Fibroblast Growth Factor-5s Mutant (FGF5sC93S) on Hair Growth","volume":"33","author":"Kim","year":"2020","journal-title":"Dermatol. Ther."},{"key":"ref_301","doi-asserted-by":"crossref","first-page":"2040","DOI":"10.1101\/gad.11.16.2040","article-title":"A Role for FGF-6 in Skeletal Muscle Regeneration","volume":"11","author":"Floss","year":"1997","journal-title":"Genes Dev."},{"key":"ref_302","doi-asserted-by":"crossref","first-page":"e149969","DOI":"10.1172\/jci.insight.149969","article-title":"Skeletal Muscle\u2013Targeted Delivery of Fgf6 Protects Mice from Diet-Induced Obesity and Insulin Resistance","volume":"6","author":"Xu","year":"2021","journal-title":"JCI Insight"},{"key":"ref_303","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1159\/000330073","article-title":"Expression and Function of Fibroblast Growth Factor (FGF) 7 during Liver Regeneration","volume":"27","author":"Tsai","year":"2011","journal-title":"Cell. Physiol. Biochem."},{"key":"ref_304","doi-asserted-by":"crossref","unstructured":"Jin, L., Yoon, S.J., Lee, D.H., Pyun, Y.C., Kim, W.Y., Lee, J.H., Khang, G., Chun, H.J., and Yang, D.H. (2021). Preparation of Foam Dressings Based on Gelatin, Hyaluronic Acid, and Carboxymethyl Chitosan Containing Fibroblast Growth Factor-7 for Dermal Regeneration. Polymers, 13.","DOI":"10.3390\/polym13193279"},{"key":"ref_305","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.jprot.2018.05.004","article-title":"Proteome Response of Dental Pulp Cells to Exogenous FGF8","volume":"183","author":"Tsikandelova","year":"2018","journal-title":"J. Proteom."},{"key":"ref_306","doi-asserted-by":"crossref","first-page":"118952","DOI":"10.1016\/j.lfs.2020.118952","article-title":"FGF9 Induces Neurite Outgrowth upon ERK Signaling in Knock-in Striatal Huntington\u2019s Disease Cells","volume":"267","author":"Yusuf","year":"2021","journal-title":"Life Sci."},{"key":"ref_307","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.cytogfr.2015.10.001","article-title":"FGF10: A Multifunctional Mesenchymal-Epithelial Signaling Growth Factor in Development, Health, and Disease","volume":"28","author":"Itoh","year":"2016","journal-title":"Cytokine Growth Factor Rev."},{"key":"ref_308","doi-asserted-by":"crossref","first-page":"1778","DOI":"10.1161\/HYPERTENSIONAHA.120.15068","article-title":"Smooth Muscle Cell Remodeling in Pulmonary Arterial Hypertension","volume":"76","author":"Yeo","year":"2020","journal-title":"Hypertension"},{"key":"ref_309","doi-asserted-by":"crossref","first-page":"4655","DOI":"10.1111\/cas.15137","article-title":"FGF13 Enhances Resistance to Platinum Drugs by Regulating HCTR1 and ATP7A via a Microtubule-Stabilizing Effect","volume":"112","author":"Yu","year":"2021","journal-title":"Cancer Sci."},{"key":"ref_310","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.jare.2020.12.009","article-title":"Fibroblast Growth Factor 13 Stabilizes Microtubules to Promote Na+ Channel Function in Nociceptive DRG Neurons and Modulates Inflammatory Pain","volume":"31","author":"Wang","year":"2021","journal-title":"J. Adv. Res."},{"key":"ref_311","doi-asserted-by":"crossref","first-page":"6752","DOI":"10.1523\/JNEUROSCI.2663-14.2015","article-title":"Intracellular FGF14 (IFGF14) Is Required for Spontaneous and Evoked Firing in Cerebellar Purkinje Neurons and for Motor Coordination and Balance","volume":"35","author":"Bosch","year":"2015","journal-title":"J. Neurosci."},{"key":"ref_312","first-page":"936","article-title":"GATA4 Regulates Fgf16 to Promote Heart Repair after Injury","volume":"143","author":"Yu","year":"2016","journal-title":"Development"},{"key":"ref_313","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1007\/s12012-013-9203-5","article-title":"FGF-2 and FGF-16 Protect Isolated Perfused Mouse Hearts from Acute Doxorubicin-Induced Contractile Dysfunction","volume":"13","author":"Sontag","year":"2013","journal-title":"Cardiovasc. Toxicol."},{"key":"ref_314","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1111\/j.1601-183X.2007.00357.x","article-title":"Abnormal Social Behaviors in Mice Lacking Fgf17","volume":"7","author":"Roberson","year":"2008","journal-title":"Genes Brain Behav."},{"key":"ref_315","doi-asserted-by":"crossref","first-page":"4435","DOI":"10.1172\/JCI70625","article-title":"FGF18 as a Prognostic and Therapeutic Biomarker in Ovarian Cancer","volume":"123","author":"Wei","year":"2013","journal-title":"J. Clin. Investig."},{"key":"ref_316","doi-asserted-by":"crossref","unstructured":"Maeda, T., Kanzaki, H., Chiba, T., Ao, J., Kanayama, K., Maruta, S., Kusakabe, Y., Saito, T., Kobayashi, K., and Kiyono, S. (2019). Serum Fibroblast Growth Factor 19 Serves as a Potential Novel Biomarker for Hepatocellular Carcinoma. BMC Cancer, 19.","DOI":"10.1186\/s12885-019-6322-9"},{"key":"ref_317","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1038\/nm.4363","article-title":"Fibroblast Growth Factor 19 Regulates Skeletal Muscle Mass and Ameliorates Muscle Wasting in Mice","volume":"23","author":"Benoit","year":"2017","journal-title":"Nat. Med."},{"key":"ref_318","doi-asserted-by":"crossref","first-page":"1560","DOI":"10.1080\/10717544.2018.1482972","article-title":"Efficient Treatment of Parkinson\u2019s Disease Using Ultrasonography-Guided Rhfgf20 Proteoliposomes","volume":"25","author":"Niu","year":"2018","journal-title":"Drug Deliv."},{"key":"ref_319","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1111\/cen.12095","article-title":"Fibroblast Growth Factor 21 as an Emerging Metabolic Regulator: Clinical Perspectives","volume":"78","author":"Woo","year":"2013","journal-title":"Clin. Endocrinol."},{"key":"ref_320","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.biologicals.2020.11.005","article-title":"Preparation, Characterization, and Pharmacological Study of a Novel Long-Acting FGF21 with a Potential Therapeutic Effect in Obesity","volume":"69","author":"Kim","year":"2021","journal-title":"Biologicals"},{"key":"ref_321","doi-asserted-by":"crossref","first-page":"130827","DOI":"10.1016\/j.cej.2021.130827","article-title":"Alginate Self-Adhesive Hydrogel Combined with Dental Pulp Stem Cells and FGF21 Repairs Hemisection Spinal Cord Injury via Apoptosis and Autophagy Mechanisms","volume":"426","author":"Zhu","year":"2021","journal-title":"Chem. Eng. J."},{"key":"ref_322","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1038\/s41598-021-00906-2","article-title":"Fibroblast Growth Factor-21 as a Novel Metabolic Factor for Regulating Thrombotic Homeostasis","volume":"12","author":"Li","year":"2022","journal-title":"Sci. Rep."},{"key":"ref_323","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1111\/cns.12760","article-title":"Fibroblast Growth Factor 22 Is a Novel Modulator of Depression through Interleukin-1\u03b2","volume":"23","author":"Xu","year":"2017","journal-title":"CNS Neurosci. Ther."},{"key":"ref_324","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1515\/med-2021-0288","article-title":"Serum Intact Fibroblast Growth Factor 23 in Healthy Paediatric Population","volume":"16","author":"Stanczyk","year":"2021","journal-title":"Open Med."},{"key":"ref_325","doi-asserted-by":"crossref","unstructured":"Kourtidou, C., Stangou, M., Marinaki, S., and Tziomalos, K. (2021). Novel Cardiovascular Risk Factors in Patients with Diabetic Kidney Disease. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms222011196"},{"key":"ref_326","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.cytogfr.2021.05.003","article-title":"Snake Venom Vascular Endothelial Growth Factors (SvVEGFs): Unravelling Their Molecular Structure, Functions, and Research Potential","volume":"60","author":"Ferreira","year":"2021","journal-title":"Cytokine Growth Factor Rev."},{"key":"ref_327","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1084\/jem.133.2.275","article-title":"Isolation of a Tumor Factor Responsible for Angiogenesis","volume":"133","author":"Folkman","year":"1971","journal-title":"J. Exp. Med."},{"key":"ref_328","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1016\/j.cell.2019.01.021","article-title":"VEGF in Signaling and Disease: Beyond Discovery and Development","volume":"176","author":"Apte","year":"2019","journal-title":"Cell"},{"key":"ref_329","doi-asserted-by":"crossref","first-page":"741","DOI":"10.3233\/JAD-170745","article-title":"VEGFR1 and VEGFR2 in Alzheimer\u2019s Disease","volume":"61","author":"Harris","year":"2018","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref_330","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/s41573-021-00355-6","article-title":"VEGFA MRNA for Regenerative Treatment of Heart Failure","volume":"21","author":"Bergenhem","year":"2022","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_331","doi-asserted-by":"crossref","first-page":"10313","DOI":"10.3389\/bjbs.2022.10313","article-title":"Angiogenesis, Metabolism, Endothelial and Platelet Markers in Diabetes and Cardiovascular Disease","volume":"79","author":"Blann","year":"2022","journal-title":"Br. J. Biomed. Sci."},{"key":"ref_332","doi-asserted-by":"crossref","first-page":"738325","DOI":"10.3389\/fcvm.2021.738325","article-title":"The Role of the VEGF Family in Coronary Heart Disease","volume":"8","author":"Zhou","year":"2021","journal-title":"Front. Cardiovasc. Med."},{"key":"ref_333","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1038\/s41598-021-03837-0","article-title":"Neuropathogenicity of Non-Viable Borrelia Burgdorferi Ex Vivo","volume":"12","author":"Parthasarathy","year":"2022","journal-title":"Sci. Rep."},{"key":"ref_334","doi-asserted-by":"crossref","first-page":"579603","DOI":"10.3389\/fmed.2020.579603","article-title":"Thrombotic Microangiopathy and Acute Kidney Injury Induced After Intravitreal Injection of Vascular Endothelial Growth Factor Inhibitors VEGF Blockade-Related TMA After Intravitreal Use","volume":"7","author":"Hanna","year":"2020","journal-title":"Front. Med."},{"key":"ref_335","doi-asserted-by":"crossref","unstructured":"Daien, V., Eldem, B.M., Talks, J.S., Korobelnik, J.F., Mitchell, P., Finger, R.P., Sakamoto, T., Wong, T.Y., Evuarherhe, O., and Carter, G. (2019). Real-World Data in Retinal Diseases Treated with Anti-Vascular Endothelial Growth Factor (Anti-VEGF) Therapy\u2014A Systematic Approach to Identify and Characterize Data Sources. BMC Ophthalmol., 19.","DOI":"10.1186\/s12886-019-1208-9"},{"key":"ref_336","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1002\/adfm.200701233","article-title":"VEGF-Functionalized Polyelectrolyte Multilayers as Proangiogenic Prosthetic Coatings","volume":"18","author":"Koenig","year":"2008","journal-title":"Adv. Funct. Mater."},{"key":"ref_337","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.biomaterials.2004.02.057","article-title":"Effect of Functionalization of Multilayered Polyelectrolyte Films on Motoneuron Growth","volume":"26","author":"Schmittbuhl","year":"2005","journal-title":"Biomater."},{"key":"ref_338","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.ultrasmedbio.2012.08.025","article-title":"Enhancement Effect of Ultrasound-Induced Microbubble Cavitation on Branched Polyethylenimine-Mediated VEGF(165) Transfection with Varied N\/P Ratio","volume":"39","author":"Zhang","year":"2013","journal-title":"Ultrasound Med. Biol."},{"key":"ref_339","doi-asserted-by":"crossref","first-page":"6229","DOI":"10.1016\/j.biomaterials.2013.04.061","article-title":"Post-Translational Regulation of a Hypoxia-Responsive VEGF Plasmid for the Treatment of Myocardial Ischemia","volume":"34","author":"Won","year":"2013","journal-title":"Biomaterials"},{"key":"ref_340","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1021\/bm061211k","article-title":"Polyelectrolyte Complexes Stabilize and Controllably Release Vascular Endothelial Growth Factor","volume":"8","author":"Huang","year":"2007","journal-title":"Biomacromolecules"},{"key":"ref_341","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.ijpharm.2013.11.027","article-title":"Gene Delivery of PAMAM Dendrimer Conjugated with the Nuclear Localization Signal Peptide Originated from Fibroblast Growth Factor 3","volume":"459","author":"Lee","year":"2014","journal-title":"Int. J. Pharm."},{"key":"ref_342","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1055\/a-1488-6054","article-title":"Non-Viral Suicide Gene Therapy: Cytosine Deaminase Gene Directed by VEGF Promoter and 5-Fluorocytosine as a Gene Directed Enzyme\/Prodrug System in Breast Cancer Model","volume":"71","author":"Emamian","year":"2021","journal-title":"Drug Res."},{"key":"ref_343","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1158\/1535-7163.MCT-05-0161","article-title":"Vascular Endothelial Growth Factor Selectively Targets Boronated Dendrimers to Tumor Vasculature","volume":"4","author":"Backer","year":"2005","journal-title":"Mol. Cancer Ther."},{"key":"ref_344","doi-asserted-by":"crossref","first-page":"25087","DOI":"10.1021\/acsami.7b05519","article-title":"Efficient Encapsulation and Sustained Release of Basic Fibroblast Growth Factor in Nanofilm: Extension of the Feeding Cycle of Human Induced Pluripotent Stem Cell Culture","volume":"9","author":"Han","year":"2017","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_345","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1016\/j.progpolymsci.2014.02.008","article-title":"Chitin and Chitosan in Selected Biomedical Applications","volume":"39","author":"Anitha","year":"2014","journal-title":"Prog. Polym. Sci."},{"key":"ref_346","doi-asserted-by":"crossref","first-page":"6017","DOI":"10.1021\/cr030441b","article-title":"Chitosan Chemistry and Pharmaceutical Perspectives","volume":"104","author":"Kumar","year":"2004","journal-title":"Chem. Rev."},{"key":"ref_347","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.ijpharm.2009.04.048","article-title":"Heparin-Functionalized Chitosan\u2013Alginate Scaffolds for Controlled Release of Growth Factor","volume":"376","author":"Ho","year":"2009","journal-title":"Int. J. Pharm."},{"key":"ref_348","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1177\/0885328208090013","article-title":"RhBMP-2 Microspheres-Loaded Chitosan\/Collagen Scaffold Enhanced Osseointegration: An Experiment in Dog","volume":"23","author":"Shi","year":"2009","journal-title":"J. Biomater. Appl."},{"key":"ref_349","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.jconrel.2009.11.026","article-title":"Local Controlled Release of VEGF and PDGF from a Combined Brushite\u2013Chitosan System Enhances Bone Regeneration","volume":"143","author":"Reyes","year":"2010","journal-title":"J. Control. Release"},{"key":"ref_350","doi-asserted-by":"crossref","unstructured":"Ishihara, M., Kishimoto, S., Nakamura, S., Sato, Y., and Hattori, H. (2019). Polyelectrolyte Complexes of Natural Polymers and Their Biomedical Applications. Polymers, 11.","DOI":"10.3390\/polym11040672"},{"key":"ref_351","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1021\/bc049755b","article-title":"Bioactive Thin Film of Acidic Fibroblast Growth Factor Fabricated by Layer-by-Layer Assembly","volume":"16","author":"Mao","year":"2005","journal-title":"Bioconjug. Chem."},{"key":"ref_352","doi-asserted-by":"crossref","first-page":"S253","DOI":"10.33549\/physiolres.933427","article-title":"Protein Interactions with Quaternized Chitosan\/Heparin Multilayers","volume":"65","author":"Kumorek","year":"2016","journal-title":"Physiol. Res."},{"key":"ref_353","doi-asserted-by":"crossref","unstructured":"Kumorek, M., Kubies, D., Filov\u00e1, E., Houska, M., Kasoju, N., Ch\u00e1nov\u00e1, E.M., Mat\u011bjka, R., Kr\u00fdslov\u00e1, M., Ba\u010d\u00e1kov\u00e1, L., and Ryp\u00e1\u010dek, F. (2015). Cellular Responses Modulated by FGF-2 Adsorbed on Albumin\/Heparin Layer-by-Layer Assemblies. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0125484"},{"key":"ref_354","doi-asserted-by":"crossref","first-page":"2629","DOI":"10.1021\/bm1005799","article-title":"Polysaccharide-Based Polyelectrolyte Multilayer Surface Coatings Can Enhance Mesenchymal Stem Cell Response to Adsorbed Growth Factors","volume":"11","author":"Bacon","year":"2010","journal-title":"Biomacromolecules"},{"key":"ref_355","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1021\/bm9014649","article-title":"Layer-by-Layer Incorporation of Growth Factors in Decellularized Aortic Heart Valve Leaflets","volume":"11","author":"Vervaet","year":"2010","journal-title":"Biomacromolecules"},{"key":"ref_356","doi-asserted-by":"crossref","first-page":"3124","DOI":"10.1002\/bit.27466","article-title":"Biomimetic Surface Delivery of NGF and BDNF to Enhance Neurite Outgrowth","volume":"117","author":"Sandoval","year":"2020","journal-title":"Biotechnol. Bioeng."},{"key":"ref_357","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0168-3659(00)00296-0","article-title":"Controlled Release of Nerve Growth Factor from a Heparin-Containing Fibrin-Based Cell Ingrowth Matrix","volume":"69","author":"Hubbell","year":"2000","journal-title":"J. Control. Release"},{"key":"ref_358","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1021\/bm0505134","article-title":"Polyelectrolyte Multilayer Films as Substrates for Photoreceptor Cells","volume":"7","author":"Tezcaner","year":"2006","journal-title":"Biomacromolecules"},{"key":"ref_359","doi-asserted-by":"crossref","first-page":"9858","DOI":"10.1096\/fj.201802600RR","article-title":"Heparin-Poloxamer Hydrogel-Encapsulated RhFGF21 Enhances Wound Healing in Diabetic Mice","volume":"33","author":"Liu","year":"2019","journal-title":"FASEB J."},{"key":"ref_360","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1002\/jbm.a.10427","article-title":"Controlled Release of Fibroblast Growth Factors and Heparin from Photocrosslinked Chitosan Hydrogels and Subsequent Effect on in Vivo Vascularization","volume":"64","author":"Ishihara","year":"2003","journal-title":"J. Biomed. Mater. Res. A"},{"key":"ref_361","doi-asserted-by":"crossref","first-page":"3437","DOI":"10.1016\/S0142-9612(03)00220-5","article-title":"Photocrosslinkable Chitosan Hydrogel Containing Fibroblast Growth Factor-2 Stimulates Wound Healing in Healing-Impaired Db \/ Db Mice","volume":"24","author":"Obara","year":"2003","journal-title":"Biomaterials"},{"key":"ref_362","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.jconrel.2015.10.028","article-title":"Heparin Desulfation Modulates VEGF Release and Angiogenesis in Diabetic Wounds","volume":"220","author":"Freudenberg","year":"2015","journal-title":"J. Control. Release"},{"key":"ref_363","doi-asserted-by":"crossref","first-page":"6054","DOI":"10.1016\/j.biomaterials.2005.03.012","article-title":"Injectable Glycosaminoglycan Hydrogels for Controlled Release of Human Basic Fibroblast Growth Factor","volume":"26","author":"Cai","year":"2005","journal-title":"Biomaterials"},{"key":"ref_364","doi-asserted-by":"crossref","first-page":"9808","DOI":"10.1038\/s41598-021-89229-w","article-title":"Half-Life Modeling of Basic Fibroblast Growth Factor Released from Growth Factor-Eluting Polyelectrolyte Multilayers","volume":"11","author":"Ding","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_365","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.jconrel.2015.04.034","article-title":"Molecular Weight and Concentration of Heparin in Hyaluronic Acid-Based Matrices Modulates Growth Factor Retention Kinetics and Stem Cell Fate","volume":"209","author":"Jha","year":"2015","journal-title":"J. Control. Release"},{"key":"ref_366","doi-asserted-by":"crossref","first-page":"596","DOI":"10.3109\/10717544.2010.509357","article-title":"Hyaluronic Acid\/Chitosan Nanoparticles as Delivery Vehicles for VEGF and PDGF-BB","volume":"17","author":"Welle","year":"2010","journal-title":"Drug Deliv."},{"key":"ref_367","doi-asserted-by":"crossref","unstructured":"O\u2019Dwyer, J., Murphy, R., Gonz\u00e1lez-V\u00e1zquez, A., Kovarova, L., Pravda, M., Velebny, V., Heise, A., Duffy, G.P., and Cryan, S.A. (2021). Translational Studies on the Potential of a Vegf Nanoparticle-Loaded Hyaluronic Acid Hydrogel. Pharmaceutics, 13.","DOI":"10.3390\/pharmaceutics13060779"},{"key":"ref_368","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1002\/jbm.10238","article-title":"Hyaluronate-Heparin Conjugate Gels for the Delivery of Basic Fibroblast Growth Factor (FGF-2)","volume":"62","author":"Liu","year":"2002","journal-title":"J. Biomed. Mater. Res."},{"key":"ref_369","doi-asserted-by":"crossref","first-page":"016104","DOI":"10.1063\/5.0035291","article-title":"Injectable, Macroporous Scaffolds for Delivery of Therapeutic Genes to the Injured Spinal Cord Injectable, Macroporous Scaffolds for Delivery of Therapeutic Genes to the Injured Spinal Cord","volume":"5","author":"Ehsanipour","year":"2021","journal-title":"APL Bioeng."}],"container-title":["Biomolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2218-273X\/13\/4\/609\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T19:05:17Z","timestamp":1760123117000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2218-273X\/13\/4\/609"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,28]]},"references-count":369,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2023,4]]}},"alternative-id":["biom13040609"],"URL":"https:\/\/doi.org\/10.3390\/biom13040609","relation":{},"ISSN":["2218-273X"],"issn-type":[{"value":"2218-273X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,28]]}}}